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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2998
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:36904
Term: elemental selenium
Definition: null
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlrdecreases activityEXP 6480464CTDSelenium deficiency results in decreased activity of LDLR proteinPMID:16317514
Ldlrdecreases expressionEXP 6480464CTDSelenium deficiency results in decreased expression of LDLR mRNAPMID:16317514
Ldlrincreases activityEXP 6480464CTDSelenium results in increased activity of LDLR proteinPMID:16271152
Ldlrincreases expressionEXP 6480464CTDSelenium results in increased expression of LDLR mRNAPMID:16271152
Ldlrmultiple interactionsEXP 6480464CTDSelenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]; Selenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]PMID:16937255
Ldlrmultiple interactionsISOLdlr (Mus musculus)6480464CTD[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of LDLR mRNA]PMID:36464106
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