Ldlr (low density lipoprotein receptor)

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Gene: Ldlr (low density lipoprotein receptor) Rattus norvegicus

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Symbol:

Ldlr

Name:

low density lipoprotein receptor

RGD ID:

2998

Description:

Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor); PARTICIPATES IN atherosclerosis pathway; bile acid transport pathway; endocytosis pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

LDL receptor; LDLRA; low-density lipoprotein receptor

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LDLR (low density lipoprotein receptor)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ldlr (low density lipoprotein receptor)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Ldlr (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ldlr (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LDLR (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ldlr (low density lipoprotein receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ldlr (low density lipoprotein receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	LDLR (low density lipoprotein receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	ldlra (low density lipoprotein receptor a)	Alliance	DIOPT (OMA\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	T13C2.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	LpR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	LpR2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Allele / Splice:

Ldlr^em4Mcwi Ldlr^em3Mcwi Ldlr^em1Mcwi Ldlr^em2Mcwi Ldlr^em1Sage Ldlr^em1 Ldlr^em1Dlli

Genetic Models:

SD-Ldlr^em1 SD-Ldlr^em1Dlli SD-Ldlr^em1Sage SS-Ldlr^em3Mcwi SS-Ldlr^em4Mcwi SS-Ldlr^em1Mcwi SS-Ldlr^em2Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	20,270,020 - 20,292,981 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	8	20,270,041 - 20,294,580 (+)	Ensembl
Rnor_6.0	8	22,750,425 - 22,773,305 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	22,750,336 - 22,774,903 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	22,804,325 - 22,827,199 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	20,824,040 - 20,846,920 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	20,824,039 - 20,846,920 (+)	NCBI
Celera	8	21,660,761 - 21,683,616 (+)	NCBI		Celera
RH 3.4 Map	8	178.16	RGD
RH 3.4 Map	8	178.16	RGD
Cytogenetic Map	8	q13	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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