Ldlr (low density lipoprotein receptor) - Rat Genome Database

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Gene: Ldlr (low density lipoprotein receptor) Mus musculus
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Symbol: Ldlr
Name: low density lipoprotein receptor
RGD ID: 10864
MGI Page MGI
Description: Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including endocytosis; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and paravertebral ganglion. Used to study familial hypercholesterolemia and steatotic liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hlb301; LDL receptor; low-density lipoprotein receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,634,872 - 21,661,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,634,779 - 21,661,215 (+)EnsemblGRCm39 Ensembl
GRCm38921,723,576 - 21,749,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,723,483 - 21,749,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,528,038 - 21,554,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,474,180 - 21,498,819 (+)NCBIMGSCv36mm8
Celera918,993,187 - 19,019,513 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alcoholic Fatty Liver  (IEP)
alpha-mannosidosis  (ISO)
Alzheimer's disease  (IMP,ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Toxoplasmosis  (IMP)
aortic atherosclerosis  (ISO)
aortic dissection  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (IMP,ISO)
carotid artery dissection  (ISO)
Carotid Artery Dissection, Internal  (ISO)
carotid artery occlusion  (ISO)
Charcot-Marie-Tooth disease dominant intermediate B  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Dyslipidemias  (ISO)
episodic ataxia type 2  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (IAGP,ISO)
Familial Hypercholesterolemia due to Ligand-Defective Apolipoprotein B  (ISO)
familial hyperlipidemia  (ISO)
genetic disease  (ISO)
glutaric acidemia I  (ISO)
hepatitis C  (ISO)
Hepatomegaly  (ISO)
Hypercholesterolemia  (IEP,ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
Hyperplasia  (ISO)
Hypertriglyceridemia  (ISO)
kidney disease  (IEP)
liver cirrhosis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP)
migraine without aura  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
Q fever  (ISO)
Reperfusion Injury  (ISO)
Smith-Lemli-Opitz syndrome  (ISO)
steatotic liver disease  (IAGP,ISO)
Stroke  (ISO)
syndromic X-linked intellectual disability Najm type  (ISO)
systemic lupus erythematosus  (ISO)
xanthomatosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-isolariciresinol  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
11-dehydro-thromboxane B2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (EXP)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (EXP,ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphotericin B  (EXP)
ampicillin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (EXP,ISO)
Archazolid B  (ISO)
argatroban  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
aucubin  (EXP)
avobenzone  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
bathocuproine disulfonic acid  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbamazepine  (EXP,ISO)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (EXP)
chloroquine  (EXP)
chlorpromazine  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
colesevelam hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP)
DDE  (ISO)
deoxycholic acid  (ISO)
desmosterol  (EXP)
desogestrel  (ISO)
dexamethasone  (ISO)
Di-n-hexyl phthalate  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ezetimibe  (ISO)
fenthion  (EXP)
flufenamic acid  (ISO)
fluoranthene  (EXP)
flusilazole  (EXP)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
Ganoderic acid A  (EXP,ISO)
gedunin  (ISO)
genistein  (EXP)
geraniol  (EXP)
Ginsenoside Rh4  (EXP)
glucose  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (EXP)
GW 3965  (ISO)
haloperidol  (ISO)
hexaconazole  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
indometacin  (EXP,ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP)
lovastatin  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
metronidazole  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitogen  (EXP)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP)
N-desethylamiodarone  (ISO)
nefazodone  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
oleic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
Phenelzine  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
proanthocyanidin  (ISO)
progesterone  (EXP,ISO)
propamocarb  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
puromycin  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
rebaudioside A  (EXP)
resveratrol  (ISO)
rifampicin  (EXP)
risperidone  (EXP)
rotenone  (ISO)
rottlerin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP)
sucrose  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (ISO)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IGI)
amyloid-beta clearance by cellular catabolic process  (IDA)
artery morphogenesis  (IMP)
cellular response to fatty acid  (IGI)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cholesterol homeostasis  (IBA,IGI,IMP,ISO)
cholesterol import  (IMP,ISO)
cholesterol metabolic process  (IMP)
cholesterol transport  (IMP,ISO)
endocytosis  (ISO)
establishment of localization in cell  (IMP)
high-density lipoprotein particle clearance  (IGI)
intestinal cholesterol absorption  (ISO)
lipid metabolic process  (IGI)
lipid transport  (IEA)
lipoprotein catabolic process  (IDA,IMP)
lipoprotein metabolic process  (IGI)
long-term memory  (IGI,ISO)
low-density lipoprotein particle clearance  (IDA,IMP,ISO)
negative regulation of amyloid fibril formation  (IGI)
negative regulation of astrocyte activation  (IGI)
negative regulation of gene expression  (IMP)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of microglial cell activation  (IGI)
negative regulation of protein metabolic process  (IDA)
negative regulation of receptor recycling  (ISO)
phagocytosis  (IDA)
phospholipid transport  (IMP)
plasma lipoprotein particle clearance  (IDA)
positive regulation of gene expression  (IGI,IMP)
positive regulation of inflammatory response  (IGI)
positive regulation of lysosomal protein catabolic process  (IDA)
positive regulation of triglyceride biosynthetic process  (IMP)
positive regulation of triglyceride catabolic process  (ISO)
receptor-mediated endocytosis  (IDA)
receptor-mediated endocytosis involved in cholesterol transport  (IBA,ISO)
regulation of cholesterol metabolic process  (IGI)
regulation of phosphatidylcholine catabolic process  (IMP)
regulation of protein metabolic process  (IGI,ISO)
response to caloric restriction  (IGI,ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to glucagon  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
steroid metabolic process  (IEA)
transcytosis  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abdominal aorta aneurysm  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal gland zona fasciculata morphology  (IAGP)
abnormal aorta bulb morphology  (IAGP)
abnormal aorta elastic fiber morphology  (IAGP)
abnormal aorta elastic tissue morphology  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal arteriole morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal ascending aorta morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal auditory brainstem response  (IEA)
abnormal beige fat cell morphology  (IAGP)
abnormal bile secretion  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal brain morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cellular extravasation  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cholesterol homeostasis  (IAGP)
abnormal cholesterol level  (IAGP)
abnormal choriocapillaris morphology  (IAGP)
abnormal circulating amino acid level  (IAGP)
abnormal circulating apolipoprotein E level  (IAGP)
abnormal circulating apolipoprotein level  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating LDL cholesterol level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal circulating VLDL cholesterol level  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal fasting circulating glucose level  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal feces composition  (IAGP)
abnormal food intake  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart ventricles weight  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal long-term spatial reference memory  (IAGP)
abnormal macrophage derived foam cell morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal Purkinje cell axon morphology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal response to new environment  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal short-term spatial reference memory  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal ST segment  (IAGP)
abnormal sterol level  (IAGP)
abnormal susceptibility to atherosclerosis  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic bouton morphology  (IAGP)
abnormal thrombosis  (IAGP)
abnormal triglyceride level  (IAGP)
abnormal uterine fat pad morphology  (IAGP)
alopecia  (IAGP)
amyloid beta deposits  (IAGP)
amyloidosis  (IAGP)
aortic aneurysm  (IAGP)
aortic valve stenosis  (IAGP)
aortitis  (IAGP)
arteriosclerosis  (IAGP)
artery occlusion  (IAGP)
atherosclerotic lesions  (IAGP)
blood vessel inflammation  (IAGP)
calcified aortic valve  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
decreased anxiety-related response  (IAGP)
decreased aorta wall thickness  (IAGP)
decreased body weight  (IAGP)
decreased brain cholesterol level  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased cholesterol level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-10 level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating troponin level  (IAGP)
decreased circulating unsaturated transferrin level  (IEA)
decreased circulating VLDL cholesterol level  (IAGP)
decreased circulating VLDL triglyceride level  (IAGP)
decreased corpus callosum size  (IAGP)
decreased IgG level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased lean body mass  (IAGP)
decreased lipoprotein lipase activity  (IAGP)
decreased liver cholesterol level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased locomotor activity  (IEA)
decreased macrophage apoptosis  (IAGP)
decreased macrophage cell number  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased partial thromboplastin time  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased prothrombin time  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to hyperlipidemia  (IAGP)
decreased susceptibility to induced aneurysm formation  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased total body fat amount  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
dilated aorta  (IAGP)
dry eyes  (IAGP)
gallstones  (IEA)
heart left ventricle hypertrophy  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
hyperlipidemia  (IAGP)
hypertension  (IAGP)
impaired glucose tolerance  (IAGP)
impaired leukocyte tethering or rolling  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired macrophage phagocytosis  (IAGP)
improved glucose tolerance  (IAGP)
increased aorta wall thickness  (IAGP)
increased apoptosis  (IAGP)
increased body weight  (IAGP)
increased cardiac output  (IAGP)
increased cardiac stroke volume  (IAGP)
increased cholesterol level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating antithrombin level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating factor VIII level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating iron level  (IEA)
increased circulating LDL cholesterol level  (IAGP)
increased circulating prothrombin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased circulating VLDL triglyceride level  (IAGP)
increased circulating von Willebrand factor level  (IAGP)
increased food intake  (IAGP)
increased grip strength  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgM level  (IAGP)
increased leukocyte cell number  (IAGP)
increased liver cholesterol level  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased locomotor activity  (IAGP)
increased lymphocyte cell number  (IAGP)
increased macrophage derived foam cell number  (IEA)
increased mean corpuscular volume  (IEA)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased pruritus  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to diet-induced aortic fatty streak lesions  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased T cell number  (IAGP)
increased total body fat amount  (IAGP)
increased vascular smooth muscle cell proliferation  (IAGP)
insulin resistance  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
maternal effect  (IAGP)
Meibomian gland atrophy  (IAGP)
microvesicular hepatic steatosis  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
oxidative stress  (IAGP)
photoreceptor outer segment degeneration  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
retina detachment  (IEA)
scaly skin  (IAGP)
skin edema  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small aortic valve  (IAGP)
spontaneous skin ulceration  (IAGP)
thick dermal layer  (IAGP)
thick skin  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
xanthoma  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Abifadel M, etal., Nat Genet. 2003 Jun;34(2):154-6.
2. Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats. Asahina M, etal., Biochem Biophys Res Commun. 2012 Feb 17;418(3):553-8. doi: 10.1016/j.bbrc.2012.01.067. Epub 2012 Jan 24.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Bertram L, etal., Neurobiol Aging. 2007 Jan;28(1):18.e1-4. Epub 2005 Dec 27.
5. Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease. Cheng D, etal., J Med Genet. 2005 Feb;42(2):129-31.
6. Low-density lipoprotein receptor structure and folding. Gent J and Braakman I, Cell Mol Life Sci. 2004 Oct;61(19-20):2461-70.
7. Genetic association of low density lipoprotein receptor and Alzheimer's disease. Gopalraj RK, etal., Neurobiol Aging. 2005 Jan;26(1):1-7.
8. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
9. Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia. Hayashi T, etal., Neurol Res. 2006 Dec;28(8):822-5.
10. Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection. Hennig BJ, etal., Genes Immun. 2002 Sep;3(6):359-67.
11. Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. Katsouri L and Georgopoulos S, PLoS One. 2011;6(7):e21880. Epub 2011 Jul 6.
12. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. Kirk EA, etal., J Nutr. 1998 Jun;128(6):954-9.
13. Genetic study evaluating LDLR polymorphisms and Alzheimer's disease. Lamsa R, etal., Neurobiol Aging. 2008 Jun;29(6):848-55. Epub 2007 Jan 18.
14. Genetic polymorphisms of low density lipoprotein receptor can modify stroke presentation. Lee JD, etal., Neurol Res. 2010 Jun;32(5):535-40. Epub 2009 Jul 8.
15. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Malloy SI, etal., Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):91-7. Epub 2003 Sep 11.
16. A common Lithuanian mutation causing familial hypercholesterolemia in Ashkenazi Jews. Meiner V, etal., Am J Hum Genet. 1991 Aug;49(2):443-9.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. Mochi M, etal., J Neurol Sci. 2003 Sep 15;213(1-2):7-10.
21. Diabetes alters LDL receptor and PCSK9 expression in rat liver. Niesen M, etal., Arch Biochem Biophys. 2008 Feb 15;470(2):111-5. Epub 2007 Nov 22.
22. Genomic characterization of five deletions in the LDL receptor gene in Danish Familial Hypercholesterolemic subjects. Nissen PH, etal., BMC Med Genet. 2006 Jun 26;7:55.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. Pallottini V, etal., J Cell Biochem. 2006 Aug 1;98(5):1044-53.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection. Portugal LR, etal., Microbes Infect. 2008 Mar;10(3):276-84. Epub 2007 Dec 8.
27. Mouse MP Annotation Import Pipeline RGD automated import pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus. Rivas L, etal., Autoimmunity. 2009 May;42(4):266-8.
31. No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk. Rodriguez E, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):541-3.
32. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442.
33. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Soutar AK and Naoumova RP, Nat Clin Pract Cardiovasc Med. 2007 Apr;4(4):214-25.
34. Combined effects of apoE-CI-CII cluster and LDL-R gene polymorphisms on chromosome 19 and coronary artery disease risk. Wang C, etal., Int J Hyg Environ Health. 2006 May;209(3):265-73. Epub 2006 Feb 3.
35. A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model. Wang HY, etal., Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802.
36. Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. Wang Z, etal., Alcohol Clin Exp Res. 2010 Mar 1;34(3):471-8. doi: 10.1111/j.1530-0277.2009.01111.x. Epub 2009 Dec 18.
37. Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. Xu ZE, etal., Am J Physiol Renal Physiol. 2011 Oct;301(4):F713-22. doi: 10.1152/ajprenal.00341.2010. Epub 2011 Jul 27.
38. Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. Zhao Y, etal., Atherosclerosis. 2018 Apr;271:26-35. doi: 10.1016/j.atherosclerosis.2018.02.015. Epub 2018 Feb 12.
Additional References at PubMed
PMID:1423604   PMID:1431103   PMID:1475710   PMID:1537850   PMID:1673105   PMID:1674729   PMID:1733675   PMID:1962754   PMID:2175917   PMID:2552446   PMID:2572508   PMID:2575592  
PMID:2576007   PMID:3066742   PMID:3513311   PMID:7499399   PMID:7538675   PMID:7544347   PMID:7558021   PMID:7559635   PMID:7592716   PMID:7595098   PMID:7685114   PMID:7741021  
PMID:7753850   PMID:7848292   PMID:7883961   PMID:7961705   PMID:8010761   PMID:8013374   PMID:8182121   PMID:8183926   PMID:8288218   PMID:8349823   PMID:8464923   PMID:8466528  
PMID:8550828   PMID:8617867   PMID:8631787   PMID:8636110   PMID:8654360   PMID:8656070   PMID:8662221   PMID:8662771   PMID:8672141   PMID:8692976   PMID:8696940   PMID:8798151  
PMID:8798405   PMID:8827514   PMID:8940032   PMID:8941642   PMID:8969230   PMID:8994037   PMID:9109446   PMID:9160753   PMID:9162757   PMID:9199434   PMID:9242189   PMID:9244438  
PMID:9326295   PMID:9344654   PMID:9409199   PMID:9409260   PMID:9417056   PMID:9435307   PMID:9449704   PMID:9466986   PMID:9539774   PMID:9545490   PMID:9598833   PMID:9616220  
PMID:9643345   PMID:9651338   PMID:9664080   PMID:9701246   PMID:9726247   PMID:9734366   PMID:9756870   PMID:9788969   PMID:9804809   PMID:10024503   PMID:10049716   PMID:10094927  
PMID:10195942   PMID:10224158   PMID:10323773   PMID:10349636   PMID:10359814   PMID:10380922   PMID:10383427   PMID:10395289   PMID:10428071   PMID:10428823   PMID:10441168   PMID:10446074  
PMID:10488949   PMID:10511293   PMID:10516643   PMID:10518564   PMID:10521476   PMID:10529267   PMID:10559025   PMID:10575007   PMID:10591674   PMID:10640811   PMID:10681404   PMID:10683382  
PMID:10712395   PMID:10712397   PMID:10712412   PMID:10712437   PMID:10727439   PMID:10737683   PMID:10760479   PMID:10760605   PMID:10764675   PMID:10765504   PMID:10777503   PMID:10811610  
PMID:10858435   PMID:10861012   PMID:10866061   PMID:10878506   PMID:10884286   PMID:10884299   PMID:10891640   PMID:10922068   PMID:10946016   PMID:10953027   PMID:10974047   PMID:10978255  
PMID:11024044   PMID:11042159   PMID:11060341   PMID:11076861   PMID:11076954   PMID:11090066   PMID:11092755   PMID:11093949   PMID:11108739   PMID:11120757   PMID:11138930   PMID:11160132  
PMID:11161810   PMID:11181749   PMID:11207293   PMID:11208732   PMID:11217851   PMID:11248083   PMID:11248122   PMID:11249874   PMID:11344083   PMID:11369802   PMID:11375415   PMID:11387232  
PMID:11390420   PMID:11394880   PMID:11397709   PMID:11433351   PMID:11438740   PMID:11445560   PMID:11451755   PMID:11457878   PMID:11457895   PMID:11483626   PMID:11483628   PMID:11493760  
PMID:11502098   PMID:11520791   PMID:11530237   PMID:11544199   PMID:11546779   PMID:11581143   PMID:11590219   PMID:11592107   PMID:11597927   PMID:11602498   PMID:11606787   PMID:11687507  
PMID:11719520   PMID:11739102   PMID:11747355   PMID:11786527   PMID:11884290   PMID:11884291   PMID:11893779   PMID:11893784   PMID:11956125   PMID:11971948   PMID:11971949   PMID:11972062  
PMID:11983917   PMID:12032330   PMID:12067909   PMID:12067910   PMID:12072432   PMID:12081998   PMID:12105225   PMID:12122008   PMID:12142344   PMID:12169628   PMID:12171798   PMID:12177164  
PMID:12193651   PMID:12270868   PMID:12364544   PMID:12426221   PMID:12446574   PMID:12466851   PMID:12471052   PMID:12477932   PMID:12518020   PMID:12520002   PMID:12551860   PMID:12562870  
PMID:12588769   PMID:12588951   PMID:12600918   PMID:12615659   PMID:12628954   PMID:12639996   PMID:12668499   PMID:12690199   PMID:12740573   PMID:12746448   PMID:12746502   PMID:12770750  
PMID:12847522   PMID:12904583   PMID:12907460   PMID:12924933   PMID:12937162   PMID:12944399   PMID:12951358   PMID:12970571   PMID:13130124   PMID:14512319   PMID:14525807   PMID:14561702  
PMID:14583618   PMID:14592455   PMID:14610273   PMID:14643015   PMID:14668325   PMID:14668345   PMID:14679168   PMID:14681047   PMID:14717654   PMID:14739216   PMID:14962950   PMID:14974682  
PMID:14993244   PMID:15031124   PMID:15044450   PMID:15047172   PMID:15059809   PMID:15113755   PMID:15117821   PMID:15145984   PMID:15149873   PMID:15175354   PMID:15175362   PMID:15178562  
PMID:15197138   PMID:15205216   PMID:15207278   PMID:15238619   PMID:15242861   PMID:15258195   PMID:15258196   PMID:15265030   PMID:15286809   PMID:15331403   PMID:15339841   PMID:15343384  
PMID:15450205   PMID:15466367   PMID:15472122   PMID:15485633   PMID:15486318   PMID:15528376   PMID:15533870   PMID:15550624   PMID:15561953   PMID:15566430   PMID:15569776   PMID:15576846  
PMID:15591216   PMID:15596719   PMID:15654122   PMID:15665085   PMID:15685207   PMID:15692094   PMID:15741654   PMID:15743994   PMID:15746436   PMID:15782199   PMID:15790756   PMID:15793583  
PMID:15795425   PMID:15805190   PMID:15805543   PMID:15831807   PMID:15834123   PMID:15840700   PMID:15863839   PMID:15888448   PMID:15897607   PMID:15911707   PMID:15944181   PMID:15947238  
PMID:15967715   PMID:16040605   PMID:16054063   PMID:16103256   PMID:16105858   PMID:16127462   PMID:16129816   PMID:16140885   PMID:16141072   PMID:16141073   PMID:16141407   PMID:16150825  
PMID:16151025   PMID:16166565   PMID:16185916   PMID:16199802   PMID:16211093   PMID:16219662   PMID:16236385   PMID:16267259   PMID:16293797   PMID:16297155   PMID:16299001   PMID:16299144  
PMID:16339113   PMID:16365197   PMID:16368783   PMID:16380418   PMID:16380543   PMID:16385085   PMID:16409997   PMID:16434491   PMID:16461760   PMID:16462800   PMID:16478678   PMID:16498401  
PMID:16565511   PMID:16581003   PMID:16602821   PMID:16603720   PMID:16609145   PMID:16624897   PMID:16636270   PMID:16639078   PMID:16698924   PMID:16709900   PMID:16712797   PMID:16723719  
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PMID:17242282   PMID:17242417   PMID:17255537   PMID:17293475   PMID:17303763   PMID:17327423   PMID:17329566   PMID:17346883   PMID:17363688   PMID:17372166   PMID:17379834   PMID:17389516  
PMID:17404153   PMID:17420351   PMID:17431181   PMID:17431188   PMID:17435771   PMID:17449864   PMID:17472705   PMID:17476031   PMID:17478727   PMID:17478758   PMID:17495224   PMID:17505534  
PMID:17546038   PMID:17551001   PMID:17563062   PMID:17566116   PMID:17581630   PMID:17587728   PMID:17603159   PMID:17606262   PMID:17615372   PMID:17616740   PMID:17669363   PMID:17685481  
PMID:17690315   PMID:17702862   PMID:17709636   PMID:17720268   PMID:17721545   PMID:17724261   PMID:17761633   PMID:17828273   PMID:17846428   PMID:17853943   PMID:17872464   PMID:17878220  
PMID:17885219   PMID:17885686   PMID:17897625   PMID:17925450   PMID:17928634   PMID:17928652   PMID:17932314   PMID:17932396   PMID:17960025   PMID:17962812   PMID:17991444   PMID:17991871  
PMID:17991873   PMID:17991882   PMID:17992262   PMID:18006491   PMID:18006500   PMID:18006857   PMID:18029360   PMID:18033753   PMID:18037370   PMID:18055554   PMID:18077828   PMID:18158360  
PMID:18160459   PMID:18160655   PMID:18162663   PMID:18172035   PMID:18172117   PMID:18175806   PMID:18182468   PMID:18192239   PMID:18217154   PMID:18227389   PMID:18239153   PMID:18250143  
PMID:18250194   PMID:18250269   PMID:18252823   PMID:18268153   PMID:18272520   PMID:18274671   PMID:18281279   PMID:18285567   PMID:18287559   PMID:18335269   PMID:18337495   PMID:18341993  
PMID:18346984   PMID:18351675   PMID:18354138   PMID:18356551   PMID:18367731   PMID:18369154   PMID:18369455   PMID:18378686   PMID:18385042   PMID:18410513   PMID:18421000   PMID:18451340  
PMID:18453637   PMID:18466986   PMID:18467644   PMID:18483254   PMID:18497424   PMID:18502767   PMID:18519229   PMID:18566402   PMID:18599739   PMID:18607722   PMID:18617646   PMID:18617647  
PMID:18628255   PMID:18632552   PMID:18644789   PMID:18666258   PMID:18669882   PMID:18669884   PMID:18675252   PMID:18711210   PMID:18728232   PMID:18752326   PMID:18754772   PMID:18787185  
PMID:18787189   PMID:18794388   PMID:18799693   PMID:18806102   PMID:18818413   PMID:18820241   PMID:18842266   PMID:18924609   PMID:18957695   PMID:18990694   PMID:18992221   PMID:19015136  
PMID:19020660   PMID:19027992   PMID:19029274   PMID:19033669   PMID:19041765   PMID:19052722   PMID:19056851   PMID:19067122   PMID:19073773   PMID:19074137   PMID:19095996   PMID:19095997  
PMID:19106413   PMID:19109140   PMID:19147818   PMID:19156198   PMID:19164803   PMID:19164809   PMID:19176597   PMID:19183106   PMID:19188600   PMID:19193942   PMID:19201688   PMID:19252100  
PMID:19273907   PMID:19286630   PMID:19318355   PMID:19380618   PMID:19390055   PMID:19393635   PMID:19416717   PMID:19416858   PMID:19433756   PMID:19435790   PMID:19443683   PMID:19478200  
PMID:19509018   PMID:19520913   PMID:19520976   PMID:19539695   PMID:19544529   PMID:19582157   PMID:19590047   PMID:19592617   PMID:19608973   PMID:19620499   PMID:19633360   PMID:19660432  
PMID:19667105   PMID:19679829   PMID:19718435   PMID:19720605   PMID:19723498   PMID:19729477   PMID:19737863   PMID:19742316   PMID:19752185   PMID:19805913   PMID:19834008   PMID:19834009  
PMID:19834103   PMID:19834105   PMID:19843511   PMID:19864403   PMID:19893012   PMID:19893047   PMID:19913637   PMID:19923390   PMID:19940766   PMID:19948739   PMID:19996016   PMID:20005821  
PMID:20024959   PMID:20026049   PMID:20049331   PMID:20097865   PMID:20100871   PMID:20110335   PMID:20110440   PMID:20110573   PMID:20114046   PMID:20124121   PMID:20124122   PMID:20142100  
PMID:20167657   PMID:20167927   PMID:20189995   PMID:20194110   PMID:20197419   PMID:20229095   PMID:20231283   PMID:20299687   PMID:20299691   PMID:20350970   PMID:20357081   PMID:20360257  
PMID:20370796   PMID:20382126   PMID:20382853   PMID:20388921   PMID:20421522   PMID:20428172   PMID:20431029   PMID:20439543   PMID:20448217   PMID:20453200   PMID:20466885   PMID:20484813  
PMID:20488992   PMID:20489139   PMID:20489161   PMID:20498851   PMID:20510003   PMID:20530000   PMID:20553794   PMID:20562239   PMID:20577049   PMID:20581153   PMID:20609438   PMID:20644648  
PMID:20651286   PMID:20651288   PMID:20667539   PMID:20674859   PMID:20674863   PMID:20694455   PMID:20697023   PMID:20705913   PMID:20724582   PMID:20736236   PMID:20798360   PMID:20808764  
PMID:20816088   PMID:20833724   PMID:20844591   PMID:20846652   PMID:20881250   PMID:20921438   PMID:20956207   PMID:20974996   PMID:20976059   PMID:21030715   PMID:21035758   PMID:21041949  
PMID:21071707   PMID:21084752   PMID:21088116   PMID:21088250   PMID:21088251   PMID:21149301   PMID:21186270   PMID:21195348   PMID:21224078   PMID:21252064   PMID:21252069   PMID:21252156  
PMID:21258337   PMID:21267068   PMID:21273557   PMID:21284936   PMID:21305474   PMID:21317532   PMID:21327868   PMID:21337463   PMID:21339485   PMID:21343340   PMID:21343632   PMID:21357531  
PMID:21357823   PMID:21372297   PMID:21382888   PMID:21393583   PMID:21398511   PMID:21402897   PMID:21408103   PMID:21414103   PMID:21454561   PMID:21459323   PMID:21471511   PMID:21474828  
PMID:21518694   PMID:21533112   PMID:21536666   PMID:21546605   PMID:21546607   PMID:21549101   PMID:21550016   PMID:21562077   PMID:21597007   PMID:21606463   PMID:21633167   PMID:21641547  
PMID:21677750   PMID:21690266   PMID:21690490   PMID:21705806   PMID:21723246   PMID:21730304   PMID:21740524   PMID:21741028   PMID:21741939   PMID:21778422   PMID:21788522   PMID:21795638  
PMID:21796016   PMID:21810592   PMID:21814576   PMID:21817094   PMID:21822774   PMID:21829488   PMID:21868698   PMID:21873635   PMID:21926346   PMID:21944998   PMID:21945034   PMID:21947380  
PMID:21949051   PMID:21959219   PMID:21960563   PMID:21968112   PMID:22007077   PMID:22015658   PMID:22015660   PMID:22020260   PMID:22021930   PMID:22022523   PMID:22038107   PMID:22051553  
PMID:22053073   PMID:22055502   PMID:22058152   PMID:22064597   PMID:22078798   PMID:22078933   PMID:22100249   PMID:22109552   PMID:22144566   PMID:22152303   PMID:22157149   PMID:22174911  
PMID:22176652   PMID:22185956   PMID:22194622   PMID:22194623   PMID:22196936   PMID:22197325   PMID:22214850   PMID:22222482   PMID:22223731   PMID:22227965   PMID:22231519   PMID:22261195  
PMID:22261820   PMID:22268108   PMID:22275087   PMID:22279185   PMID:22295101   PMID:22308341   PMID:22355094   PMID:22355095   PMID:22359597   PMID:22370449   PMID:22383525   PMID:22383701  
PMID:22388324   PMID:22389493   PMID:22403608   PMID:22405072   PMID:22426206   PMID:22428014   PMID:22445600   PMID:22446027   PMID:22459073   PMID:22465074   PMID:22465673   PMID:22470565  
PMID:22474254   PMID:22484817   PMID:22500017   PMID:22500026   PMID:22509320   PMID:22516063   PMID:22522614   PMID:22535745   PMID:22539767   PMID:22558236   PMID:22561298   PMID:22580896  
PMID:22580897   PMID:22580899   PMID:22581286   PMID:22593575   PMID:22628578   PMID:22638071   PMID:22649381   PMID:22666465   PMID:22698985   PMID:22699504   PMID:22739374   PMID:22748276  
PMID:22751695   PMID:22771189   PMID:22795892   PMID:22806614   PMID:22822027   PMID:22826357   PMID:22837469   PMID:22841818   PMID:22848640   PMID:22872154   PMID:22903822   PMID:22912808  
PMID:22912809   PMID:22913986   PMID:22914621   PMID:22927332   PMID:22927427   PMID:22948212   PMID:22982464   PMID:22985620   PMID:22991462   PMID:22992388   PMID:23001779   PMID:23011471  
PMID:23021221   PMID:23023371   PMID:23023374   PMID:23028961   PMID:23042815   PMID:23047899   PMID:23056165   PMID:23056485   PMID:23064364   PMID:23087171   PMID:23103473   PMID:23119030  
PMID:23133551   PMID:23135270   PMID:23144813   PMID:23203971   PMID:23204275   PMID:23236507   PMID:23241410   PMID:23242187   PMID:23243415   PMID:23257360   PMID:23285030   PMID:23285120  
PMID:23288159   PMID:23288165   PMID:23288947   PMID:23291186   PMID:23298460   PMID:23300532   PMID:23300554   PMID:23307875   PMID:23333278   PMID:23334894   PMID:23341579   PMID:23349189  
PMID:23349943   PMID:23355893   PMID:23381569   PMID:23382219   PMID:23396975   PMID:23417039   PMID:23420833   PMID:23426179   PMID:23430612   PMID:23430613   PMID:23444136   PMID:23454129  
PMID:23457508   PMID:23469003   PMID:23470631   PMID:23485468   PMID:23501697   PMID:23505495   PMID:23510830   PMID:23536783   PMID:23542898   PMID:23549085   PMID:23554922   PMID:23564731  
PMID:23564733   PMID:23572498   PMID:23580231   PMID:23584088   PMID:23589850   PMID:23593499   PMID:23620818   PMID:23640484   PMID:23663736   PMID:23663738   PMID:23675503   PMID:23676495  
PMID:23684818   PMID:23685555   PMID:23690465   PMID:23700419   PMID:23709089   PMID:23712050   PMID:23722970   PMID:23723060   PMID:23744992   PMID:23752203   PMID:23804810   PMID:23812556  
PMID:23814116   PMID:23817038   PMID:23846497   PMID:23874490   PMID:23880190   PMID:23883163   PMID:23884339   PMID:23887641   PMID:23903754   PMID:23908345   PMID:23922490   PMID:23924793  
PMID:23933982   PMID:23934128   PMID:23936482   PMID:23948654   PMID:23950143   PMID:23959870   PMID:23963755   PMID:23977256   PMID:23990206   PMID:23991137   PMID:23995233   PMID:24006456  
PMID:24014832   PMID:24036126   PMID:24043250   PMID:24068673   PMID:24072697   PMID:24115036   PMID:24158514   PMID:24220638   PMID:24223214   PMID:24225494   PMID:24236066   PMID:24244746  
PMID:24255059   PMID:24260508   PMID:24297735   PMID:24311381   PMID:24312444   PMID:24333561   PMID:24349031   PMID:24357053   PMID:24370889   PMID:24374972   PMID:24376654   PMID:24376657  
PMID:24412220   PMID:24412615   PMID:24438079   PMID:24445679   PMID:24466075   PMID:24474649   PMID:24487918   PMID:24488984   PMID:24489659   PMID:24506864   PMID:24512598   PMID:24519928  
PMID:24551105   PMID:24563511   PMID:24577472   PMID:24586211   PMID:24623101   PMID:24647396   PMID:24667818   PMID:24675665   PMID:24677271   PMID:24687132   PMID:24691202   PMID:24692543  
PMID:24723556   PMID:24726364   PMID:24747111   PMID:24747115   PMID:24781986   PMID:24792245   PMID:24792925   PMID:24799533   PMID:24833800   PMID:24837748   PMID:24864274   PMID:24891335  
PMID:24903096   PMID:24906644   PMID:24935961   PMID:24940687   PMID:24947527   PMID:24954421   PMID:24956536   PMID:25001623   PMID:25007801   PMID:25008143   PMID:25022542   PMID:25023761  
PMID:25024399   PMID:25037606   PMID:25038458   PMID:25056439   PMID:25092171   PMID:25093698   PMID:25104800   PMID:25147951   PMID:25176150   PMID:25186795   PMID:25201910   PMID:25223984  
PMID:25231636   PMID:25239141   PMID:25240046   PMID:25251587   PMID:25258384   PMID:25279794   PMID:25286043   PMID:25301841   PMID:25324572   PMID:25341894   PMID:25345495   PMID:25347070  
PMID:25348165   PMID:25360548   PMID:25392271   PMID:25404299   PMID:25413784   PMID:25451156   PMID:25462563   PMID:25465389   PMID:25474352   PMID:25505264   PMID:25524771   PMID:25524774  
PMID:25546260   PMID:25553467   PMID:25568062   PMID:25572138   PMID:25587044   PMID:25593281   PMID:25613181   PMID:25639537   PMID:25662586   PMID:25682030   PMID:25691624   PMID:25695999  
PMID:25712206   PMID:25714599   PMID:25724068   PMID:25754609   PMID:25765938   PMID:25770025   PMID:25797218   PMID:25801013   PMID:25801026   PMID:25815343   PMID:25817537   PMID:25826262  
PMID:25830298   PMID:25840831   PMID:25866184   PMID:25870274   PMID:25881051   PMID:25904598   PMID:25912129   PMID:25926396   PMID:25936306   PMID:25938460   PMID:25946330   PMID:25954050  
PMID:25966442   PMID:25969427   PMID:25983325   PMID:25991812   PMID:26020946   PMID:26034040   PMID:26034041   PMID:26044581   PMID:26046657   PMID:26059978   PMID:26061292   PMID:26068045  
PMID:26072030   PMID:26074075   PMID:26075824   PMID:26085133   PMID:26088575   PMID:26092098   PMID:26100857   PMID:26108225   PMID:26112011   PMID:26117323   PMID:26136384   PMID:26160172  
PMID:26160324   PMID:26172853   PMID:26178198   PMID:26187995   PMID:26224810   PMID:26235422   PMID:26253613   PMID:26258894   PMID:26313756   PMID:26323289   PMID:26367277   PMID:26395740  
PMID:26411684   PMID:26449606   PMID:26489464   PMID:26494229   PMID:26494623   PMID:26508642   PMID:26517695   PMID:26520906   PMID:26521149   PMID:26523989   PMID:26547624   PMID:26564818  
PMID:26582899   PMID:26619823   PMID:26628375   PMID:26642365   PMID:26681751   PMID:26685326   PMID:26686234   PMID:26721885   PMID:26733684   PMID:26761430   PMID:26775176   PMID:26786161  
PMID:26800565   PMID:26819196   PMID:26821944   PMID:26822081   PMID:26828750   PMID:26839333   PMID:26843191   PMID:26848160   PMID:26848161   PMID:26891734   PMID:26891738   PMID:26921684  
PMID:26941018   PMID:26947073   PMID:26950217   PMID:26950419   PMID:26952642   PMID:26965651   PMID:26965826   PMID:26966280   PMID:26974699   PMID:26980204   PMID:26980442   PMID:26988592  
PMID:26993520   PMID:27005486   PMID:27010651   PMID:27043821   PMID:27053419   PMID:27055902   PMID:27062406   PMID:27063951   PMID:27090939   PMID:27098250   PMID:27102962   PMID:27108697  
PMID:27131506   PMID:27133569   PMID:27135421   PMID:27150391   PMID:27166946   PMID:27171436   PMID:27181051   PMID:27185735   PMID:27199450   PMID:27223895   PMID:27230129   PMID:27234908  
PMID:27239755   PMID:27279328   PMID:27284008   PMID:27295082   PMID:27297110   PMID:27299860   PMID:27315776   PMID:27318830   PMID:27321128   PMID:27335232   PMID:27339627   PMID:27344248  
PMID:27351842   PMID:27363580   PMID:27365402   PMID:27373983   PMID:27383786   PMID:27384322   PMID:27400128   PMID:27417580   PMID:27417587   PMID:27430239   PMID:27435231   PMID:27440004  
PMID:27444197   PMID:27460411   PMID:27467817   PMID:27470509   PMID:27475954   PMID:27482882   PMID:27496881   PMID:27522265   PMID:27525442   PMID:27564380   PMID:27581498   PMID:27647324  
PMID:27665711   PMID:27668800   PMID:27720451   PMID:27721414   PMID:27731409   PMID:27756793   PMID:27789842   PMID:27801847   PMID:27811230   PMID:27815372   PMID:27816810   PMID:27869117  
PMID:27903567   PMID:27916814   PMID:27958361   PMID:27992511   PMID:28012647   PMID:28030540   PMID:28031458   PMID:28060909   PMID:28062492   PMID:28062509   PMID:28067100   PMID:28067670  
PMID:28077357   PMID:28108572   PMID:28122051   PMID:28153881   PMID:28186192   PMID:28202909   PMID:28207798   PMID:28213272   PMID:28220041   PMID:28257760   PMID:28275068   PMID:28377486  
PMID:28377633   PMID:28414328   PMID:28416579   PMID:28428217   PMID:28457625   PMID:28474500   PMID:28481921   PMID:28486149   PMID:28499924   PMID:28500865   PMID:28511572   PMID:28513806  
PMID:28522295   PMID:28589929   PMID:28596373   PMID:28600283   PMID:28604703   PMID:28607102   PMID:28607103   PMID:28615690   PMID:28620068   PMID:28636844   PMID:28636934   PMID:28637783  
PMID:28642237   PMID:28674080   PMID:28678519   PMID:28678821   PMID:28696252   PMID:28724798   PMID:28729463   PMID:28750079   PMID:28759039   PMID:28771609   PMID:28771708   PMID:28792970  
PMID:28793265   PMID:28796818   PMID:28798142   PMID:28825717   PMID:28827223   PMID:28899902   PMID:28917158   PMID:28935569   PMID:28935571   PMID:28935758   PMID:28942921   PMID:28970592  
PMID:29016728   PMID:29023576   PMID:29030487   PMID:29035781   PMID:29042581   PMID:29043563   PMID:29047330   PMID:29055004   PMID:29066718   PMID:29096854   PMID:29097367   PMID:29122890  
PMID:29130930   PMID:29142166   PMID:29142309   PMID:29180444   PMID:29183623   PMID:29244772   PMID:29273600   PMID:29290366   PMID:29312959   PMID:29328911   PMID:29329335   PMID:29346401  
PMID:29351469   PMID:29396908   PMID:29428719   PMID:29431742   PMID:29444171   PMID:29483174   PMID:29483182   PMID:29483823   PMID:29487597   PMID:29494675   PMID:29496995   PMID:29500407  
PMID:29539583   PMID:29540796   PMID:29545199   PMID:29545616   PMID:29559522   PMID:29563333   PMID:29571225   PMID:29581235   PMID:29588315   PMID:29599135   PMID:29599136   PMID:29599140  
PMID:29601818   PMID:29615651   PMID:29615924   PMID:29626090   PMID:29643120   PMID:29674474   PMID:29700117   PMID:29708512   PMID:29724817   PMID:29739755   PMID:29800228   PMID:29874587  
PMID:29875324   PMID:29891514   PMID:29891593   PMID:29891894   PMID:29899135   PMID:29899496   PMID:29902229   PMID:29903736   PMID:29930002   PMID:29930022   PMID:29937375   PMID:29950315  
PMID:29960897   PMID:29976576   PMID:29989851   PMID:30008441   PMID:30021121   PMID:30026271   PMID:30026278   PMID:30060257   PMID:30067974   PMID:30100244   PMID:30134173   PMID:30139760  
PMID:30282838   PMID:30286201   PMID:30291029   PMID:30323247   PMID:30354205   PMID:30354208   PMID:30354229   PMID:30354246   PMID:30359200   PMID:30375985   PMID:30378752   PMID:30385871  
PMID:30389414   PMID:30420641   PMID:30429524   PMID:30451917   PMID:30463003   PMID:30464343   PMID:30508567   PMID:30556039   PMID:30566603   PMID:30567480   PMID:30567482   PMID:30567484  
PMID:30571460   PMID:30582442   PMID:30582457   PMID:30586719   PMID:30651003   PMID:30659108   PMID:30674978   PMID:30683705   PMID:30700132   PMID:30700910   PMID:30721842   PMID:30723096  
PMID:30753095   PMID:30760925   PMID:30816678   PMID:30831144   PMID:30850299   PMID:30867470   PMID:30889221   PMID:30897380   PMID:30905786   PMID:30905828   PMID:30935996   PMID:30943218  
PMID:30944250   PMID:30972070   PMID:31023188   PMID:31045580   PMID:31064810   PMID:31070450   PMID:31085638   PMID:31092015   PMID:31116977   PMID:31121182   PMID:31154825   PMID:31163988  
PMID:31167564   PMID:31189595   PMID:31217881   PMID:31304837   PMID:31332008   PMID:31356236   PMID:31388055   PMID:31391339   PMID:31462091   PMID:31469849   PMID:31529020   PMID:31533471  
PMID:31567014   PMID:31578081   PMID:31584834   PMID:31589306   PMID:31618063   PMID:31619061   PMID:31628414   PMID:31641089   PMID:31666640   PMID:31709830   PMID:31710686   PMID:31740486  
PMID:31757993   PMID:31778654   PMID:31796057   PMID:31803904   PMID:31818196   PMID:31821039   PMID:31846369   PMID:31852219   PMID:31868000   PMID:31907281   PMID:31914876   PMID:31942916  
PMID:31978760   PMID:31996020   PMID:31996024   PMID:31996466   PMID:32004476   PMID:32160132   PMID:32170024   PMID:32188273   PMID:32191637   PMID:32197071   PMID:32198436   PMID:32217100  
PMID:32219872   PMID:32238693   PMID:32243809   PMID:32295848   PMID:32325033   PMID:32349535   PMID:32360427   PMID:32384892   PMID:32409492   PMID:32422642   PMID:32423823   PMID:32472598  
PMID:32493841   PMID:32495699   PMID:32496646   PMID:32586906   PMID:32588196   PMID:32641587   PMID:32667970   PMID:32673528   PMID:32717023   PMID:32736671   PMID:32752134   PMID:32788595  
PMID:32796843   PMID:32849641   PMID:32861845   PMID:32881885   PMID:32883094   PMID:32895539   PMID:32907369   PMID:32913121   PMID:32949768   PMID:32968066   PMID:32988222   PMID:33020528  
PMID:33021969   PMID:33049978   PMID:33054390   PMID:33054396   PMID:33065235   PMID:33135458   PMID:33135461   PMID:33141760   PMID:33162986   PMID:33193444   PMID:33246135   PMID:33247205  
PMID:33257753   PMID:33262333   PMID:33293576   PMID:33301423   PMID:33329050   PMID:33356393   PMID:33369150   PMID:33406854   PMID:33421943   PMID:33427054   PMID:33427062   PMID:33462514  
PMID:33494008   PMID:33504177   PMID:33542347   PMID:33561256   PMID:33576385   PMID:33591571   PMID:33594095   PMID:33606190   PMID:33625789   PMID:33626909   PMID:33630758   PMID:33636128  
PMID:33731931   PMID:33737240   PMID:33772096   PMID:33774223   PMID:33775772   PMID:33914863   PMID:33983975   PMID:34003795   PMID:34077868   PMID:34092712   PMID:34118252   PMID:34118596  
PMID:34153284   PMID:34201526   PMID:34280453   PMID:34385562   PMID:34433968   PMID:34440796   PMID:34458258   PMID:34461308   PMID:34479964   PMID:34508778   PMID:34530175   PMID:34551590  
PMID:34569651   PMID:34587757   PMID:34658858   PMID:34680102   PMID:34686657   PMID:34695512   PMID:34698806   PMID:34718444   PMID:34784501   PMID:34846914   PMID:34888367   PMID:34890852  
PMID:34914849   PMID:34957248   PMID:34957260   PMID:34994492   PMID:35004870   PMID:35013582   PMID:35017526   PMID:35017550   PMID:35025664   PMID:35065166   PMID:35127876   PMID:35145079  
PMID:35145523   PMID:35181718   PMID:35183904   PMID:35189703   PMID:35278409   PMID:35320283   PMID:35334307   PMID:35383201   PMID:35433874   PMID:35440634   PMID:35457157   PMID:35470061  
PMID:35477759   PMID:35567428   PMID:35778407   PMID:35817960   PMID:35861973   PMID:35955518   PMID:35985474   PMID:36029186   PMID:36041358   PMID:36051444   PMID:36129440   PMID:36130017  
PMID:36220546   PMID:36224248   PMID:36288700   PMID:36291054   PMID:36319730   PMID:36325910   PMID:36376513   PMID:36453279   PMID:36474072   PMID:36481344   PMID:36523570   PMID:36611838  
PMID:36691048   PMID:36708961   PMID:36709358   PMID:36761778   PMID:36844738   PMID:36871792   PMID:36876496   PMID:36894641   PMID:36950286   PMID:37078290   PMID:37153468   PMID:37182573  
PMID:37235726   PMID:37244259   PMID:37396582   PMID:37499656   PMID:37520709   PMID:37541847   PMID:37591406   PMID:37626870   PMID:37651538   PMID:37664585   PMID:37762509   PMID:37824329  
PMID:37892238   PMID:37973188   PMID:38000296   PMID:38123514  


Genomics

Comparative Map Data
Ldlr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,634,872 - 21,661,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,634,779 - 21,661,215 (+)EnsemblGRCm39 Ensembl
GRCm38921,723,576 - 21,749,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,723,483 - 21,749,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37921,528,038 - 21,554,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,474,180 - 21,498,819 (+)NCBIMGSCv36mm8
Celera918,993,187 - 19,019,513 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.87NCBI
LDLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,089,463 - 11,133,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,089,418 - 11,133,820 (+)EnsemblGRCh38hg38GRCh38
GRCh371911,200,139 - 11,244,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,061,132 - 11,105,490 (+)NCBINCBI36Build 36hg18NCBI36
Build 341911,061,131 - 11,105,490NCBI
Celera1911,094,887 - 11,139,322 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,777,128 - 10,820,847 (+)NCBIHuRef
CHM1_11911,201,264 - 11,245,760 (+)NCBICHM1_1
T2T-CHM13v2.01911,216,460 - 11,260,830 (+)NCBIT2T-CHM13v2.0
Ldlr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,546,191 - 28,569,075 (+)NCBIGRCr8
mRatBN7.2820,270,020 - 20,292,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,270,041 - 20,294,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,305,445 - 24,328,327 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,600,993 - 22,623,875 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,499,706 - 20,522,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,750,425 - 22,773,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,750,336 - 22,774,903 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,804,325 - 22,827,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,824,040 - 20,846,920 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,824,039 - 20,846,920 (+)NCBI
Celera821,660,761 - 21,683,616 (+)NCBICelera
RH 3.4 Map8178.16RGD
RH 3.4 Map8178.16RGD
Cytogenetic Map8q13NCBI
Ldlr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,114,434 - 2,138,056 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,114,702 - 2,135,584 (+)NCBIChiLan1.0ChiLan1.0
LDLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,006,932 - 16,050,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,005,600 - 15,049,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,640,225 - 10,683,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,357,311 - 11,402,736 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,357,311 - 11,396,791 (+)Ensemblpanpan1.1panPan2
LDLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,115,175 - 50,152,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,048,736 - 50,152,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,988,705 - 50,026,032 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,636,154 - 50,673,474 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,636,157 - 50,673,423 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,846,492 - 49,883,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,273,144 - 50,310,479 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,515,859 - 50,553,174 (-)NCBIUU_Cfam_GSD_1.0
Ldlr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,054,161 - 209,095,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,259,369 - 1,302,294 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,259,405 - 1,300,545 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,828,332 - 69,864,827 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,828,348 - 69,864,823 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,193,426 - 70,206,818 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LDLR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,062,204 - 10,091,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,062,790 - 10,091,377 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,815,946 - 9,867,321 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ldlr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,999,169 - 3,021,987 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,999,122 - 3,021,893 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ldlr
653 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1256
Count of miRNA genes:600
Interacting mature miRNAs:732
Transcripts:ENSMUST00000034713
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse

Markers in Region
Ldlr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,744,313 - 21,745,831UniSTSGRCm38
MGSCv37921,553,930 - 21,554,297UniSTSGRCm37
Celera919,013,908 - 19,015,426UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
cM Map95.0UniSTS
UniSTS:225086  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,749,144 - 21,749,331UniSTSGRCm38
MGSCv37921,553,588 - 21,553,775UniSTSGRCm37
Celera919,018,738 - 19,018,925UniSTS
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS
Ldlr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38921,749,486 - 21,749,853UniSTSGRCm38
MGSCv37921,553,930 - 21,554,297UniSTSGRCm37
Celera919,019,080 - 19,019,447UniSTS
Cytogenetic Map9A3UniSTS
Ldlr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A3UniSTS
cM Map95.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001252659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF425607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY235019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z19520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z19521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000034713   ⟹   ENSMUSP00000034713
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,634,779 - 21,661,215 (+)Ensembl
GRCm38.p6 Ensembl921,723,483 - 21,749,919 (+)Ensembl
RefSeq Acc Id: ENSMUST00000213114   ⟹   ENSMUSP00000149431
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,634,928 - 21,661,211 (+)Ensembl
GRCm38.p6 Ensembl921,723,632 - 21,749,915 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,634,937 - 21,649,828 (+)Ensembl
GRCm38.p6 Ensembl921,723,641 - 21,738,532 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,656,619 - 21,661,210 (+)Ensembl
GRCm38.p6 Ensembl921,745,323 - 21,749,914 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,634,895 - 21,651,382 (+)Ensembl
GRCm38.p6 Ensembl921,723,599 - 21,740,086 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217111
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,634,935 - 21,652,298 (+)Ensembl
GRCm38.p6 Ensembl921,723,639 - 21,741,002 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217613
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl921,647,403 - 21,651,382 (+)Ensembl
GRCm38.p6 Ensembl921,736,107 - 21,740,086 (+)Ensembl
RefSeq Acc Id: NM_001252658   ⟹   NP_001239587
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,634,872 - 21,661,215 (+)NCBI
GRCm38921,723,576 - 21,749,919 (+)ENTREZGENE
Celera918,993,169 - 19,019,513 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252659   ⟹   NP_001239588
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,634,872 - 21,661,215 (+)NCBI
GRCm38921,723,576 - 21,749,919 (+)ENTREZGENE
Celera918,993,169 - 19,019,513 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010700   ⟹   NP_034830
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39921,634,872 - 21,661,215 (+)NCBI
GRCm38921,723,576 - 21,749,919 (+)ENTREZGENE
MGSCv37921,528,038 - 21,554,363 (+)RGD
Celera918,993,169 - 19,019,513 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034830   ⟸   NM_010700
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6GTJ9 (UniProtKB/Swiss-Prot),   P35951 (UniProtKB/Swiss-Prot),   Q3TVR4 (UniProtKB/TrEMBL),   Q3U8R7 (UniProtKB/TrEMBL),   Q8VCT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239587   ⟸   NM_001252658
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A1L1SRE8 (UniProtKB/TrEMBL),   Q3TDD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239588   ⟸   NM_001252659
- Peptide Label: isoform 3 presursor precursor
- UniProtKB: Q3TVR4 (UniProtKB/TrEMBL),   Q3U8R7 (UniProtKB/TrEMBL),   Q8VCT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034713   ⟸   ENSMUST00000034713
RefSeq Acc Id: ENSMUSP00000149431   ⟸   ENSMUST00000213114
Protein Domains
EGF-like   LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35951-F1-model_v2 AlphaFold P35951 1-862 view protein structure

Promoters
RGD ID:6844733
Promoter ID:MM_KWN:56586
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000070068,   NM_010700,   UC009OMG.1,   UC009OMH.1,   UC009OMJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36921,527,866 - 21,528,366 (+)MPROMDB
RGD ID:6848426
Promoter ID:MM_ACW:49815
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:LDLR.HSEP07-UNSPLICED,   LDLR.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36921,541,636 - 21,543,577 (+)MPROMDB
RGD ID:8668970
Promoter ID:EPDNEW_M12516
Type:initiation region
Name:Ldlr_1
Description:Mus musculus low density lipoprotein receptor , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38921,723,639 - 21,723,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96765 AgrOrtholog
Ensembl Genes ENSMUSG00000032193 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034713 ENTREZGENE
  ENSMUST00000034713.9 UniProtKB/Swiss-Prot
  ENSMUST00000213114 ENTREZGENE
  ENSMUST00000213114.2 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type module UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16835 UniProtKB/Swiss-Prot
MGD MGI:96765 ENTREZGENE
NCBI Gene 16835 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LDLR RGD
PhenoGen Ldlr PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SRE8 ENTREZGENE, UniProtKB/TrEMBL
  LDLR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TDD1 ENTREZGENE, UniProtKB/TrEMBL
  Q3TVR4 ENTREZGENE, UniProtKB/TrEMBL
  Q3U8R7 ENTREZGENE, UniProtKB/TrEMBL
  Q6GTJ9 ENTREZGENE
  Q8CAV5_MOUSE UniProtKB/TrEMBL
  Q8VCT0 ENTREZGENE, UniProtKB/TrEMBL
  Q91ZJ1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q6GTJ9 UniProtKB/Swiss-Prot