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Gene: Lipe (lipase, hormone sensitive) Mus musculus
Symbol: Lipe
Name: lipase, hormone sensitive
Description: Exhibits protein kinase binding activity; serine hydrolase activity; and triglyceride lipase activity. Involved in diacylglycerol catabolic process; long-chain fatty acid catabolic process; and triglyceride catabolic process. Localizes to cytosol and lipid droplet. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (R)-adrenaline; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4933403G17Rik; H; hormone-sensitive lipase; HSL; monoacylglycerol lipase LIPE; REH; retinyl ester hydrolase
Homo sapiens (human) : LIPE (lipase E, hormone sensitive type)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lipe (lipase E, hormone sensitive type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lipe (lipase E, hormone sensitive type)
Pan paniscus (bonobo/pygmy chimpanzee) : LIPE (lipase E, hormone sensitive type)
Canis lupus familiaris (dog) : LIPE (lipase E, hormone sensitive type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lipe (lipase E, hormone sensitive type)
Sus scrofa (pig) : LIPE (lipase E, hormone sensitive type)
Chlorocebus sabaeus (African green monkey) : LIPE (lipase E, hormone sensitive type)
Heterocephalus glaber (naked mole-rat) : Lipe (lipase E, hormone sensitive type)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl725,379,527 - 25,398,710 (-)EnsemblGRCm38mm10GRCm38
GRCm38725,379,527 - 25,398,486 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37726,164,546 - 26,181,006 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,088,287 - 25,104,747 (-)NCBImm8
Celera719,994,853 - 20,011,313 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lipe
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10872
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.