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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:9648
Term: tramadol
Definition: A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Originally developed by Gruenenthal GmbH and launched in 1977, it was subsequently isolated from the root bark of the South African tree Nauclea latifolia.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aincreases activityEXP 6480464CTDTramadol results in increased activity of HTR2A protein

PMID:18417104
Htr2aincreases expressionEXP 6480464CTDTramadol results in increased expression of HTR2A mRNA

PMID:18417104
Htr2amultiple interactionsEXP 6480464CTDKetanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

PMID:18417104
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.