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Gene: Egln2 (egl-9 family hypoxia-inducible factor 2) Rattus norvegicus
Symbol: Egln2
Name: egl-9 family hypoxia-inducible factor 2
RGD ID: 631376
Description: Exhibits peptidyl-proline 4-dioxygenase activity. Involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to localize to cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH ammonium chloride; bisphenol A; C60 fullerene.
Type: protein-coding
Also known as: EGL nine homolog 2; EGL nine homolog 2 (C. elegans); HIF-1alpha prolyl-4-hydroxylase-1; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 1; MGC93662; MGC93666; PHD-1; PHD1; prolyl hydroxylase domain-containing protein 1; prolyl hydroxylase EGLN2
Homo sapiens (human) : EGLN2 (egl-9 family hypoxia inducible factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Egln2 (egl-9 family hypoxia-inducible factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln2 (egl-9 family hypoxia inducible factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Canis lupus familiaris (dog) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln2 (egl-9 family hypoxia inducible factor 2)
Sus scrofa (pig) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Chlorocebus sabaeus (African green monkey) : EGLN2 (egl-9 family hypoxia inducible factor 2)
Heterocephalus glaber (naked mole-rat) : Egln2 (egl-9 family hypoxia inducible factor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0183,969,456 - 83,977,665 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,969,457 - 83,977,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,180,394 - 85,188,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,233,239 - 82,240,990 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,311,350 - 82,318,466 (-)NCBI
Celera176,864,947 - 76,872,062 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Egln2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631376
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.