Gene: Tph1 (tryptophan hydroxylase 1) Rattus norvegicus
Symbol: Tph1
Name: tryptophan hydroxylase 1
Description: ENCODES a protein that exhibits tryptophan 5-monooxygenase activity; INVOLVED IN circadian rhythm; negative regulation of ossification; response to immobilization stress; PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH mental depression; alcohol use disorder (ortholog); Alzheimer's disease (ortholog); FOUND IN neuron projection; cytoplasm (ortholog); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-sulfonyldiphenol; acrylamide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Tph; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1; tryptophan hydroxylase
Homo sapiens (human) : TPH1 (tryptophan hydroxylase 1)  HGNC  Alliance
Mus musculus (house mouse) : Tph1 (tryptophan hydroxylase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tph1 (tryptophan hydroxylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH1 (tryptophan hydroxylase 1)
Canis lupus familiaris (dog) : TPH1 (tryptophan hydroxylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph1 (tryptophan hydroxylase 1)
Sus scrofa (pig) : TPH1 (tryptophan hydroxylase 1)
more info ...
Allele / Splice: Tph1em1Mcwi   Tph1em3Mcwi   Tph1em4Mcwi  
Genetic Models: WKY-Tph1em1Mcwi DA-Tph1em4Mcwi WKY-Tph1em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tph1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3895
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE