RGD Reference Report - Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients. - Rat Genome Database

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Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients.

Authors: Qian, N  Ueno, T  Kawaguchi-Sakita, N  Kawashima, M  Yoshida, N  Mikami, Y  Wakasa, T  Shintaku, M  Tsuyuki, S  Inamoto, T  Toi, M 
Citation: Qian N, etal., Cancer Sci. 2011 Aug;102(8):1590-6. doi: 10.1111/j.1349-7006.2011.01985.x. Epub 2011 Jun 27.
RGD ID: 8661766
Pubmed: PMID:21585620   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1349-7006.2011.01985.x   (Journal Full-text)

Caveolin-1 (Cav-1) has been extensively characterized in cancer biological research. However, the role of Cav-1 in the interaction between tumor and stromal cells remains unclear. In the present study, we examined Cav-1 expression in tumor cells and stromal cells in breast cancer tissue by immunohistochemical analysis and evaluated its prognostic value in a training cohort. Immunohistochemical analysis of Cav-1 expression was scored as (++), (+) or (-) according to the proportion of positively stained tumor cells (T) and stromal cells (S). Correlation analysis between tumor/stromal Cav-1 expression and clinicopathological parameters revealed that only T(++) Cav-1 status was positively associated with tumor size and histological nodal status (P = 0.019 and 0.021, respectively). Univariate analysis revealed that combined T(++)/S(-) status was significantly correlated with unfavorable prognostic outcomes (P < 0.001). Multivariate analysis demonstrated that this combined status is an independent prognostic factor for primary breast cancer (P = 0.002). Clinical outcomes in different subgroups of breast cancer patients were also strictly dependent on this combined status (P < 0.05). The prognostic value of T(++)/S(-) Cav-1 status was also validated in the testing cohort. Collectively, our data indicate that high Cav-1 expression in tumor cells and lack of this expression in stromal cells could help identify a particular subgroup of breast cancer patients with potentially poor survival. Further studies are required to understand the regulatory mechanism of Cav-1 in the tumor microenvironment.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CAV1Humanbreast cancer disease_progressionIEP  RGD 
Cav1Ratbreast cancer disease_progressionISOCAV1 (Homo sapiens) RGD 
Cav1Mousebreast cancer disease_progressionISOCAV1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cav1  (caveolin 1)

Genes (Mus musculus)
Cav1  (caveolin 1, caveolae protein)

Genes (Homo sapiens)
CAV1  (caveolin 1)


Additional Information