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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2998
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:28667
Term: 11-dehydro-thromboxane B2
Definition: A thromboxane obtained by formal oxidation of the hemiacetal hydroxy function of thromboxane B2.
Chemical ID: MESH:C049235
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlrmultiple interactionsISOLDLR (Homo sapiens)6480464CTDAspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; dazoxiben inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]; tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]PMID:20530721
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