Tph1 (tryptophan hydroxylase 1) - Rat Genome Database

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Gene: Tph1 (tryptophan hydroxylase 1) Rattus norvegicus
Analyze
Symbol: Tph1
Name: tryptophan hydroxylase 1
RGD ID: 3895
Description: Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Located in neuron projection. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-sulfonyldiphenol; 5-hydroxytryptophan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tph; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1; tryptophan hydroxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tph1em1Mcwi   Tph1em3Mcwi   Tph1em4Mcwi  
Genetic Models: WKY-Tph1em1Mcwi DA-Tph1em4Mcwi WKY-Tph1em3Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2197,157,375 - 97,178,415 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)Ensembl
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,TAS)
neuron projection  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Chamas F and Sabban EL, J Neurochem 2002 Aug;82(3):645-54.
2. Chamas FM, etal., Biol Psychiatry. 2004 Feb 1;55(3):278-83.
3. Craig D, etal., Neurosci Lett. 2004 Jun 17;363(3):199-202.
4. Darmon MC, etal., J Neurochem 1988 Jul;51(1):312-6.
5. Dees C, etal., J Exp Med. 2011 May 9;208(5):961-72. Epub 2011 Apr 25.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Gizatullin R, etal., Biol Psychiatry. 2006 Feb 15;59(4):295-300. Epub 2005 Sep 13.
8. Halmoy A, etal., Arch Gen Psychiatry. 2010 Oct;67(10):1033-43.
9. Ham BJ, etal., Psychiatr Genet. 2005 Dec;15(4):299-301.
10. Huang Z, etal., J Pineal Res. 2008 Nov;45(4):506-14. Epub 2008 Aug 13.
11. Iida Y, etal., Eur J Biochem 2002 Oct;269(19):4780-8.
12. Izikki M, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1045-52. Epub 2007 Aug 3.
13. Jokela M, etal., J Affect Disord. 2007 Jun;100(1-3):191-7. Epub 2006 Nov 28.
14. Lai TJ, etal., BMC Med Genet. 2005 Mar 31;6:14.
15. Li J, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141(2):126-9.
16. Liu D, etal., Exp Biol Med (Maywood). 2014 Mar;239(3):330-6. doi: 10.1177/1535370213513987. Epub 2014 Feb 4.
17. Mergen H, etal., Psychiatr Genet. 2006 Apr;16(2):53.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Nelson LM, etal., Spine (Phila Pa 1976). 2011 Jan 1;36(1):37-40.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. Pipeline to import SMPDB annotations from SMPDB into RGD
22. Reuter M and Hennig J, Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134(1):20-4.
23. RGD automated data pipeline
24. RGD automated import pipeline for gene-chemical interactions
25. Rujescu D, etal., Biol Psychiatry. 2003 Aug 15;54(4):465-73.
26. Sekizawa T, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128(1):24-6.
27. Sun HS, etal., Alcohol Clin Exp Res. 2005 Jan;29(1):1-7.
28. Sun HS, etal., Genes Brain Behav. 2004 Dec;3(6):328-36.
29. Takahashi Y, etal., J Orthop Res. 2011 Jul;29(7):1055-8. doi: 10.1002/jor.21347. Epub 2011 Feb 9.
30. Tang G, etal., Am J Med Genet. 2001 Aug 8;105(6):485-8.
31. Wang H, etal., Spine (Phila Pa 1976). 2008 Sep 15;33(20):2199-203.
32. Yadav VK, etal., Nat Med. 2010 Mar;16(3):308-12. Epub 2010 Feb 7.
33. You JS, etal., Psychiatr Genet. 2005 Mar;15(1):7-11.
34. Zaboli G, etal., Neuropsychopharmacology. 2006 Sep;31(9):1982-90. Epub 2006 Feb 22.
Additional References at PubMed
PMID:1645430   PMID:2110547   PMID:2780283   PMID:2875901   PMID:12065627   PMID:12911638   PMID:14960274   PMID:14960297   PMID:15194882   PMID:16198203   PMID:18197473   PMID:18221757  
PMID:18414394   PMID:19041748   PMID:20719859   PMID:22253933   PMID:22819790   PMID:23500099   PMID:25930119   PMID:31124080   PMID:31997472   PMID:32641996   PMID:33750988  


Genomics

Comparative Map Data
Tph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2197,157,375 - 97,178,415 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)Ensembl
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
TPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,017,555 - 18,046,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1118,017,555 - 18,046,269 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,039,102 - 18,067,816 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,999,114 - 18,018,885 (-)NCBINCBI36hg18NCBI36
Build 341117,999,113 - 18,018,885NCBI
Celera1118,174,092 - 18,194,347 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1117,724,789 - 17,745,045 (-)NCBIHuRef
CHM1_11118,041,619 - 18,061,874 (-)NCBICHM1_1
Tph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,294,065 - 46,321,961 (-)NCBIGRCm39mm39
GRCm39 Ensembl746,294,065 - 46,321,961 (-)Ensembl
GRCm38746,644,641 - 46,672,537 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,644,641 - 46,672,537 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,902,501 - 53,927,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv36746,515,218 - 46,540,579 (-)NCBImm8
Celera742,121,305 - 42,146,712 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.43NCBI
Tph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,800,477 - 32,828,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,803,417 - 32,828,682 (-)NCBIChiLan1.0ChiLan1.0
TPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,754,885 - 17,778,076 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,754,893 - 17,778,076 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01118,070,576 - 18,099,539 (-)NCBIMhudiblu_PPA_v0panPan3
TPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,545,379 - 40,571,620 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,547,682 - 40,566,572 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,047,325 - 40,065,811 (-)NCBI
ROS_Cfam_1.02141,651,924 - 41,675,891 (-)NCBI
ROS_Cfam_1.0 Ensembl2141,651,924 - 41,676,027 (-)Ensembl
UMICH_Zoey_3.12140,664,759 - 40,683,241 (-)NCBI
UNSW_CanFamBas_1.02140,872,839 - 40,891,326 (-)NCBI
UU_Cfam_GSD_1.02141,211,247 - 41,229,722 (-)NCBI
Tph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,056,550 - 45,082,283 (+)NCBI
SpeTri2.0NW_0049365281,090,529 - 1,116,081 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,028,692 - 41,108,928 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,075,623 - 41,109,005 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,133,225 - 44,170,984 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,921,682 - 46,947,906 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038144,311,303 - 144,337,308 (+)NCBIVero_WHO_p1.0
Tph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247669,629,951 - 9,687,772 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D1Wox40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,158,593 - 97,158,914 (+)MAPPERmRatBN7.2
Rnor_6.01102,671,053 - 102,671,371NCBIRnor6.0
Rnor_5.01103,748,063 - 103,748,381UniSTSRnor5.0
RGSC_v3.4197,187,256 - 97,187,574UniSTSRGSC3.4
Celera191,405,954 - 91,406,272UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat


Genetic Models
This gene Tph1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:729
Count of miRNA genes:283
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000056109
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 1 14 13 2 2 11 22 26 10 2
Below cutoff 33 26 24 6 24 6 9 59 11 14 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056109   ⟹   ENSRNOP00000052959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl197,157,409 - 97,178,344 (-)Ensembl
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)Ensembl
RefSeq Acc Id: NM_001100634   ⟹   NP_001094104
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,157,409 - 97,178,344 (-)NCBI
Rnor_6.01102,669,868 - 102,699,442 (-)NCBI
Rnor_5.01103,746,878 - 103,774,100 (-)NCBI
RGSC_v3.4197,186,071 - 97,207,551 (-)RGD
Celera191,404,769 - 91,425,505 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101020   ⟹   XP_038956948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2197,157,375 - 97,178,415 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094104 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956948 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42262 (Get FASTA)   NCBI Sequence Viewer  
  EDM07261 (Get FASTA)   NCBI Sequence Viewer  
  P09810 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094104   ⟸   NM_001100634
- UniProtKB: P09810 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052959   ⟸   ENSRNOT00000056109
RefSeq Acc Id: XP_038956948   ⟸   XM_039101020
- Peptide Label: isoform X1
Protein Domains
ACT

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AF-P09810-F1-model_v2 AlphaFold P09810 1-444 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690063
Promoter ID:EPDNEW_R588
Type:single initiation site
Name:Tph1_1
Description:tryptophan hydroxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,699,404 - 102,699,464EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3895 AgrOrtholog
BioCyc Gene G2FUF-59620 BioCyc
BioCyc Pathway PWY-6030 [serotonin and melatonin biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000011672 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000052959 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056109 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.800.10 UniProtKB/Swiss-Prot
InterPro ACT-like_dom_sf UniProtKB/Swiss-Prot
  ACT_dom UniProtKB/Swiss-Prot
  ArAA_hydroxylase UniProtKB/Swiss-Prot
  ArAA_hydroxylase_Fe/CU_BS UniProtKB/Swiss-Prot
  ArAA_hydroxylase_sf UniProtKB/Swiss-Prot
  Aro-AA_hydroxylase_C_sf UniProtKB/Swiss-Prot
  Aromatic-AA_hydroxylase_C UniProtKB/Swiss-Prot
  Trp_5_mOase UniProtKB/Swiss-Prot
  TrpOH_cat UniProtKB/Swiss-Prot
  Tyrosine_3-monooxygenase-like UniProtKB/Swiss-Prot
KEGG Report rno:24848 UniProtKB/Swiss-Prot
NCBI Gene 24848 ENTREZGENE
PANTHER PTHR11473 UniProtKB/Swiss-Prot
Pfam Biopterin_H UniProtKB/Swiss-Prot
PharmGKB TPH1 RGD
PhenoGen Tph1 PhenoGen
PIRSF PIRSF000336 UniProtKB/Swiss-Prot
PRINTS FYWHYDRXLASE UniProtKB/Swiss-Prot
PROSITE ACT UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_1 UniProtKB/Swiss-Prot
  BH4_AAA_HYDROXYL_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55021 UniProtKB/Swiss-Prot
  SSF56534 UniProtKB/Swiss-Prot
TIGRFAMs Trp_5_monoox UniProtKB/Swiss-Prot
UniProt P09810 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Tph1  tryptophan hydroxylase 1      Symbol and Name updated 1299863 APPROVED
2002-06-10 Tph  Tryptophan hydroxylase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation protein turnover driven by ATP-dependent action of 26S-proteasomes 724750