Cav1 (caveolin 1) - Rat Genome Database

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Gene: Cav1 (caveolin 1) Ictidomys tridecemlineatus
Analyze
Symbol: Cav1
Name: caveolin 1
RGD ID: 12588602
Description: ENCODES a protein that exhibits kinase binding (ortholog); nitric-oxide synthase binding (ortholog); receptor serine/threonine kinase binding (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ regeneration (ortholog); basement membrane organization (ortholog); PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acoustic neuroma (ortholog); Acute Lung Injury (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caveolin 1, transcript variant X1; caveolin 1, transcript variant X2; caveolin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,504,224 - 2,537,170 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acoustic neuroma  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
basal cell carcinoma  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiomegaly  (ISO)
congenital generalized lipodystrophy type 3  (ISO)
cystic fibrosis  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diffuse scleroderma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial partial lipodystrophy  (ISO)
Familial Partial Lipodystrophy Type 7  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (ISO)
invasive ductal carcinoma  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
osteoarthritis  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary open angle glaucoma  (ISO)
primary pulmonary hypertension  (ISO)
primary pulmonary hypertension 3  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Sarcopenia  (ISO)
sciatic neuropathy  (ISO)
silicosis  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiotensin-activated signaling pathway  (IEA)
animal organ regeneration  (ISO)
apoptotic signaling pathway  (IEA)
basement membrane organization  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
calcium ion transport  (IEA,ISO)
canonical Wnt signaling pathway  (IEA)
caveola assembly  (IEA,ISO)
caveolin-mediated endocytosis  (IEA,ISO)
cell differentiation  (IEA)
cell population proliferation  (IEA,ISO)
cellular response to exogenous dsRNA  (IEA)
cellular response to hyperoxia  (IEA)
cellular response to hypoxia  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to misfolded protein  (IEA)
cellular response to peptide hormone stimulus  (IEA)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular senescence  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (IEA,ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glandular epithelial cell differentiation  (IEA,ISO)
insulin receptor internalization  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular nitric oxide homeostasis  (IEA,ISO)
lactation  (IEA,ISO)
lipid storage  (IEA,ISO)
maintenance of protein location in cell  (ISO)
mammary gland development  (IEA,ISO)
mammary gland involution  (IEA,ISO)
MAPK cascade  (IEA,ISO)
membrane depolarization  (IEA,ISO)
microtubule polymerization  (ISO)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of anoikis  (IEA)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of calcium ion import across plasma membrane  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cation channel activity  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cytokine-mediated signaling pathway  (IEA,ISO)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of inward rectifier potassium channel activity  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of necroptotic process  (IEA)
negative regulation of neuron differentiation  (ISO)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of pinocytosis  (IEA)
negative regulation of potassium ion transmembrane transport  (IEA)
negative regulation of protein ubiquitination  (IEA)
negative regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
negative regulation of signal transduction  (IEA,ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of calcium ion transport into cytosol  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of cell adhesion molecule production  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cholesterol efflux  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of endocytosis  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERAD pathway  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of gap junction assembly  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (IEA)
positive regulation of microtubule polymerization  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA)
positive regulation of signal transduction  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (IEA)
positive regulation of vasoconstriction  (IEA,ISO)
post-transcriptional regulation of gene expression  (IEA)
protein localization  (IEA,ISO)
protein localization to basolateral plasma membrane  (ISO)
protein localization to plasma membrane raft  (ISO)
protein transport  (IEA,ISO)
receptor internalization  (IEA)
receptor-mediated endocytosis of virus by host cell  (IEA)
regulation of blood coagulation  (IEA)
regulation of cell communication by electrical coupling involved in cardiac conduction  (IEA)
regulation of cytosolic calcium ion concentration  (IEA)
regulation of entry of bacterium into host cell  (IEA)
regulation of fatty acid metabolic process  (IEA,ISO)
regulation of heart rate by cardiac conduction  (IEA)
regulation of membrane repolarization during action potential  (IEA)
regulation of peptidase activity  (ISO)
regulation of ruffle assembly  (IEA)
regulation of smooth muscle contraction  (IEA,ISO)
regulation of the force of heart contraction  (IEA,ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA)
response to bacterium  (IEA)
response to calcium ion  (IEA)
response to estrogen  (IEA,ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (IEA,ISO)
response to ischemia  (IEA,ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to progesterone  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle tissue development  (IEA,ISO)
T cell costimulation  (IEA)
triglyceride metabolic process  (IEA,ISO)
tyrosine phosphorylation of STAT protein  (ISO)
vasculogenesis  (IEA,ISO)
vasoconstriction  (IEA,ISO)
vesicle organization  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,504,224 - 2,537,170 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
T2T-CHM13v2.07117,840,041 - 117,876,175 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
Cav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,306,387 - 17,341,323 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)EnsemblGRCm39 Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBIMGSCv36mm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.73NCBI
Cav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,606,538 - 46,639,616 (+)NCBIGRCr8
mRatBN7.2445,640,624 - 45,673,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,634,918 - 45,673,705 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx450,634,317 - 50,667,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,555,310 - 46,588,376 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,969,814 - 45,002,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q22NCBI
Cav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
CAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26153,356,633 - 153,393,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan175,367,106 - 5,403,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
CAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1455,503,040 - 55,536,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBIUU_Cfam_GSD_1.0
CAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,222,724 - 85,258,562 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248272,844,115 - 2,879,179 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000027493   ⟹   ENSSTOP00000015394
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365892,504,224 - 2,537,170 (-)Ensembl
RefSeq Acc Id: XM_005332279   ⟹   XP_005332336
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBI
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021731028   ⟹   XP_021586703
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511844,153,775 - 44,185,619 (+)NCBI
SpeTri2.0NW_0049365892,504,235 - 2,535,981 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005332336 (Get FASTA)   NCBI Sequence Viewer  
  XP_021586703 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015394.1
GenBank Protein KAG3277687 (Get FASTA)   NCBI Sequence Viewer  
  KAG3277688 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005332336   ⟸   XM_005332279
- Peptide Label: isoform X1
- UniProtKB: I3MTE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021586703   ⟸   XM_021731028
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSSTOP00000015394   ⟸   ENSSTOT00000027493


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000029133 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027493.2 UniProtKB/TrEMBL
InterPro Caveolin UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/TrEMBL
NCBI Gene Cav1 ENTREZGENE
PANTHER PTHR10844 UniProtKB/TrEMBL
  PTHR10844:SF18 UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/TrEMBL
PROSITE CAVEOLIN UniProtKB/TrEMBL
UniProt I3MTE9 ENTREZGENE, UniProtKB/TrEMBL