Akt2 (AKT serine/threonine kinase 2) - Rat Genome Database

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Gene: Akt2 (AKT serine/threonine kinase 2) Rattus norvegicus
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Symbol: Akt2
Name: AKT serine/threonine kinase 2
RGD ID: 2082
Description: Exhibits ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of ion transport; and positive regulation of nitrogen compound metabolic process. Localizes to several cellular components, including insulin-responsive compartment; mitochondrion; and sarcoplasmic reticulum. Used to study high grade glioma and ischemia. Biomarker of colorectal cancer; hepatocellular carcinoma; hypertension; and obesity. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; altered insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AKT2 kinase; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; protein kinase Akt-2; protein kinase B beta; protein kinase B, beta; RAC protein kinase beta RAC-PK beta; RAC protein kinase beta, RAC-PK beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,877,228 - 82,933,828 (+)NCBI
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0184,400,939 - 84,451,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0185,617,612 - 85,667,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,686,233 - 82,726,544 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,764,343 - 82,804,655 (+)NCBI
Celera177,307,278 - 77,345,638 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
2-nitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
Bergenin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bromochloroacetic acid  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clenbuterol  (EXP)
clozapine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocin-1  (ISO)
curcumin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
dimethoate  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
genistein  (ISO)
glucose  (ISO)
haloperidol  (EXP)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
losartan  (ISO)
maleic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
methylglyoxal  (ISO)
methylseleninic acid  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP,ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
propiconazole  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium tungstate  (ISO)
streptozocin  (EXP)
sulindac  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triciribine  (ISO)
triphenylstannane  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
vincristine  (EXP)
xanthohumol  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (IEA,ISO)
carbohydrate transport  (IEA)
cellular response to high light intensity  (IEA,ISO)
cellular response to hormone stimulus  (IEP)
cellular response to insulin stimulus  (ISO)
cellular response to organic cyclic compound  (IDA)
glucose metabolic process  (IEA,ISO)
glycogen biosynthetic process  (IEA)
insulin receptor signaling pathway  (IEA,ISO)
intracellular protein transmembrane transport  (IEA,ISO,ISS)
intracellular signal transduction  (IBA)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
negative regulation of long-chain fatty acid import across plasma membrane  (IEA,ISO)
negative regulation of RNA splicing  (IMP)
peptidyl-serine phosphorylation  (IBA)
peripheral nervous system myelin maintenance  (IEA,ISO)
positive regulation of cell migration  (IEA,IMP,ISO)
positive regulation of cell motility  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of fatty acid beta-oxidation  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of glucose import  (IEA,IMP,ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of glycogen biosynthetic process  (IEA,ISO)
positive regulation of mitochondrial membrane potential  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of positive chemotaxis  (IDA)
positive regulation of protein phosphorylation  (IEA,IMP,ISO)
positive regulation of protein targeting to membrane  (IEA,ISO,ISS)
positive regulation of signal transduction  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of vesicle fusion  (IEA,ISO,ISS)
protein kinase B signaling  (IMP)
protein localization to nucleus  (ISO)
protein localization to plasma membrane  (IEA,ISO)
protein phosphorylation  (IDA,IEA,ISO,TAS)
regulation of translation  (IEA)
response to hypoxia  (IEP)
response to insulin  (IDA,IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
response to osmotic stress  (IEP)
retinal rod cell apoptotic process  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
endometrial cancer pathway  (IEA,ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
insulin responsive facilitative sugar transporter mediated glucose transport pathway  (IMP,ISO)
insulin signaling pathway  (IEA,ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway  (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA)
pancreatic cancer pathway  (IEA,ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (IMP,ISO)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (ISO)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
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2. Brozinick JT Jr, etal., Diabetes. 2003 Apr;52(4):935-41.
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4. Chen J, etal., PLoS One. 2012;7(7):e40817. doi: 10.1371/journal.pone.0040817. Epub 2012 Jul 18.
5. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
6. Chin YR, etal., Cancer Discov. 2014 Aug;4(8):942-55. doi: 10.1158/2159-8290.CD-13-0873. Epub 2014 May 16.
7. Cho H, etal., Science 2001 Jun 1;292(5522):1728-31.
8. Choi CS, etal., Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. Epub 2007 Oct 8.
9. Cozzone D, etal., Diabetologia. 2008 Mar;51(3):512-21. Epub 2008 Jan 18.
10. Dash S, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9350-5. doi: 10.1073/pnas.0900909106. Epub 2009 May 22.
11. Dillon RL, etal., Cancer Res. 2009 Jun 15;69(12):5057-64. Epub 2009 Jun 2.
12. Dreixler JC, etal., Exp Eye Res. 2009 Mar;88(3):512-21. Epub 2008 Dec 3.
13. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
14. Finocchietto P, etal., PLoS One. 2008 Mar 12;3(3):e1749.
15. Fornage M, etal., Physiol Genomics. 2003 Sep 29;15(1):75-83.
16. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. George S, etal., Science. 2004 May 28;304(5675):1325-8.
19. GOA data from the GO Consortium
20. He Z, etal., Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):787-93. Epub 2006 Feb 9.
21. Hernandez R, etal., FEBS Lett. 2001 Apr 13;494(3):225-31.
22. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
23. Hussain K, etal., Science. 2011 Oct 28;334(6055):474. doi: 10.1126/science.1210878. Epub 2011 Oct 6.
24. Jiang G, etal., Diabetes. 2002 Aug;51(8):2412-9.
25. Jiang K, etal., Endocrinology. 2009 May;150(5):2087-97. Epub 2008 Dec 30.
26. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
27. Konishi H, etal., Biochem Biophys Res Commun 1994 Nov 30;205(1):817-25.
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29. Kupriyanova TA and Kandror KV, J Biol Chem. 1999 Jan 15;274(3):1458-64.
30. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
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32. Maroulakou IG, etal., Cancer Res. 2007 Jan 1;67(1):167-77.
33. Martin-Gronert MS, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R494-500. Epub 2007 Dec 19.
34. MGD data from the GO Consortium
35. Mure H, etal., Neuro Oncol. 2010 Mar;12(3):221-32. doi: 10.1093/neuonc/nop026. Epub 2009 Dec 21.
36. Nakayama K, etal., Cancer Biol Ther. 2006 Jul;5(7):779-85. Epub 2006 Jul 26.
37. NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
39. OMIM Disease Annotation Pipeline
40. Patel NA, etal., J Biol Chem. 2005 Apr 8;280(14):14302-9. Epub 2005 Jan 31.
41. Peng XD, etal., Genes Dev 2003 Jun 1;17(11):1352-65.
42. Peterson JM, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8. Epub 2008 May 28.
43. Pipeline to import KEGG annotations from KEGG into RGD
44. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. Pu P, etal., Tumour Biol. 2004 Jul-Aug;25(4):172-8.
46. Rajala RV, etal., Vitam Horm. 2009;80:583-612.
47. Resjo S, etal., Cell Signal. 2002 Mar;14(3):231-8.
48. RGD automated data pipeline
49. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. RGD automated import pipeline for gene-chemical interactions
51. Roy HK, etal., Carcinogenesis. 2002 Jan;23(1):201-5.
52. Saito T, etal., J Biol Chem. 2007 Nov 2;282(44):32280-7. Epub 2007 Sep 11.
53. Sakamoto K, etal., J Biol Chem. 2002 Apr 5;277(14):11910-7. Epub 2002 Jan 23.
54. Sasaki T, etal., Biochem Biophys Res Commun. 2010 Aug 13;399(1):79-83. doi: 10.1016/j.bbrc.2010.07.045. Epub 2010 Jul 16.
55. Tan K, etal., Diabetes. 2007 Mar;56(3):714-9.
56. Taniai E, etal., Cancer Sci. 2009 May;100(5):813-20. Epub 2009 Mar 20.
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Additional References at PubMed
PMID:10983986   PMID:12181135   PMID:12767043   PMID:12799317   PMID:14701745   PMID:15546921   PMID:15764607   PMID:15802290   PMID:16236484   PMID:16338927   PMID:16452480   PMID:16540465  
PMID:16814735   PMID:17021050   PMID:17202487   PMID:17332325   PMID:18535289   PMID:18757828   PMID:18854316   PMID:18931307   PMID:19372382   PMID:19477150   PMID:20059950   PMID:20339009  
PMID:20448149   PMID:20728450   PMID:20923964   PMID:21148297   PMID:21907143   PMID:22031698   PMID:22391142   PMID:22778840   PMID:23229735   PMID:23499910   PMID:23746671   PMID:23785074  
PMID:24150286   PMID:25025572   PMID:25428377   PMID:26739650   PMID:27786542   PMID:27821807   PMID:28365702   PMID:30444896  


Genomics

Comparative Map Data
Akt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,877,228 - 82,933,828 (+)NCBI
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0184,400,939 - 84,451,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0185,617,612 - 85,667,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,686,233 - 82,726,544 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,764,343 - 82,804,655 (+)NCBI
Celera177,307,278 - 77,345,638 (+)NCBICelera
Cytogenetic Map1q21NCBI
AKT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1940,230,317 - 40,285,536 (-)EnsemblGRCh38hg38GRCh38
GRCh381940,230,317 - 40,285,531 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371940,736,224 - 40,791,252 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,428,064 - 45,483,105 (-)NCBINCBI36hg18NCBI36
Build 341945,431,555 - 45,483,034NCBI
Celera1937,535,771 - 37,590,707 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,171,156 - 37,226,119 (-)NCBIHuRef
CHM1_11940,735,896 - 40,790,984 (-)NCBICHM1_1
Akt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,290,977 - 27,340,251 (+)NCBIGRCm39mm39
GRCm39 Ensembl727,290,977 - 27,340,251 (+)Ensembl
GRCm38727,591,552 - 27,640,826 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,591,552 - 27,640,826 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,376,579 - 28,424,472 (+)NCBIGRCm37mm9NCBIm37
MGSCv36727,314,618 - 27,348,214 (+)NCBImm8
Celera722,173,505 - 22,221,607 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.94NCBI
Akt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578967,593 - 1,004,438 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578950,258 - 1,004,438 (+)NCBIChiLan1.0ChiLan1.0
AKT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11945,791,043 - 45,846,359 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,791,800 - 45,840,271 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01937,275,799 - 37,331,971 (-)NCBIMhudiblu_PPA_v0panPan3
AKT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,359,038 - 113,407,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,359,575 - 113,407,131 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,790,741 - 112,808,659 (+)NCBI
ROS_Cfam_1.01113,957,825 - 114,008,296 (+)NCBI
UMICH_Zoey_3.11113,546,597 - 113,564,514 (+)NCBI
UNSW_CanFamBas_1.01113,179,139 - 113,197,049 (+)NCBI
UU_Cfam_GSD_1.01114,172,976 - 114,190,895 (+)NCBI
Akt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,224,502 - 14,265,970 (-)NCBI
SpeTri2.0NW_0049366612,652,568 - 2,694,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,555,789 - 48,587,919 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,555,785 - 48,620,472 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,331,695 - 44,393,119 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKT2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,688,585 - 34,740,458 (-)NCBI
ChlSab1.1 Ensembl634,690,462 - 34,720,781 (-)Ensembl
Vero_WHO_p1.0NW_02366607312,782,360 - 12,833,428 (-)NCBI
Akt2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624925262,590 - 322,440 (-)NCBI

Position Markers
SGC30851  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,930,435 - 82,930,690 (+)MAPPER
Rnor_6.0184,447,831 - 84,448,085NCBIRnor6.0
Rnor_5.0185,664,031 - 85,664,285UniSTSRnor5.0
RGSC_v3.4182,724,213 - 82,724,467UniSTSRGSC3.4
Celera177,343,307 - 77,343,561UniSTS
Cytogenetic Map1q22UniSTS
RH94820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X20,796,317 - 20,796,420 (+)MAPPER
mRatBN7.2182,932,647 - 82,932,762 (+)MAPPER
Rnor_6.0184,450,043 - 84,450,157NCBIRnor6.0
Rnor_6.0X21,396,878 - 21,396,980NCBIRnor6.0
Rnor_5.0185,666,243 - 85,666,357UniSTSRnor5.0
Rnor_5.0X22,053,861 - 22,053,963UniSTSRnor5.0
RGSC_v3.4X41,188,897 - 41,188,999UniSTSRGSC3.4
RGSC_v3.4182,726,425 - 82,726,539UniSTSRGSC3.4
Celera177,345,519 - 77,345,633UniSTS
CeleraX21,078,285 - 21,078,387UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map1q22UniSTS
AA957331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,931,325 - 82,932,499 (+)MAPPER
Rnor_6.0184,448,721 - 84,449,894NCBIRnor6.0
Rnor_5.0185,664,921 - 85,666,094UniSTSRnor5.0
Rnor_5.0X22,054,121 - 22,054,316UniSTSRnor5.0
RGSC_v3.4182,725,103 - 82,726,276UniSTSRGSC3.4
Celera177,344,197 - 77,345,370UniSTS
RH 3.4 Map1826.5UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14190724986907249Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14957857794578577Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15052271494225616Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)16722768394201552Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17968976594909507Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)183502376128502376Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)183656882126240667Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:44
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000025303
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D30041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ198085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025303   ⟹   ENSRNOP00000025303
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl184,411,726 - 84,450,162 (+)Ensembl
RefSeq Acc Id: NM_017093   ⟹   NP_058789
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,894,322 - 82,932,767 (+)NCBI
Rnor_6.0184,411,726 - 84,450,162 (+)NCBI
Rnor_5.0185,617,612 - 85,667,423 (+)NCBI
RGSC_v3.4182,686,233 - 82,726,544 (+)RGD
Celera177,307,278 - 77,345,638 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759108   ⟹   XP_008757330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,898,053 - 82,933,828 (+)NCBI
Rnor_6.0184,413,060 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759109   ⟹   XP_008757331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,883,521 - 82,933,823 (+)NCBI
Rnor_6.0184,400,939 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759110   ⟹   XP_008757332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,897,970 - 82,933,823 (+)NCBI
Rnor_6.0184,413,060 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759111   ⟹   XP_008757333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,900,028 - 82,933,823 (+)NCBI
Rnor_6.0184,417,302 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017588811   ⟹   XP_017444300
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,417,302 - 84,451,223 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101465   ⟹   XP_038957393
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,889,068 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101467   ⟹   XP_038957395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,887,465 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101469   ⟹   XP_038957397
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,877,228 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101472   ⟹   XP_038957400
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,900,366 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101473   ⟹   XP_038957401
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,884,658 - 82,933,823 (+)NCBI
RefSeq Acc Id: XM_039101474   ⟹   XP_038957402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,883,520 - 82,933,828 (+)NCBI
RefSeq Acc Id: XM_039101475   ⟹   XP_038957403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,900,940 - 82,933,828 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058789   ⟸   NM_017093
- UniProtKB: P47197 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757331   ⟸   XM_008759109
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757330   ⟸   XM_008759108
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757332   ⟸   XM_008759110
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757333   ⟸   XM_008759111
- Peptide Label: isoform X2
- UniProtKB: Q3HSE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444300   ⟸   XM_017588811
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000025303   ⟸   ENSRNOT00000025303
RefSeq Acc Id: XP_038957397   ⟸   XM_039101469
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957402   ⟸   XM_039101474
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957401   ⟸   XM_039101473
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957395   ⟸   XM_039101467
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957393   ⟸   XM_039101465
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957400   ⟸   XM_039101472
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957403   ⟸   XM_039101475
- Peptide Label: isoform X4
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689857
Promoter ID:EPDNEW_R382
Type:single initiation site
Name:Akt2_1
Description:AKT serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,411,683 - 84,411,743EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2082 AgrOrtholog
Ensembl Genes ENSRNOG00000018677 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025303 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025303 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Akt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_PKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25233 UniProtKB/Swiss-Prot
NCBI Gene 25233 ENTREZGENE
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKT2 RGD
PhenoGen Akt2 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AKT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3HSE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt2  AKT serine/threonine kinase 2  Akt2  v-akt murine thymoma viral oncogene homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt2  v-akt murine thymoma viral oncogene homolog 2  Akt2  thymoma viral proto-oncogene 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akt2  thymoma viral proto-oncogene 2    murine thymoma viral (v-akt) oncogene homolog 2  Name updated 1299863 APPROVED
2002-06-10 Akt2  Murine thymoma viral (v-akt) oncogene homolog 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology domain 632176
gene_domains contains a protein-serine/threonine kinase catalytic domain 632176
gene_expression expressed in testis and other tissues 632176
gene_function may act as a protein-serine/threonine kinase 632176
gene_physical_interaction may bind protein kinase C 632176
gene_process may play a role in the phosphatidylinositol 3-kinase (PI3-K) signaling pathway 632179
gene_protein protein sequence contains 481 amino acids 632176