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Gene: Akt2 (AKT serine/threonine kinase 2) Rattus norvegicus
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Symbol: Akt2
Name: AKT serine/threonine kinase 2
Description: Exhibits ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of nitrogen compound metabolic process; and positive regulation of transport. Localizes to the cytoplasm; nucleus; and plasma membrane. Used to study ischemia and malignant glioma. Biomarker of colorectal cancer; hepatocellular carcinoma; hypertension; and obesity. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; altered insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',5,5'-tetrachlorobiphenyl; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AKT2 kinase; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; protein kinase Akt-2; protein kinase B beta; protein kinase B, beta; RAC protein kinase beta RAC-PK beta; RAC protein kinase beta, RAC-PK beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
Orthologs:
Homo sapiens (human) : AKT2 (AKT serine/threonine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Akt2 (thymoma viral proto-oncogene 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt2 (AKT serine/threonine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT2 (AKT serine/threonine kinase 2)
Canis lupus familiaris (dog) : AKT2 (AKT serine/threonine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt2 (AKT serine/threonine kinase 2)
Sus scrofa (pig) : AKT2 (AKT serine/threonine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0184,400,939 - 84,451,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0185,617,612 - 85,667,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,686,233 - 82,726,544 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,764,343 - 82,804,655 (+)NCBI
Celera177,307,278 - 77,345,638 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Akt2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2082
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.