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Gene: Ldlr (low density lipoprotein receptor) Rattus norvegicus
Symbol: Ldlr
Name: low density lipoprotein receptor
RGD ID: 2998
Description: Exhibits low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Localizes to caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor); PARTICIPATES IN atherosclerosis pathway; bile acid transport pathway; endocytosis pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: LDL receptor; LDLRA; low-density lipoprotein receptor
Homo sapiens (human) : LDLR (low density lipoprotein receptor)  HGNC  Alliance
Mus musculus (house mouse) : Ldlr (low density lipoprotein receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ldlr (low density lipoprotein receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LDLR (low density lipoprotein receptor)
Canis lupus familiaris (dog) : LDLR (low density lipoprotein receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ldlr (low density lipoprotein receptor)
Sus scrofa (pig) : LDLR (low density lipoprotein receptor)
Chlorocebus sabaeus (African green monkey) : LDLR (low density lipoprotein receptor)
Heterocephalus glaber (naked mole-rat) : Ldlr (low density lipoprotein receptor)
more info ...
Allele / Splice: Ldlrem4Mcwi   Ldlrem3Mcwi   Ldlrem1Mcwi   Ldlrem2Mcwi   Ldlrem1Sage   Ldlrem1  
Genetic Models: SD-Ldlrem1 SD-Ldlrem1Sage SS-Ldlrem2Mcwi SS-Ldlrem4Mcwi SS-Ldlrem1Mcwi SS-Ldlrem3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0822,750,425 - 22,773,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,750,336 - 22,774,903 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,804,325 - 22,827,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,824,040 - 20,846,920 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,824,039 - 20,846,920 (+)NCBI
Celera821,660,761 - 21,683,616 (+)NCBICelera
Cytogenetic Map8q13NCBI
RH 3.4 Map8178.16RGD
RH 3.4 Map8178.16RGD
JBrowse: View Region in Genome Browser (JBrowse)