Strain Report - Rat Genome Database

Name: SD- Ldlr em1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Ldlr^em1

Symbol:

SD-Ldlr^em1

Strain:

SD-Ldlr^em1

RGD ID:

12910101

Citation ID:

RRID:RGD_12910101

Ontology ID:

RS:0004461

Alleles:

Ldlr^em1

Previously known as:

SD-Ldlrem1

Type:

mutant

Source:

Not Available

Origin:

This model possesses a 19-bp deletion in the seventh exon of the ldlr gene by ZFN method.

Genetic Status:

Homozygous

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	20,270,020 - 20,292,981	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	8	22,750,425 - 22,773,305	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	8	22,804,325 - 22,827,199	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	8	20,824,040 - 20,846,920	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Dyslipidemias (IMP)

Hypercholesterolemia (IMP)

Hypertriglyceridemia (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased liver free fatty acids level (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

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Clinical Measurement

plasma high density lipoprotein cholesterol level

plasma low density lipoprotein cholesterol level

plasma very low density lipoprotein cholesterol level

References

References - curated

#	Reference Title	Reference Citation
1.	A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model.	Wang HY, etal., Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802.

Region

Rat Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type
Ldlrem1-var1	chr8	20283596	20283614	TGGTGGACGGCCACCAGTG	-	deletion
Ldlrem1-var1	chr8	22763920	22763938	TGGTGGACGGCCACCAGTG	-	deletion

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Ldlrem1

Related Phenotype Data for Term "SD-Ldlrem1" (RS:0004461)

Strain: SD-Ldlr^em1