Kcnj8 (potassium inwardly-rectifying channel, subfamily J, member 8) - Rat Genome Database

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Gene: Kcnj8 (potassium inwardly-rectifying channel, subfamily J, member 8) Rattus norvegicus
Symbol: Kcnj8
Name: potassium inwardly-rectifying channel, subfamily J, member 8
RGD ID: 2960
Description: Enables ATP binding activity; monoatomic cation transmembrane transporter activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Located in sarcolemma. Part of inward rectifying potassium channel. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study hypertension. Biomarker of Parkinsonism and sciatic neuropathy. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
Previously known as: ATP-sensitive inward rectifier potassium channel 8; inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive); Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); Kir6.1; potassium channel, inwardly rectifying subfamily J member 8; potassium channel, inwardly rectifying subfamily J, member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1; UKATP1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.24175,508,908 - 175,515,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,508,912 - 175,515,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,804,515 - 181,810,357 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,588,783 - 177,594,629 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,209,354 - 176,215,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,783,287 - 176,789,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,782,498 - 176,789,304 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,996,986 - 241,003,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,144,084 - 180,149,935 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,388,422 - 180,395,042 (-)NCBI
Celera4164,042,167 - 164,048,023 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetylcholine  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dichlorine  (EXP)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
formaldehyde  (EXP)
glafenine  (EXP)
glyburide  (EXP,ISO)
hydrogen peroxide  (ISO)
irinotecan  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylseleninic acid  (ISO)
Muraglitazar  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
potassium atom  (EXP)
progesterone  (ISO)
rotenone  (ISO)
rubidium atom  (EXP)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium disulfite  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP,ISO)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
adaptive immune response  (ISO)
apoptotic process  (ISO)
atrioventricular node cell differentiation  (ISO)
blood vessel development  (ISO)
calcium ion transmembrane transport  (ISO)
CAMKK-AMPK signaling cascade  (ISO)
cardiac pacemaker cell differentiation  (ISO)
cell population proliferation  (ISO)
circulatory system development  (ISO)
coronary vasculature development  (ISO)
defense response to virus  (ISO)
determination of adult lifespan  (ISO)
establishment of cell polarity  (ISO)
fat cell differentiation  (ISO)
fatty acid transport  (ISO)
fibroblast proliferation  (ISO)
gene expression  (ISO)
glutamate secretion, neurotransmission  (ISO)
heart development  (ISO)
heart morphogenesis  (ISO)
inflammatory response  (ISO)
inorganic cation transmembrane transport  (IGI)
kidney development  (IEP)
membrane repolarization during ventricular cardiac muscle cell action potential  (ISO)
microglial cell activation  (ISO)
nervous system process  (ISO)
neuromuscular process  (ISO)
NLRP3 inflammasome complex assembly  (ISO)
p38MAPK cascade  (ISO)
potassium ion import across plasma membrane  (IBA,IDA,ISO)
potassium ion transmembrane transport  (ISO)
potassium ion transport  (IDA,IMP)
protein secretion  (ISO)
reactive gliosis  (ISO)
regulation of blood pressure  (ISO)
regulation of heart rate  (ISO)
regulation of monoatomic ion transmembrane transport  (IBA)
regulation of presynaptic membrane potential  (IEA)
response to ATP  (ISO)
response to cytokine  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to exogenous dsRNA  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to resveratrol  (ISO)
response to stress  (ISO)
response to xenobiotic stimulus  (ISO)
synaptic assembly at neuromuscular junction  (ISO)
transmission of nerve impulse  (ISO)
vasculature development  (ISO)
vasodilation  (ISO)
ventricular cardiac muscle tissue development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)


References - curated
# Reference Title Reference Citation
1. Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43). Ahmad Waza A, etal., Exp Cell Res. 2012 Dec 10;318(20):2559-66. doi: 10.1016/j.yexcr.2012.08.004. Epub 2012 Aug 30.
2. Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts. Akao M, etal., J Clin Invest. 1997 Dec 15;100(12):3053-9.
3. Developmental expression and functional significance of Kir channel subunits in ureteric bud and nephron epithelia. Braun GS, etal., Pflugers Arch. 2002 Dec;445(3):321-30. Epub 2002 Nov 6.
4. KATP channel conductance of descending vasa recta pericytes. Cao C, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1235-45. Epub 2005 Jul 26.
5. Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
6. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
7. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Cuong DV, etal., Mitochondrion. 2005 Apr;5(2):121-33.
8. Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces. Dong K, etal., EMBO J. 2005 Apr 6;24(7):1318-29. Epub 2005 Mar 17.
9. Infection with AV-SUR2A protects H9C2 cells against metabolic stress: a mechanism of SUR2A-mediated cytoprotection independent from the K(ATP) channel activity. Du Q, etal., Biochim Biophys Acta. 2010 Mar;1803(3):405-15. doi: 10.1016/j.bbamcr.2010.01.018. Epub 2010 Feb 1.
10. Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion. Emanuele E, etal., Int J Mol Med. 2003 Oct;12(4):509-12.
11. Mitochondrial ATP-sensitive K+ channels prevent oxidative stress, permeability transition and cell death. Facundo HT, etal., J Bioenerg Biomembr. 2005 Apr;37(2):75-82.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. Inagaki N, etal., J Biol Chem. 1995 Mar 17;270(11):5691-4.
15. K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect. Lawrence KM, etal., Circulation 2002 Sep 17;106(12):1556-62.
16. Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery. Light PE, etal., FASEB J. 2001 Dec;15(14):2586-94.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Miki T, etal., Nat Med. 2002 May;8(5):466-72.
19. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
20. Enhancement of liver regeneration by adenosine triphosphate-sensitive K¿ channel opener (diazoxide) after partial hepatectomy. Nakagawa Y, etal., Transplantation. 2012 Jun 15;93(11):1094-100. doi: 10.1097/TP.0b013e31824ef1d1.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. Sampson LJ, etal., Circ Res. 2004 Nov 12;95(10):1012-8. Epub 2004 Oct 21.
27. ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo. Santa N, etal., Stroke 2003 May;34(5):1276-80.
28. Regulation of ATP-sensitive potassium channel mRNA expression in rat kidney following ischemic injury. Sgard F, etal., Biochem Biophys Res Commun. 2000 Mar 16;269(2):618-22.
29. Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. Soundarapandian MM, etal., J Neurochem. 2007 Dec;103(5):1982-8. doi: 10.1111/j.1471-4159.2007.04883.x. Epub 2007 Sep 18.
30. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
31. Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channel. Szamosfalvi B, etal., Kidney Int 2002 May;61(5):1739-49.
32. The carboxyl termini of K(ATP) channels bind nucleotides. Vanoye CG, etal., J Biol Chem. 2002 Jun 28;277(26):23260-70. doi: 10.1074/jbc.M112004200. Epub 2002 Apr 15.
33. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
34. Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. Wang W, etal., J Tradit Chin Med. 2015 Oct;35(5):577-82.
35. Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes. Wu SN, etal., Life Sci. 2007 Jan 2;80(4):378-87. Epub 2006 Oct 17.
36. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Wu XF, etal., Pain. 2011 Nov;152(11):2605-15. doi: 10.1016/j.pain.2011.08.003. Epub 2011 Sep 9.
37. A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats. Xue H, etal., J Pharmacol Exp Ther. 2005 Nov;315(2):501-9. Epub 2005 Jul 28.
38. ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes. Zhou M, etal., J Histochem Cytochem. 2005 Dec;53(12):1491-500. Epub 2005 Jun 27.
Additional References at PubMed
PMID:12965237   PMID:14724757   PMID:15044189   PMID:15739238   PMID:16085792   PMID:16820413   PMID:16891388   PMID:17341678   PMID:17512536   PMID:17548268   PMID:17714708   PMID:17942071  
PMID:18026101   PMID:18048350   PMID:18202312   PMID:18471810   PMID:19056241   PMID:19959479   PMID:20456845   PMID:20558321   PMID:20624795   PMID:21216949   PMID:21482559   PMID:22144717  
PMID:22480512   PMID:22636679   PMID:23418587   PMID:23974906   PMID:24037327   PMID:25599573   PMID:26505750   PMID:27035370   PMID:29353068   PMID:33523201  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.24175,508,908 - 175,515,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,508,912 - 175,515,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,804,515 - 181,810,357 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,588,783 - 177,594,629 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,209,354 - 176,215,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,783,287 - 176,789,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,782,498 - 176,789,304 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,996,986 - 241,003,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,144,084 - 180,149,935 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,388,422 - 180,395,042 (-)NCBI
Celera4164,042,167 - 164,048,023 (-)NCBICelera
Cytogenetic Map4q44NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381221,764,955 - 21,774,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,764,955 - 21,775,600 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,917,889 - 21,927,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,809,156 - 21,819,014 (-)NCBINCBI36Build 36hg18NCBI36
Build 341221,809,155 - 21,819,014NCBI
Celera1227,072,901 - 27,082,758 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,691,442 - 21,701,306 (-)NCBIHuRef
CHM1_11221,883,171 - 21,893,034 (-)NCBICHM1_1
T2T-CHM13v2.01221,643,637 - 21,653,388 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396142,510,563 - 142,517,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,510,563 - 142,517,340 (-)EnsemblGRCm39 Ensembl
GRCm386142,564,837 - 142,571,614 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,564,837 - 142,571,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv376142,513,459 - 142,519,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,522,161 - 142,528,581 (-)NCBIMGSCv36mm8
Celera6145,626,686 - 145,633,104 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.31NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541317,364,213 - 17,371,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,364,447 - 17,371,255 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11275,022,673 - 75,033,355 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,522,172 - 64,532,848 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,126,584 - 67,137,128 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,127,263 - 67,137,128 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12725,368,565 - 25,375,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,368,810 - 25,375,009 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,985,001 - 20,992,186 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,588,424 - 25,595,600 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,588,452 - 25,595,598 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,386,897 - 25,394,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,410,445 - 25,417,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,155,847 - 21,163,033 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494587,202,938 - 87,209,604 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,125,555 - 5,133,078 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365485,125,583 - 5,132,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl551,696,188 - 51,703,813 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,695,927 - 51,704,402 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2554,978,919 - 54,987,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11121,624,963 - 21,634,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,624,970 - 21,634,042 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,508,221 - 13,518,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475216,939,384 - 16,946,723 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,939,289 - 16,945,692 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Kcnj8
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:384
Count of miRNA genes:224
Interacting mature miRNAs:258
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,508,998 - 175,509,218 (+)MAPPERmRatBN7.2
Rnor_6.04176,782,593 - 176,782,812NCBIRnor6.0
Rnor_5.04240,996,292 - 240,996,511UniSTSRnor5.0
RGSC_v3.44180,143,390 - 180,143,609UniSTSRGSC3.4
Celera4164,041,473 - 164,041,692UniSTS
RH 3.4 Map41046.1UniSTS
Cytogenetic Map4q44UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 26 6 4 13 4 4 4 20 23 5 4
Low 1 17 51 37 6 37 4 7 70 15 16 6 4
Below cutoff 4 2


RefSeq Acc Id: ENSRNOT00000018057   ⟹   ENSRNOP00000018057
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4175,508,912 - 175,515,603 (-)Ensembl
Rnor_6.0 Ensembl4176,782,498 - 176,789,304 (-)Ensembl
RefSeq Acc Id: NM_017099   ⟹   NP_058795
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,509,693 - 175,515,553 (-)NCBI
Rnor_6.04176,783,287 - 176,789,143 (-)NCBI
Rnor_5.04240,996,986 - 241,003,081 (-)NCBI
RGSC_v3.44180,144,084 - 180,149,935 (-)RGD
Celera4164,042,167 - 164,048,023 (-)RGD
RefSeq Acc Id: XM_039107115   ⟹   XP_038963043
Rat AssemblyChrPosition (strand)Source
mRatBN7.24175,508,908 - 175,515,829 (-)NCBI
RefSeq Acc Id: NP_058795   ⟸   NM_017099
- UniProtKB: Q9JM49 (UniProtKB/Swiss-Prot),   Q9JM50 (UniProtKB/Swiss-Prot),   Q63664 (UniProtKB/Swiss-Prot),   A6IMU7 (UniProtKB/TrEMBL),   Q6AYX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018057   ⟸   ENSRNOT00000018057
RefSeq Acc Id: XP_038963043   ⟸   XM_039107115
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63664-F1-model_v2 AlphaFold Q63664 1-424 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693491
Promoter ID:EPDNEW_R4015
Type:single initiation site
Description:potassium voltage-gated channel subfamily J member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,789,217 - 176,789,277EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2960 AgrOrtholog
BioCyc Gene G2FUF-42490 BioCyc
Ensembl Genes ENSRNOG00000013463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010196 UniProtKB/Swiss-Prot
  ENSRNOG00060007578 UniProtKB/Swiss-Prot
  ENSRNOG00065005793 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018057 ENTREZGENE
  ENSRNOT00000018057.6 UniProtKB/Swiss-Prot
  ENSRNOT00055017217 UniProtKB/Swiss-Prot
  ENSRNOT00060012503 UniProtKB/Swiss-Prot
  ENSRNOT00065008658 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir6.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25472 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnj8 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013463 RatGTEx
  ENSRNOG00055010196 RatGTEx
  ENSRNOG00060007578 RatGTEx
  ENSRNOG00065005793 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q9JM49 UniProtKB/Swiss-Prot
  Q9JM50 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj8  potassium inwardly-rectifying channel, subfamily J, member 8  Kcnj8  potassium voltage-gated channel subfamily J member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj8  potassium voltage-gated channel subfamily J member 8  Kcnj8  potassium channel, inwardly rectifying subfamily J, member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj8  potassium channel, inwardly rectifying subfamily J, member 8  Kcnj8  potassium inwardly-rectifying channel, subfamily J, member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Kcnj8  potassium inwardly-rectifying channel, subfamily J, member 8      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs channel function is inhibited by glibenclamide, and opened by pinacidil 724755