Cyp2t1 (cytochrome P450, family 2, subfamily t, polypeptide 1) - Rat Genome Database

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Gene: Cyp2t1 (cytochrome P450, family 2, subfamily t, polypeptide 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2t1
Name: cytochrome P450, family 2, subfamily t, polypeptide 1
RGD ID: 620086
Description: Predicted to enable arachidonic acid epoxygenase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in epoxygenase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome P450 monooxygenase CYP2T1
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,573,923 - 91,579,215 (+)NCBIGRCr8
mRatBN7.2182,446,321 - 82,451,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,446,921 - 82,451,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,851,318 - 87,855,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,337,641 - 96,341,346 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,607,183 - 89,610,890 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,965,370 - 83,969,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,965,608 - 83,969,559 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,176,324 - 85,180,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,229,581 - 82,233,249 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,307,691 - 82,311,359 (+)NCBI
Celera176,861,288 - 76,864,957 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cyp2t1
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000068322
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
BF418972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,451,320 - 82,451,503 (+)MAPPERmRatBN7.2
Rnor_6.0183,969,223 - 83,969,405NCBIRnor6.0
Rnor_5.0185,180,161 - 85,180,343UniSTSRnor5.0
RGSC_v3.4182,233,006 - 82,233,188UniSTSRGSC3.4
Celera176,864,714 - 76,864,896UniSTS
RH 3.4 Map1840.4UniSTS
Cytogenetic Map1q21UniSTS
RH125240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,451,578 - 82,451,695 (+)MAPPERmRatBN7.2
Rnor_6.0183,969,481 - 83,969,597NCBIRnor6.0
Rnor_5.0185,180,419 - 85,180,535UniSTSRnor5.0
RGSC_v3.4182,233,264 - 82,233,380UniSTSRGSC3.4
Celera176,864,972 - 76,865,088UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 18 15 15 4 7 9 10
Low 1 41 39 26 19 26 8 11 70 28 32 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000068322   ⟹   ENSRNOP00000061482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,446,921 - 82,451,563 (+)Ensembl
Rnor_6.0 Ensembl183,965,798 - 83,969,465 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079995   ⟹   ENSRNOP00000072323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,447,047 - 82,451,563 (+)Ensembl
Rnor_6.0 Ensembl183,965,608 - 83,969,559 (+)Ensembl
RefSeq Acc Id: NM_134369   ⟹   NP_599196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,575,510 - 91,579,215 (+)NCBI
mRatBN7.2182,447,859 - 82,451,564 (+)NCBI
Rnor_6.0183,965,798 - 83,969,466 (+)NCBI
Rnor_5.0185,176,324 - 85,180,404 (+)NCBI
RGSC_v3.4182,229,581 - 82,233,249 (+)RGD
Celera176,861,288 - 76,864,957 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228558   ⟹   XP_006228620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,573,923 - 91,579,215 (+)NCBI
mRatBN7.2182,447,447 - 82,451,564 (+)NCBI
Rnor_6.0183,965,370 - 83,969,466 (+)NCBI
Rnor_5.0185,176,324 - 85,180,404 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_599196 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK53421 (Get FASTA)   NCBI Sequence Viewer  
  EDM07973 (Get FASTA)   NCBI Sequence Viewer  
  EDM07974 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061482.2
  ENSRNOP00000072323
  ENSRNOP00000072323.1
RefSeq Acc Id: NP_599196   ⟸   NM_134369
- Peptide Label: precursor
- UniProtKB: A0A0G2K2P4 (UniProtKB/TrEMBL),   E9PSZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228620   ⟸   XM_006228558
- Peptide Label: isoform X1
- UniProtKB: E9PSZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072323   ⟸   ENSRNOT00000079995
RefSeq Acc Id: ENSRNOP00000061482   ⟸   ENSRNOT00000068322

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2P4-F1-model_v2 AlphaFold A0A0G2K2P4 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689859
Promoter ID:EPDNEW_R367
Type:multiple initiation site
Name:Cyp2t1_1
Description:cytochrome P450, family 2, subfamily t, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,965,782 - 83,965,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620086 AgrOrtholog
BioCyc Gene G2FUF-60326 BioCyc
Ensembl Genes ENSRNOG00000028891 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068322.2 UniProtKB/TrEMBL
  ENSRNOT00000079995 ENTREZGENE
  ENSRNOT00000079995.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP2_fam UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report rno:171380 UniProtKB/TrEMBL
NCBI Gene 171380 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450, FAMILY 2, SUBFAMILY T, POLYPEPTIDE 4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp2t1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2F UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028891 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A0G2K2P4 ENTREZGENE, UniProtKB/TrEMBL
  A6J9B0_RAT UniProtKB/TrEMBL
  A6J9B1_RAT UniProtKB/TrEMBL
  E9PSZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q91Y29_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2t1  cytochrome P450, family 2, subfamily t, polypeptide 1  Cyp2t1  cytochrome P450 monooxygenase CYP2T1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Cyp2t1  cytochrome P450 monooxygenase CYP2T1      Symbol and Name status set to provisional 70820 PROVISIONAL