RGD Reference Report - Association of a CAV-1 haplotype to familial aggressive prostate cancer. - Rat Genome Database

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Association of a CAV-1 haplotype to familial aggressive prostate cancer.

Authors: Haeusler, J  Hoegel, J  Bachmann, N  Herkommer, K  Paiss, T  Vogel, W  Maier, C 
Citation: Haeusler J, etal., Prostate. 2005 Oct 1;65(2):171-7.
RGD ID: 2289104
Pubmed: PMID:15948133   (View Abstract at PubMed)
DOI: DOI:10.1002/pros.20256   (Journal Full-text)

BACKGROUND: Multiple lines of evidence have implicated the CAV-1 gene in prostate cancer progression. CAV-1 is located within the prostate cancer aggressiveness locus at 7q31-33, and was identified as being overexpressed in prostate tumors. Mutation screening was performed as well as a case-control study to examine if polymorphisms in CAV-1 are associated with prostate cancer aggressiveness in a German population. METHODS: We sequenced the CAV-1 promoter region and its open reading frame in prostate cancer families with linkage to chromosome 7q31-33. Additionally, 105 unrelated familial prostate cancer probands, 190 sporadic cases, and 191 controls were genotyped at four intronic single nucleotide polymorphisms. Resulting haplotypes were tested for association using age at diagnosis, tumor grade, TNM stage, and follow up information to stratify for aggressive disease. RESULTS: No mutation was found in the CAV-1 coding region or in the promoter. One of the 11 observed haplotypes showed an increased frequency in cases with high tumor stage (P = 0.03). CONCLUSIONS: This is the first report providing evidence for CAV-1 being involved in predisposition to aggressive prostate cancer. The association of a potential risk haplotype agrees well with a role of CAV-1 in tumor progression but needs further confirmation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CAV1Humanprostate cancer disease_progressionIAGP  RGD 
Cav1Ratprostate cancer disease_progressionISOCAV1 (Homo sapiens) RGD 
Cav1Mouseprostate cancer disease_progressionISOCAV1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cav1  (caveolin 1)

Genes (Mus musculus)
Cav1  (caveolin 1, caveolae protein)

Genes (Homo sapiens)
CAV1  (caveolin 1)


Additional Information