Cav1 (caveolin 1) - Rat Genome Database

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Gene: Cav1 (caveolin 1) Chinchilla lanigera
Symbol: Cav1
Name: caveolin 1
RGD ID: 9046719
Description: ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); angiotensin-activated signaling pathway involved in heart process (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acoustic neuroma (ortholog); Acute Lung Injury (ortholog); FOUND IN acrosomal membrane (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caveolin 1, caveolae protein, 22kDa; caveolin-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acoustic neuroma  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiomegaly  (ISO)
congenital generalized lipodystrophy type 3  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic neuropathy  (ISO)
diffuse scleroderma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial partial lipodystrophy  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
invasive ductal carcinoma  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
Lipodystrophy with Congenital Cataracts and Neurodegeneration  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
osteoarthritis  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary open angle glaucoma  (ISO)
primary pulmonary hypertension  (ISO)
Primary Pulmonary Hypertension, 3  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Sarcopenia  (ISO)
sciatic neuropathy  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
angiotensin-activated signaling pathway involved in heart process  (ISO)
animal organ regeneration  (ISO)
apoptotic signaling pathway  (ISO)
basement membrane organization  (ISO)
calcium ion homeostasis  (ISO)
calcium ion transport  (ISO)
caveola assembly  (ISO)
caveolin-mediated endocytosis  (ISO)
cell population proliferation  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to exogenous dsRNA  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular senescence  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (ISO)
cytokine-mediated signaling pathway  (ISO)
endothelial cell proliferation  (ISO)
establishment of localization in cell  (ISO)
fibroblast proliferation  (ISO)
glandular epithelial cell differentiation  (ISO)
insulin receptor internalization  (ISO)
lactation  (ISO)
lipid storage  (ISO)
maintenance of protein location in cell  (ISO)
mammary gland development  (ISO)
mammary gland involution  (ISO)
MAPK cascade  (ISO)
membrane depolarization  (ISO)
microtubule polymerization  (ISO)
muscle cell cellular homeostasis  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion import across plasma membrane  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cation channel activity  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of inward rectifier potassium channel activity  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-tyrosine autophosphorylation  (ISO)
negative regulation of pinocytosis  (ISO)
negative regulation of potassium ion transmembrane transport  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein tyrosine kinase activity  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide homeostasis  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell adhesion molecule production  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ER-associated ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (ISO)
positive regulation of vasoconstriction  (ISO)
post-transcriptional regulation of gene expression  (ISO)
protein localization  (ISO)
protein localization to basolateral plasma membrane  (ISO)
protein localization to plasma membrane raft  (ISO)
protein transport  (ISO)
receptor internalization  (ISO)
receptor internalization involved in canonical Wnt signaling pathway  (ISO)
receptor-mediated endocytosis of virus by host cell  (ISO)
regulation of blood coagulation  (ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (ISO)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of entry of bacterium into host cell  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane repolarization during action potential  (ISO)
regulation of peptidase activity  (ISO)
regulation of ruffle assembly  (ISO)
regulation of smooth muscle contraction  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by chemical signal  (ISO)
regulation of ventricular cardiac muscle cell action potential  (ISO)
response to bacterium  (ISO)
response to calcium ion  (ISO)
response to estrogen  (ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle tissue development  (ISO)
T cell costimulation  (ISO)
triglyceride metabolic process  (ISO)
tyrosine phosphorylation of STAT protein  (ISO)
vasculogenesis  (ISO)
vasoconstriction  (ISO)
vesicle organization  (ISO)
wound healing  (ISO)


References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline


Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBI
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
T2T-CHM13v2.07117,840,041 - 117,876,175 (+)NCBI
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39617,306,287 - 17,341,327 (+)NCBIGRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBImm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)Ensembl
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q21NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBI
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBI
ROS_Cfam_1.0 Ensembl1455,503,040 - 55,536,538 (+)Ensembl
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBI
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBI
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBI
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12185,222,724 - 85,258,562 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248272,844,115 - 2,879,179 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBIHetGla_female_1.0hetGla2



Reference Sequences
RefSeq Acc Id: ENSCLAT00000007780   ⟹   ENSCLAP00000007661
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)Ensembl
RefSeq Acc Id: XM_005388120   ⟹   XP_005388177
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005388177 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005388177   ⟸   XM_005388120
- Sequence:
RefSeq Acc Id: ENSCLAP00000007661   ⟸   ENSCLAT00000007780

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000007661 ENTREZGENE
  ENSCLAP00000007661.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007780 ENTREZGENE
  ENSCLAT00000007780.1 UniProtKB/TrEMBL
InterPro CAV-1 UniProtKB/TrEMBL
  Caveolin UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/TrEMBL
  PTHR10844:SF18 UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Cav1  caveolin 1    caveolin 1, caveolae protein, 22kDa  Symbol and/or name change 5135510 APPROVED