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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2998
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlrdecreases expressionISOLDLR (Homo sapiens)6480464CTDDactinomycin results in decreased expression of LDLR mRNAPMID:32913121
Ldlrmultiple interactionsISOLDLR (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [Dactinomycin results in decreased expression of LDLR mRNA]PMID:32913121
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