Obox2l1 (oocyte specific homeobox 2 like 1) - Rat Genome Database

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Gene: Obox2l1 (oocyte specific homeobox 2 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Obox2l1 (Ensembl: LOC691325)
Name: oocyte specific homeobox 2 like 1 (Ensembl:similar to oocyte specific homeobox 3)
RGD ID: 1585091
Description: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein Hox-B3a; homeobox protein Hox-B3a-like; LOC502295; LOC691325; oocyte-specific homeobox protein 5; retinal homeobox protein Rx3-like; RGD1564236; similar to OBOX3; similar to oocyte specific homeobox 3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,211,572 - 77,213,511 (+)NCBIGRCr8
mRatBN7.2168,182,725 - 68,184,559 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,183,045 - 68,184,743 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0171,765,971 - 71,767,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,765,944 - 71,767,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0173,156,242 - 73,157,781 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,892,684 - 66,894,181 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera168,621,842 - 68,627,371 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline

Genomics

Variants

.
Variants in Obox2l1
29 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
D1Got371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,186,460 - 68,186,754 (+)MAPPERmRatBN7.2
Rnor_6.0171,769,383 - 71,769,678NCBIRnor6.0
Rnor_6.0171,770,060 - 71,770,348NCBIRnor6.0
Rnor_5.0173,159,654 - 73,159,949UniSTSRnor5.0
RGSC_v3.4166,910,930 - 66,911,218UniSTSRGSC3.4
RGSC_v3.4166,896,096 - 66,896,391UniSTSRGSC3.4
Celera168,890,327 - 68,890,622UniSTS
Cytogenetic Map1q12UniSTS
AU049812  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,186,520 - 68,186,779 (+)MAPPERmRatBN7.2
Rnor_6.0171,770,035 - 71,770,290NCBIRnor6.0
Rnor_6.0171,769,443 - 71,769,703NCBIRnor6.0
Rnor_5.0173,159,714 - 73,159,974UniSTSRnor5.0
RGSC_v3.4166,910,990 - 66,911,243UniSTSRGSC3.4
RGSC_v3.4166,896,156 - 66,896,416UniSTSRGSC3.4
Celera168,890,302 - 68,890,562UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
reproductive system
5 1 1 1 1 1 5 36

Sequence


Ensembl Acc Id: ENSRNOT00000045660   ⟹   ENSRNOP00000051380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,183,045 - 68,184,542 (+)Ensembl
Rnor_6.0 Ensembl9101,197,255 - 101,198,758 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050817   ⟹   ENSRNOP00000043870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,202,754 - 68,204,251 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091103   ⟹   ENSRNOP00000074798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl171,765,944 - 71,767,411 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094214   ⟹   ENSRNOP00000093280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,183,045 - 68,184,743 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119453   ⟹   ENSRNOP00000082904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,202,754 - 68,204,452 (+)Ensembl
RefSeq Acc Id: XM_001077719   ⟹   XP_001077719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,211,572 - 77,213,511 (+)NCBI
mRatBN7.2168,182,725 - 68,184,559 (+)NCBI
Rnor_6.0171,765,971 - 71,767,523 (+)NCBI
Rnor_5.0173,156,242 - 73,157,781 (+)NCBI
RGSC_v3.4166,892,684 - 66,894,181 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_001077719 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048058.5
  ENSRNOP00000051380.3
  ENSRNOP00000082904.1
  ENSRNOP00000093280.1
RefSeq Acc Id: XP_001077719   ⟸   XM_001077719
- UniProtKB: D3ZYG1 (UniProtKB/TrEMBL),   F1LV35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074798   ⟸   ENSRNOT00000091103
Ensembl Acc Id: ENSRNOP00000051380   ⟸   ENSRNOT00000045660
Ensembl Acc Id: ENSRNOP00000043870   ⟸   ENSRNOT00000050817
Ensembl Acc Id: ENSRNOP00000082904   ⟸   ENSRNOT00000119453
Ensembl Acc Id: ENSRNOP00000093280   ⟸   ENSRNOT00000094214
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYG1-F1-model_v2 AlphaFold D3ZYG1 1-312 view protein structure
AF-A0A0G2K8Z7-F1-model_v2 AlphaFold A0A0G2K8Z7 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585091 AgrOrtholog
BioCyc Gene G2FUF-60913 BioCyc
Ensembl Genes ENSRNOG00000021972 UniProtKB/TrEMBL
  ENSRNOG00000029702 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000060136 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045660.3 UniProtKB/TrEMBL
  ENSRNOT00000046416.5 UniProtKB/TrEMBL
  ENSRNOT00000094214.1 UniProtKB/TrEMBL
  ENSRNOT00000119453.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Distal-less_Homeobox_TF UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
KEGG Report rno:691325 UniProtKB/TrEMBL
NCBI Gene 691325 ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  OBOX1-RELATED UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PhenoGen Obox2l1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021972 RatGTEx
  ENSRNOG00000029702 RatGTEx
  ENSRNOG00000060136 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8I5ZYU4_RAT UniProtKB/TrEMBL
  A0A8I6AJS2_RAT UniProtKB/TrEMBL
  D3ZYG1 ENTREZGENE, UniProtKB/TrEMBL
  F1LV35 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Obox2l1  oocyte specific homeobox 2 like 1  LOC691325  similar to oocyte specific homeobox 3  Symbol and Name Changed 1299863 APPROVED
2021-03-09 LOC691325  similar to oocyte specific homeobox 3  RGD1564236  similar to OBOX3  Data merged from RGD:1564236 737654 PROVISIONAL
2008-04-30 RGD1564236  similar to OBOX3   RGD1564236_predicted  similar to OBOX3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC691325  similar to oocyte specific homeobox 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1564236_predicted  similar to OBOX3 (predicted)  LOC502295  similar to OBOX3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502295  similar to OBOX3      Symbol and Name status set to provisional 70820 PROVISIONAL