Tyrobp (Tyro protein tyrosine kinase binding protein)

Gene: Tyrobp (Tyro protein tyrosine kinase binding protein) Rattus norvegicus

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Symbol:

Tyrobp

Name:

Tyro protein tyrosine kinase binding protein

Description:

Predicted to have identical protein binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine biosynthetic process; and regulation of lymphocyte activation. Predicted to localize to the cell surface. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (TYRO protein tyrosine kinase binding protein); INTERACTS WITH (RS)-amphetamine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

DAP12; DNAX-activation protein 12; Karap; killer cell activating receptor-associated protein; LOC361537; TYRO protein tyrosine kinase-binding protein

Orthologs:

Homo sapiens (human) : TYROBP (TYRO protein tyrosine kinase binding protein) HGNC Alliance
Mus musculus (house mouse) : Tyrobp (TYRO protein tyrosine kinase binding protein) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrobp (TYRO protein tyrosine kinase binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TYROBP (TYRO protein tyrosine kinase binding protein)
Canis lupus familiaris (dog) : TYROBP (TYRO protein tyrosine kinase binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrobp (TYRO protein tyrosine kinase binding protein)
Sus scrofa (pig) : TYROBP (TYRO protein tyrosine kinase binding protein)

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	1	88,875,370 - 88,879,305 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	90,031,123 - 90,034,976 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	85,365,371 - 85,369,224 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	85,443,481 - 85,447,330 (+)	NCBI
Celera	1	80,045,174 - 80,049,027 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

Gene-Chemical Interaction Annotations

Gene Ontology Annotations

References - curated

References - uncurated

RGD Disease Portals

Genomics

Comparative Map Data

QTLs in Region (Rnor_6.0)

miRNA Target Status

Sequence

Nucleotide Sequences

Protein Sequences

Transcriptome

Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links

Nomenclature History

More on Tyrobp
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: rn5 rn6
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1303081
Created:	2004-12-03
Species:	Rattus norvegicus
Last Modified:	2019-08-20
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble for Mouse Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble for Mouse Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

Gene Enrichment unavailable	Ortholog Finder unavailable
Gene Enrichment	Ortholog Finder

Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - OMIM