CAV1 (caveolin 1) - Rat Genome Database

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Gene: CAV1 (caveolin 1) Pan paniscus
Analyze
Symbol: CAV1
Name: caveolin 1
RGD ID: 11965308
Description: ENCODES a protein that exhibits ATPase binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); angiotensin-activated signaling pathway involved in heart process (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acoustic neuroma (ortholog); Acute Lung Injury (ortholog); FOUND IN acrosomal membrane (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: caveolin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acoustic neuroma  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Liver Diseases  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
Carcinogenesis  (ISO)
Cardiomegaly  (ISO)
congenital generalized lipodystrophy type 3  (ISO)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic neuropathy  (ISO)
diffuse scleroderma  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial partial lipodystrophy  (ISO)
genetic disease  (ISO)
Hemorrhage  (ISO)
high grade glioma  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
invasive ductal carcinoma  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
Lipodystrophy with Congenital Cataracts and Neurodegeneration  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Neoplasm Metastasis  (ISO)
Nephrogenic Fibrosing Dermopathy  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
osteoarthritis  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary open angle glaucoma  (ISO)
primary pulmonary hypertension  (ISO)
Primary Pulmonary Hypertension, 3  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Sarcopenia  (ISO)
sciatic neuropathy  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Weight Gain  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
angiotensin-activated signaling pathway involved in heart process  (ISO)
animal organ regeneration  (ISO)
apoptotic signaling pathway  (ISO)
basement membrane organization  (ISO)
calcium ion homeostasis  (ISO)
calcium ion transport  (ISO)
caveola assembly  (ISO)
caveolin-mediated endocytosis  (ISO)
cellular calcium ion homeostasis  (ISO)
cellular response to exogenous dsRNA  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to starvation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular senescence  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (ISO)
insulin receptor internalization  (ISO)
lactation  (ISO)
lipid storage  (ISO)
maintenance of protein location in cell  (ISO)
mammary gland development  (ISO)
mammary gland involution  (ISO)
membrane depolarization  (ISO)
microtubule polymerization  (ISO)
negative regulation of anoikis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cation channel activity  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of inward rectifier potassium channel activity  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of peptidyl-tyrosine autophosphorylation  (ISO)
negative regulation of pinocytosis  (ISO)
negative regulation of potassium ion transmembrane transport  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein tyrosine kinase activity  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
nitric oxide homeostasis  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell adhesion molecule production  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ER-associated ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of gap junction assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of signal transduction  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (ISO)
positive regulation of vasoconstriction  (ISO)
posttranscriptional regulation of gene expression  (ISO)
protein localization  (ISO)
protein localization to basolateral plasma membrane  (ISO)
protein localization to plasma membrane raft  (ISO)
protein transport  (ISO)
receptor internalization  (ISO)
receptor internalization involved in canonical Wnt signaling pathway  (ISO)
receptor-mediated endocytosis of virus by host cell  (ISO)
regulation of blood coagulation  (ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (ISO)
regulation of cytosolic calcium ion concentration  (ISO)
regulation of entry of bacterium into host cell  (ISO)
regulation of fatty acid metabolic process  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane repolarization during action potential  (ISO)
regulation of peptidase activity  (ISO)
regulation of ruffle assembly  (ISO)
regulation of smooth muscle contraction  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by chemical signal  (ISO)
regulation of ventricular cardiac muscle cell action potential  (ISO)
response to bacterium  (ISO)
response to calcium ion  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to progesterone  (ISO)
skeletal muscle tissue development  (ISO)
T cell costimulation  (ISO)
triglyceride metabolic process  (ISO)
vasculogenesis  (ISO)
vasoconstriction  (ISO)
vesicle organization  (ISO)
wound healing  (ISO)

References

Genomics

Comparative Map Data
CAV1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17121,193,678 - 121,229,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBIMhudiblu_PPA_v0panPan3
CAV1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7116,524,994 - 116,561,179 (+)EnsemblGRCh38hg38GRCh38
GRCh387116,525,009 - 116,561,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377116,165,063 - 116,201,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,952,075 - 115,988,466 (+)NCBINCBI36hg18NCBI36
Build 347115,758,789 - 115,795,181NCBI
Celera7110,972,249 - 111,008,654 (+)NCBI
Cytogenetic Map7q31.2NCBI
HuRef7110,530,835 - 110,566,784 (+)NCBIHuRef
CHM1_17116,098,482 - 116,134,827 (+)NCBICHM1_1
CRA_TCAGchr7v27115,560,275 - 115,596,679 (+)NCBI
Cav1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,306,287 - 17,341,327 (+)NCBIGRCm39mm39
GRCm39 Ensembl617,306,334 - 17,341,451 (+)Ensembl
GRCm38617,306,335 - 17,341,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,306,335 - 17,341,452 (+)EnsemblGRCm38mm10GRCm38
MGSCv37617,256,370 - 17,291,324 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,256,370 - 17,291,324 (+)NCBImm8
Celera617,378,835 - 17,414,670 (+)NCBICelera
Cytogenetic Map6A2NCBI
Cav1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2445,640,624 - 45,673,708 (+)NCBI
Rnor_6.0 Ensembl444,597,123 - 44,630,200 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q21NCBI
Cav1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,258,250 - 22,292,403 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543222,258,262 - 22,292,403 (+)NCBIChiLan1.0ChiLan1.0
CAV1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,458,934 - 55,494,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,461,048 - 55,492,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1454,856,462 - 54,888,069 (+)NCBI
ROS_Cfam_1.01455,500,946 - 55,536,541 (+)NCBI
UMICH_Zoey_3.11455,530,973 - 55,562,566 (+)NCBI
UNSW_CanFamBas_1.01455,219,411 - 55,251,015 (+)NCBI
UU_Cfam_GSD_1.01455,590,528 - 55,622,125 (+)NCBI
Cav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511844,152,891 - 44,185,619 (+)NCBI
SpeTri2.0NW_0049365892,504,235 - 2,536,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,649,992 - 29,682,465 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11829,648,120 - 29,682,451 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,745,664 - 31,778,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAV1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12185,222,724 - 85,258,562 (+)NCBI
ChlSab1.1 Ensembl2185,222,879 - 85,258,627 (+)Ensembl
Vero_WHO_p1.0NW_02366604218,474,866 - 18,510,943 (-)NCBI
Cav1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248272,844,855 - 2,878,367 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000050191   ⟹   ENSPPAP00000027351
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7121,193,424 - 121,229,655 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000050193   ⟹   ENSPPAP00000027353
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7121,194,002 - 121,229,655 (+)Ensembl
RefSeq Acc Id: XM_003808654   ⟹   XP_003808702
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.17121,193,678 - 121,229,655 (+)NCBI
Mhudiblu_PPA_v07108,497,125 - 108,533,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960724   ⟹   XP_008958972
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.17121,195,005 - 121,229,655 (+)NCBI
Mhudiblu_PPA_v07108,498,503 - 108,533,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960725   ⟹   XP_008958973
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.17121,194,002 - 121,229,655 (+)NCBI
Mhudiblu_PPA_v07108,497,853 - 108,533,090 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003808702 (Get FASTA)   NCBI Sequence Viewer  
  XP_008958972 (Get FASTA)   NCBI Sequence Viewer  
  XP_008958973 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003808702   ⟸   XM_003808654
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008958973   ⟸   XM_008960725
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008958972   ⟸   XM_008960724
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000027353   ⟸   ENSPPAT00000050193
RefSeq Acc Id: ENSPPAP00000027351   ⟸   ENSPPAT00000050191


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036739 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000027351 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000027353 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050191 UniProtKB/TrEMBL
  ENSPPAT00000050193 UniProtKB/TrEMBL
InterPro CAV-1 UniProtKB/TrEMBL
  Caveolin UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/TrEMBL
KEGG Report pps:100992465 UniProtKB/TrEMBL
NCBI Gene CAV1 ENTREZGENE
PANTHER PTHR10844 UniProtKB/TrEMBL
  PTHR10844:SF18 UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/TrEMBL
PROSITE CAVEOLIN UniProtKB/TrEMBL
UniProt A0A2R9BCI3_PANPA UniProtKB/TrEMBL
  A0A2R9BGE7_PANPA UniProtKB/TrEMBL