Lipe (lipase E, hormone sensitive type) - Rat Genome Database

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Gene: Lipe (lipase E, hormone sensitive type) Rattus norvegicus
Analyze
Symbol: Lipe
Name: lipase E, hormone sensitive type
RGD ID: 3010
Description: Enables carboxylic ester hydrolase activity. Involved in female pregnancy; response to xenobiotic stimulus; and triglyceride catabolic process. Located in extracellular space. Used to study arteriosclerosis and heart disease. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 6 and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (+)-catechin; (R)-adrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hormone - sensitive lipase testicular isoform; hormone-sensitive lipase; HSL; lipase E; lipase E, hormone sensitive; lipase hormone sensitive; lipase, hormone sensitive; monoacylglycerol lipase LIPE; REH; retinyl ester hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lipem1Mcwi   Lipem2Mcwi  
Genetic Models: FHH-Lipem1Mcwi BN-Lipem2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,093,433 - 90,112,117 (-)NCBIGRCr8
mRatBN7.2180,965,612 - 80,984,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,965,627 - 80,984,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,357,834 - 86,376,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,909,045 - 94,927,749 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,113,613 - 88,132,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,248,031 - 82,266,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,511,504 - 83,530,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,663,791 - 80,682,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,741,901 - 80,760,591 (-)NCBI
Celera175,407,246 - 75,425,931 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
all-trans-retinyl palmitate  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
ATP  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
bucladesine  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corosolic acid  (ISO)
Cuprizon  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
finasteride  (EXP)
flavonoids  (EXP)
fructose  (EXP)
gadolinium trichloride  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
imidacloprid  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
Licarin A  (ISO)
lipoic acid  (ISO)
loliolide  (ISO)
methamphetamine  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
ozone  (EXP,ISO)
papaverine  (EXP)
paracetamol  (EXP)
perfluorooctanoic acid  (EXP)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
scopoletin  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (ISO)
Tesaglitazar  (EXP)
theophylline  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
tuberostemonine  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IEA,ISS)
cytoplasm  (ISS)
cytosol  (IBA,IEA,ISO,ISS,TAS)
extracellular space  (IDA)
lipid droplet  (IEA,ISO,ISS,TAS)
membrane  (ISO,ISS)
mitochondrion  (ISS)
nucleus  (ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. Aboulaich N, etal., Biochem Biophys Res Commun. 2006 Nov 24;350(3):657-61. Epub 2006 Sep 28.
2. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. Aboulaich N, etal., Biochem J. 2004 Oct 15;383(Pt 2):237-48.
3. The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension. Bernard N, etal., J Hum Genet. 2007;52(3):244-54. Epub 2007 Feb 15.
4. Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages. Escary JL, etal., J Lipid Res. 1999 Mar;40(3):397-404.
5. PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control. Festuccia WT, etal., Diabetologia. 2006 Oct;49(10):2427-36. Epub 2006 Aug 14.
6. Positional specificity of hormone-sensitive lipase from rat adipose tissue. Fredrikson G and Belfrage P, J Biol Chem. 1983 Dec 10;258(23):14253-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Gertz K, etal., Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Low level expression of hormone-sensitive lipase in arterial macrophage-derived foam cells: potential explanation for low rates of cholesteryl ester hydrolysis. Harte RA, etal., Atherosclerosis. 2000 Apr;149(2):343-50.
11. Nucleotide sequence of rat adipose hormone sensitive lipase cDNA. Holm C, etal., Nucleic Acids Res 1988 Oct 25;16(20):9879.
12. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. Holst LS, etal., Genomics 1996 Aug 1;35(3):441-7.
13. Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. Jansa P, etal., EMBO J. 1998 May 15;17(10):2855-64.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. [Gene expression of hormone sensitive lipase and lipoprotein lipase in obesity-prone and obesity-resistant rats induced by high-fat diet] Ma W, etal., Wei Sheng Yan Jiu. 2007 May;36(3):320-2.
16. Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation. Macpherson RE, etal., Physiol Rep. 2013 Sep;1(4):e00084. doi: 10.1002/phy2.84. Epub 2013 Sep 17.
17. Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation. Martin-Hidalgo A, etal., J Lipid Res. 2005 Apr;46(4):658-68. Epub 2005 Jan 16.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Analysis of lipolysis in adipocytes using a fluorescent fatty acid derivative. Muller G, etal., Biochimie. 2003 Dec;85(12):1245-56.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Sensitive assay for hormone-sensitive lipase using NBD-labeled monoacylglycerol to detect low activities in rat adipocytes. Petry S, etal., J Lipid Res. 2005 Mar;46(3):603-14. Epub 2005 Jan 1.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Changes in mammary fat pad composition and lipolytic capacity throughout pregnancy. Pujol E, etal., Cell Tissue Res. 2006 Mar;323(3):505-511. Epub 2005 Nov 22.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Scribner KA, etal., Metabolism. 2000 Sep;49(9):1106-10.
28. Hormone-sensitive lipase functions as an oligomer. Shen WJ, etal., Biochemistry. 2000 Mar 7;39(9):2392-8. doi: 10.1021/bi992283h.
29. Interaction of hormone-sensitive lipase with steroidogenic acute regulatory protein: facilitation of cholesterol transfer in adrenal. Shen WJ, etal., J Biol Chem. 2003 Oct 31;278(44):43870-6. Epub 2003 Aug 18.
30. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein. Shen WJ, etal., Proc Natl Acad Sci U S A 1999 May 11;96(10):5528-32.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice. Ueno M, etal., Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1109-18. Epub 2008 Apr 15.
33. Mutational analysis of the "regulatory module" of hormone-sensitive lipase. Wang J, etal., Biochemistry. 2005 Feb 15;44(6):1953-9.
34. Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion. Watt MJ, etal., Diabetologia. 2005 Jan;48(1):105-12. Epub 2004 Dec 18.
35. Retinyl ester hydrolysis and retinol efflux from BFC-1beta adipocytes. Wei S, etal., J Biol Chem. 1997 May 30;272(22):14159-65. doi: 10.1074/jbc.272.22.14159.
Additional References at PubMed
PMID:10671541   PMID:11717312   PMID:12477932   PMID:12882923   PMID:14576146   PMID:15033481   PMID:15878856   PMID:15887043   PMID:16804080   PMID:16818490   PMID:17074755   PMID:18824635  
PMID:19246492   PMID:19664063   PMID:20708600   PMID:25448749   PMID:26141235   PMID:31150775  


Genomics

Comparative Map Data
Lipe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,093,433 - 90,112,117 (-)NCBIGRCr8
mRatBN7.2180,965,612 - 80,984,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,965,627 - 80,984,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,357,834 - 86,376,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,909,045 - 94,927,749 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,113,613 - 88,132,294 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,248,031 - 82,266,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,511,504 - 83,530,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,663,791 - 80,682,480 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,741,901 - 80,760,591 (-)NCBI
Celera175,407,246 - 75,425,931 (-)NCBICelera
Cytogenetic Map1q21NCBI
LIPE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,401,514 - 42,427,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,401,514 - 42,427,388 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,905,666 - 42,931,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,597,506 - 47,623,418 (-)NCBINCBI36Build 36hg18NCBI36
Build 341947,597,505 - 47,623,418NCBI
Celera1939,706,455 - 39,732,367 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,335,797 - 39,361,703 (-)NCBIHuRef
CHM1_11942,907,316 - 42,933,231 (-)NCBICHM1_1
T2T-CHM13v2.01945,220,900 - 45,246,776 (-)NCBIT2T-CHM13v2.0
Lipe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,078,952 - 25,097,911 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,078,952 - 25,098,135 (-)EnsemblGRCm39 Ensembl
GRCm38725,379,527 - 25,398,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,379,527 - 25,398,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,164,546 - 26,181,006 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,088,287 - 25,104,747 (-)NCBIMGSCv36mm8
Celera719,994,853 - 20,011,313 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.78NCBI
Lipe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555514,410 - 530,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555511,085 - 531,165 (+)NCBIChiLan1.0ChiLan1.0
LIPE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,506,457 - 48,534,733 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,375,028 - 50,400,941 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,289,162 - 39,315,067 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,881,292 - 47,907,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,881,292 - 47,907,066 (-)Ensemblpanpan1.1panPan2
LIPE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,987,862 - 112,006,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,988,029 - 112,006,461 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,412,499 - 111,431,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,598,798 - 112,617,839 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,607,340 - 112,617,499 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,153,322 - 112,171,913 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,788,548 - 111,807,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,715,381 - 112,734,429 (+)NCBIUU_Cfam_GSD_1.0
Lipe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,772,658 - 15,792,162 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706128,133 - 141,276 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706122,939 - 139,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,540,708 - 49,560,125 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,543,671 - 49,560,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,443,742 - 45,454,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q12NCBI
LIPE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,604,822 - 36,630,648 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,605,126 - 36,630,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,849,833 - 14,875,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lipe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907363,572 - 379,194 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907360,462 - 379,266 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lipe
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000027910
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
D1Rat339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,968,042 - 80,968,185 (+)MAPPERmRatBN7.2
Rnor_6.0182,250,462 - 82,250,604NCBIRnor6.0
Rnor_5.0183,513,935 - 83,514,077UniSTSRnor5.0
RGSC_v3.4180,666,206 - 80,666,349RGDRGSC3.4
RGSC_v3.4180,666,207 - 80,666,349UniSTSRGSC3.4
RGSC_v3.1180,744,317 - 80,744,460RGD
Celera175,409,662 - 75,409,804UniSTS
SHRSP x BN Map142.2999RGD
SHRSP x BN Map142.2999UniSTS
Cytogenetic Map1q21UniSTS
D1Bda5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,965,649 - 80,965,878 (+)MAPPERmRatBN7.2
Rnor_6.0182,248,069 - 82,248,297NCBIRnor6.0
Rnor_5.0183,511,542 - 83,511,770UniSTSRnor5.0
RGSC_v3.4180,663,814 - 80,664,042UniSTSRGSC3.4
Celera175,407,269 - 75,407,497UniSTS
Cytogenetic Map1q21UniSTS
RH131319  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,965,690 - 80,965,871 (+)MAPPERmRatBN7.2
Rnor_6.0182,248,110 - 82,248,290NCBIRnor6.0
Rnor_5.0183,511,583 - 83,511,763UniSTSRnor5.0
RGSC_v3.4180,663,855 - 80,664,035UniSTSRGSC3.4
Celera175,407,310 - 75,407,490UniSTS
RH 3.4 Map1841.5UniSTS
Cytogenetic Map1q21UniSTS
RH94620  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,965,645 - 80,965,801 (+)MAPPERmRatBN7.2
Rnor_6.0182,248,065 - 82,248,220NCBIRnor6.0
Rnor_5.0183,511,538 - 83,511,693UniSTSRnor5.0
RGSC_v3.4180,663,810 - 80,663,965UniSTSRGSC3.4
Celera175,407,265 - 75,407,420UniSTS
Cytogenetic Map1q21UniSTS
BG381659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,985,084 - 80,985,325 (+)MAPPERmRatBN7.2
Rnor_6.0182,267,502 - 82,267,742NCBIRnor6.0
Rnor_5.0183,530,975 - 83,531,215UniSTSRnor5.0
RGSC_v3.4180,683,255 - 80,683,495UniSTSRGSC3.4
Celera175,426,706 - 75,426,946UniSTS
RH 3.4 Map1824.5UniSTS
Cytogenetic Map1q21UniSTS


Genetic Models
This gene Lipe is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19 12 5 2 8 5 17 11
Low 3 24 45 41 14 41 8 9 66 30 24 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000027910   ⟹   ENSRNOP00000027911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl180,965,627 - 80,984,310 (-)Ensembl
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099694   ⟹   ENSRNOP00000096661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl180,965,627 - 80,981,553 (-)Ensembl
RefSeq Acc Id: NM_012859   ⟹   NP_036991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,093,433 - 90,112,117 (-)NCBI
mRatBN7.2180,965,627 - 80,984,310 (-)NCBI
Rnor_6.0182,248,046 - 82,266,727 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
RGSC_v3.4180,663,791 - 80,682,480 (-)RGD
Celera175,407,246 - 75,425,931 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228391   ⟹   XP_006228453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,093,692 - 90,109,341 (-)NCBI
mRatBN7.2180,965,612 - 80,981,826 (-)NCBI
Rnor_6.0182,248,031 - 82,264,021 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228393   ⟹   XP_006228455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,093,692 - 90,102,989 (-)NCBI
mRatBN7.2180,965,612 - 80,975,296 (-)NCBI
Rnor_6.0182,248,031 - 82,257,619 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228394   ⟹   XP_006228456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,093,692 - 90,104,042 (-)NCBI
mRatBN7.2180,965,612 - 80,976,529 (-)NCBI
Rnor_6.0182,248,031 - 82,260,279 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101579   ⟹   XP_038957507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,098,793 - 90,111,924 (-)NCBI
mRatBN7.2180,970,991 - 80,984,313 (-)NCBI
RefSeq Acc Id: XM_063281687   ⟹   XP_063137757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8190,093,692 - 90,111,183 (-)NCBI
RefSeq Acc Id: NP_036991   ⟸   NM_012859
- UniProtKB: Q6LCQ2 (UniProtKB/Swiss-Prot),   P15304 (UniProtKB/Swiss-Prot),   A6J957 (UniProtKB/TrEMBL),   G3V8R5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228453   ⟸   XM_006228391
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228456   ⟸   XM_006228394
- Peptide Label: isoform X4
- UniProtKB: A6J958 (UniProtKB/TrEMBL),   A0A8I6GLP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228455   ⟸   XM_006228393
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GLP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027911   ⟸   ENSRNOT00000027910
RefSeq Acc Id: XP_038957507   ⟸   XM_039101579
- Peptide Label: isoform X5
- UniProtKB: Q6AYV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096661   ⟸   ENSRNOT00000099694
RefSeq Acc Id: XP_063137757   ⟸   XM_063281687
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLP7 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15304-F1-model_v2 AlphaFold P15304 1-1068 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689815
Promoter ID:EPDNEW_R340
Type:multiple initiation site
Name:Lipe_1
Description:lipase E, hormone sensitive type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,266,726 - 82,266,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3010 AgrOrtholog
BioCyc Gene G2FUF-60386 BioCyc
BioCyc Pathway LIPAS-PWY [triacylglycerol degradation] BioCyc
  PWY-7420 [monoacylglycerol metabolism (yeast)] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
BioCyc Pathway Image LIPAS-PWY BioCyc
  PWY-7420 BioCyc
  PWY-8052 BioCyc
Ensembl Genes ENSRNOG00000020546 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027910.3 UniProtKB/TrEMBL
  ENSRNOT00000099694.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_GDXG_HIS_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_GDXG_put_SER_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25330 UniProtKB/Swiss-Prot
NCBI Gene 25330 ENTREZGENE
PANTHER HORMONE-SENSITIVE LIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIACYLGLYCEROL LIPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lipe PhenoGen
PROSITE LIPASE_GDXG_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPASE_GDXG_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020546 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233459
UniProt A0A8I6GLP7 ENTREZGENE, UniProtKB/TrEMBL
  A6J957 ENTREZGENE, UniProtKB/TrEMBL
  A6J958 ENTREZGENE, UniProtKB/TrEMBL
  G3V8R5 ENTREZGENE, UniProtKB/TrEMBL
  LIPS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AYV9 ENTREZGENE, UniProtKB/TrEMBL
  Q6LCQ2 ENTREZGENE
UniProt Secondary Q6LCQ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipe  lipase E, hormone sensitive type  Lipe  lipase E, hormone sensitive  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipe  lipase E, hormone sensitive  Lipe  lipase, hormone sensitive  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Lipe  Hormone - sensitive lipase, testicular isoform      Name withdrawn 67952 WITHDRAWN
2001-07-23 Lipe  lipase, hormone sensitive      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis in the spermatids and spermatozoa 729199