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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2141
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp1
Name: aquaporin 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of AQP1 mRNAPMID:33387578
Aqp1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of AQP1 mRNAPMID:26232522 PMID:32109520 PMID:34747641
Aqp1affects expressionISOAqp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of AQP1 mRNAPMID:26377647
Aqp1decreases expressionISOAqp1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of AQP1 mRNAPMID:21354282 PMID:33956508
Aqp1multiple interactionsISOAqp1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of AQP1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of AQP1 mRNA]PMID:15667827 PMID:17942748
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