Akt2 (AKT serine/threonine kinase 2) - Rat Genome Database

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Gene: Akt2 (AKT serine/threonine kinase 2) Rattus norvegicus
Analyze
Symbol: Akt2
Name: AKT serine/threonine kinase 2
RGD ID: 2082
Description: Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of glucose import; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within cellular response to insulin stimulus and positive regulation of sodium ion transport. Located in insulin-responsive compartment and sarcoplasmic reticulum. Used to study high grade glioma and ischemia. Biomarker of colorectal cancer; hepatocellular carcinoma; hypertension; and obesity. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; altered insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AKT2 kinase; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; protein kinase Akt-2; protein kinase B beta; protein kinase B, beta; RAC protein kinase beta RAC-PK beta; RAC protein kinase beta, RAC-PK beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,877,228 - 82,933,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,883,547 - 82,933,817 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,296,913 - 88,335,355 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0196,784,353 - 96,822,706 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0190,052,776 - 90,091,219 (+)NCBIRnor_WKY
Rnor_6.0184,400,939 - 84,451,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,617,612 - 85,667,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,686,233 - 82,726,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,764,343 - 82,804,655 (+)NCBI
Celera177,307,278 - 77,345,638 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-gambogic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
2-nitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
Bergenin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clenbuterol  (EXP)
clozapine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocin-1  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
dimethoate  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
genistein  (ISO)
glucose  (ISO)
haloperidol  (EXP)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
losartan  (ISO)
maleic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP,ISO)
nitenpyram  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
propiconazole  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium tungstate  (ISO)
streptozocin  (EXP)
sulindac  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triciribine  (ISO)
triphenylstannane  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
vincristine  (EXP)
xanthohumol  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IEA,ISO)
carbohydrate transport  (IEA)
cellular response to high light intensity  (IEA,ISO)
cellular response to hormone stimulus  (IEP)
cellular response to insulin stimulus  (IMP,ISO)
cellular response to organic cyclic compound  (IDA)
glucose metabolic process  (IEA,ISO)
glycogen biosynthetic process  (IEA)
insulin receptor signaling pathway  (IEA,ISO)
intracellular protein transmembrane transport  (IEA,ISO,ISS)
intracellular signal transduction  (IBA)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
negative regulation of long-chain fatty acid import across plasma membrane  (IEA,ISO)
negative regulation of RNA splicing  (IMP)
peptidyl-serine phosphorylation  (IBA)
peripheral nervous system myelin maintenance  (IEA,ISO)
positive regulation of adipose tissue development  (ISO)
positive regulation of cell migration  (IEA,IMP,ISO)
positive regulation of cell motility  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of fatty acid beta-oxidation  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of glucose import  (IEA,IMP,ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (IEA,ISO)
positive regulation of mitochondrial membrane potential  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of positive chemotaxis  (IDA)
positive regulation of protein phosphorylation  (IEA,IMP,ISO)
positive regulation of protein targeting to membrane  (IEA,ISO,ISS)
positive regulation of signal transduction  (IMP)
positive regulation of sodium ion transport  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of vesicle fusion  (IEA,ISO,ISS)
protein kinase B signaling  (IMP)
protein localization to nucleus  (ISO)
protein localization to plasma membrane  (IEA,ISO)
protein phosphorylation  (IDA,IEA,ISO,TAS)
regulation of translation  (IEA)
response to hypoxia  (IEP)
response to insulin  (IDA,IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
retinal rod cell apoptotic process  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
endometrial cancer pathway  (IEA,ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
insulin responsive facilitative sugar transporter mediated glucose transport pathway  (IMP,ISO)
insulin signaling pathway  (IEA,ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway  (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
pancreatic cancer pathway  (IEA,ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (IMP,ISO)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (ISO)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Prolactin-modulated gene expression profiles in pancreatic islets from adult female rats. Bordin S, etal., Mol Cell Endocrinol. 2004 May 31;220(1-2):41-50.
2. Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Brozinick JT Jr, etal., Diabetes. 2003 Apr;52(4):935-41.
3. Insulin increases the association of Akt-2 with Glut4-containing vesicles. Calera MR, etal., J Biol Chem. 1998 Mar 27;273(13):7201-4.
4. Genetic variations in a PTEN/AKT/mTOR axis and prostate cancer risk in a Chinese population. Chen J, etal., PLoS One. 2012;7(7):e40817. doi: 10.1371/journal.pone.0040817. Epub 2012 Jul 18.
5. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
6. PTEN-deficient tumors depend on AKT2 for maintenance and survival. Chin YR, etal., Cancer Discov. 2014 Aug;4(8):942-55. doi: 10.1158/2159-8290.CD-13-0873. Epub 2014 May 16.
7. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Cho H, etal., Science 2001 Jun 1;292(5522):1728-31.
8. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Choi CS, etal., Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.
9. Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients. Cozzone D, etal., Diabetologia. 2008 Mar;51(3):512-21. Epub 2008 Jan 18.
10. A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia. Dash S, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. doi: 10.1073/pnas.0900909106. Epub 2009 May 22.
11. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Dillon RL, etal., Cancer Res. 2009 Jun 15;69(12):5057-64. Epub 2009 Jun 2.
12. The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning. Dreixler JC, etal., Exp Eye Res. 2009 Mar;88(3):512-21. Epub 2008 Dec 3.
13. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
14. Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome. Finocchietto P, etal., PLoS One. 2008 Mar 12;3(3):e1749.
15. Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility. Fornage M, etal., Physiol Genomics. 2003 Sep 29;15(1):75-83.
16. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. A family with severe insulin resistance and diabetes due to a mutation in AKT2. George S, etal., Science. 2004 May 28;304(5675):1325-8.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. He Z, etal., Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):787-93. Epub 2006 Feb 9.
21. Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. Hernandez R, etal., FEBS Lett. 2001 Apr 13;494(3):225-31.
22. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
23. An activating mutation of AKT2 and human hypoglycemia. Hussain K, etal., Science. 2011 Oct 28;334(6055):474. doi: 10.1126/science.1210878. Epub 2011 Oct 6.
24. Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists. Jiang G, etal., Diabetes. 2002 Aug;51(8):2412-9.
25. Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid. Jiang K, etal., Endocrinology. 2009 May;150(5):2087-97. Epub 2008 Dec 30.
26. The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
27. Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Konishi H, etal., Biochem Biophys Res Commun 1994 Nov 30;205(1):817-25.
28. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Konishi H, etal., Biochem Biophys Res Commun 1995 Nov 13;216(2):526-34.
29. Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin. Kupriyanova TA and Kandror KV, J Biol Chem. 1999 Jan 15;274(3):1458-64.
30. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
31. Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling. Lucchinetti E, etal., Physiol Genomics. 2006 Apr 13;25(2):314-24. Epub 2006 Jan 17.
32. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Maroulakou IG, etal., Cancer Res. 2007 Jan 1;67(1):167-77.
33. Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspring. Martin-Gronert MS, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R494-500. Epub 2007 Dec 19.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Akt2 and Akt3 play a pivotal role in malignant gliomas. Mure H, etal., Neuro Oncol. 2010 Mar;12(3):221-32. doi: 10.1093/neuonc/nop026. Epub 2009 Dec 21.
36. Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Nakayama K, etal., Cancer Biol Ther. 2006 Jul;5(7):779-85. Epub 2006 Jul 26.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. Patel NA, etal., J Biol Chem. 2005 Apr 8;280(14):14302-9. Epub 2005 Jan 31.
41. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Peng XD, etal., Genes Dev 2003 Jun 1;17(11):1352-65.
42. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Peterson JM, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8. Epub 2008 May 28.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. Antisense and dominant-negative AKT2 cDNA inhibits glioma cell invasion. Pu P, etal., Tumour Biol. 2004 Jul-Aug;25(4):172-8.
46. Retinal insulin receptor signaling in hyperosmotic stress. Rajala RV, etal., Vitam Horm. 2009;80:583-612.
47. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Resjo S, etal., Cell Signal. 2002 Mar;14(3):231-8.
48. GOA pipeline RGD automated data pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Roy HK, etal., Carcinogenesis. 2002 Jan;23(1):201-5.
52. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. Saito T, etal., J Biol Chem. 2007 Nov 2;282(44):32280-7. Epub 2007 Sep 11.
53. Contraction regulation of Akt in rat skeletal muscle. Sakamoto K, etal., J Biol Chem. 2002 Apr 5;277(14):11910-7. Epub 2002 Jan 23.
54. Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo. Sasaki T, etal., Biochem Biophys Res Commun. 2010 Aug 13;399(1):79-83. doi: 10.1016/j.bbrc.2010.07.045. Epub 2010 Jul 16.
55. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
56. Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. Tan K, etal., Diabetes. 2007 Mar;56(3):714-9.
57. Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Taniai E, etal., Cancer Sci. 2009 May;100(5):813-20. Epub 2009 Mar 20.
58. Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. Temofonte N, etal., Diabetologia. 2009 Jan;52(1):60-4. Epub 2008 Oct 30.
59. Enhanced protection against cytokine- and fatty acid-induced apoptosis in pancreatic beta cells by combined treatment with glucagon-like peptide-1 receptor agonists and insulin analogues. Tews D, etal., Horm Metab Res. 2008 Mar;40(3):172-80.
60. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Turinsky J and Damrau-Abney A, Am J Physiol. 1999 Jan;276(1 Pt 2):R277-82.
61. Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Villar M, etal., Biochim Biophys Acta. 2006 Feb;1763(2):197-206. Epub 2006 Jan 4.
62. Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes. Wang LE, etal., J Cancer Res Clin Oncol. 2012 Mar;138(3):377-85. doi: 10.1007/s00432-011-1103-0. Epub 2011 Dec 7.
63. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
64. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
65. The effect Akt2 deletion on tumor development in Pten(+/-) mice. Xu PZ, etal., Oncogene. 2012 Jan 26;31(4):518-26. doi: 10.1038/onc.2011.243. Epub 2011 Jul 11.
66. Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle. Yaspelkis BB 3rd, etal., Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E941-9. Epub 2007 Jul 10.
67. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
68. Reduction of Akt2 inhibits migration and invasion of glioma cells. Zhang B, etal., Int J Cancer. 2009 Aug 1;125(3):585-95.
Additional References at PubMed
PMID:10983986   PMID:12181135   PMID:12767043   PMID:12799317   PMID:14701745   PMID:15546921   PMID:15764607   PMID:15802290   PMID:16236484   PMID:16338927   PMID:16452480   PMID:16540465  
PMID:16814735   PMID:17021050   PMID:17202487   PMID:17332325   PMID:18535289   PMID:18757828   PMID:18854316   PMID:18931307   PMID:19372382   PMID:19477150   PMID:20059950   PMID:20339009  
PMID:20448149   PMID:20728450   PMID:20923964   PMID:21148297   PMID:21907143   PMID:22031698   PMID:22391142   PMID:22778840   PMID:23229735   PMID:23499910   PMID:23746671   PMID:23785074  
PMID:24150286   PMID:25025572   PMID:25428377   PMID:26739650   PMID:27786542   PMID:27821807   PMID:28365702   PMID:30444896   PMID:36427136  


Genomics

Comparative Map Data
Akt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,877,228 - 82,933,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,883,547 - 82,933,817 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,296,913 - 88,335,355 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0196,784,353 - 96,822,706 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0190,052,776 - 90,091,219 (+)NCBIRnor_WKY
Rnor_6.0184,400,939 - 84,451,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,617,612 - 85,667,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,686,233 - 82,726,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,764,343 - 82,804,655 (+)NCBI
Celera177,307,278 - 77,345,638 (+)NCBICelera
Cytogenetic Map1q21NCBI
AKT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,230,317 - 40,285,345 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1940,230,317 - 40,285,536 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,736,224 - 40,791,252 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,428,064 - 45,483,105 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,431,555 - 45,483,034NCBI
Celera1937,535,771 - 37,590,707 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,171,156 - 37,226,119 (-)NCBIHuRef
CHM1_11940,735,896 - 40,790,984 (-)NCBICHM1_1
T2T-CHM13v2.01943,050,812 - 43,105,845 (-)NCBIT2T-CHM13v2.0
Akt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,290,977 - 27,340,251 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,290,977 - 27,340,251 (+)EnsemblGRCm39 Ensembl
GRCm38727,591,552 - 27,640,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,591,552 - 27,640,826 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,376,579 - 28,424,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,314,618 - 27,348,214 (+)NCBIMGSCv36mm8
Celera722,173,505 - 22,221,607 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.94NCBI
Akt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578967,593 - 1,004,438 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578950,258 - 1,004,438 (+)NCBIChiLan1.0ChiLan1.0
AKT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11948,360,226 - 48,417,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,275,799 - 37,331,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,791,043 - 45,846,359 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,791,800 - 45,840,271 (-)Ensemblpanpan1.1panPan2
AKT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,359,038 - 113,407,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,359,575 - 113,407,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,790,741 - 112,808,659 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,957,825 - 114,008,296 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,958,298 - 114,008,293 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,546,597 - 113,564,514 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,179,139 - 113,197,049 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,172,976 - 114,190,895 (+)NCBIUU_Cfam_GSD_1.0
Akt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,224,502 - 14,265,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,652,566 - 2,694,086 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366612,652,568 - 2,694,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,555,795 - 48,587,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,555,785 - 48,620,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,331,695 - 44,393,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,688,585 - 34,740,458 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,690,462 - 34,720,781 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,782,360 - 12,833,428 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925273,881 - 326,984 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925262,590 - 322,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akt2
236 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:44
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000025303
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
SGC30851  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,930,435 - 82,930,690 (+)MAPPERmRatBN7.2
Rnor_6.0184,447,831 - 84,448,085NCBIRnor6.0
Rnor_5.0185,664,031 - 85,664,285UniSTSRnor5.0
RGSC_v3.4182,724,213 - 82,724,467UniSTSRGSC3.4
Celera177,343,307 - 77,343,561UniSTS
Cytogenetic Map1q22UniSTS
RH94820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X20,796,317 - 20,796,420 (+)MAPPERmRatBN7.2
mRatBN7.2182,932,647 - 82,932,762 (+)MAPPERmRatBN7.2
Rnor_6.0184,450,043 - 84,450,157NCBIRnor6.0
Rnor_6.0X21,396,878 - 21,396,980NCBIRnor6.0
Rnor_5.0185,666,243 - 85,666,357UniSTSRnor5.0
Rnor_5.0X22,053,861 - 22,053,963UniSTSRnor5.0
RGSC_v3.4X41,188,897 - 41,188,999UniSTSRGSC3.4
RGSC_v3.4182,726,425 - 82,726,539UniSTSRGSC3.4
Celera177,345,519 - 77,345,633UniSTS
CeleraX21,078,285 - 21,078,387UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map1q22UniSTS
AA957331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,931,325 - 82,932,499 (+)MAPPERmRatBN7.2
Rnor_6.0184,448,721 - 84,449,894NCBIRnor6.0
Rnor_5.0185,664,921 - 85,666,094UniSTSRnor5.0
Rnor_5.0X22,054,121 - 22,054,316UniSTSRnor5.0
RGSC_v3.4182,725,103 - 82,726,276UniSTSRGSC3.4
Celera177,344,197 - 77,345,370UniSTS
RH 3.4 Map1826.5UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D30041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ198085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025303   ⟹   ENSRNOP00000025303
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,883,700 - 82,933,817 (+)Ensembl
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100544   ⟹   ENSRNOP00000076786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,910,684 - 82,933,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105853   ⟹   ENSRNOP00000078809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,883,700 - 82,933,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118840   ⟹   ENSRNOP00000095075
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,883,547 - 82,933,696 (+)Ensembl
RefSeq Acc Id: NM_017093   ⟹   NP_058789
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,894,322 - 82,932,767 (+)NCBI
Rnor_6.0184,411,726 - 84,450,162 (+)NCBI
Rnor_5.0185,617,612 - 85,667,423 (+)NCBI
RGSC_v3.4182,686,233 - 82,726,544 (+)RGD
Celera177,307,278 - 77,345,638 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759108   ⟹   XP_008757330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,898,053 - 82,933,828 (+)NCBI
Rnor_6.0184,413,060 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759109   ⟹   XP_008757331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,883,521 - 82,933,823 (+)NCBI
Rnor_6.0184,400,939 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759110   ⟹   XP_008757332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,897,970 - 82,933,823 (+)NCBI
Rnor_6.0184,413,060 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759111   ⟹   XP_008757333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,900,028 - 82,933,823 (+)NCBI
Rnor_6.0184,417,302 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101465   ⟹   XP_038957393
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,889,068 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101467   ⟹   XP_038957395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,887,465 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101469   ⟹   XP_038957397
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,877,228 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101472   ⟹   XP_038957400
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,900,366 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101473   ⟹   XP_038957401
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,884,658 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101474   ⟹   XP_038957402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,883,520 - 82,933,828 (+)NCBI
RefSeq Acc Id: XM_039101475   ⟹   XP_038957403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,900,940 - 82,933,828 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058789   ⟸   NM_017093
- UniProtKB: P47197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757331   ⟸   XM_008759109
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757330   ⟸   XM_008759108
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757332   ⟸   XM_008759110
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757333   ⟸   XM_008759111
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025303   ⟸   ENSRNOT00000025303
RefSeq Acc Id: XP_038957397   ⟸   XM_039101469
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957402   ⟸   XM_039101474
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957401   ⟸   XM_039101473
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957395   ⟸   XM_039101467
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957393   ⟸   XM_039101465
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957400   ⟸   XM_039101472
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957403   ⟸   XM_039101475
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000095075   ⟸   ENSRNOT00000118840
RefSeq Acc Id: ENSRNOP00000076786   ⟸   ENSRNOT00000100544
RefSeq Acc Id: ENSRNOP00000078809   ⟸   ENSRNOT00000105853
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47197-F1-model_v2 AlphaFold P47197 1-481 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689857
Promoter ID:EPDNEW_R382
Type:single initiation site
Name:Akt2_1
Description:AKT serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,411,683 - 84,411,743EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2082 AgrOrtholog
BioCyc Gene G2FUF-60302 BioCyc
Ensembl Genes ENSRNOG00000018677 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025303 ENTREZGENE
  ENSRNOP00000025303.4 UniProtKB/TrEMBL
  ENSRNOP00000076786.1 UniProtKB/TrEMBL
  ENSRNOP00000078809.1 UniProtKB/TrEMBL
  ENSRNOP00000095075 ENTREZGENE
  ENSRNOP00000095075.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025303 ENTREZGENE
  ENSRNOT00000025303.4 UniProtKB/TrEMBL
  ENSRNOT00000100544.1 UniProtKB/TrEMBL
  ENSRNOT00000105853.1 UniProtKB/TrEMBL
  ENSRNOT00000118840 ENTREZGENE
  ENSRNOT00000118840.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Akt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_PKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25233 UniProtKB/Swiss-Prot
NCBI Gene 25233 ENTREZGENE
PANTHER NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKT2 RGD
PhenoGen Akt2 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y943_RAT UniProtKB/TrEMBL
  A0A8I5ZLJ3_RAT UniProtKB/TrEMBL
  A0A8I6ASU3_RAT UniProtKB/TrEMBL
  AKT2_RAT UniProtKB/Swiss-Prot
  F7EKK8_RAT UniProtKB/TrEMBL
  P47197 ENTREZGENE
  Q3HSE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt2  AKT serine/threonine kinase 2  Akt2  v-akt murine thymoma viral oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt2  v-akt murine thymoma viral oncogene homolog 2  Akt2  thymoma viral proto-oncogene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akt2  thymoma viral proto-oncogene 2    murine thymoma viral (v-akt) oncogene homolog 2  Name updated 1299863 APPROVED
2002-06-10 Akt2  Murine thymoma viral (v-akt) oncogene homolog 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology domain 632176
gene_domains contains a protein-serine/threonine kinase catalytic domain 632176
gene_expression expressed in testis and other tissues 632176
gene_function may act as a protein-serine/threonine kinase 632176
gene_physical_interaction may bind protein kinase C 632176
gene_process may play a role in the phosphatidylinositol 3-kinase (PI3-K) signaling pathway 632179
gene_protein protein sequence contains 481 amino acids 632176