Ezr (ezrin) - Rat Genome Database

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Gene: Ezr (ezrin) Rattus norvegicus
Symbol: Ezr
Name: ezrin
RGD ID: 621161
Description: Enables protein domain specific binding activity. Involved in epithelial cell differentiation and filopodium assembly. Located in several cellular components, including basolateral plasma membrane; microspike; and microvillus. Orthologous to human EZR (ezrin); PARTICIPATES IN FasL mediated signaling pathway; parathyroid hormone signaling pathway; protein kinase A (PKA) signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: cytovillin; MGC94076; p81; Vil2; villin 2; villin-2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx147,516,906 - 47,560,444 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,504,177 - 53,547,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,592,352 - 47,635,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Celera142,655,531 - 42,699,079 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
aniline  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclohexanols  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
haloperidol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
isobutanol  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
menadione  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
microcystin-LR  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
neomycin  (EXP)
nicotine  (ISO)
nitric oxide  (EXP)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
Propiverine  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium hydroxide  (ISO)
Soman  (EXP)
starch  (EXP)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triton X-100  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
withaferin A  (ISO)
Y-27632  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament bundle assembly  (IEA,ISO,ISS)
astral microtubule organization  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cortical microtubule organization  (IEA,ISO)
epithelial cell differentiation  (IEP)
establishment of centrosome localization  (IEA,ISO)
establishment of endothelial barrier  (IEA,ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of apical/basal cell polarity  (IEA,ISO)
filopodium assembly  (IEA,IMP,ISO)
gland morphogenesis  (ISO)
intestinal D-glucose absorption  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA,ISO)
membrane to membrane docking  (IEA,ISO)
microvillus assembly  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of interleukin-2 production  (IEA,ISO)
negative regulation of p38MAPK cascade  (IEA,ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of early endosome to late endosome transport  (IBA,IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein localization to early endosome  (IBA,IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
postsynaptic actin cytoskeleton organization  (IEA,ISO)
protein kinase A signaling  (IEA,ISO)
protein localization to cell cortex  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
protein-containing complex localization  (IEA,ISO)
receptor internalization  (IEA,ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell shape  (IBA,IEA,ISO)
regulation of cell size  (ISO)
regulation of microvillus length  (IEA,ISO)
regulation of non-canonical NF-kappaB signal transduction  (ISO)
regulation of organelle assembly  (IBA,IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA,ISO)
terminal web assembly  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. Antoine-Bertrand J, etal., Mol Biol Cell. 2011 Oct;22(19):3734-46. doi: 10.1091/mbc.E10-11-0917. Epub 2011 Aug 17.
2. Transcriptional regulation of the ezrin gene during rat intestinal development and epithelial differentiation. Barila D, etal., Biochim Biophys Acta 1995 Aug 22;1263(2):133-40.
3. Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium. Bonilha VL and Rodriguez-Boulan E, Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3274-82.
4. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.
5. ERM proteins mediate the effects of Na+/H+ exchanger (NHE1) activation in cardiac myocytes. Darmellah A, etal., Cardiovasc Res. 2009 Feb 1;81(2):294-300. doi: 10.1093/cvr/cvn320. Epub 2008 Nov 21.
6. Asymmetric ERM activation at the Schwann cell process tip is required in axon-associated motility. Gatto CL, etal., J Cell Physiol. 2007 Jan;210(1):122-32.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. A functional FERM domain binding motif in neurofascin. Gunn-Moore FJ, etal., Mol Cell Neurosci. 2006 Dec;33(4):441-6. Epub 2006 Oct 12.
10. Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Lavialle M, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12915-9. doi: 10.1073/pnas.1100957108. Epub 2011 Jul 13.
11. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. ERMs colocalize transiently with L1 during neocortical axon outgrowth. Mintz CD, etal., J Comp Neurol 2003 Sep 29;464(4):438-48.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin. Orlando RA, etal., J Am Soc Nephrol. 2001 Aug;12(8):1589-98.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes. Smith PM, etal., Endocrinology. 2004 Jul;145(7):3075-83. Epub 2004 Mar 24.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
22. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
23. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
Additional References at PubMed
PMID:7844168   PMID:9472040   PMID:9852149   PMID:9890997   PMID:10793131   PMID:11285285   PMID:11598191   PMID:11728336   PMID:12082081   PMID:14625387   PMID:14996907   PMID:15177033  
PMID:15489334   PMID:15498789   PMID:15797715   PMID:16365167   PMID:16502470   PMID:17065554   PMID:17122142   PMID:17138661   PMID:17292355   PMID:17634366   PMID:17825285   PMID:17911601  
PMID:18321067   PMID:18478542   PMID:19190083   PMID:19783662   PMID:19946888   PMID:20458337   PMID:20551175   PMID:20551903   PMID:21120533   PMID:21134835   PMID:21148287   PMID:21282464  
PMID:21377456   PMID:21423176   PMID:21451047   PMID:21666723   PMID:21988832   PMID:22114352   PMID:22132106   PMID:22206666   PMID:22291017   PMID:22467863   PMID:22658674   PMID:22681889  
PMID:22797597   PMID:22871113   PMID:23106337   PMID:23264465   PMID:23284756   PMID:23376485   PMID:23533145   PMID:23857773   PMID:24091598   PMID:24184478   PMID:24284068   PMID:24385580  
PMID:24726496   PMID:24862762   PMID:25051438   PMID:25097019   PMID:25468996   PMID:25486435   PMID:25554515   PMID:25652626   PMID:25854562   PMID:25889165   PMID:28077322   PMID:29568061  
PMID:30654004   PMID:31931020  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx147,516,906 - 47,560,444 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,504,177 - 53,547,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0147,592,352 - 47,635,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Celera142,655,531 - 42,699,079 (-)NCBICelera
Cytogenetic Map1q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386158,765,748 - 158,819,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6158,765,741 - 158,819,368 (-)EnsemblGRCh38hg38GRCh38
GRCh376159,186,780 - 159,240,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366159,106,764 - 159,159,247 (-)NCBINCBI36Build 36hg18NCBI36
Build 346159,157,186 - 159,209,668NCBI
Celera6159,834,789 - 159,888,323 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6156,657,307 - 156,711,123 (-)NCBIHuRef
CHM1_16159,449,491 - 159,503,058 (-)NCBICHM1_1
T2T-CHM13v2.06160,010,984 - 160,064,812 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39177,005,530 - 7,050,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,005,440 - 7,050,183 (-)EnsemblGRCm39 Ensembl
GRCm38176,738,131 - 6,782,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl176,738,041 - 6,782,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv37176,942,480 - 6,987,129 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36176,587,789 - 6,632,438 (-)NCBIMGSCv36mm8
Celera1514,687,905 - 14,732,667 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.38NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554393,703,013 - 3,740,345 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554393,701,722 - 3,740,345 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan16176,774,286 - 176,828,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06156,656,146 - 156,709,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16161,670,483 - 161,723,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1148,160,206 - 48,210,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl148,346,327 - 48,397,690 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648910,412,710 - 10,458,201 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl18,403,453 - 8,452,742 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118,403,362 - 8,452,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2110,423,530 - 10,432,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11386,342,954 - 86,399,827 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1386,344,051 - 86,370,622 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604058,721,321 - 58,778,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624929826,531 - 873,572 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624929827,275 - 873,743 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ezr
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:61
Interacting mature miRNAs:65
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,967,667 - 46,967,854 (+)MAPPERmRatBN7.2
Rnor_6.0147,287,579 - 47,287,765NCBIRnor6.0
Rnor_5.0148,590,678 - 48,590,864UniSTSRnor5.0
RGSC_v3.4141,177,902 - 41,178,088UniSTSRGSC3.4
Celera142,655,238 - 42,655,424UniSTS
RH 3.4 Map1541.1UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2146,970,865 - 46,971,872 (+)MAPPERmRatBN7.2
Rnor_6.0147,290,777 - 47,291,783NCBIRnor6.0
Rnor_5.0148,593,876 - 48,594,882UniSTSRnor5.0
RGSC_v3.4141,181,100 - 41,182,106UniSTSRGSC3.4
Celera142,658,436 - 42,659,442UniSTS
Cytogenetic Map1q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 40 24 19 24 74 35 34 11
Low 17 17 17 8 11 7 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000046746   ⟹   ENSRNOP00000046593
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,967,963 - 47,011,505 (-)Ensembl
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090033   ⟹   ENSRNOP00000074514
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,967,658 - 46,988,735 (-)Ensembl
Rnor_6.0 Ensembl147,288,576 - 47,307,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105371   ⟹   ENSRNOP00000076572
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,967,658 - 46,988,155 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112255   ⟹   ENSRNOP00000087725
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,967,658 - 47,011,114 (-)Ensembl
RefSeq Acc Id: NM_019357   ⟹   NP_062230
Rat AssemblyChrPosition (strand)Source
mRatBN7.2146,967,961 - 47,011,505 (-)NCBI
Rnor_6.0147,287,872 - 47,331,412 (-)NCBI
Rnor_5.0148,590,971 - 48,634,511 (-)NCBI
RGSC_v3.4141,178,195 - 41,221,735 (-)RGD
Celera142,655,531 - 42,699,079 (-)RGD
RefSeq Acc Id: NP_062230   ⟸   NM_019357
- UniProtKB: Q66H97 (UniProtKB/Swiss-Prot),   Q5WQV4 (UniProtKB/Swiss-Prot),   Q8VHK3 (UniProtKB/Swiss-Prot),   P31977 (UniProtKB/Swiss-Prot),   A6KP14 (UniProtKB/TrEMBL),   A0A8I5Y4R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074514   ⟸   ENSRNOT00000090033
RefSeq Acc Id: ENSRNOP00000046593   ⟸   ENSRNOT00000046746
RefSeq Acc Id: ENSRNOP00000076572   ⟸   ENSRNOT00000105371
RefSeq Acc Id: ENSRNOP00000087725   ⟸   ENSRNOT00000112255
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31977-F1-model_v2 AlphaFold P31977 1-586 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621161 AgrOrtholog
BioCyc Gene G2FUF-61612 BioCyc
Ensembl Genes ENSRNOG00000018524 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000046593 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074514.2 UniProtKB/TrEMBL
  ENSRNOP00000076572.1 UniProtKB/TrEMBL
  ENSRNOP00000087725.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046746 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000090033.2 UniProtKB/TrEMBL
  ENSRNOT00000105371.1 UniProtKB/TrEMBL
  ENSRNOT00000112255.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.360.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54319 UniProtKB/Swiss-Prot
  PTHR23281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ezr PhenoGen
PIRSF ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48678 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K890_RAT UniProtKB/TrEMBL
UniProt Secondary Q5WQV4 UniProtKB/Swiss-Prot
  Q66H97 UniProtKB/Swiss-Prot
  Q8VHK3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Ezr  ezrin  Vil2  villin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Vil2  villin 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vil2  villin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process may play an important role during development and differentiation of the intestinal epithelium 729995