Ldlr (low density lipoprotein receptor) - Rat Genome Database

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Gene: Ldlr (low density lipoprotein receptor) Rattus norvegicus
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Symbol: Ldlr
Name: low density lipoprotein receptor
RGD ID: 2998
Description: Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor); PARTICIPATES IN atherosclerosis pathway; bile acid transport pathway; endocytosis pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LDL receptor; LDLRA; low-density lipoprotein receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ldlrem4Mcwi   Ldlrem3Mcwi   Ldlrem1Mcwi   Ldlrem2Mcwi   Ldlrem1Sage   Ldlrem1   Ldlrem1Dlli  
Genetic Models: SD-Ldlrem1 SD-Ldlrem1Dlli SD-Ldlrem1Sage SS-Ldlrem3Mcwi SS-Ldlrem4Mcwi SS-Ldlrem1Mcwi SS-Ldlrem2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2820,270,020 - 20,292,981 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl820,270,041 - 20,294,580 (+)Ensembl
Rnor_6.0822,750,425 - 22,773,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,750,336 - 22,774,903 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,804,325 - 22,827,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,824,040 - 20,846,920 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,824,039 - 20,846,920 (+)NCBI
Celera821,660,761 - 21,683,616 (+)NCBICelera
RH 3.4 Map8178.16RGD
RH 3.4 Map8178.16RGD
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model