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Gene: Tyrobp (Tyro protein tyrosine kinase binding protein) Rattus norvegicus
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Symbol: Tyrobp
Name: Tyro protein tyrosine kinase binding protein
Description: Predicted to have identical protein binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine biosynthetic process; and regulation of lymphocyte activation. Predicted to localize to the cell surface. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (TYRO protein tyrosine kinase binding protein); INTERACTS WITH (RS)-amphetamine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DAP12; DNAX-activation protein 12; Karap; killer cell activating receptor-associated protein; LOC361537; TYRO protein tyrosine kinase-binding protein
Orthologs:
Homo sapiens (human) : TYROBP (TYRO protein tyrosine kinase binding protein)  HGNC  Alliance
Mus musculus (house mouse) : Tyrobp (TYRO protein tyrosine kinase binding protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrobp (TYRO protein tyrosine kinase binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TYROBP (TYRO protein tyrosine kinase binding protein)
Canis lupus familiaris (dog) : TYROBP (TYRO protein tyrosine kinase binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrobp (TYRO protein tyrosine kinase binding protein)
Sus scrofa (pig) : TYROBP (TYRO protein tyrosine kinase binding protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0188,875,370 - 88,879,305 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0190,031,123 - 90,034,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,365,371 - 85,369,224 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1185,443,481 - 85,447,330 (+)NCBI
Celera180,045,174 - 80,049,027 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tyrobp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1303081
Created: 2004-12-03
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.