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Gene: PVR (PVR cell adhesion molecule) Homo sapiens
Symbol: PVR
Name: PVR cell adhesion molecule
Description: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD155; FLJ25946; HVED; Necl-5; NECL5; nectin-like 5; nectin-like protein 5; poliovirus receptor; PVS; TAGE4; tumor-associated antigen 1
Mus musculus (house mouse) : Pvr (poliovirus receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pvr (PVR cell adhesion molecule)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : PVR (PVR cell adhesion molecule)
Canis lupus familiaris (dog) : PVR (PVR cell adhesion molecule)
Sus scrofa (pig) : LOC100525346 (poliovirus receptor homolog)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381944,643,798 - 44,666,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371945,147,098 - 45,169,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361949,839,066 - 49,858,690 (+)NCBINCBI36hg18NCBI36
Build 341949,839,065 - 49,858,689NCBI
Celera1941,951,144 - 41,973,471 (+)NCBI
Cytogenetic Map19q13.31NCBI
HuRef1941,579,341 - 41,601,754 (+)NCBIHuRef
CHM1_11945,149,748 - 45,172,111 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PVR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736513
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.