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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cav1
Name: caveolin 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cav1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CAV1 protein modified formPMID:26357463
Cav1multiple interactionsEXP 6480464CTD4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CAV1 protein]; AG 1879 inhibits the reaction [Lipopolysaccharides results in increased expression of CAV1 protein modified form]; AG 1879 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CAV1 protein]; Lipopolysaccharides results in increased phosphorylation of and affects the localization of CAV1 protein; methyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides results in increased expression of CAV1 protein modified form]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CAV1 protein]; saracatinib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CAV1 protein]PMID:26357463
Cav1affects expressionISOCav1 (Mus musculus)6480464CTDLipopolysaccharides affects the expression of CAV1 mRNA; Lipopolysaccharides affects the expression of CAV1 proteinPMID:10948129
Cav1increases expressionISOCAV1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CAV1 protein modified formPMID:26357463
Cav1multiple interactionsISOCav1 (Mus musculus)6480464CTDCAV1 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; CAV1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]PMID:24835767
Cav1multiple interactionsISOCAV1 (Homo sapiens)6480464CTD[NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CAV1 mRNA; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CAV1 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of CAV1 mRNA; CAV1 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; CAV1 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]; CAV1 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of NOX4 mRNA]; Lipopolysaccharides results in increased phosphorylation of and affects the localization of CAV1 proteinPMID:24835767 PMID:26357463 PMID:35811015 PMID:35877022
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