Lipe (lipase E, hormone sensitive type) - Rat Genome Database
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Gene: Lipe (lipase E, hormone sensitive type) Rattus norvegicus
Analyze
Symbol: Lipe
Name: lipase E, hormone sensitive type
RGD ID: 3010
Description: Exhibits carboxylic ester hydrolase activity. Involved in female pregnancy; response to drug; and triglyceride catabolic process. Localizes to cytoplasm and extracellular space. Used to study arteriosclerosis and heart disease. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 6 and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (+)-catechin; (R)-adrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Hormone - sensitive lipase testicular isoform; hormone-sensitive lipase; HSL; lipase E; lipase E, hormone sensitive; lipase hormone sensitive; lipase, hormone sensitive; monoacylglycerol lipase LIPE; REH; retinyl ester hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lipem1Mcwi   Lipem2Mcwi  
Genetic Models: FHH-Lipem1Mcwi BN-Lipem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,965,612 - 80,984,313 (-)NCBI
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0182,248,031 - 82,266,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,511,504 - 83,530,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,663,791 - 80,682,480 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,741,901 - 80,760,591 (-)NCBI
Celera175,407,246 - 75,425,931 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucosamine 6-phosphate  (ISO)
all-trans-retinyl palmitate  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ATP  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
bucladesine  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
finasteride  (EXP)
flavonoids  (EXP)
gadolinium trichloride  (ISO)
genistein  (ISO)
glycidol  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
Licarin A  (ISO)
lipoic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
ozone  (EXP,ISO)
papaverine  (EXP)
perfluorooctanoic acid  (EXP)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
scopoletin  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (ISO)
Tesaglitazar  (EXP)
theophylline  (EXP,ISO)
titanium dioxide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IEA,ISS)
cytoplasm  (IDA,ISS)
cytosol  (IEA,ISO,ISS,TAS)
extracellular space  (IDA)
lipid droplet  (IEA,ISO,ISS,TAS)
membrane  (ISO,ISS)
mitochondrion  (ISS)
nucleus  (ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aboulaich N, etal., Biochem Biophys Res Commun. 2006 Nov 24;350(3):657-61. Epub 2006 Sep 28.
2. Aboulaich N, etal., Biochem J. 2004 Oct 15;383(Pt 2):237-48.
3. Bernard N, etal., J Hum Genet. 2007;52(3):244-54. Epub 2007 Feb 15.
4. Escary JL, etal., J Lipid Res. 1999 Mar;40(3):397-404.
5. Festuccia WT, etal., Diabetologia. 2006 Oct;49(10):2427-36. Epub 2006 Aug 14.
6. Fredrikson G and Belfrage P, J Biol Chem. 1983 Dec 10;258(23):14253-6.
7. GOA data from the GO Consortium
8. Harte RA, etal., Atherosclerosis. 2000 Apr;149(2):343-50.
9. Holm C, etal., Nucleic Acids Res 1988 Oct 25;16(20):9879.
10. Holst LS, etal., Genomics 1996 Aug 1;35(3):441-7.
11. Jansa P, etal., EMBO J. 1998 May 15;17(10):2855-64.
12. KEGG
13. Ma W, etal., Wei Sheng Yan Jiu. 2007 May;36(3):320-2.
14. Macpherson RE, etal., Physiol Rep. 2013 Sep;1(4):e00084. doi: 10.1002/phy2.84. Epub 2013 Sep 17.
15. Martin-Hidalgo A, etal., J Lipid Res. 2005 Apr;46(4):658-68. Epub 2005 Jan 16.
16. MGD data from the GO Consortium
17. Muller G, etal., Biochimie. 2003 Dec;85(12):1245-56.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline
20. Petry S, etal., J Lipid Res. 2005 Mar;46(3):603-14. Epub 2005 Jan 1.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Pujol E, etal., Cell Tissue Res. 2006 Mar;323(3):505-511. Epub 2005 Nov 22.
23. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. RGD automated import pipeline for gene-chemical interactions
25. Scribner KA, etal., Metabolism. 2000 Sep;49(9):1106-10.
26. Shen WJ, etal., Biochemistry. 2000 Mar 7;39(9):2392-8. doi: 10.1021/bi992283h.
27. Shen WJ, etal., J Biol Chem. 2003 Oct 31;278(44):43870-6. Epub 2003 Aug 18.
28. Shen WJ, etal., Proc Natl Acad Sci U S A 1999 May 11;96(10):5528-32.
29. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Ueno M, etal., Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1109-18. Epub 2008 Apr 15.
31. Wang J, etal., Biochemistry. 2005 Feb 15;44(6):1953-9.
32. Watt MJ, etal., Diabetologia. 2005 Jan;48(1):105-12. Epub 2004 Dec 18.
33. Wei S, etal., J Biol Chem. 1997 May 30;272(22):14159-65. doi: 10.1074/jbc.272.22.14159.
Additional References at PubMed
PMID:10671541   PMID:11717312   PMID:12477932   PMID:12882923   PMID:14576146   PMID:15033481   PMID:15878856   PMID:15887043   PMID:16804080   PMID:16818490   PMID:17074755   PMID:18824635  
PMID:19246492   PMID:19664063   PMID:20708600   PMID:25448749   PMID:26141235   PMID:31150775  


Genomics

Comparative Map Data
Lipe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,965,612 - 80,984,313 (-)NCBI
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0182,248,031 - 82,266,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,511,504 - 83,530,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,663,791 - 80,682,480 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1180,741,901 - 80,760,591 (-)NCBI
Celera175,407,246 - 75,425,931 (-)NCBICelera
Cytogenetic Map1q21NCBI
LIPE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1942,401,514 - 42,427,388 (-)EnsemblGRCh38hg38GRCh38
GRCh381942,401,512 - 42,427,421 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371942,905,664 - 42,931,578 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371942,905,666 - 42,931,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,597,506 - 47,623,418 (-)NCBINCBI36hg18NCBI36
Build 341947,597,505 - 47,623,418NCBI
Celera1939,706,455 - 39,732,367 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1939,335,797 - 39,361,703 (-)NCBIHuRef
CHM1_11942,907,309 - 42,933,231 (-)NCBICHM1_1
Lipe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,078,952 - 25,097,911 (-)NCBIGRCm39mm39
GRCm38725,379,527 - 25,398,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,379,527 - 25,398,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,164,546 - 26,181,006 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,088,287 - 25,104,747 (-)NCBImm8
Celera719,994,853 - 20,011,313 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.78NCBI
Lipe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555514,410 - 530,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555511,085 - 531,165 (+)NCBIChiLan1.0ChiLan1.0
LIPE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11947,881,292 - 47,907,066 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,881,292 - 47,907,066 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01939,289,162 - 39,315,067 (-)NCBIMhudiblu_PPA_v0panPan3
LIPE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1111,988,029 - 112,006,461 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11111,987,862 - 112,006,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lipe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936706122,939 - 139,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,540,907 - 49,560,126 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,543,671 - 49,560,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,443,742 - 45,454,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q12NCBI
LIPE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,604,822 - 36,630,648 (-)NCBI
ChlSab1.1 Ensembl636,605,126 - 36,630,376 (-)Ensembl
Lipe
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624907360,462 - 379,266 (+)NCBI

Position Markers
D1Rat339  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0182,250,462 - 82,250,604NCBIRnor6.0
Rnor_5.0183,513,935 - 83,514,077UniSTSRnor5.0
RGSC_v3.4180,666,206 - 80,666,349RGDRGSC3.4
RGSC_v3.4180,666,207 - 80,666,349UniSTSRGSC3.4
RGSC_v3.1180,744,317 - 80,744,460RGD
Celera175,409,662 - 75,409,804UniSTS
SHRSP x BN Map142.2999UniSTS
SHRSP x BN Map142.2999RGD
Cytogenetic Map1q21UniSTS
D1Bda5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0182,248,069 - 82,248,297NCBIRnor6.0
Rnor_5.0183,511,542 - 83,511,770UniSTSRnor5.0
RGSC_v3.4180,663,814 - 80,664,042UniSTSRGSC3.4
Celera175,407,269 - 75,407,497UniSTS
Cytogenetic Map1q21UniSTS
RH131319  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0182,248,110 - 82,248,290NCBIRnor6.0
Rnor_5.0183,511,583 - 83,511,763UniSTSRnor5.0
RGSC_v3.4180,663,855 - 80,664,035UniSTSRGSC3.4
Celera175,407,310 - 75,407,490UniSTS
RH 3.4 Map1841.5UniSTS
Cytogenetic Map1q21UniSTS
RH94620  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0182,248,065 - 82,248,220NCBIRnor6.0
Rnor_5.0183,511,538 - 83,511,693UniSTSRnor5.0
RGSC_v3.4180,663,810 - 80,663,965UniSTSRGSC3.4
Celera175,407,265 - 75,407,420UniSTS
Cytogenetic Map1q21UniSTS
BG381659  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0182,267,502 - 82,267,742NCBIRnor6.0
Rnor_5.0183,530,975 - 83,531,215UniSTSRnor5.0
RGSC_v3.4180,683,255 - 80,683,495UniSTSRGSC3.4
Celera175,426,706 - 75,426,946UniSTS
RH 3.4 Map1824.5UniSTS
Cytogenetic Map1q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14190724986907249Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14954732883657083Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14957857794578577Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15052271494225616Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15385134883657083Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15385134883657083Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)16722768394201552Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17968976594909507Rat


Genetic Models
This gene Lipe is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000027910
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19 12 5 2 8 5 17 11
Low 3 24 45 41 14 41 8 9 66 30 24 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027910   ⟹   ENSRNOP00000027911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl182,248,046 - 82,266,727 (-)Ensembl
RefSeq Acc Id: NM_012859   ⟹   NP_036991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,965,627 - 80,984,310 (-)NCBI
Rnor_6.0182,248,046 - 82,266,727 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
RGSC_v3.4180,663,791 - 80,682,480 (-)RGD
Celera175,407,246 - 75,425,931 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228391   ⟹   XP_006228453
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,965,612 - 80,981,826 (-)NCBI
Rnor_6.0182,248,031 - 82,264,021 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228393   ⟹   XP_006228455
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,965,612 - 80,975,296 (-)NCBI
Rnor_6.0182,248,031 - 82,257,619 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228394   ⟹   XP_006228456
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,965,612 - 80,976,529 (-)NCBI
Rnor_6.0182,248,031 - 82,260,279 (-)NCBI
Rnor_5.0183,511,504 - 83,530,200 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758895   ⟹   XP_008757117
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,248,031 - 82,257,812 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101579   ⟹   XP_038957507
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,970,991 - 80,984,313 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036991   ⟸   NM_012859
- UniProtKB: P15304 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006228453   ⟸   XM_006228391
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006228456   ⟸   XM_006228394
- Peptide Label: isoform X3
- UniProtKB: P15304 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006228455   ⟸   XM_006228393
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008757117   ⟸   XM_008758895
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000027911   ⟸   ENSRNOT00000027910
RefSeq Acc Id: XP_038957507   ⟸   XM_039101579
- Peptide Label: isoform X4
Protein Domains
Abhydrolase_3   HSL_N

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689815
Promoter ID:EPDNEW_R340
Type:multiple initiation site
Name:Lipe_1
Description:lipase E, hormone sensitive type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,266,726 - 82,266,786EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3010 AgrOrtholog
Ensembl Genes ENSRNOG00000020546 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027911 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027910 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_GDXG_HIS_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipase_GDXG_put_SER_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25330 UniProtKB/Swiss-Prot
NCBI Gene 25330 ENTREZGENE
Pfam Abhydrolase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lipe PhenoGen
PROSITE LIPASE_GDXG_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPASE_GDXG_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233459
UniProt G3V8R5_RAT UniProtKB/TrEMBL
  LIPS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AYV9_RAT UniProtKB/TrEMBL
UniProt Secondary Q6LCQ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Lipe  lipase E, hormone sensitive type  Lipe  lipase E, hormone sensitive  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Lipe  lipase E, hormone sensitive  Lipe  lipase, hormone sensitive  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Lipe  Hormone - sensitive lipase, testicular isoform      Name withdrawn 67952 WITHDRAWN
2001-07-23 Lipe  lipase, hormone sensitive      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in testis in the spermatids and spermatozoa 729199