Ldlr (low density lipoprotein receptor)

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Gene: Ldlr (low density lipoprotein receptor) Rattus norvegicus

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Symbol:

Ldlr

Name:

low density lipoprotein receptor

Description:

ENCODES a protein that exhibits low-density lipoprotein particle receptor activity; amyloid-beta binding (ortholog); identical protein binding (ortholog); INVOLVED IN aging; endocytosis; positive regulation of triglyceride catabolic process; PARTICIPATES IN atherosclerosis pathway; bile acid transport pathway; endocytosis pathway; ASSOCIATED WITH increased liver free fatty acids level; ASSOCIATED WITH atherosclerosis; Diabetes Mellitus, Experimental ; Hypercholesterolemia; FOUND IN caveola; plasma membrane; recycling endosome membrane; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

LDL receptor; LDLRA; low-density lipoprotein receptor

Orthologs:

Homo sapiens (human) : LDLR (low density lipoprotein receptor) HGNC Alliance
Mus musculus (house mouse) : Ldlr (low density lipoprotein receptor) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ldlr (low density lipoprotein receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LDLR (low density lipoprotein receptor)
Canis lupus familiaris (dog) : LDLR (low density lipoprotein receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ldlr (low density lipoprotein receptor)
Sus scrofa (pig) : LDLR (low density lipoprotein receptor)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LDLR (low density lipoprotein receptor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ldlr (low density lipoprotein receptor)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Ldlr (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ldlr (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	VLDLR (very low density lipoprotein receptor)	HGNC	OrthoMCL
Homo sapiens (human):	LRP8 (LDL receptor related protein 8)	HGNC	OrthoMCL
Alliance orthologs ³
Mus musculus (house mouse):	Ldlr (low density lipoprotein receptor)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):	LDLR (low density lipoprotein receptor)	Alliance	DIOPT (HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):	ldlra (low density lipoprotein receptor a)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):	T13C2.6 (null)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):	LpR1 (null)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB)
Drosophila melanogaster (fruit fly):	LpR2 (null)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB)

Allele / Splice:

Ldlr^em4Mcwi Ldlr^em3Mcwi Ldlr^em1Mcwi Ldlr^em2Mcwi Ldlr^em1Sage Ldlr^em1

Genetic Models:

SD-Ldlr^em1 SD-Ldlr^em1Sage SS-Ldlr^em2Mcwi SS-Ldlr^em4Mcwi SS-Ldlr^em1Mcwi SS-Ldlr^em3Mcwi

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	8	22,750,425 - 22,773,305 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	22,804,325 - 22,827,199 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	20,824,040 - 20,846,920 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	20,824,039 - 20,846,920 (+)	NCBI
Celera	8	21,660,761 - 21,683,616 (+)	NCBI		Celera
Cytogenetic Map	8	q13	NCBI
RH 3.4 Map	8	178.16	RGD
RH 3.4 Map	8	178.16	RGD

JBrowse:

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Model

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Disease Annotations

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Phenotype Annotations

References - curated

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble for Mouse Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble for Mouse Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

RGD Manual Annotations

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - Genetic Association Database

Imported Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)