RGD Reference Report - T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients and healthy controls. - Rat Genome Database

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T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients and healthy controls.

Authors: Yu, BN  Wang, A  Zhou, G  Zhang, W  Hu, DL  Li, Q  He, YJ  Zhou, HH 
Citation: Yu BN, etal., Clin Exp Pharmacol Physiol. 2004 Dec;31(12):847-9.
RGD ID: 1624371
Pubmed: PMID:15659047   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1440-1681.2004.04124.x   (Journal Full-text)

1. The 5-HT(2A) receptor belongs to the G-protein superfamily. It plays an important role in vascular regulation. 2. Previous reports in the UK have indicated that there is an association of the T102C genetic polymorphism of the 5-HT(2A) receptor with hypertension, but no studies have been made on the T102C genetic polymorphism in Chinese hypertensive patients. In the present study, we investigated the T102C genetic polymorphism of 5-HT(2A) receptors in Chinese hypertensive patients to determine whether there is an association of this polymorphism with hypertension in Chinese. 3. The present study was conducted on 198 hypertensive patients and 164 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism was used to identify the T102C genetic polymorphism of the 5-HT(2A) receptor. 4. In the present study, the C allele frequency of the 5-HT(2A) receptor genetic polymorphism was 0.343 in hypertensive patients, which was not significantly different to that in healthy controls (0.393; chi(2) = 1.922; P = 0.166; odds ratio = 0.807, 95% confidence interval 0.596-1.093). In addition, no gender differences were observed. 5. In conclusion, to our knowledge, this is the first report on the T102C genetic polymorphism of the 5-HT(2A) receptor in Chinese hypertensive patients. We find that no correlation exists between the T102C genetic polymorphism and hypertension, which affords useful information on the pathogenesis of hypertension in the Chinese population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HTR2AHumanhypertension no_associationIAGP DNA:polymorphism: :g.102T>CRGD 
Htr2aRathypertension no_associationISOHTR2A (Homo sapiens)DNA:polymorphism: :g.102T>CRGD 
Htr2aMousehypertension no_associationISOHTR2A (Homo sapiens)DNA:polymorphism: :g.102T>CRGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr2a  (5-hydroxytryptamine receptor 2A)

Genes (Mus musculus)
Htr2a  (5-hydroxytryptamine (serotonin) receptor 2A)

Genes (Homo sapiens)
HTR2A  (5-hydroxytryptamine receptor 2A)


Additional Information