CAV1 (caveolin 1) - Rat Genome Database

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Gene: CAV1 (caveolin 1) Canis lupus familiaris
Analyze
Symbol: CAV1
Name: caveolin 1
RGD ID: 12250353
Description: ENCODES a protein that exhibits enzyme binding (ortholog); kinase binding (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN caveola assembly; protein localization to basolateral plasma membrane; protein localization to plasma membrane raft; PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acoustic neuroma (ortholog); Acute Lung Injury (ortholog); FOUND IN caveola; exocytic vesicle; apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: caveolin-1; vesicular integral-membrane protein VIP21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBI
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBI
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBI
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBI
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acoustic neuroma  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiomegaly  (ISO)
congenital generalized lipodystrophy type 3  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic neuropathy  (ISO)
diffuse scleroderma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial partial lipodystrophy  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
invasive ductal carcinoma  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
Lipodystrophy with Congenital Cataracts and Neurodegeneration  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
osteoarthritis  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary open angle glaucoma  (ISO)
primary pulmonary hypertension  (ISO)
Primary Pulmonary Hypertension, 3  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Sarcopenia  (ISO)
sciatic neuropathy  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiotensin-activated signaling pathway involved in heart process  (IEA)
animal organ regeneration  (ISO)
apoptotic signaling pathway  (IEA)
basement membrane organization  (IEA,ISO)
calcium ion homeostasis  (ISO)
calcium ion transport  (IEA,ISO)
caveola assembly  (IBA,IDA,IEA,ISO)
caveolin-mediated endocytosis  (IEA,ISO)
cell differentiation  (IBA)
cellular calcium ion homeostasis  (ISO)
cellular response to exogenous dsRNA  (IEA)
cellular response to hyperoxia  (IEA)
cellular response to mechanical stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular senescence  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (IEA,ISO)
insulin receptor internalization  (IEA)
lactation  (IEA,ISO)
lipid storage  (IEA,ISO)
maintenance of protein location in cell  (ISO)
mammary gland development  (ISO)
mammary gland involution  (IEA,ISO)
membrane depolarization  (IEA,ISO)
microtubule polymerization  (ISO)
negative regulation of anoikis  (IEA)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cation channel activity  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine-mediated signaling pathway  (IEA,ISO)
negative regulation of endothelial cell proliferation  (IBA,ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inward rectifier potassium channel activity  (IEA)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of necroptotic process  (IEA)
negative regulation of neuron differentiation  (ISO)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO)
negative regulation of nitric-oxide synthase activity  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (IEA)
negative regulation of peptidyl-tyrosine autophosphorylation  (IEA)
negative regulation of pinocytosis  (IEA)
negative regulation of potassium ion transmembrane transport  (ISO)
negative regulation of protein binding  (IEA)
negative regulation of protein tyrosine kinase activity  (IBA)
negative regulation of protein ubiquitination  (IEA)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISS)
negative regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
nitric oxide homeostasis  (IEA,ISO)
obsolete inactivation of MAPK activity  (IEA)
positive regulation of calcium ion transport into cytosol  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of cell adhesion molecule production  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cholesterol efflux  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of endocytosis  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ER-associated ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of gap junction assembly  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (IEA)
positive regulation of microtubule polymerization  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of peptidase activity  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of protein binding  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of signal transduction  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (IEA)
positive regulation of vasoconstriction  (IEA,ISO)
posttranscriptional regulation of gene expression  (IEA)
protein localization  (ISO)
protein localization to basolateral plasma membrane  (IDA)
protein localization to plasma membrane raft  (IDA)
protein transport  (IEA,ISO)
receptor internalization  (ISS)
receptor internalization involved in canonical Wnt signaling pathway  (IEA)
receptor-mediated endocytosis of virus by host cell  (IEA)
regulation of blood coagulation  (IEA)
regulation of cell communication by electrical coupling involved in cardiac conduction  (IEA)
regulation of cytosolic calcium ion concentration  (IBA)
regulation of entry of bacterium into host cell  (IEA)
regulation of fatty acid metabolic process  (IEA,ISO)
regulation of heart rate by cardiac conduction  (IEA)
regulation of membrane repolarization during action potential  (IEA)
regulation of peptidase activity  (ISO)
regulation of ruffle assembly  (IEA)
regulation of smooth muscle contraction  (IEA,ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
regulation of ventricular cardiac muscle cell action potential  (IEA)
response to bacterium  (IEA)
response to calcium ion  (IEA)
response to drug  (ISO)
response to estrogen  (IEA,ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (IEA,ISO)
response to ischemia  (IEA,ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to progesterone  (ISO)
skeletal muscle tissue development  (IEA,ISO)
T cell costimulation  (ISS)
triglyceride metabolic process  (IEA,ISO)
vasculogenesis  (IEA,ISO)
vasoconstriction  (IEA,ISO)
vesicle organization  (IDA)
wound healing  (ISO)

References
Additional References at PubMed
PMID:1512286   PMID:7568142   PMID:7608210   PMID:7896831   PMID:8349730   PMID:8385608   PMID:8621645   PMID:12633858   PMID:12743374   PMID:12917688   PMID:16260622   PMID:16332692  
PMID:17785436   PMID:17947532   PMID:18397999   PMID:18504258   PMID:20153867   PMID:20153868   PMID:20504340   PMID:20936466   PMID:21914371   PMID:22370882   PMID:23360510   PMID:23401359  
PMID:25609711   PMID:29502342   PMID:31810383  


Genomics

Comparative Map Data
CAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBI
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBI
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBI
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBI
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBI
CAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBI
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
Cav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,306,287 - 17,341,327 (+)NCBIGRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBImm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
Cav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2445,640,624 - 45,673,708 (+)NCBI
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q21NCBI
Cav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
CAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0panPan3
Cav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBI
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,222,724 - 85,258,562 (+)NCBI
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)Ensembl
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBI
Cav1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 4
Medium 5 5 15 6 6 6 12 6 6
Low 7 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000005462   ⟹   ENSCAFP00000005060
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000062220   ⟹   ENSCAFP00000060860
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1455,462,057 - 55,492,935 (+)Ensembl
RefSeq Acc Id: NM_001003296   ⟹   NP_001003296
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11455,461,084 - 55,492,691 (+)NCBI
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBI
ROS_Cfam_1.01455,503,099 - 55,534,670 (+)NCBI
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBI
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBI
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005628347   ⟹   XP_005628404
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11455,461,683 - 55,494,563 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014118875   ⟹   XP_013974350
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11455,458,934 - 55,494,563 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038685936   ⟹   XP_038541864
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01455,503,677 - 55,536,541 (+)NCBI
RefSeq Acc Id: XM_038685937   ⟹   XP_038541865
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_013974350   ⟸   XM_014118875
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001003296   ⟸   NM_001003296
- UniProtKB: P33724 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005628404   ⟸   XM_005628347
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000005060   ⟸   ENSCAFT00000005462
RefSeq Acc Id: ENSCAFP00000060860   ⟸   ENSCAFT00000062220
RefSeq Acc Id: XP_038541865   ⟸   XM_038685937
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038541864   ⟸   XM_038685936
- Peptide Label: isoform X1

Promoters
RGD ID:13685822
Promoter ID:EPDNEW_C3890
Type:initiation region
Name:CAV1_1
Description:caveolin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11455,461,034 - 55,461,094EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030007606 UniProtKB/Swiss-Prot
  ENSCAFG00040016536 UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000005060 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFP00000060860 UniProtKB/TrEMBL
  ENSCAFP00030012265 UniProtKB/Swiss-Prot
  ENSCAFP00040026553 UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000005462 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFT00000062220 UniProtKB/TrEMBL
  ENSCAFT00030014054 UniProtKB/Swiss-Prot
  ENSCAFT00040030547 UniProtKB/Swiss-Prot
InterPro CAV-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caveolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403980 UniProtKB/Swiss-Prot
NCBI Gene CAV1 ENTREZGENE
PANTHER PTHR10844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10844:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CAVEOLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F4D7T0_CANLF UniProtKB/TrEMBL
  CAV1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0M8U8 UniProtKB/Swiss-Prot
VGNC ID VGNC:38751 ENTREZGENE