Klk1c8 (kallikrein 1-related peptidase C8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Klk1c8 (kallikrein 1-related peptidase C8) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klk1c8
Name: kallikrein 1-related peptidase C8
RGD ID: 1305359
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH acrylamide; benomyl; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glandular kallikrein-8; kallikrein; kallikrein 1-related peptidase b21; kallikrein 6; Klk1b21; Klk6; KLK8; LOC100911764; LOC103690048; LOC292866; P1 Kallikrein; prostatic glandular kallikrein-6; prostatic glandular kallikrein-6-like; rGK-8; rk8; serine protease; tissue kallikrein
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,684,293 - 103,688,155 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,684,293 - 103,688,155 (+)EnsemblGRCr8
mRatBN7.2194,547,774 - 94,552,287 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,547,774 - 94,551,636 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,933,152 - 99,937,013 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,405,785 - 108,409,650 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,696,428 - 101,700,286 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,352,114 - 99,355,976 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,352,141 - 99,355,932 (+)Ensemblrn6Rnor6.0
Rnor_5.01101,101,949 - 101,105,740 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,527,344 - 94,531,135 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,814,679 - 88,818,470 (+)NCBICelera
RGSC_v3.1194,605,412 - 94,609,291 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
acrylamide  (EXP)
benomyl  (EXP)
bisphenol A  (EXP)
DDE  (EXP)
diuron  (EXP)
flutamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Disparate tissue-specific expression of members of the tissue kallikrein multigene family of the rat. MacDonald RJ, etal., J Biol Chem 1996 Jun 7;271(23):13684-90.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Olsson AY, etal., Genomics 2004 Jul;84(1):147-56.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2765531  


Genomics

Variants

.
Variants in Klk1c8
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:98
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000071721
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 4 6 10 5 1 3 1 1 29 9 4 17 15 4

Sequence


Ensembl Acc Id: ENSRNOT00000071721   ⟹   ENSRNOP00000066639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl199,352,141 - 99,355,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072124   ⟹   ENSRNOP00000067862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,037,072 - 100,040,863 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099173   ⟹   ENSRNOP00000084273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,684,293 - 103,688,155 (+)Ensembl
mRatBN7.2 Ensembl194,547,774 - 94,551,636 (+)Ensembl
RefSeq Acc Id: NM_001013067   ⟹   NP_001013085
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,684,293 - 103,688,155 (+)NCBI
mRatBN7.2194,547,774 - 94,551,636 (+)NCBI
Rnor_6.0199,352,114 - 99,355,976 (+)NCBI
Rnor_5.01101,101,949 - 101,105,740 (+)NCBI
RGSC_v3.4194,527,344 - 94,531,135 (+)RGD
Celera188,814,679 - 88,818,470 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013085 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42036 (Get FASTA)   NCBI Sequence Viewer  
  EDM07522 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084273
GenBank Protein P36374 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013085   ⟸   NM_001013067
- Peptide Label: precursor
- UniProtKB: P36374 (UniProtKB/Swiss-Prot),   G3V8G8 (UniProtKB/TrEMBL),   A6JAL2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067862   ⟸   ENSRNOT00000072124
Ensembl Acc Id: ENSRNOP00000066639   ⟸   ENSRNOT00000071721
Ensembl Acc Id: ENSRNOP00000084273   ⟸   ENSRNOT00000099173
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36374-F1-model_v2 AlphaFold P36374 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305359 AgrOrtholog
BioCyc Gene G2FUF-59804 BioCyc
Ensembl Genes ENSRNOG00000048901 Ensembl
  ENSRNOG00000049279 Ensembl
  ENSRNOG00000070110 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000099173 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
NCBI Gene 292866 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Klk1c8 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000048901 RatGTEx
  ENSRNOG00000049279 RatGTEx
  ENSRNOG00000070110 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A6JAL2 ENTREZGENE, UniProtKB/TrEMBL
  G3V8G8 ENTREZGENE, UniProtKB/TrEMBL
  KLK6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Klk1c8  kallikrein 1-related peptidase C8  LOC103690048  prostatic glandular kallikrein-6-like  Data merged from RGD:9176004 737654 PROVISIONAL
2015-07-29 Klk1c8  kallikrein 1-related peptidase C8  LOC100911764  prostatic glandular kallikrein-6-like  Data merged from RGD:6490936 737654 PROVISIONAL
2014-08-25 LOC103690048  prostatic glandular kallikrein-6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100911764  prostatic glandular kallikrein-6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-06-29 Klk1c8  kallikrein 1-related peptidase C8  Klk1b21  kallikrein 1-related peptidase b21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-08 Klk1b21  kallikrein 1-related peptidase b21  Klk6_predicted  kallikrein 6 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Klk6_predicted  kallikrein 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED