Cyp2b3 (cytochrome P450, family 2, subfamily b, polypeptide 3) - Rat Genome Database

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Gene: Cyp2b3 (cytochrome P450, family 2, subfamily b, polypeptide 3) Rattus norvegicus
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
RGD ID: 628627
Description: Predicted to enable heme binding activity and monooxygenase activity. Involved in response to organic cyclic compound and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; human immunodeficiency virus infectious disease; and tuberculosis. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp2b6; CYPIIB3; cytochrome P450 2B3; cytochrome P450 2B3-like; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; cytochrome P450IIB3
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2181,652,762 - 81,732,153 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,652,787 - 81,732,143 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,073,523 - 87,141,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,571,804 - 95,642,315 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,829,353 - 88,897,077 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,163,103 - 83,236,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,163,079 - 83,236,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,445,481 - 84,491,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,084,984 - 81,185,251 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,486,546 - 81,659,871 (+)NCBI
Celera176,082,604 - 76,158,885 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-isoborneol  (ISO)
(+)-Nornicotine  (ISO)
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-cotinine  (ISO)
(-)-selegiline  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-roxithromycin  (ISO)
(E,E)-germacrone  (ISO)
(R)-camphor  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,4-naphthoquinone  (ISO)
1,8-cineole  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-Dechloroethylifosfamide  (ISO)
2-n-Propyl-4-pentenoic acid  (ISO)
2-Naphthalenethiol  (ISO)
2-naphthol  (ISO)
2-nitroanisole  (ISO)
2-nitrophenol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,5-xylenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(methylsulfinyl)phenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-Aminophenyl ether  (ISO)
4-bromo-2-chlorophenol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-Hydroxyvalproic acid  (ISO)
4-nonylphenol  (ISO)
5-hydroxydiclofenac  (ISO)
5-Hydroxyflavone  (ISO)
5-Hydroxyvalproic acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxy-N,N-diisopropyltryptamine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldrin  (ISO)
allyl isothiocyanate  (ISO)
Aloe emodin  (ISO)
alpha-methyltryptamine  (ISO)
aminoguanidine  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amitriptylinoxide  (ISO)
amlodipine  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (ISO)
aniline  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
artemether  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
Avasimibe  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
barnidipine  (ISO)
benfuracarb  (ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzphetamine  (ISO)
berberine  (ISO)
bergomottin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
brucine  (EXP)
bupropion  (ISO)
butachlor  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium sulfate  (ISO)
calciol  (ISO)
camphor  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbendazim  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
carbosulfan  (ISO)
cerivastatin  (ISO)
CGP 52608  (ISO)
Chalepensin  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorfluazuron  (ISO)
chlorotoluron  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
chrysophanol  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
citral  (ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
clorgyline  (ISO)
clothianidin  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cumene hydroperoxide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cyproterone  (ISO)
dapsone  (ISO)
Dechloroethylcyclophosphamide  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarylheptanoid  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
dimemorfan  (ISO)
dimethyl sulfoxide  (ISO)
diuron  (ISO)
domperidone  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
endrin  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
ethanol  (ISO)
farnesol  (ISO)
felodipine  (ISO)
fenitrothion  (ISO)
fenofibrate  (ISO)
fenproporex  (ISO)
fenvalerate  (ISO)
finasteride  (EXP)
fipronil  (ISO)
flavonoids  (EXP)
fludioxonil  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
fluxapyroxad  (ISO)
folic acid  (ISO)
furathiocarb  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geranial  (ISO)
geraniol  (ISO)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
griseofulvin  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
halothane  (ISO)
helenalin  (ISO)
herbicide  (ISO)
hexaflumuron  (ISO)
hexane  (ISO)
hydroquinone  (ISO)
Hydroxybupropion  (ISO)
hyperforin  (ISO)
ifosfamide  (ISO)
imidazoles  (ISO)
imipramine oxide  (ISO)
indometacin  (EXP)
isoimperatorin  (ISO)
isoproturon  (ISO)
isoxazoles  (ISO)
Isradipine  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lamotrigine  (ISO)
lead diacetate  (ISO)
lefetamine  (ISO)
leflunomide  (ISO)
lycopene  (ISO)
malathion  (ISO)
mancozeb  (ISO)
Meclizine  (ISO)
mefenacet  (ISO)
mephenytoin  (ISO)
mercury dichloride  (ISO)
metazachlor  (ISO)
metformin  (ISO)
methiocarb  (ISO)
methiocarb-sulfoxide  (ISO)
methoxychlor  (ISO)
methoxyflurane  (ISO)
methylisothiazolinone  (ISO)
metolachlor  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
monocrotaline  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (ISO)
moricizine  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP,ISO)
nevirapine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
Nicotine imine  (ISO)
nimesulide  (EXP,ISO)
Nonylphenol  (ISO)
norflurazon  (ISO)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
orphenadrine  (ISO)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
parathion  (ISO)
Pargyline  (ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
pazopanib  (ISO)
PCB138  (ISO)
pencycuron  (ISO)
pendimethalin  (ISO)
pentachlorophenol  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perillyl aldehyde  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phencyclidine  (ISO)
Phenelzine  (ISO)
phenobarbital  (EXP,ISO)
phenthoate  (ISO)
phenytoin  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
physcion  (ISO)
piclamilast  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
PK-11195  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
primaquine  (ISO)
prochloraz  (ISO)
profenofos  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
propofol  (ISO)
pterostilbene  (ISO)
pyrene  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
sibutramine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
steviol  (ISO)
streptozocin  (ISO)
Sudan I  (ISO)
sulconazole  (ISO)
sulfinpyrazone  (ISO)
sulfluramid  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
tebufenozide  (ISO)
teriflunomide  (ISO)
tert-butanol  (ISO)
testosterone  (ISO)
Testosterone propionate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
thalidomide  (ISO)
thiabendazole  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
Thiotepa  (ISO)
ticlopidine  (ISO)
tienilic acid  (ISO)
tirapazamine  (ISO)
titanium dioxide  (ISO)
toxaphene  (ISO)
tranylcypromine  (ISO)
triadimefon  (EXP)
triclocarban  (ISO)
triclosan  (ISO)
triflumuron  (ISO)
trifluralin  (ISO)
Tris(1-aziridinyl)phosphine oxide  (ISO)
troglitazone  (ISO)
tryptamines  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vatalanib  (ISO)
ziram  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
carbamazepine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
clopidogrel pharmacodynamics pathway  (ISO)
clopidogrel pharmacokinetics pathway  (ISO)
cyclophosphamide pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacokinetics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ifosfamide pharmacodynamics pathway  (ISO)
ifosfamide pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
neviparine pharmacokinetics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nicotine pharmacokinetics pathway  (ISO)
organophosphate response pathway  (ISO)
paracetamol drug pathway  (ISO)
phase I biotransformation pathway via cytochrome P450  (IEA)
piroxicam pharmacodynamics pathway  (ISO)
retinol metabolic pathway  (IEA,ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sorafenib pharmacokinetics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tamoxifen pharmacodynamics pathway  (ISO)
tamoxifen pharmacokinetics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
tramadol pharmacokinetics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)
valproic acid pharmacokinetics pathway  (ISO)
vitamin A deficiency pathway  (ISO)


References - curated
# Reference Title Reference Citation
1. New proteins in the rat CYP2B subfamily: presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA. Desrochers M, etal., Biochem Pharmacol. 1996 Oct 25;52(8):1311-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A constitutive member of the rat cytochrome P450IIB subfamily: full-length coding sequence of the P450IIB3 cDNA. Labbe D, etal., DNA 1988 May;7(4):253-60.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat. Sakuma T, etal., Xenobiotica. 2001 Apr;31(4):223-37.
10. High efavirenz serum concentrations in TB/HIV-coinfected Ugandan adults with a CYP2B6 516 TT genotype on anti-TB treatment. von Braun A, etal., J Antimicrob Chemother. 2019 Jan 1;74(1):135-138. doi: 10.1093/jac/dky379.
11. Association of CYP2B6 gene polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese population. Wang Y, etal., Infect Genet Evol. 2017 Jul;51:198-202. doi: 10.1016/j.meegid.2017.04.001. Epub 2017 Apr 5.
12. Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients. Wyen C, etal., J Antimicrob Chemother. 2008 Apr;61(4):914-8. doi: 10.1093/jac/dkn029. Epub 2008 Feb 14.
13. High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naive HIV patients from Ethiopia: a prospective cohort study. Yimer G, etal., Pharmacogenomics J. 2012 Dec;12(6):499-506. doi: 10.1038/tpj.2011.34. Epub 2011 Aug 23.
Additional References at PubMed
PMID:3013548   PMID:6885818   PMID:8068203   PMID:12477932   PMID:12865317   PMID:15489334   PMID:17086191   PMID:18356043   PMID:19029318   PMID:19651758   PMID:20061448   PMID:21289075  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2181,652,762 - 81,732,153 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,652,787 - 81,732,143 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,073,523 - 87,141,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0195,571,804 - 95,642,315 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,829,353 - 88,897,077 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,163,103 - 83,236,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,163,079 - 83,236,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,445,481 - 84,491,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,084,984 - 81,185,251 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,486,546 - 81,659,871 (+)NCBI
Celera176,082,604 - 76,158,885 (+)NCBICelera
Cytogenetic Map1q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381940,991,282 - 41,018,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,991,282 - 41,018,398 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,497,187 - 41,524,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,189,044 - 46,216,141 (+)NCBINCBI36Build 36hg18NCBI36
Build 341946,189,043 - 46,216,141NCBI
Celera1938,297,361 - 38,324,463 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,929,211 - 37,956,335 (+)NCBIHuRef
CHM1_11941,496,934 - 41,524,020 (+)NCBICHM1_1
T2T-CHM13v2.01943,812,191 - 43,839,297 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39725,872,775 - 25,910,086 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,872,836 - 25,910,086 (+)EnsemblGRCm39 Ensembl
GRCm38726,173,350 - 26,210,661 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,173,411 - 26,210,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,958,428 - 26,995,679 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,882,169 - 25,919,420 (+)NCBIMGSCv36mm8
Celera720,779,234 - 20,803,450 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11949,088,771 - 49,114,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,003,083 - 38,028,980 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,509,370 - 46,534,672 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,509,370 - 46,534,672 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11112,817,561 - 112,833,294 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,816,502 - 112,833,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,220,751 - 112,236,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,415,892 - 113,431,675 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,415,766 - 113,431,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,976,144 - 112,991,691 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,607,509 - 112,623,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,602,017 - 113,617,585 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl649,110,812 - 49,178,334 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,158,175 - 49,173,872 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,968,257 - 44,978,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1635,392,699 - 35,418,171 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,393,342 - 35,418,106 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607313,588,241 - 13,611,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Cyp2b3
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:115
Interacting mature miRNAs:127
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,777,564 - 81,777,720 (+)MAPPERmRatBN7.2
Rnor_6.0183,282,659 - 83,282,814NCBIRnor6.0
Rnor_5.0184,537,073 - 84,537,228UniSTSRnor5.0
RGSC_v3.4181,548,753 - 81,548,909RGDRGSC3.4
RGSC_v3.4181,548,754 - 81,548,909UniSTSRGSC3.4
RGSC_v3.1181,626,865 - 81,627,020RGD
Celera176,204,150 - 76,204,305UniSTS
RH 3.4 Map1841.1UniSTS
RH 3.4 Map1841.1RGD
FHH x ACI Map142.2599UniSTS
FHH x ACI Map142.2599RGD
Cytogenetic Map1q21UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 23 23 23
Low 3 1 1 1 2 2
Below cutoff 8 18 8 13 8 7 8 4 9 9 6 7


RefSeq Acc Id: ENSRNOT00000034845   ⟹   ENSRNOP00000030069
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,652,787 - 81,732,143 (+)Ensembl
Rnor_6.0 Ensembl183,163,100 - 83,236,615 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077725   ⟹   ENSRNOP00000074818
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,163,079 - 83,236,576 (+)Ensembl
RefSeq Acc Id: NM_173294   ⟹   NP_775416
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,652,785 - 81,732,153 (+)NCBI
Rnor_6.0183,163,103 - 83,236,615 (+)NCBI
Rnor_5.0184,445,481 - 84,491,180 (+)NCBI
Celera176,082,604 - 76,158,885 (+)RGD
RefSeq Acc Id: XM_039102697   ⟹   XP_038958625
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,652,762 - 81,706,530 (+)NCBI
RefSeq Acc Id: NP_775416   ⟸   NM_173294
- Peptide Label: precursor
- UniProtKB: Q3B8R5 (UniProtKB/Swiss-Prot),   A1L121 (UniProtKB/Swiss-Prot),   Q64585 (UniProtKB/Swiss-Prot),   P13107 (UniProtKB/Swiss-Prot),   A6J997 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074818   ⟸   ENSRNOT00000077725
RefSeq Acc Id: ENSRNOP00000030069   ⟸   ENSRNOT00000034845
RefSeq Acc Id: XP_038958625   ⟸   XM_039102697
- Peptide Label: isoform X1
- UniProtKB: Q6LCX2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13107-F1-model_v2 AlphaFold P13107 1-491 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628627 AgrOrtholog
BioCyc Gene G2FUF-60346 BioCyc
Ensembl Genes ENSRNOG00000033164 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000030069 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034845 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286953 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp2b3 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A6J998_RAT UniProtKB/TrEMBL
  CP2B3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1L121 UniProtKB/Swiss-Prot
  Q3B8R5 UniProtKB/Swiss-Prot
  Q64585 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Cyp2b3  cytochrome P450, family 2, subfamily b, polypeptide 3  LOC100359973  cytochrome P450 2B3-like  Data Merged 1643240 APPROVED
2010-05-06 LOC100359973  cytochrome P450 2B3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-19 Cyp2b3  cytochrome P450, family 2, subfamily b, polypeptide 3  Cyp2b3  cytochrome P450IIB3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Cyp2b3  cytochrome P450IIB3  Cyp2b6  cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6  Data Merged 1643240 APPROVED
2003-02-27 Cyp2b3  cytochrome P450IIB3      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Cyp2b6  cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6      Symbol and Name status set to provisional 70820 PROVISIONAL