Strain: SD-Ldlrem1Sage

Symbol: SD-Ldlrem1Sage
Strain: SD-Ldlrem1
Substrain: Sage
Ontology ID: RS:0004448
Alleles: Ldlrem1Sage
Also known as: TGRS4060 ; SD- Ldlr tm1sage; Ldlr Knockout Rat
Type: mutant
Source: Horizon Discovery
Origin: This ZFN induced model possesses a total of 337 bp were deleted at the junction of intron 3 and exon 4 (on chromosome 8), and 4 bp ccgt were inserted rat Ldlr gene on chromosome 8. Homozygous knockout rats display loss of LDLR protein via Western blot . Homozygous knockout rats have increased body weight as compared to wild type. Homozygous knockout rats show significantly elevated serum cholesterol levels
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-24)
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0822,750,425 - 22,773,305RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0822,804,325 - 22,827,199RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4820,824,040 - 20,846,920RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations
Phenotype Annotations
Experimental Data Annotations
References - curated
RGD Disease Portals


Additional Information

More on this Strain
Strain Nomenclature
Strain Registration

RGD Object Information
RGD ID: 12904908
Created: 2017-05-24
Species: Rattus norvegicus
Last Modified: 2017-05-24
Status: ACTIVE