Htr2a (5-hydroxytryptamine (serotonin) receptor 2A) - Rat Genome Database

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Gene: Htr2a (5-hydroxytryptamine (serotonin) receptor 2A) Mus musculus
Analyze
Symbol: Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
RGD ID: 62092
MGI Page MGI
Description: Enables protein tyrosine kinase activator activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphate metabolic process; and protein localization to cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neurofilament. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and heart. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-2; 5-HT-2A; 5-HT2A receptor; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; E030013E04; Htr; Htr-; Htr-2; Htr2; MGC124301; MGC124302; serotonin receptor 2A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391474,878,314 - 74,944,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)EnsemblGRCm39 Ensembl
GRCm381474,640,874 - 74,706,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,040,647 - 75,106,666 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,374,995 - 73,441,014 (+)NCBIMGSCv36mm8
Celera1472,148,249 - 72,214,245 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Htr2aMouseAcute Stress Disorders, Traumatic treatmentISOHtr2a (Rattus norvegicus)401900762 RGD 
Htr2aMousealcohol dependence  ISOHtr2a (Rattus norvegicus)401900737protein:decreased expression:agranular insular cortex more ...RGD 
Htr2aMousealcohol dependence disease_progressionISOHTR2A (Homo sapiens)401900291DNA:SNP: :102T>C (rs6313)RGD 
Htr2aMousealcohol dependence  ISOHTR2A (Homo sapiens)401900297DNA:SNP: :102T>C (rs6313)RGD 
Htr2aMousealcohol dependence no_associationISOHTR2A (Homo sapiens)401900304DNA:SNP:promoter:-1438G>A (rs6311)RGD 
Htr2aMousealcohol dependence  ISOHTR2A (Homo sapiens)401900293 RGD 
Htr2aMousealcohol dependence treatmentISOHtr2a (Rattus norvegicus)401900739 RGD 
Htr2aMousealcohol use disorder  ISOHtr2a (Rattus norvegicus)401900740 RGD 
Htr2aMousealcohol use disorder  ISOHtr2a (Rattus norvegicus)401900301mRNA more ...RGD 
Htr2aMousealcohol use disorder treatmentISOHtr2a (Rattus norvegicus)401900760 RGD 
Htr2aMousealcohol use disorder  ISOHtr2a (Rattus norvegicus)401900742protein:increased expression:dorsal raphe and nucleus accumbensRGD 
Htr2aMousealcoholic psychosis  ISOHTR2A (Homo sapiens)401900738DNA:SNP:promoter:-1438G>ARGD 
Htr2aMouseAlzheimer's disease treatmentISOHtr2a (Rattus norvegicus)401901085 RGD 
Htr2aMouseBack Pain  ISOHtr2a (Rattus norvegicus)1624379 RGD 
Htr2aMousebladder neck obstruction  ISOHtr2a (Rattus norvegicus)7257660mRNA:increased expression:urinary bladderRGD 
Htr2aMouseCardiomegaly  IEP 401938624protein:increased expression:heartRGD 
Htr2aMousechronic obstructive pulmonary disease susceptibilityISOHTR2A (Homo sapiens)401900295DNA:SNP: :rs6313RGD 
Htr2aMousecocaine abuse treatmentISOHtr2a (Rattus norvegicus)401901179 RGD 
Htr2aMousecocaine abuse  ISOHtr2a (Rattus norvegicus)401900753mRNA:increased expression:orbitofrontal cortexRGD 
Htr2aMousecocaine abuse  ISOHtr2a (Rattus norvegicus)401900755 RGD 
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Htr2aMouseCocaine-Related Disorders  ISOHTR2A (Homo sapiens)8554872ClinVar Annotator: match by term: Cocaine-Related DisordersClinVarPMID:12476319 more ...
Htr2aMouseobsessive-compulsive disorder  ISOHTR2A (Homo sapiens)8554872ClinVar Annotator: match by term: Obsessive-compulsive disorder and susceptibility toClinVarPMID:12476319 more ...
Htr2aMouseschizophrenia  ISOHTR2A (Homo sapiens)8554872ClinVar Annotator: match by term: Schizophrenia and susceptibility toClinVarPMID:8622505 and PMID:9130948
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Htr2aMouseasthma  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25322896
Htr2aMouseautistic disorder  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17280648
Htr2aMousebasal ganglia disease  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18480698
Htr2aMousebipolar disorder  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14708030
Htr2aMousechronic obstructive pulmonary disease  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22048642
Htr2aMouseCocaine-Related Disorders  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11259563 more ...
Htr2aMousecognitive disorder  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29294249
Htr2aMousedisease of metabolism  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19142110
Htr2aMouseDyskinesias  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11526996
Htr2aMouseFever  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19879056
Htr2aMouseHallucinations  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29748632
Htr2aMouseHyperalgesia  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17888573 and PMID:18930597
Htr2aMouseHyperkinesis  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16300424 and PMID:19347958
Htr2aMousemajor depressive disorder  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Htr2aMouseMemory Disorders  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29294249
Htr2aMousemigraine  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12482207
Htr2aMouseobesity  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17097612
Htr2aMouseobsessive-compulsive disorder  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19644229
Htr2aMousepsychotic disorder  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14708030
Htr2aMouseschizophrenia  ISOHTR2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14708030 and PMID:18513383
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Htr2aMousebipolar disorder  IEA 1331525 GAD 
Htr2aMousedepressive disorder  IEA 1331525 GAD 
Htr2aMousehypertension  ISOHTR2A (Homo sapiens)1331525 GAD 
Htr2aMouseschizophrenia  IEA 1331525 GAD 
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Htr2aMousemajor depressive disorder susceptibilityISOHTR2A (Homo sapiens)7240710 OMIM 
Htr2aMouseobsessive-compulsive disorder susceptibilityISOHTR2A (Homo sapiens)7240710 OMIM 
Htr2aMouseschizophrenia susceptibilityISOHTR2A (Homo sapiens)7240710 OMIM 

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Htr2aMouse(R,R)-tramadol increases activityISOHtr2a (Rattus norvegicus)6480464Tramadol results in increased activity of HTR2A proteinCTDPMID:18417104
Htr2aMouse(R,R)-tramadol increases expressionISOHtr2a (Rattus norvegicus)6480464Tramadol results in increased expression of HTR2A mRNACTDPMID:18417104
Htr2aMouse(R,R)-tramadol multiple interactionsISOHtr2a (Rattus norvegicus)6480464Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]CTDPMID:18417104
Htr2aMouse(S)-nicotine multiple interactionsISOHtr2a (Rattus norvegicus)6480464[Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein and Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]CTDPMID:21316381 and PMID:30247698
Htr2aMouse(S)-nicotine increases expressionISOHtr2a (Rattus norvegicus)6480464Nicotine results in increased expression of HTR2A proteinCTDPMID:30247698
Htr2aMouse1,2-dichloroethane decreases expressionEXP 6480464ethylene dichloride results in decreased expression of HTR2A mRNACTDPMID:28960355
Htr2aMouse1-(3-chlorophenyl)piperazine increases response to substanceISOHTR2A (Homo sapiens)6480464HTR2A gene SNP results in increased susceptibility to 1-(3-chlorophenyl)piperazineCTDPMID:16314884
Htr2aMouse1-(3-chlorophenyl)piperazine multiple interactionsISOHTR2A (Homo sapiens)64804641-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2A proteinCTDPMID:16314884
Htr2aMouse1-(3-chlorophenyl)piperazine affects response to substanceISOHTR2A (Homo sapiens)6480464HTR2A protein affects the susceptibility to 1-(3-chlorophenyl)piperazineCTDPMID:16314884
Htr2aMouse1-bromopropane decreases expressionISOHtr2a (Rattus norvegicus)64804641-bromopropane results in decreased expression of HTR2A mRNACTDPMID:19576243
Htr2aMouse17beta-estradiol affects expressionISOHtr2a (Rattus norvegicus)6480464Estradiol affects the expression of HTR2A mRNACTDPMID:12008023
Htr2aMouse17beta-estradiol multiple interactionsISOHtr2a (Rattus norvegicus)6480464[Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNA and Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA]CTDPMID:18650020
Htr2aMouse17beta-estradiol 3-benzoate multiple interactionsISOHtr2a (Rattus norvegicus)6480464Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA] and Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]CTDPMID:17398000
Htr2aMouse17beta-estradiol 3-benzoate increases expressionISOHtr2a (Rattus norvegicus)6480464estradiol 3-benzoate results in increased expression of HTR2A mRNA and estradiol 3-benzoate results in increased expression of HTR2A proteinCTDPMID:17398000
Htr2aMouse2,2',5,5'-tetrachlorobiphenyl increases expressionISOHtr2a (Rattus norvegicus)64804642 more ...CTDPMID:23829299
Htr2aMouse2,2',5,5'-tetrachlorobiphenyl increases expressionISOHTR2A (Homo sapiens)64804642 more ...CTDPMID:36804509
Htr2aMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHtr2a (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of HTR2A mRNACTDPMID:32109520
Htr2aMouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISOHtr2a (Rattus norvegicus)64804642 more ...CTDPMID:32109520
Htr2aMouse2,4,6-trinitrobenzenesulfonic acid increases expressionISOHtr2a (Rattus norvegicus)6480464Trinitrobenzenesulfonic Acid results in increased expression of HTR2A mRNACTDPMID:23537331
Htr2aMouse2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine multiple interactionsISOHtr2a (Rattus norvegicus)64804644-iodo-2 more ...CTDPMID:10773215 more ...

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Biological Process
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Htr2aMouseartery smooth muscle contraction  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:14752059 and REF_RGD_ID:7257678
Htr2aMouseartery smooth muscle contraction involved_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMouseartery smooth muscle contraction involved_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousebehavioral response to cocaine  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:23390419 and REF_RGD_ID:7257659
Htr2aMousebehavioral response to cocaine involved_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousebehavioral response to cocaine involved_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMousechemical synaptic transmission involved_inIBAPANTHER:PTN000664111 more ...2290270 GO_CentralGO_REF:0000033
Htr2aMousedetection of mechanical stimulus involved in sensory perception of pain involved_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMousedetection of mechanical stimulus involved in sensory perception of pain involved_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousedetection of mechanical stimulus involved in sensory perception of pain  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:20531396 and REF_RGD_ID:7257680
Htr2aMousedetection of temperature stimulus involved in sensory perception of pain involved_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMousedetection of temperature stimulus involved in sensory perception of pain involved_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousedetection of temperature stimulus involved in sensory perception of pain  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:20531396 and REF_RGD_ID:7257680
Htr2aMouseG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger involved_inIBAPANTHER:PTN000664111 more ...2290270 GO_CentralGO_REF:0000033
Htr2aMouseG protein-coupled serotonin receptor signaling pathway involved_inISOUniProtKB:P282232290270 GO_CentralGO_REF:0000119
Htr2aMouseglycolytic process acts_upstream_ofIMP 2290270 PMID:17408640MGIPMID:17408640
Htr2aMouseintracellular calcium ion homeostasis involved_inISOUniProtKB:P282232290270 GO_CentralGO_REF:0000119
Htr2aMouseintracellular calcium ion homeostasis involved_inIEAUniProtKB:P28223 and ensembl:ENSP000004377372290270 EnsemblGO_REF:0000107
Htr2aMousememory involved_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousememory involved_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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Cellular Component
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Htr2aMouseaxon located_inIEAUniProtKB-SubCell:SL-02792290270 UniProtGO_REF:0000044
Htr2aMousecaveola located_inIEAUniProtKB-SubCell:SL-00352290270 UniProtGO_REF:0000044
Htr2aMousecell body fiber located_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMousecell body fiber located_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousecell body fiber  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:23390419 and REF_RGD_ID:7257659
Htr2aMousecytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09682290270 UniProtGO_REF:0000043
Htr2aMousedendrite  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:10524335 and REF_RGD_ID:1624398
Htr2aMousedendrite is_active_inIBAPANTHER:PTN000664111 more ...2290270 GO_CentralGO_REF:0000033
Htr2aMousedendrite located_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMousedendritic shaft located_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMousedendritic shaft located_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMousedendritic shaft  ISOHtr2a (Rattus norvegicus)9068941 RGDPMID:18622042 and REF_RGD_ID:2303638
Htr2aMouseG protein-coupled serotonin receptor complex part_ofIEAUniProtKB:P28223 and ensembl:ENSP000004377372290270 EnsemblGO_REF:0000107
Htr2aMouseG protein-coupled serotonin receptor complex part_ofISOUniProtKB:P282232290270 GO_CentralGO_REF:0000119
Htr2aMouseglutamatergic synapse is_active_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMouseglutamatergic synapse located_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMouseneurofilament located_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMouseneurofilament located_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMouseneuronal cell body located_inISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMouseneuronal cell body located_inIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
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Molecular Function
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Htr2aMouse1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding enablesIEAUniProtKB:P28223 and ensembl:ENSP000004377372290270 EnsemblGO_REF:0000107
Htr2aMouse1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding enablesISOUniProtKB:P282232290270 GO_CentralGO_REF:0000119
Htr2aMouseG protein-coupled serotonin receptor activity enablesIBAPANTHER:PTN000664111 more ...2290270 GO_CentralGO_REF:0000033
Htr2aMouseG protein-coupled serotonin receptor activity enablesISOUniProtKB:P282232290270 PMID:7582481GO_CentralGO_REF:0000119 and PMID:7582481
Htr2aMouseGq/11-coupled serotonin receptor activity enablesISOUniProtKB:P282232290270 GO_CentralGO_REF:0000119
Htr2aMouseGq/11-coupled serotonin receptor activity enablesIEAUniProtKB:P28223 and ensembl:ENSP000004377372290270 EnsemblGO_REF:0000107
Htr2aMouseidentical protein binding enablesIEAUniProtKB:P28223 and ensembl:ENSP000004377372290270 EnsemblGO_REF:0000107
Htr2aMouseidentical protein binding enablesISOUniProtKB:P282232290270 GO_CentralGO_REF:0000119
Htr2aMouseneurotransmitter receptor activity enablesIBAPANTHER:PTN000664111 more ...2290270 GO_CentralGO_REF:0000033
Htr2aMouseprotein binding enablesISOUniProtKB:P186549068941 PMID:16537434IntActPMID:16537434
Htr2aMouseprotein binding enablesISOUniProtKB:P28335 and UniProtKB:P415959068941 PMID:28258217IntActPMID:28258217
Htr2aMouseprotein binding enablesISOUniProtKB:P28335 and UniProtKB:P28335-19068941 PMID:30157263IntActPMID:30157263
Htr2aMouseprotein binding enablesISOUniProtKB:O889109068941 PMID:14988405UniProtPMID:14988405
Htr2aMouseprotein binding enablesISOUniProtKB:Q144169068941 PMID:18297054IntActPMID:18297054
Htr2aMouseprotein binding enablesISOUniProtKB:P314219068941PMID:19590495IntActPMID:19590495 and REF_RGD_ID:8553550
Htr2aMouseprotein binding  ISODlg1 (Rattus norvegicus) and Dlg4 (Rattus norvegicus)9068941associated with Diabetic Neuropathies:RGDPMID:20531396 and REF_RGD_ID:7257680
Htr2aMouseprotein tyrosine kinase activator activity enablesIMP 2290270 PMID:17720578MGIPMID:17720578
Htr2aMouseprotein-containing complex binding enablesISOHtr2a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Htr2aMouseprotein-containing complex binding enablesIEAUniProtKB:P14842 and ensembl:ENSRNOP000000134082290270 EnsemblGO_REF:0000107
Htr2aMouseprotein-containing complex binding  ISOCav1 (Rattus norvegicus) and Kcna5 (Rattus norvegicus)9068941 RGDPMID:16527989 and REF_RGD_ID:1582161
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Reference Title
Reference Citation
1. Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. Abe Y, etal., J Sleep Res. 2012 Jun;21(3):289-96. doi: 10.1111/j.1365-2869.2011.00961.x. Epub 2011 Oct 1.
2. Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats. Adamec R, etal., Eur J Pharmacol. 2004 Nov 3;504(1-2):79-96. doi: 10.1016/j.ejphar.2004.09.017.
3. Response to novelty, social and self-control behaviors, in rats exposed to neonatal anoxia: modulatory effects of an enriched environment. Adriani W, etal., Psychopharmacology (Berl). 2006 Jan;184(2):155-65. Epub 2005 Dec 16.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Binetti J, etal., Life (Basel). 2020 Oct 16;10(10):245. doi: 10.3390/life10100245.
6. Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study. Castellano O, etal., Behav Brain Res. 2013 Apr 1;242:178-90. doi: 10.1016/j.bbr.2012.12.036. Epub 2013 Jan 4.
7. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. Cunningham KA, etal., ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.
8. 5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization. Davidson C, etal., Eur J Pharmacol. 2002 Oct 25;453(2-3):255-63. doi: 10.1016/s0014-2999(02)02390-7.
9. Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells. Desjardins S, etal., Neuropharmacology. 2008 Dec;55(8):1347-54. doi: 10.1016/j.neuropharm.2008.08.027. Epub 2008 Aug 30.
10. Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT reuptake sites. Druse MJ, etal., Alcohol Clin Exp Res. 1997 Oct;21(7):1157-64.
11. Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats. Ercan Z, etal., J Mol Neurosci. 2023 Oct;73(9-10):831-842. doi: 10.1007/s12031-023-02159-2. Epub 2023 Oct 4.
12. Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments. Fedeli A, etal., Res Commun Mol Pathol Pharmacol. 2002;112(1-4):113-27.
13. Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. Fernàndez-Castillo N, etal., Genes Brain Behav. 2013 Feb;12(1):39-46. doi: 10.1111/gbb.12013. Epub 2013 Jan 10.
14. Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats. Filip M, Pharmacol Rep. 2005 Jan-Feb;57(1):35-46.
15. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Fletcher PJ, etal., Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8.
16. Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains. Fomsgaard L, etal., Mol Neurobiol. 2018 Mar;55(3):1998-2012. doi: 10.1007/s12035-017-0457-y. Epub 2017 Mar 6.
17. [The analysis of serotonin receptor type 2A gene polymorphism in patients of different nationalities with acute alcoholic psychosis]. Galeeva AR, etal., Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(1):53-5.
18. Decreased cerebral cortex and liver 5-HT2A receptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures. George AK, etal., Neurol Res. 2010 Jun;32(5):510-8. doi: 10.1179/174313209X385554.
19. Sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, attenuates neurogenic pain induced by nucleus pulposus in rats. Hashizume H, etal., Spine. 2007 Feb 1;32(3):315-20.
20. Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Hofmann AD, etal., J Pediatr Surg. 2014 Jun;49(6):871-4; discussion 874-5. doi: 10.1016/j.jpedsurg.2014.01.015. Epub 2014 Jan 31.
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1 to 10 of 15 rows
PMID:1323014   PMID:1333538   PMID:1381232   PMID:1980030   PMID:2032718   PMID:7558022   PMID:7582481   PMID:8626761   PMID:8672130   PMID:8747920   PMID:8833241   PMID:8833759  
PMID:9027485   PMID:9109526   PMID:9165122   PMID:9241279   PMID:9415715   PMID:9465310   PMID:10087302   PMID:10349636   PMID:10454512   PMID:10627607   PMID:10799679   PMID:10978843  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11390667   PMID:11801601   PMID:11960784   PMID:12097814   PMID:12477932   PMID:12486201   PMID:12614326   PMID:12682061   PMID:12761567  
PMID:12867255   PMID:12887695   PMID:14523084   PMID:14754868   PMID:14988405   PMID:15590675   PMID:15932887   PMID:16141072   PMID:16141073   PMID:16339018   PMID:16602821   PMID:16648258  
PMID:16873667   PMID:16884969   PMID:16902991   PMID:17097612   PMID:17250964   PMID:17270739   PMID:17408640   PMID:17537836   PMID:17684015   PMID:17720578   PMID:18195357   PMID:18297054  
PMID:18483284   PMID:18516987   PMID:18675814   PMID:18783379   PMID:19019202   PMID:19041748   PMID:19269287   PMID:19322172   PMID:19353636   PMID:19426283   PMID:19563850   PMID:19646988  
PMID:19728996   PMID:19737523   PMID:20006646   PMID:20128812   PMID:20345894   PMID:20399747   PMID:20413853   PMID:20719859   PMID:20802802   PMID:20926677   PMID:20942998   PMID:21070242  
PMID:21118683   PMID:21276828   PMID:21289196   PMID:21340474   PMID:21664256   PMID:21789169   PMID:21821099   PMID:21873635   PMID:22118459   PMID:22119732   PMID:22318950   PMID:22531372  
PMID:22569571   PMID:22609381   PMID:22640814   PMID:22692564   PMID:22722027   PMID:22864611   PMID:22871913   PMID:22975078   PMID:23045337   PMID:23119095   PMID:23129762   PMID:23346101  
PMID:23372779   PMID:23376711   PMID:23411676   PMID:23440396   PMID:23508685   PMID:23933143   PMID:24570000   PMID:24801750   PMID:24894823   PMID:24952961   PMID:25034809   PMID:25087754  
1 to 10 of 15 rows



Htr2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391474,878,314 - 74,944,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)EnsemblGRCm39 Ensembl
GRCm381474,640,874 - 74,706,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,040,647 - 75,106,666 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,374,995 - 73,441,014 (+)NCBIMGSCv36mm8
Celera1472,148,249 - 72,214,245 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.37NCBI
HTR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381346,831,546 - 46,898,082 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1346,831,546 - 46,897,076 (-)EnsemblGRCh38hg38GRCh38
GRCh371347,405,681 - 47,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361346,305,514 - 46,368,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341346,305,513 - 46,368,176NCBI
Celera1328,463,441 - 28,527,123 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1328,199,237 - 28,264,796 (-)NCBIHuRef
CHM1_11347,373,460 - 47,438,997 (-)NCBICHM1_1
T2T-CHM13v2.01346,052,771 - 46,119,333 (-)NCBIT2T-CHM13v2.0
Htr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81556,360,647 - 56,428,703 (+)NCBIGRCr8
mRatBN7.21549,950,035 - 50,022,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,102,628 - 54,169,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,214,204 - 55,281,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,047,008 - 52,120,825 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
Htr2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955431580,713 - 647,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955431583,165 - 646,991 (-)NCBIChiLan1.0ChiLan1.0
HTR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21448,275,990 - 48,342,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11346,927,083 - 46,993,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01327,976,415 - 28,042,941 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11346,694,273 - 46,759,826 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1346,694,273 - 46,759,826 (-)Ensemblpanpan1.1panPan2
HTR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,453,715 - 4,510,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,453,715 - 4,511,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha224,498,607 - 4,555,448 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,566,315 - 4,626,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,565,931 - 4,625,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1224,348,779 - 4,405,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0224,412,667 - 4,469,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0224,417,008 - 4,474,072 (+)NCBIUU_Cfam_GSD_1.0
Htr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945156,850,452 - 156,910,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936565334,393 - 394,715 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936565335,238 - 394,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1120,555,963 - 20,619,625 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,555,939 - 20,620,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,895,106 - 20,956,369 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1324,820,029 - 24,884,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl324,820,035 - 24,883,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605719,114,044 - 19,177,668 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247488,155,107 - 8,223,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247488,154,288 - 8,223,226 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Htr2a
2537 total Variants

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:119
Interacting mature miRNAs:130
Transcripts:ENSMUST00000036653
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474352296108352384Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse

1 to 10 of 21 rows
Htr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371475,105,809 - 75,106,007UniSTSGRCm37
Celera1472,213,388 - 72,213,586UniSTS
Cytogenetic Map14D2UniSTS
cM Map1441.5UniSTS
cM Map1441.5UniSTS
cM Map1441.5UniSTS
Htr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381474,706,002 - 74,706,200UniSTSGRCm38
MGSCv371475,105,809 - 75,106,007UniSTSGRCm37
Celera1472,213,388 - 72,213,586UniSTS
Cytogenetic Map14D2UniSTS
cM Map1441.5UniSTS
Htr2a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D2UniSTS
cM Map1441.5UniSTS







Ensembl Acc Id: ENSMUST00000036653   ⟹   ENSMUSP00000047774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)Ensembl
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)Ensembl
RefSeq Acc Id: NM_172812   ⟹   NP_766400
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391474,878,314 - 74,944,299 (+)NCBI
GRCm381474,640,874 - 74,706,859 (+)NCBI
MGSCv371475,040,647 - 75,106,666 (+)RGD
Celera1472,148,249 - 72,214,245 (+)RGD
cM Map14 ENTREZGENE
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_766400 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB24369 (Get FASTA)   NCBI Sequence Viewer  
  AAI08973 (Get FASTA)   NCBI Sequence Viewer  
  AAI08974 (Get FASTA)   NCBI Sequence Viewer  
  BAC35279 (Get FASTA)   NCBI Sequence Viewer  
  EDL35846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000047774
  ENSMUSP00000047774.4
GenBank Protein P35363 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_766400   ⟸   NM_172812
- UniProtKB: P35363 (UniProtKB/Swiss-Prot),   Q543D4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000047774   ⟸   ENSMUST00000036653
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-P35363-F1-model_v2 AlphaFold P35363 1-471 view protein structure

RGD ID:8682974
Promoter ID:EPDNEW_M19518
Type:initiation region
Name:Htr2a_1
Description:Mus musculus 5-hydroxytryptamine receptor 2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19519  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381474,640,877 - 74,640,937EPDNEW
RGD ID:8682976
Promoter ID:EPDNEW_M19519
Type:initiation region
Name:Htr2a_2
Description:Mus musculus 5-hydroxytryptamine receptor 2A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M19518  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381474,641,308 - 74,641,368EPDNEW
RGD ID:6825067
Promoter ID:MM_KWN:17452
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   MEF_B4,   MEF_B6
Transcripts:NM_172812
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361475,040,854 - 75,041,354 (+)MPROMDB


1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000034997 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000036653 ENTREZGENE
  ENSMUST00000036653.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT2A_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:15558 UniProtKB/Swiss-Prot
MGD MGI:109521 ENTREZGENE
NCBI Gene 15558 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR24247:SF30 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR2A RGD
PhenoGen Htr2a PhenoGen
PRINTS 5HT2ARECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q543D4 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows