GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ldlr | decreases activity | EXP | | 6480464 | CTD | Cholesterol results in decreased activity of LDLR protein | PMID:16271152 PMID:16317514 PMID:16937255 | Ldlr | decreases expression | EXP | | 6480464 | CTD | Cholesterol results in decreased expression of LDLR mRNA | PMID:16271152 PMID:16317514 PMID:16937255 PMID:21535835 | Ldlr | multiple interactions | EXP | | 6480464 | CTD | [Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA; [Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; [turmeric extract co-treated with Cholesterol] results in increased expression of LDLR mRNA; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]; Selenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]; Selenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]; turmeric extract inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA] | PMID:16937255 PMID:20578043 PMID:21535835 PMID:30273964 | Ldlr | affects abundance | ISO | Ldlr (Mus musculus) | 6480464 | CTD | LDLR protein affects the abundance of Cholesterol | PMID:30950489 | Ldlr | increases response to substance | ISO | Ldlr (Mus musculus) | 6480464 | CTD | LDLR gene mutant form results in increased susceptibility to Cholesterol | PMID:25263595 | Ldlr | increases uptake | ISO | LDLR (Homo sapiens) | 6480464 | CTD | LDLR protein results in increased uptake of Cholesterol | PMID:16477808 | Ldlr | multiple interactions | ISO | Ldlr (Mus musculus) | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [LDLR gene mutant form results in increased susceptibility to Cholesterol]; [LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol; [Tobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]] which results in increased abundance of Cholesterol; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]; SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol] | PMID:22659316 PMID:22841818 PMID:25263595 PMID:30950489 | Ldlr | multiple interactions | ISO | LDLR (Homo sapiens) | 6480464 | CTD | [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]; LDLR gene mutant form results in increased susceptibility to [25-hydroxycholesterol co-treated with Cholesterol] | PMID:12477733 PMID:16477808 | | ||||||||||||||||||||||
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