Tph1 (tryptophan hydroxylase 1) - Rat Genome Database

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Gene: Tph1 (tryptophan hydroxylase 1) Rattus norvegicus
Symbol: Tph1
Name: tryptophan hydroxylase 1
RGD ID: 3895
Description: Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Predicted to be located in cytoplasm. Predicted to be active in neuron projection. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-sulfonyldiphenol; 5-hydroxytryptophan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tph; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1; tryptophan hydroxylase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tph1em1Mcwi   Tph1em3Mcwi   Tph1em4Mcwi  
Genetic Models: WKY-Tph1em1Mcwi DA-Tph1em4Mcwi WKY-Tph1em3Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2197,157,375 - 97,178,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,543,405 - 102,564,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,015,397 - 111,036,438 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,305,773 - 104,326,712 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Role of the 5' untranslated region (UTR) in the tissue-specific regulation of rat tryptophan hydroxylase gene expression by stress. Chamas F and Sabban EL, J Neurochem 2002 Aug;82(3):645-54.
2. Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei. Chamas FM, etal., Biol Psychiatry. 2004 Feb 1;55(3):278-83.
3. Allelic variation at the A218C tryptophan hydroxylase polymorphism influences agitation and aggression in Alzheimer's disease. Craig D, etal., Neurosci Lett. 2004 Jun 17;363(3):199-202.
4. Sequence of two mRNAs encoding active rat tryptophan hydroxylase. Darmon MC, etal., J Neurochem 1988 Jul;51(1):312-6.
5. Platelet-derived serotonin links vascular disease and tissue fibrosis. Dees C, etal., J Exp Med. 2011 May 9;208(5):961-72. Epub 2011 Apr 25.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression. Gizatullin R, etal., Biol Psychiatry. 2006 Feb 15;59(4):295-300. Epub 2005 Sep 13.
8. Attention-deficit/hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production. Halmoy A, etal., Arch Gen Psychiatry. 2010 Oct;67(10):1033-43.
9. No association between the tryptophan hydroxylase gene polymorphism and major depressive disorders and antidepressant response in a Korean population. Ham BJ, etal., Psychiatr Genet. 2005 Dec;15(4):299-301.
10. Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. Huang Z, etal., J Pineal Res. 2008 Nov;45(4):506-14. Epub 2008 Aug 13.
11. Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line. Iida Y, etal., Eur J Biochem 2002 Oct;269(19):4780-8.
12. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. Izikki M, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.
13. Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults. Jokela M, etal., J Affect Disord. 2007 Jun;100(1-3):191-7. Epub 2006 Nov 28.
14. Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan. Lai TJ, etal., BMC Med Genet. 2005 Mar 31;6:14.
15. Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population. Li J, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141(2):126-9.
16. Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats. Liu D, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):330-6. doi: 10.1177/1535370213513987. Epub 2014 Feb 4.
17. Lack of association between the serotonin transporter and tryptophan hydroxylase gene polymorphisms and completed suicide. Mergen H, etal., Psychiatr Genet. 2006 Apr;16(2):53.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis. Nelson LM, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):37-40.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. Reuter M and Hennig J, Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134(1):20-4.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. Rujescu D, etal., Biol Psychiatry. 2003 Aug 15;54(4):465-73.
26. Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism. Sekizawa T, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128(1):24-6.
27. A functional polymorphism in the promoter region of the tryptophan hydroxylase gene is associated with alcohol dependence in one aboriginal group in Taiwan. Sun HS, etal., Alcohol Clin Exp Res. 2005 Jan;29(1):1-7.
28. Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Sun HS, etal., Genes Brain Behav. 2004 Dec;3(6):328-36.
29. Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. Takahashi Y, etal., J Orthop Res. 2011 Jul;29(7):1055-8. doi: 10.1002/jor.21347. Epub 2011 Feb 9.
30. Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population. Tang G, etal., Am J Med Genet. 2001 Aug 8;105(6):485-8.
31. Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese. Wang H, etal., Spine (Phila Pa 1976). 2008 Sep 15;33(20):2199-203.
32. Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Yadav VK, etal., Nat Med. 2010 Mar;16(3):308-12. Epub 2010 Feb 7.
33. Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. You JS, etal., Psychiatr Genet. 2005 Mar;15(1):7-11.
34. Tryptophan hydroxylase-1 gene variants associate with a group of suicidal borderline women. Zaboli G, etal., Neuropsychopharmacology. 2006 Sep;31(9):1982-90. Epub 2006 Feb 22.
Additional References at PubMed
PMID:1645430   PMID:2110547   PMID:2780283   PMID:2875901   PMID:12065627   PMID:12911638   PMID:14960274   PMID:14960297   PMID:15194882   PMID:16198203   PMID:18197473   PMID:18221757  
PMID:18414394   PMID:19041748   PMID:20719859   PMID:22253933   PMID:22819790   PMID:23500099   PMID:25930119   PMID:31124080   PMID:31997472   PMID:32641996   PMID:33750988  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2197,157,375 - 97,178,415 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1102,543,405 - 102,564,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,015,397 - 111,036,438 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,305,773 - 104,326,712 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381118,017,555 - 18,046,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,017,555 - 18,046,269 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,039,102 - 18,067,816 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,999,114 - 18,018,885 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,999,113 - 18,018,885NCBI
Celera1118,174,092 - 18,194,347 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,724,789 - 17,745,045 (-)NCBIHuRef
CHM1_11118,041,619 - 18,061,874 (-)NCBICHM1_1
T2T-CHM13v2.01118,115,170 - 18,143,890 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39746,294,065 - 46,321,961 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,294,065 - 46,321,961 (-)EnsemblGRCm39 Ensembl
GRCm38746,644,641 - 46,672,537 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,644,641 - 46,672,537 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,902,501 - 53,927,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,515,218 - 46,540,579 (-)NCBIMGSCv36mm8
Celera742,121,305 - 42,146,712 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.43NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541432,800,477 - 32,828,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,803,417 - 32,828,682 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11120,311,362 - 20,334,990 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,070,576 - 18,099,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,754,885 - 17,778,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,754,893 - 17,778,076 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12140,545,379 - 40,571,620 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,547,682 - 40,566,572 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,047,325 - 40,065,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,651,924 - 41,675,891 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,651,924 - 41,676,027 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,664,759 - 40,683,241 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,872,839 - 40,891,326 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,211,247 - 41,229,722 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494745,056,550 - 45,082,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,096,352 - 1,115,688 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365281,090,529 - 1,116,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl241,075,628 - 41,109,437 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,075,623 - 41,109,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,133,225 - 44,170,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1146,921,682 - 46,947,906 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038144,311,303 - 144,337,308 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247669,629,849 - 9,668,393 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,629,951 - 9,687,772 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tph1
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:729
Count of miRNA genes:283
Interacting mature miRNAs:373
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,158,593 - 97,158,914 (+)MAPPERmRatBN7.2
Rnor_6.01102,671,053 - 102,671,371NCBIRnor6.0
Rnor_5.01103,748,063 - 103,748,381UniSTSRnor5.0
RGSC_v3.4197,187,256 - 97,187,574UniSTSRGSC3.4
Celera191,405,954 - 91,406,272UniSTS
Cytogenetic Map1q22UniSTS

Genetic Models
This gene Tph1 is modified in the following models/strains


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2
Low 1 14 13 2 2 11 22 26 10 2
Below cutoff 33 26 24 6 24 6 9 59 11 14 1 6


RefSeq Acc Id: ENSRNOT00000056109   ⟹   ENSRNOP00000052959
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)Ensembl
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)Ensembl
RefSeq Acc Id: NM_001100634   ⟹   NP_001094104
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,157,409 - 97,178,344 (-)NCBI
Rnor_6.01102,669,868 - 102,699,442 (-)NCBI
Rnor_5.01103,746,878 - 103,774,100 (-)NCBI
RGSC_v3.4197,186,071 - 97,207,551 (-)RGD
Celera191,404,769 - 91,425,505 (-)RGD
RefSeq Acc Id: XM_039101020   ⟹   XP_038956948
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,157,375 - 97,178,415 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094104 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956948 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42262 (Get FASTA)   NCBI Sequence Viewer  
  EDM07261 (Get FASTA)   NCBI Sequence Viewer  
  P09810 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094104   ⟸   NM_001100634
- UniProtKB: P09810 (UniProtKB/Swiss-Prot),   A6JBC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052959   ⟸   ENSRNOT00000056109
RefSeq Acc Id: XP_038956948   ⟸   XM_039101020
- Peptide Label: isoform X1
- UniProtKB: P09810 (UniProtKB/Swiss-Prot),   A6JBC3 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09810-F1-model_v2 AlphaFold P09810 1-444 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3895 AgrOrtholog
BioCyc Gene G2FUF-59620 BioCyc
BioCyc Pathway PWY-6030 [serotonin and melatonin biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000011672 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000052959 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056109 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp_5_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrpOH_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24848 UniProtKB/Swiss-Prot
Pfam Biopterin_H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tph1 PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ACT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ACT-like UniProtKB/TrEMBL
  Aromatic aminoacid monoxygenases, catalytic and oligomerization domains UniProtKB/TrEMBL
  SSF55021 UniProtKB/Swiss-Prot
  SSF56534 UniProtKB/Swiss-Prot
  P09810 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Tph1  tryptophan hydroxylase 1      Symbol and Name updated 1299863 APPROVED
2002-06-10 Tph  Tryptophan hydroxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation protein turnover driven by ATP-dependent action of 26S-proteasomes 724750