Htr2a (5-hydroxytryptamine (serotonin) receptor 2A) - Rat Genome Database

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Gene: Htr2a (5-hydroxytryptamine (serotonin) receptor 2A) Mus musculus
Analyze
Symbol: Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
RGD ID: 62092
MGI Page MGI
Description: Enables protein tyrosine kinase activator activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphate metabolic process; and protein localization to cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neurofilament. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and heart. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-2; 5-HT-2A; 5-HT2A receptor; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; E030013E04; Htr; Htr-; Htr-2; Htr2; MGC124301; MGC124302; serotonin receptor 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391474,878,314 - 74,944,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)EnsemblGRCm39 Ensembl
GRCm381474,640,874 - 74,706,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,040,647 - 75,106,666 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,374,995 - 73,441,014 (+)NCBIMGSCv36mm8
Celera1472,148,249 - 72,214,245 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Stress Disorders, Traumatic  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
alcoholic psychosis  (ISO)
Alzheimer's disease  (ISO)
anorexia nervosa  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
Back Pain  (ISO)
basal ganglia disease  (ISO)
bipolar disorder  (IEA,ISO)
bladder neck obstruction  (ISO)
Cardiomegaly  (IEP)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
depressive disorder  (IEA,ISO)
Diabetic Nephropathies  (ISO)
disease of metabolism  (ISO)
Dyskinesias  (ISO)
endotoxin shock  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fever  (ISO)
Hallucinations  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hyperkinesis  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
inflammatory and toxic neuropathy  (ISO)
Insulin Resistance  (ISO)
Intervertebral Disc Displacement  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IDA)
migraine  (ISO)
morphine dependence  (IEP)
nicotine dependence  (ISO)
non-alcoholic fatty liver  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
opioid abuse  (IEP)
pancreatitis  (ISO)
pathological gambling  (ISO)
psychotic disorder  (ISO)
schizophrenia  (IEA,ISO)
Sleep Bruxism  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
steatotic liver disease  (ISO)
stress-related disorder  (ISO)
Urinary Incontinence  (ISO)
Urination Disorders  (ISO)
withdrawal disorder  (IMP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1-(3-chlorophenyl)piperazine  (ISO)
1-bromopropane  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenoxybenzoic acid  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
adinazolam  (ISO)
albiflorin  (ISO)
alprenolol  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
Bardoxolone methyl  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bupropion  (ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cinchocaine  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
Clozapine N-oxide  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
corticotropin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproheptadine  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
desipramine  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
dopamine  (ISO)
fenfluramine  (ISO)
fentanyl  (ISO)
fluoxetine  (EXP,ISO)
fluphenazine  (ISO)
fluvoxamine  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Geniposide  (EXP)
genistein  (EXP)
Goe 6976  (ISO)
GR 127935  (ISO)
haloperidol  (ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
imipramine  (ISO)
ketanserin  (EXP,ISO)
lithium chloride  (ISO)
loxapine  (ISO)
metergoline  (EXP)
metformin  (ISO)
methamidophos  (EXP)
methamphetamine  (ISO)
methiothepin  (EXP)
mianserin  (EXP)
monocrotaline  (ISO)
N,N-dimethyltryptamine  (ISO)
N-desmethylclozapine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nitrates  (ISO)
nitrofen  (ISO)
olanzapine  (EXP,ISO)
paliperidone palmitate  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
phencyclidine  (ISO)
Phenoxybenzamine  (ISO)
phorbol 12,13-dibutanoate  (ISO)
picloram  (ISO)
piperazines  (ISO)
poly(I:C)  (EXP)
progesterone  (ISO)
quercetin  (ISO)
quetiapine fumarate  (ISO)
raloxifene  (ISO)
risperidone  (ISO)
ritanserin  (ISO)
rotenone  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 206553  (ISO)
serotonin  (EXP,ISO)
sertraline  (ISO)
sodium arsenite  (ISO)
spiperone  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tramadol  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
tryptamine  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
yohimbine  (EXP)
zalcitabine  (EXP,ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery smooth muscle contraction  (IEA,ISO)
behavioral response to cocaine  (IEA,ISO)
chemical synaptic transmission  (IBA)
detection of mechanical stimulus involved in sensory perception of pain  (IEA,ISO)
detection of temperature stimulus involved in sensory perception of pain  (IEA,ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (ISO)
glycolytic process  (IMP)
intracellular calcium ion homeostasis  (IEA,ISO)
memory  (IEA,ISO)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of synaptic transmission, glutamatergic  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipase C-activating serotonin receptor signaling pathway  (IBA,IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cytokine production involved in immune response  (IEA,ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of DNA biosynthetic process  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of execution phase of apoptosis  (IEA,ISO)
positive regulation of fat cell differentiation  (IMP)
positive regulation of glycolytic process  (IMP)
positive regulation of heat generation  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phosphatidylinositol biosynthetic process  (IEA,ISO)
positive regulation of platelet aggregation  (IEA,ISO)
positive regulation of vasoconstriction  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
protein localization to cytoskeleton  (IDA)
regulation of dopamine secretion  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IBA,IEA,ISO)
response to cocaine  (ISO)
response to xenobiotic stimulus  (IBA,IEA,ISO)
sensitization  (IEA,ISO)
sensory perception of temperature stimulus  (ISO)
serotonin receptor signaling pathway  (IBA)
temperature homeostasis  (IEA,ISO)
urinary bladder smooth muscle contraction  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. Abe Y, etal., J Sleep Res. 2012 Jun;21(3):289-96. doi: 10.1111/j.1365-2869.2011.00961.x. Epub 2011 Oct 1.
2. Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats. Adamec R, etal., Eur J Pharmacol. 2004 Nov 3;504(1-2):79-96. doi: 10.1016/j.ejphar.2004.09.017.
3. Response to novelty, social and self-control behaviors, in rats exposed to neonatal anoxia: modulatory effects of an enriched environment. Adriani W, etal., Psychopharmacology (Berl). 2006 Jan;184(2):155-65. Epub 2005 Dec 16.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Binetti J, etal., Life (Basel). 2020 Oct 16;10(10):245. doi: 10.3390/life10100245.
6. Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study. Castellano O, etal., Behav Brain Res. 2013 Apr 1;242:178-90. doi: 10.1016/j.bbr.2012.12.036. Epub 2013 Jan 4.
7. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. Cunningham KA, etal., ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.
8. 5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization. Davidson C, etal., Eur J Pharmacol. 2002 Oct 25;453(2-3):255-63. doi: 10.1016/s0014-2999(02)02390-7.
9. Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells. Desjardins S, etal., Neuropharmacology. 2008 Dec;55(8):1347-54. doi: 10.1016/j.neuropharm.2008.08.027. Epub 2008 Aug 30.
10. Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT reuptake sites. Druse MJ, etal., Alcohol Clin Exp Res. 1997 Oct;21(7):1157-64.
11. Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats. Ercan Z, etal., J Mol Neurosci. 2023 Oct;73(9-10):831-842. doi: 10.1007/s12031-023-02159-2. Epub 2023 Oct 4.
12. Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments. Fedeli A, etal., Res Commun Mol Pathol Pharmacol. 2002;112(1-4):113-27.
13. Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. Fernàndez-Castillo N, etal., Genes Brain Behav. 2013 Feb;12(1):39-46. doi: 10.1111/gbb.12013. Epub 2013 Jan 10.
14. Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats. Filip M, Pharmacol Rep. 2005 Jan-Feb;57(1):35-46.
15. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Fletcher PJ, etal., Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8.
16. Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains. Fomsgaard L, etal., Mol Neurobiol. 2018 Mar;55(3):1998-2012. doi: 10.1007/s12035-017-0457-y. Epub 2017 Mar 6.
17. [The analysis of serotonin receptor type 2A gene polymorphism in patients of different nationalities with acute alcoholic psychosis]. Galeeva AR, etal., Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(1):53-5.
18. Decreased cerebral cortex and liver 5-HT2A receptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures. George AK, etal., Neurol Res. 2010 Jun;32(5):510-8. doi: 10.1179/174313209X385554.
19. Sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, attenuates neurogenic pain induced by nucleus pulposus in rats. Hashizume H, etal., Spine. 2007 Feb 1;32(3):315-20.
20. Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Hofmann AD, etal., J Pediatr Surg. 2014 Jun;49(6):871-4; discussion 874-5. doi: 10.1016/j.jpedsurg.2014.01.015. Epub 2014 Jan 31.
21. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Hu Z, etal., Exp Ther Med. 2016 Jan;11(1):89-97. doi: 10.3892/etm.2015.2868. Epub 2015 Nov 13.
22. The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. Jakubczyk A, etal., J Psychiatr Res. 2012 Jan;46(1):44-9. doi: 10.1016/j.jpsychires.2011.09.001. Epub 2011 Sep 17.
23. The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment. Jakubczyk A, etal., J Psychiatr Res. 2013 Apr;47(4):527-33. doi: 10.1016/j.jpsychires.2012.12.004. Epub 2013 Jan 12.
24. The effect of a 5-HT2A receptor antagonist on pain-related behavior, endogenous 5-hydroxytryptamine production, and the expression 5-HT2A receptors in dorsal root ganglia in a rat lumbar disc herniation model. Kato K, etal., Spine (Phila Pa 1976). 2015 Mar 15;40(6):357-62. doi: 10.1097/BRS.0000000000000769.
25. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Kim JA, etal., Alcohol Clin Exp Res. 1997 Oct;21(7):1169-78.
26. Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease. Kim M, etal., Eur J Med Chem. 2022 Sep 5;239:114517. doi: 10.1016/j.ejmech.2022.114517. Epub 2022 Jun 15.
27. Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA. Kitamura Y, etal., Biol Pharm Bull. 2008 Feb;31(2):246-9. doi: 10.1248/bpb.31.246.
28. Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy. Kobayashi S, etal., Clin Exp Nephrol. 2008 Apr;12(2):119-25. doi: 10.1007/s10157-007-0011-8. Epub 2008 Jan 5.
29. Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2A receptor antagonist, in patients with peripheral arterial disease. Kokubu N, etal., Circ J. 2006 Nov;70(11):1451-6.
30. [Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. Korytina GF, etal., Mol Biol (Mosk). 2017 Jul-Aug;51(4):603-614. doi: 10.7868/S0026898417040127.
31. Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter. Lee YS, etal., Eur Addict Res. 2009;15(1):39-46. doi: 10.1159/000173008. Epub 2008 Dec 2.
32. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
33. Association study of the 5-HT(2A) receptor gene polymorphism, T102C and essential hypertension. Liolitsa D, etal., J Hum Hypertens. 2001 May;15(5):335-9.
34. The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14. Liu J, etal., Genomics 1991 Sep;11(1):231-4.
35. Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2. Lopez-Lopez JG, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):400-7. Epub 2011 Apr 26.
36. Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. McMahon LR and Cunningham KA, J Pharmacol Exp Ther. 2001 Apr;297(1):357-63.
37. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
38. MGDs mouse GO annotations MGD data from the GO Consortium
39. Suppression of alcohol preference in high alcohol drinking rats: efficacy of amperozide versus naltrexone. Myers RD and Lankford MF, Neuropsychopharmacology. 1996 Feb;14(2):139-49. doi: 10.1016/0893-133X(95)00081-N.
40. Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Nishiyama T, Eur J Pharmacol. 2009 Jul 1;614(1-3):122-7. doi: 10.1016/j.ejphar.2009.03.041. Epub 2009 Mar 24.
41. Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. Ogawa T, etal., Eur J Pharmacol. 2005 Oct 3;521(1-3):156-63. Epub 2005 Sep 22.
42. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Blockade of Serotonin 5-HT2A Receptors Suppresses Behavioral Sensitization and Naloxone-Precipitated Withdrawal Symptoms in Morphine-Treated Mice. Pang G, etal., Front Pharmacol. 2016 Dec 26;7:514. doi: 10.3389/fphar.2016.00514. eCollection 2016.
45. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Pichon X, etal., Mol Ther. 2010 Aug;18(8):1462-70. doi: 10.1038/mt.2010.101. Epub 2010 Jun 8.
46. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Qvigstad E, etal., Circ Res. 2005 Aug 5;97(3):268-76. Epub 2005 Jul 7.
47. Study of polymorphic variants of the serotonin 2A receptor gene (5-HT2A) and its possible effects on smoking habits of a population from northeastern Brazil. Ramos Neto ES, etal., Genet Mol Res. 2014 Oct 20;13(4):8268-77. doi: 10.4238/2014.October.20.3.
48. Mouse MP Annotation Import Pipeline RGD automated import pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol. Roberts AJ, etal., Psychopharmacology (Berl). 1998 May;137(1):25-32. doi: 10.1007/s002130050589.
52. Differential role of serotonergic polymorphisms in alcohol and heroin dependence. Saiz PA, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):695-700. doi: 10.1016/j.pnpbp.2009.03.016. Epub 2009 Mar 26.
53. 5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats. Sakai T, etal., Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F1020-7. doi: 10.1152/ajprenal.00365.2012. Epub 2013 Jan 23.
54. Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats. Sakloth F, etal., Exp Clin Psychopharmacol. 2019 Jun;27(3):215-226. doi: 10.1037/pha0000253. Epub 2019 Jan 10.
55. No evidence of association between the serotonin 2A receptor--1438G/A promoter polymorphism and childhood obesity in a Spanish population: A case-parent study and a matched case-control study. Santos JL, etal., Nutr Neurosci. 2005 Aug;8(4):207-11.
56. Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence? Schwanke CH, etal., Braz J Med Biol Res. 2007 Oct;40(10):1315-22. doi: 10.1590/s0100-879x2006005000151. Epub 2007 Jul 31.
57. Effects of peripheral administration of 5-hydroxytryptamine (5-HT ) on 2-deoxy-D-glucose-induced hyperphagia in rats. Sugimoto Y, etal., Biol Pharm Bull. 2002 Oct;25(10):1364-6.
58. Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. Supornsilpchai W, etal., Headache. 2010 Feb;50(2):185-97. doi: 10.1111/j.1526-4610.2009.01591.x. Epub 2009 Dec 21.
59. The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased gamma-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: a prospective cohort study over 5 years. Suwazono Y, etal., Int J Mol Med. 2006 Jan;17(1):77-82.
60. Sarpogrelate hydrochloride, a serotonin2A receptor antagonist, reduces albuminuria in diabetic patients with early-stage diabetic nephropathy. Takahashi T, etal., Diabetes Res Clin Pract. 2002 Nov;58(2):123-9.
61. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat. Thibault K, etal., Pain. 2008 Nov 30;140(2):305-322. doi: 10.1016/j.pain.2008.09.006. Epub 2008 Oct 18.
62. Serotonin (5-HT)2A/2C receptor agonist (2,5-dimethoxy-4-idophenyl)-2-aminopropane hydrochloride (DOI) improves voiding efficiency in the diabetic rat. Tu H, etal., BJU Int. 2015 Jul;116(1):147-55. doi: 10.1111/bju.12684. Epub 2015 Mar 27.
63. Role of spinal serotonin 5-HT2A receptor in 2',3'-dideoxycytidine-induced neuropathic pain in the rat and the mouse. Van Steenwinckel J, etal., Pain. 2008 Jul;137(1):66-80. doi: 10.1016/j.pain.2007.08.014. Epub 2007 Sep 20.
64. Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors. Vindis C, etal., Biochem Biophys Res Commun. 2010 Jan 1;391(1):979-83. doi: 10.1016/j.bbrc.2009.12.001. Epub 2009 Dec 11.
65. Family-based association analysis of serotonin genes in pathological gambling disorder: evidence of vulnerability risk in the 5HT-2A receptor gene. Wilson D, etal., J Mol Neurosci. 2013 Mar;49(3):550-3. doi: 10.1007/s12031-012-9846-x. Epub 2012 Jun 28.
66. Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure. Wright AM, etal., Cereb Cortex. 2017 Dec 1;27(12):5463-5476. doi: 10.1093/cercor/bhw312.
67. Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia. Xiong Y, etal., J Med Chem. 2010 Aug 12;53(15):5696-706. doi: 10.1021/jm100479q.
68. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Yamada J, etal., Eur J Pharmacol. 1997 Apr 4;323(2-3):235-40.
69. T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients and healthy controls. Yu BN, etal., Clin Exp Pharmacol Physiol. 2004 Dec;31(12):847-9.
70. Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats. Zaniewska M, etal., J Neurochem. 2015 Aug;134(4):704-16. doi: 10.1111/jnc.13192. Epub 2015 Jun 26.
71. Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. Zayara AE, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):321-35. doi: 10.1007/s00213-010-1996-3. Epub 2010 Sep 3.
72. Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis. Zhang Y, etal., Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.
Additional References at PubMed
PMID:1323014   PMID:1333538   PMID:1381232   PMID:1980030   PMID:2032718   PMID:7558022   PMID:7582481   PMID:8626761   PMID:8672130   PMID:8747920   PMID:8833241   PMID:8833759  
PMID:9027485   PMID:9109526   PMID:9165122   PMID:9241279   PMID:9415715   PMID:9465310   PMID:10087302   PMID:10349636   PMID:10454512   PMID:10627607   PMID:10799679   PMID:10978843  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11390667   PMID:11801601   PMID:11960784   PMID:12097814   PMID:12477932   PMID:12486201   PMID:12614326   PMID:12682061   PMID:12761567  
PMID:12867255   PMID:12887695   PMID:14523084   PMID:14754868   PMID:14988405   PMID:15590675   PMID:15932887   PMID:16141072   PMID:16141073   PMID:16339018   PMID:16602821   PMID:16648258  
PMID:16873667   PMID:16884969   PMID:16902991   PMID:17097612   PMID:17250964   PMID:17270739   PMID:17408640   PMID:17537836   PMID:17684015   PMID:17720578   PMID:18195357   PMID:18297054  
PMID:18483284   PMID:18516987   PMID:18675814   PMID:18783379   PMID:19019202   PMID:19041748   PMID:19269287   PMID:19322172   PMID:19353636   PMID:19426283   PMID:19563850   PMID:19646988  
PMID:19728996   PMID:19737523   PMID:20006646   PMID:20128812   PMID:20345894   PMID:20399747   PMID:20413853   PMID:20719859   PMID:20802802   PMID:20926677   PMID:20942998   PMID:21070242  
PMID:21118683   PMID:21276828   PMID:21289196   PMID:21340474   PMID:21664256   PMID:21789169   PMID:21821099   PMID:21873635   PMID:22118459   PMID:22119732   PMID:22318950   PMID:22531372  
PMID:22569571   PMID:22609381   PMID:22640814   PMID:22692564   PMID:22722027   PMID:22864611   PMID:22871913   PMID:22975078   PMID:23045337   PMID:23119095   PMID:23129762   PMID:23346101  
PMID:23372779   PMID:23376711   PMID:23411676   PMID:23440396   PMID:23508685   PMID:23933143   PMID:24570000   PMID:24801750   PMID:24894823   PMID:24952961   PMID:25034809   PMID:25087754  
PMID:25416380   PMID:25602134   PMID:25637489   PMID:25857407   PMID:26053401   PMID:26080602   PMID:26158621   PMID:26590419   PMID:26621247   PMID:26758213   PMID:26903620   PMID:27114257  
PMID:27422820   PMID:28031476   PMID:28258217   PMID:28485378   PMID:28591153   PMID:28735749   PMID:28783139   PMID:28807414   PMID:29568676   PMID:29917056   PMID:30367948   PMID:30446669  
PMID:30685409   PMID:30716416   PMID:30755421   PMID:30770253   PMID:31072928   PMID:31505254   PMID:31704949   PMID:31787571   PMID:31806625   PMID:32519137   PMID:32594910   PMID:33080227  
PMID:33082287   PMID:33278025   PMID:33479368   PMID:34074761   PMID:34759890   PMID:35001075   PMID:35002622   PMID:35459266   PMID:35954229   PMID:36100039   PMID:36795823   PMID:37659688  
PMID:37808655   PMID:38145872   PMID:38187761   PMID:38509093  


Genomics

Comparative Map Data
Htr2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391474,878,314 - 74,944,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)EnsemblGRCm39 Ensembl
GRCm381474,640,874 - 74,706,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,040,647 - 75,106,666 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,374,995 - 73,441,014 (+)NCBIMGSCv36mm8
Celera1472,148,249 - 72,214,245 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.37NCBI
HTR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381346,831,546 - 46,898,082 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1346,831,546 - 46,897,076 (-)EnsemblGRCh38hg38GRCh38
GRCh371347,405,681 - 47,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361346,305,514 - 46,368,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341346,305,513 - 46,368,176NCBI
Celera1328,463,441 - 28,527,123 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1328,199,237 - 28,264,796 (-)NCBIHuRef
CHM1_11347,373,460 - 47,438,997 (-)NCBICHM1_1
T2T-CHM13v2.01346,052,771 - 46,119,333 (-)NCBIT2T-CHM13v2.0
Htr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81556,360,647 - 56,428,703 (+)NCBIGRCr8
mRatBN7.21549,950,035 - 50,022,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,102,628 - 54,169,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,214,204 - 55,281,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,047,008 - 52,120,825 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
Htr2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955431580,713 - 647,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955431583,165 - 646,991 (-)NCBIChiLan1.0ChiLan1.0
HTR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21448,275,990 - 48,342,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11346,927,083 - 46,993,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01327,976,415 - 28,042,941 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11346,694,273 - 46,759,826 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1346,694,273 - 46,759,826 (-)Ensemblpanpan1.1panPan2
HTR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,453,715 - 4,510,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,453,715 - 4,511,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha224,498,607 - 4,555,448 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,566,315 - 4,626,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,565,931 - 4,625,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1224,348,779 - 4,405,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0224,412,667 - 4,469,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0224,417,008 - 4,474,072 (+)NCBIUU_Cfam_GSD_1.0
Htr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945156,850,452 - 156,910,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936565334,393 - 394,715 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936565335,238 - 394,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1120,555,963 - 20,619,625 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,555,939 - 20,620,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,895,106 - 20,956,369 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1324,820,029 - 24,884,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl324,820,035 - 24,883,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605719,114,044 - 19,177,668 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247488,155,107 - 8,223,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247488,154,288 - 8,223,226 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Htr2a
2537 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:119
Interacting mature miRNAs:130
Transcripts:ENSMUST00000036653
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474352296108352384Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470863768104863926Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1471221224105221344Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474394976108395093Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

Markers in Region
Htr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371475,105,809 - 75,106,007UniSTSGRCm37
Celera1472,213,388 - 72,213,586UniSTS
Cytogenetic Map14D2UniSTS
cM Map1441.5UniSTS
cM Map1441.5UniSTS
cM Map1441.5UniSTS
Htr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381474,706,002 - 74,706,200UniSTSGRCm38
MGSCv371475,105,809 - 75,106,007UniSTSGRCm37
Celera1472,213,388 - 72,213,586UniSTS
Cytogenetic Map14D2UniSTS
cM Map1441.5UniSTS
Htr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D2UniSTS
cM Map1441.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000036653   ⟹   ENSMUSP00000047774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)Ensembl
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)Ensembl
RefSeq Acc Id: NM_172812   ⟹   NP_766400
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391474,878,314 - 74,944,299 (+)NCBI
GRCm381474,640,874 - 74,706,859 (+)NCBI
MGSCv371475,040,647 - 75,106,666 (+)RGD
Celera1472,148,249 - 72,214,245 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_766400 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB24369 (Get FASTA)   NCBI Sequence Viewer  
  AAI08973 (Get FASTA)   NCBI Sequence Viewer  
  AAI08974 (Get FASTA)   NCBI Sequence Viewer  
  BAC35279 (Get FASTA)   NCBI Sequence Viewer  
  EDL35846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047774
  ENSMUSP00000047774.4
GenBank Protein P35363 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_766400   ⟸   NM_172812
- UniProtKB: P35363 (UniProtKB/Swiss-Prot),   Q543D4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000047774   ⟸   ENSMUST00000036653
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35363-F1-model_v2 AlphaFold P35363 1-471 view protein structure

Promoters
RGD ID:8682974
Promoter ID:EPDNEW_M19518
Type:initiation region
Name:Htr2a_1
Description:Mus musculus 5-hydroxytryptamine receptor 2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19519  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381474,640,877 - 74,640,937EPDNEW
RGD ID:8682976
Promoter ID:EPDNEW_M19519
Type:initiation region
Name:Htr2a_2
Description:Mus musculus 5-hydroxytryptamine receptor 2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19518  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381474,641,308 - 74,641,368EPDNEW
RGD ID:6825067
Promoter ID:MM_KWN:17452
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   MEF_B4,   MEF_B6
Transcripts:NM_172812
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361475,040,854 - 75,041,354 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109521 AgrOrtholog
Ensembl Genes ENSMUSG00000034997 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036653 ENTREZGENE
  ENSMUST00000036653.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5HT2A_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15558 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109521 ENTREZGENE
NCBI Gene 15558 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24247:SF30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HTR2A RGD
PhenoGen Htr2a PhenoGen
PRINTS 5HT2ARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HTRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q543D4 ENTREZGENE, UniProtKB/TrEMBL