Ftl1 (ferritin light chain 1) - Rat Genome Database

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Gene: Ftl1 (ferritin light chain 1) Rattus norvegicus
Analyze
Symbol: Ftl1
Name: ferritin light chain 1
RGD ID: 61813
Description: Predicted to enable identical protein binding activity and iron ion binding activity. Involved in response to lead ion. Predicted to be located in autolysosome. Predicted to be part of intracellular ferritin complex. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain); PARTICIPATES IN iron storage pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ferritin L subunit 1; ferritin light chain; ferritin, light polypeptide; Ftl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ftl1-ps14  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,936,387 - 95,938,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,936,387 - 95,939,725 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1044,257,727 - 44,258,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,321,817 - 101,323,664 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,794,493 - 109,796,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,084,890 - 103,086,737 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,448,190 - 101,450,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,527,136 - 102,528,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,929,248 - 95,931,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,007,368 - 96,009,121 (-)NCBI
Celera190,192,302 - 90,194,146 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-(hydroxymethyl)cytosine  (ISO)
5-azacytidine  (EXP)
5-Hydroxythalidomide  (ISO)
6-propyl-2-thiouracil  (EXP)
7beta-aminocephalosporanic acid  (ISO)
[6]-Shogaol  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
alcohol  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
aniline  (ISO)
antimonite  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
citraconic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
desferrioxamine B  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
ellipticine  (ISO)
endosulfan  (EXP)
epichlorohydrin  (ISO)
ethanol  (ISO)
Ethyl maltol  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
ferric ammonium citrate  (ISO)
ferrostatin-1  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
ginkgetin  (ISO)
glucose  (EXP)
glutathione  (EXP)
hemin  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
inulin  (ISO)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) citrate  (ISO)
isoeugenol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenacetin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (EXP)
potassium nitrate  (ISO)
propan-2-ol  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
rac-lactic acid  (ISO)
razoxane  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP)
thifluzamide  (ISO)
thiram  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. Barbeito AG, etal., J Neurochem. 2009 May;109(4):1067-78. Epub 2009 Mar 30.
3. Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation. Chinnery PF, etal., Brain. 2007 Jan;130(Pt 1):110-9. Epub 2006 Dec 2.
4. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Curtis AR, etal., Nat Genet. 2001 Aug;28(4):350-4.
5. Isolation of cDNA clones corresponding to genes differentially expressed in two colon-carcinoma cell lines differing by their tumorigenicity. Denis MG, etal., Int J Cancer 1992 Apr 1;50(6):930-6.
6. Clinical features and natural history of neuroferritinopathy caused by the 458dupA FTL mutation. Devos D, etal., Brain. 2009 Jun;132(Pt 6):e109. Epub 2008 Oct 14.
7. Ferritin expression in rat hepatocytes and Kupffer cells after lead nitrate treatment. Fan Y, etal., Toxicol Pathol. 2009;37(2):209-17.
8. Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Finazzi D and Arosio P, Arch Toxicol. 2014 Oct;88(10):1787-802. doi: 10.1007/s00204-014-1329-0. Epub 2014 Aug 15.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Hereditary hyperferritinemia-cataract syndrome caused by a 29-base pair deletion in the iron responsive element of ferritin L-subunit gene. Girelli D, etal., Blood. 1997 Sep 1;90(5):2084-8.
11. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
12. A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: description of clinical features and implications for genotype-phenotype correlations. Kubota A, etal., Mov Disord. 2009 Feb 15;24(3):441-5.
13. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
14. Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes. Leibold EA and Munro HN, J Biol Chem 1987 May 25;262(15):7335-41.
15. Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit. Leibold EA, etal., J Biol Chem 1984 Apr 10;259(7):4327-34.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Hereditary Hyperferritinemia Cataract Syndrome: Clinical, Genetic, and Laboratory Findings in 5 Families. Nonnenmacher L, etal., Klin Padiatr. 2011 Oct 21.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. Vidal R, etal., J Neuropathol Exp Neurol. 2004 Apr;63(4):363-80.
26. The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single-centre, retrospective, observational study in Wuhan. Zhang Y, etal., Diabetes Obes Metab. 2020 May 14. doi: 10.1111/dom.14086.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16169070   PMID:16189514   PMID:16790936   PMID:18996141   PMID:19056867   PMID:19923220   PMID:19946888   PMID:20159981   PMID:22206666   PMID:22207220  
PMID:23376485   PMID:23533145   PMID:24693535   PMID:25327288   PMID:25416956   PMID:25502805   PMID:25910212   PMID:31515488   PMID:31674712   PMID:33255702   PMID:36446230  


Genomics

Comparative Map Data
Ftl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,936,387 - 95,938,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,936,387 - 95,939,725 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1044,257,727 - 44,258,273 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,321,817 - 101,323,664 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,794,493 - 109,796,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,084,890 - 103,086,737 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,448,190 - 101,450,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,527,136 - 102,528,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,929,248 - 95,931,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,007,368 - 96,009,121 (-)NCBI
Celera190,192,302 - 90,194,146 (-)NCBICelera
Cytogenetic Map1q22NCBI
FTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,965,309 - 48,966,879 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,965,309 - 48,966,879 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,468,566 - 49,470,136 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,160,378 - 54,161,948 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,160,377 - 54,161,947NCBI
Celera1946,335,916 - 46,337,486 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,845,481 - 45,847,051 (+)NCBIHuRef
CHM1_11949,470,772 - 49,472,342 (+)NCBICHM1_1
T2T-CHM13v2.01951,960,189 - 51,961,759 (+)NCBIT2T-CHM13v2.0
Ftl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,107,368 - 45,109,310 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,107,368 - 45,109,308 (-)EnsemblGRCm39 Ensembl
GRCm38745,457,944 - 45,459,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,457,944 - 45,459,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,713,314 - 52,715,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,325,990 - 45,327,877 (-)NCBIMGSCv36mm8
Celera740,913,993 - 40,915,936 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.32NCBI
Ftl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,691,722 - 1,693,381 (-)NCBIChiLan1.0ChiLan1.0
FTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11956,996,423 - 56,998,031 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,966,431 - 45,968,015 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,788,853 - 54,790,466 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,788,854 - 54,790,465 (-)Ensemblpanpan1.1panPan2
FTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,418,457 - 107,419,923 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,418,458 - 107,419,923 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,941,044 - 106,942,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,943,144 - 107,944,610 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,943,145 - 107,944,610 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,610,673 - 107,612,136 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,257,026 - 107,258,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,092,628 - 108,094,094 (-)NCBIUU_Cfam_GSD_1.0
Ftl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,358,130 - 21,359,683 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,976,314 - 2,977,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,976,325 - 2,977,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,231,172 - 54,232,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,231,121 - 54,232,756 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,095,907 - 50,097,543 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,196,682 - 42,198,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,196,538 - 42,199,614 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,081,812 - 22,099,843 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ftl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,046,208 - 5,047,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,046,207 - 5,047,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ftl1
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 16 55 55 5 55 72 40 22 2
Medium 4 70 59 27 33 27 15 21 76 30 60 20 15
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L01122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028315   ⟹   ENSRNOP00000028315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,936,387 - 95,938,234 (-)Ensembl
Rnor_6.0 Ensembl1101,448,346 - 101,449,829 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000054440   ⟹   ENSRNOP00000082353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,257,727 - 44,258,273 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115869   ⟹   ENSRNOP00000086074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,936,401 - 95,939,725 (-)Ensembl
RefSeq Acc Id: NM_022500   ⟹   NP_071945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2195,936,387 - 95,938,234 (-)NCBI
Rnor_6.01101,448,190 - 101,450,034 (-)NCBI
Rnor_5.01102,527,136 - 102,528,980 (-)NCBI
RGSC_v3.4195,929,248 - 95,931,092 (-)RGD
Celera190,192,302 - 90,194,146 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_071945   ⟸   NM_022500
- UniProtKB: Q6P7T1 (UniProtKB/Swiss-Prot),   P02793 (UniProtKB/Swiss-Prot),   A6JB33 (UniProtKB/TrEMBL),   A0A8I6GIG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028315   ⟸   ENSRNOT00000028315
RefSeq Acc Id: ENSRNOP00000082353   ⟸   ENSRNOT00000054440
RefSeq Acc Id: ENSRNOP00000086074   ⟸   ENSRNOT00000115869
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02793-F1-model_v2 AlphaFold P02793 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61813 AgrOrtholog
BioCyc Gene G2FUF-59683 BioCyc
Ensembl Genes ENSRNOG00000020843 Ensembl
  ENSRNOG00000064385 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000065602 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028315.7 UniProtKB/TrEMBL
  ENSRNOT00000096014.1 UniProtKB/TrEMBL
  ENSRNOT00000115869 ENTREZGENE
  ENSRNOT00000115869.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921603 IMAGE-MGC_LOAD
  IMAGE:7307718 IMAGE-MGC_LOAD
  IMAGE:7307747 IMAGE-MGC_LOAD
InterPro Ferritin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360087 UniProtKB/Swiss-Prot
  rno:29292 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105275 IMAGE-MGC_LOAD
  MGC:105276 IMAGE-MGC_LOAD
  MGC:72644 IMAGE-MGC_LOAD
NCBI Gene 29292 ENTREZGENE
PANTHER FERRITIN LIGHT CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ftl1 PhenoGen
PROSITE FERRITIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020843 RatGTEx
  ENSRNOG00000064385 RatGTEx
  ENSRNOG00000065602 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216466
UniProt A0A8I6A2Z0_RAT UniProtKB/TrEMBL
  A0A8I6GIG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QFK4_RAT UniProtKB/TrEMBL
  A6JB33 ENTREZGENE, UniProtKB/TrEMBL
  FRIL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7T1 ENTREZGENE
UniProt Secondary Q6P7T1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-02 Ftl1  ferritin light chain 1  Ftl  ferritin, light polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ftl  ferritin, light polypeptide  Ftl1  ferritin light chain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ftl1  ferritin light chain 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 82% amino acid identity to human spleen homolog 632730
gene_protein 182 amino acids 632730