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Gene: Shh (sonic hedgehog signaling molecule) Rattus norvegicus
Symbol: Shh
Name: sonic hedgehog signaling molecule
RGD ID: 3673
Description: Predicted to have several functions, including laminin-1 binding activity; metal ion binding activity; and patched binding activity. Involved in several processes, including animal organ development; negative regulation of cell death; and nervous system development. Localizes to several cellular components, including membrane raft; neuronal cell body; and synaptic vesicle. Used to study myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule); PARTICIPATES IN altered Hedgehog signaling pathway; forkhead class A signaling pathway; glypican signaling pathway; INTERACTS WITH (S)-amphetamine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol.
Type: protein-coding
Also known as: shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; sonic hedgehog; sonic hedgehog homolog; sonic hedgehog homolog (Drosophila); sonic hedgehog homolog, (Drosophila); sonic hedgehog protein
Homo sapiens (human) : SHH (sonic hedgehog signaling molecule)  HGNC  Alliance
Mus musculus (house mouse) : Shh (sonic hedgehog)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shh (sonic hedgehog signaling molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : SHH (sonic hedgehog signaling molecule)
Canis lupus familiaris (dog) : SHH (sonic hedgehog signaling molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shh (sonic hedgehog signaling molecule)
Sus scrofa (pig) : SHH (sonic hedgehog signaling molecule)
Chlorocebus sabaeus (African green monkey) : SHH (sonic hedgehog signaling molecule)
Heterocephalus glaber (naked mole-rat) : Shh (sonic hedgehog signaling molecule)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04718,538 - 727,691 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4718,538 - 727,691 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04711,420 - 720,573 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.442,200,504 - 2,209,657 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.142,200,503 - 2,209,657 (+)NCBI
Celera43,316,537 - 3,325,690 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Shh
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3673
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.