Predicted to enable cell adhesion molecule binding activity; protein homodimerization activity; and receptor ligand activity. Predicted to be involved in several processes, including coreceptor-mediated virion attachment to host cell; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of lymphocyte mediated immunity. Predicted to act upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in several cellular components, including cell surface; cell-cell contact zone; and zonula adherens. Predicted to be active in apical junction complex and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of NECTIN2 mRNA
Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter] more ...
[Clofibrate co-treated with Acetaminophen] affects the expression of NECTIN2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NECTIN2 mRNA]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NECTIN2 mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of NECTIN2 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of NECTIN2 mRNA]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NECTIN2 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NECTIN2 mRNA