Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PVR (PVR cell adhesion molecule) Homo sapiens
Analyze
Symbol: PVR
Name: PVR cell adhesion molecule
Description: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD155; FLJ25946; HVED; Necl-5; NECL5; nectin-like 5; nectin-like protein 5; poliovirus receptor; PVS; TAGE4; tumor-associated antigen 1
Orthologs:
Mus musculus (house mouse) : Pvr (poliovirus receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pvr (PVR cell adhesion molecule)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : PVR (PVR cell adhesion molecule)
Canis lupus familiaris (dog) : PVR (PVR cell adhesion molecule)
Sus scrofa (pig) : LOC100525346 (poliovirus receptor homolog)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,643,798 - 44,666,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371945,147,098 - 45,169,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361949,839,066 - 49,858,690 (+)NCBINCBI36hg18NCBI36
Build 341949,839,065 - 49,858,689NCBI
Celera1941,951,144 - 41,973,471 (+)NCBI
Cytogenetic Map19q13.31NCBI
HuRef1941,579,341 - 41,601,754 (+)NCBIHuRef
CHM1_11945,149,748 - 45,172,111 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PVR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736513
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.