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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2998
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:17737
Term: desmosterol
Definition: A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.
Chemical ID: MESH:D003897
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlrdecreases expressionISOLdlr (Mus musculus)6480464CTDDesmosterol results in decreased expression of LDLR proteinPMID:19260826
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