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Strain: SD-Ldlrem1Sage

Symbol: SD-Ldlrem1Sage
Strain: SD-Ldlrem1
Substrain: Sage
RGD ID: 12904908
Citation ID: RRID:RGD_12904908
Ontology ID: RS:0004448
Alleles: Ldlrem1Sage
Previously known as: TGRS4060 ; SD- Ldlr tm1sage; Ldlr Knockout Rat ; SD-Ldlrem1Sage
Type: mutant
Source: Horizon Discovery
Origin: In this ZFN induced model, a total of 337 bp were deleted at the junction of intron 3 and exon 4 (on chromosome 8), and 4 bp ccgt were inserted rat Ldlr gene on chromosome 8. Homozygous knockout rats display loss of LDLR protein via Western blot. Homozygous knockout rats have increased body weight as compared to wild type. Homozygous knockout rats show significantly elevated serum cholesterol levels.
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-24)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,270,020 - 20,292,981RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0822,750,425 - 22,773,305RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0822,804,325 - 22,827,199RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4820,824,040 - 20,846,920RGD_MAPPER_PIPELINERGSC3.4





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References

References - curated
# Reference Title Reference Citation
1. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
2. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442.

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