RGD Reference Report - Aquaporin-1 in the choroid plexuses of developing mammalian brain. - Rat Genome Database

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Aquaporin-1 in the choroid plexuses of developing mammalian brain.

Authors: Johansson, PA  Dziegielewska, KM  Ek, CJ  Habgood, MD  Mollgard, K  Potter, A  Schuliga, M  Saunders, NR 
Citation: Johansson PA, etal., Cell Tissue Res. 2005 Dec;322(3):353-64. Epub 2005 Aug 26.
RGD ID: 8553876
Pubmed: PMID:16133142   (View Abstract at PubMed)
DOI: DOI:10.1007/s00441-005-1120-x   (Journal Full-text)

The normal brain develops within a well-controlled stable internal "milieu" protected by specialised mechanisms referred to collectively as blood-brain barriers. A fundamental feature of this environment is the control of water flow in and out of the developing brain. Because of limited vascularisation of the immature brain, choroid plexuses, via the cerebrospinal fluid, have been proposed as the main route of fluid exchange between the blood and brain interfaces. We describe the temporal expression and appearance of aquaporin-1 (AQP1) which is important for water transfer across adult choroid plexuses. AQP1 expression was studied in rat embryos using real time reverse transcription/polymerase chain reaction. mRNA for AQP1 was present in rat brain at embryonic day 12 (E12) one day before the protein was detectable in the fourth ventricular choroid plexus (the first plexus to appear); its relative levels increased at E13-E14 when more AQP1-immunoreactive cells appeared in all plexuses. The presence of AQP1 was determined immunocytochemically in five different mammalian species (rat, mouse, human, sheep and opossum) in all four choroid plexuses from their earliest appearance. In all five species studied, the appearance of AQP1 immunoreactivity followed the same developmental sequence: the fourth, lateral and, finally, third ventricular choroid plexus. The stage of choroid plexus development when AQP1 was first detected in all five species and in all four choroid plexuses corresponded to the transition between Stages I and II. The cellular localisation of AQP1 in all choroid plexuses, as soon as it was detectable, had the characteristic apical membrane distribution previously described in the adult; a basolateral membrane localisation was also observed.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lateral ventricle development involved_inIEP 8553876PMID:16133142UniProt 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
apical plasma membrane located_inIDA 8553876PMID:16133142UniProt 
basolateral plasma membrane located_inIDA 8553876PMID:16133142UniProt 
brush border located_inIDA 8553876PMID:16133142UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Aqp1  (aquaporin 1)


Additional Information