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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:3892
Term: corticotropin
Definition: A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.
Chemical ID: MESH:D000324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aaffects expressionEXP 6480464CTDAdrenocorticotropic Hormone affects the expression of HTR2A mRNA

PMID:18239281
Htr2amultiple interactionsEXP 6480464CTDBupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA]

PMID:18239281
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