Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Nucb1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NUCB1 mRNA | CTD | PMID:22206623 | Nucb1 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Nucb1 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of NUCB1 mRNA | CTD | PMID:17555576 | Nucb1 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUCB1 mRNA | CTD | PMID:17942748 | Nucb1 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of NUCB1 mRNA | CTD | PMID:17942748 | Nucb1 | Rat | 17beta-estradiol | affects expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Estradiol affects the expression of NUCB1 mRNA | CTD | PMID:22574217 | Nucb1 | Rat | 17beta-hydroxy-5alpha-androstan-3-one | decreases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Dihydrotestosterone results in decreased expression of NUCB1 mRNA | CTD | PMID:17023530 | Nucb1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of NUCB1 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NUCB1 mRNA | CTD | PMID:16214954 and PMID:17942748 | Nucb1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NUCB1 mRNA | CTD | PMID:33387578 and PMID:34747641 | Nucb1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NUCB1 mRNA | CTD | PMID:15328365 more ... | Nucb1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Nucb1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NUCB1 mRNA | CTD | PMID:21570461 | Nucb1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NUCB1 mRNA | CTD | PMID:21632981 | Nucb1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of NUCB1 mRNA | CTD | PMID:36843608 | Nucb1 | Rat | acrolein | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NUCB1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Nucb1 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of NUCB1 mRNA | CTD | PMID:28959563 | Nucb1 | Rat | acrylamide | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of NUCB1 mRNA | CTD | PMID:32763439 | Nucb1 | Rat | all-trans-retinoic acid | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of NUCB1 mRNA | CTD | PMID:33167477 | Nucb1 | Rat | alpha-pinene | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NUCB1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of NUCB1 mRNA | CTD | PMID:32699268 | Nucb1 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NUCB1 mRNA | CTD | PMID:16483693 | Nucb1 | Rat | aristolochic acid A | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of NUCB1 mRNA | CTD | PMID:33212167 | Nucb1 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of NUCB1 mRNA | CTD | PMID:19850644 | Nucb1 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of NUCB1 mRNA] | CTD | PMID:19850644 | Nucb1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of NUCB1 mRNA | CTD | PMID:25181051 | Nucb1 | Rat | bisphenol A | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of NUCB1 mRNA | CTD | PMID:32156529 | Nucb1 | Rat | bisphenol A | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | [Dextran Sulfate co-treated with bisphenol A] results in decreased expression of NUCB1 protein | CTD | PMID:35999755 | Nucb1 | Rat | bisphenol A | affects expression | ISO | NUCB1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of NUCB1 protein | CTD | PMID:34186270 | Nucb1 | Rat | bisphenol A | decreases methylation | ISO | NUCB1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of NUCB1 gene | CTD | PMID:31601247 | Nucb1 | Rat | bisphenol A | decreases expression | ISO | Nucb1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of NUCB1 mRNA | CTD | PMID:33221593 | Nucb1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of NUCB1 mRNA and bisphenol A results in decreased expression of NUCB1 protein | CTD | PMID:30816183 more ... | Nucb1 | Rat | bisphenol A | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of NUCB1 mRNA and bisphenol A results in increased expression of NUCB1 protein | CTD | PMID:29275510 and PMID:37567409 | Nucb1 | Rat | Bisphenol B | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of NUCB1 protein | CTD | PMID:34186270 | Nucb1 | Rat | bisphenol F | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of NUCB1 protein | CTD | PMID:34186270 | Nucb1 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of NUCB1 mRNA | CTD | PMID:19167457 | Nucb1 | Rat | cadmium dichloride | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Cadmium Chloride results in increased expression of NUCB1 mRNA | CTD | PMID:20883709 | Nucb1 | Rat | cadmium dichloride | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of NUCB1 mRNA | CTD | PMID:38568856 | Nucb1 | Rat | caffeine | increases phosphorylation | ISO | NUCB1 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of NUCB1 protein | CTD | PMID:35688186 | Nucb1 | Rat | chlorpyrifos | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of NUCB1 mRNA | CTD | PMID:37019170 | Nucb1 | Rat | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of NUCB1 protein | CTD | PMID:17321087 | Nucb1 | Rat | clofibrate | decreases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of NUCB1 mRNA | CTD | PMID:17585979 | Nucb1 | Rat | cobalt dichloride | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of NUCB1 mRNA | CTD | PMID:19376846 | Nucb1 | Rat | dextran sulfate | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | [Dextran Sulfate co-treated with bisphenol A] results in decreased expression of NUCB1 protein | CTD | PMID:35999755 | Nucb1 | Rat | diallyl trisulfide | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | diallyl trisulfide results in decreased expression of NUCB1 protein | CTD | PMID:19550292 | Nucb1 | Rat | dimethylselenide | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of NUCB1-AS1 mRNA] which results in decreased expression of NUCB1 mRNA | CTD | PMID:33656867 | Nucb1 | Rat | doxorubicin | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of NUCB1 mRNA | CTD | PMID:29803840 | Nucb1 | Rat | elemental selenium | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Selenium results in increased expression of NUCB1 mRNA | CTD | PMID:19244175 | Nucb1 | Rat | fluoxetine | affects expression | EXP | | 6480464 | Fluoxetine affects the expression of NUCB1 mRNA | CTD | PMID:21852994 | Nucb1 | Rat | folic acid | multiple interactions | ISO | Nucb1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NUCB1 mRNA | CTD | PMID:22206623 | Nucb1 | Rat | fonofos | increases methylation | ISO | NUCB1 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of NUCB1 promoter | CTD | PMID:22847954 | Nucb1 | Rat | FR900359 | increases phosphorylation | ISO | NUCB1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of NUCB1 protein | CTD | PMID:37730182 | Nucb1 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of NUCB1 gene | CTD | PMID:22079235 | Nucb1 | Rat | gold atom | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA | CTD | PMID:28433809 | Nucb1 | Rat | gold(0) | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA | CTD | PMID:28433809 | Nucb1 | Rat | hydroxyl | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of NUCB1-AS1 mRNA] which results in decreased expression of NUCB1 mRNA | CTD | PMID:33656867 | Nucb1 | Rat | ivermectin | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of NUCB1 protein | CTD | PMID:32959892 | Nucb1 | Rat | lead(0) | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Lead results in decreased expression of NUCB1 mRNA | CTD | PMID:19921347 | Nucb1 | Rat | lovastatin | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Lovastatin results in increased expression of NUCB1 mRNA | CTD | PMID:20493250 | Nucb1 | Rat | methidathion | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | methidathion results in increased expression of NUCB1 mRNA | CTD | PMID:34813904 | Nucb1 | Rat | nickel sulfate | decreases expression | ISO | Nucb1 (Mus musculus) | 6480464 | nickel sulfate results in decreased expression of NUCB1 mRNA | CTD | PMID:16100012 | Nucb1 | Rat | ozone | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NUCB1 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Nucb1 | Rat | parathion | increases methylation | ISO | NUCB1 (Homo sapiens) | 6480464 | Parathion results in increased methylation of NUCB1 promoter | CTD | PMID:22847954 | Nucb1 | Rat | quercetin | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Quercetin results in increased expression of NUCB1 mRNA | CTD | PMID:21632981 | Nucb1 | Rat | resveratrol | affects secretion | ISO | NUCB1 (Homo sapiens) | 6480464 | resveratrol affects the secretion of NUCB1 protein | CTD | PMID:24802182 | Nucb1 | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of NUCB1 protein | CTD | PMID:35544339 | Nucb1 | Rat | SB 431542 | multiple interactions | ISO | NUCB1 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of NUCB1 protein | CTD | PMID:37664457 | Nucb1 | Rat | selenium atom | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Selenium results in increased expression of NUCB1 mRNA | CTD | PMID:19244175 | Nucb1 | Rat | silicon dioxide | decreases secretion | ISO | NUCB1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased secretion of NUCB1 protein | CTD | PMID:25895662 | Nucb1 | Rat | silicon dioxide | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of NUCB1 mRNA | CTD | PMID:25895662 | Nucb1 | Rat | sodium arsenite | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of NUCB1 mRNA | CTD | PMID:20883709 | Nucb1 | Rat | T-2 toxin | affects expression | EXP | | 6480464 | T-2 Toxin affects the expression of NUCB1 protein | CTD | PMID:26141394 | Nucb1 | Rat | tamoxifen | affects expression | ISO | Nucb1 (Mus musculus) | 6480464 | Tamoxifen affects the expression of NUCB1 mRNA | CTD | PMID:17555576 | Nucb1 | Rat | terbufos | increases methylation | ISO | NUCB1 (Homo sapiens) | 6480464 | terbufos results in increased methylation of NUCB1 promoter | CTD | PMID:22847954 | Nucb1 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of NUCB1 mRNA | CTD | PMID:15336504 | Nucb1 | Rat | testosterone | decreases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of NUCB1 mRNA | CTD | PMID:33848595 | Nucb1 | Rat | titanium dioxide | decreases methylation | ISO | Nucb1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of NUCB1 gene | CTD | PMID:35295148 | Nucb1 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of NUCB1 mRNA | CTD | PMID:19448997 | Nucb1 | Rat | triphenyl phosphate | affects expression | ISO | NUCB1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of NUCB1 mRNA | CTD | PMID:37042841 | Nucb1 | Rat | triptonide | decreases expression | ISO | Nucb1 (Mus musculus) | 6480464 | triptonide results in decreased expression of NUCB1 mRNA | CTD | PMID:33045310 | Nucb1 | Rat | tunicamycin | increases expression | ISO | NUCB1 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of NUCB1 mRNA | CTD | PMID:22378314 and PMID:29453283 | Nucb1 | Rat | valproic acid | increases methylation | ISO | NUCB1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of NUCB1 gene | CTD | PMID:29154799 | Nucb1 | Rat | valproic acid | affects expression | ISO | Nucb1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of NUCB1 mRNA | CTD | PMID:17292431 | Nucb1 | Rat | warfarin | increases expression | ISO | Nucb1 (Mus musculus) | 6480464 | Warfarin results in increased expression of NUCB1 mRNA | CTD | PMID:20493250 | |