Relb (RELB proto-oncogene, NF-kB subunit) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Relb (RELB proto-oncogene, NF-kB subunit) Rattus norvegicus
Analyze
Symbol: Relb
Name: RELB proto-oncogene, NF-kB subunit
RGD ID: 2321078
Description: Enables DNA binding activity. Involved in cellular response to osmotic stress. Predicted to be located in several cellular components, including centrosome; chromatin; and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in cytoplasm; nucleus; and synapse. Used to study kidney disease; muscular atrophy; and ureteral obstruction. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit); PARTICIPATES IN interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: avian reticuloendotheliosis viral (v-rel) oncogene related B; LOC100360982; transcription factor RelB; v-rel avian reticuloendotheliosis viral oncogene homolog B; v-rel reticuloendotheliosis viral oncogene homolog B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,385,717 - 88,413,380 (-)NCBIGRCr8
mRatBN7.2179,257,738 - 79,285,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,257,725 - 79,285,507 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0180,517,081 - 80,545,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,517,411 - 80,544,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,783,102 - 81,810,793 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera173,717,263 - 73,744,749 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloroethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzhydrazide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
abexinostat  (ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (EXP)
alpha-amanitin  (ISO)
amiodarone  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethylbenzene  (ISO)
fluoranthene  (ISO)
folpet  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
mangiferin  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
motexafin gadolinium  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nitrates  (ISO)
o-anisidine  (ISO)
o-xylene  (ISO)
omacetaxine mepesuccinate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IEA,ISO)
synapse  (IEA,ISO)
transcription repressor complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis. Barton D, etal., Eur J Immunol. 2000 Aug;30(8):2323-32.
2. Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat. Bieg S, etal., Pancreas. 2000 Jan;20(1):47-54.
3. RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland. Demicco EG, etal., Mol Cell Biol. 2005 Nov;25(22):10136-47.
4. Hyperosmotic stress activates p65/RelB NFkappaB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. Eisner V, etal., FEBS Lett. 2006 Jun 12;580(14):3469-76. Epub 2006 May 15.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy. Hunter RB, etal., FASEB J. 2002 Apr;16(6):529-38.
7. Peripheral T lymphocytes from women with breast cancer exhibit abnormal protein expression of several signaling molecules. Kurt RA, etal., Int J Cancer. 1998 Sep 25;78(1):16-20.
8. Rapid communication. Enalapril decreases nuclear factor kappa B activation in the kidney with ureteral obstruction. Morrissey JJ and Klahr S, Kidney Int. 1997 Oct;52(4):926-33.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors. Romieu-Mourez R, etal., Mol Cell Biol. 2003 Aug;23(16):5738-54.
12. Up-regulation of Cks1 and Skp2 with TNFalpha/NF-kappaB signaling in chronic progressive nephropathy. Suzuki S, etal., Genes Cells. 2011 Nov;16(11):1110-20. doi: 10.1111/j.1365-2443.2011.01553.x.
13. Interaction of aryl hydrocarbon receptor and NF-kappaB subunit RelB in breast cancer is associated with interleukin-8 overexpression. Vogel CF, etal., Arch Biochem Biophys. 2011 Aug 1;512(1):78-86. doi: 10.1016/j.abb.2011.05.011. Epub 2011 May 26.
14. [Expression of NF-kappa B in human bladder cancer and its clinical significance] Xie DH, etal., Ai Zheng. 2002 Jun;21(6):663-7.
15. Immune tolerance induced by RelB short-hairpin RNA interference dendritic cells in liver transplantation. Xie J, etal., J Surg Res. 2013 Mar;180(1):169-75. doi: 10.1016/j.jss.2012.10.021. Epub 2012 Nov 1.
16. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
Additional References at PubMed
PMID:7845467   PMID:8441398   PMID:10925280   PMID:11931770   PMID:14499111   PMID:15944286   PMID:16081776   PMID:16154093   PMID:19158276   PMID:20873783   PMID:21874024   PMID:22065573  
PMID:22894897   PMID:23583643   PMID:23729669   PMID:26385063   PMID:26824492  


Genomics

Comparative Map Data
Relb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,385,717 - 88,413,380 (-)NCBIGRCr8
mRatBN7.2179,257,738 - 79,285,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,257,725 - 79,285,507 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0180,517,081 - 80,545,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,517,411 - 80,544,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,783,102 - 81,810,793 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera173,717,263 - 73,744,749 (-)NCBICelera
Cytogenetic Map1q21NCBI
RELB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,001,464 - 45,038,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,001,461 - 45,038,192 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,504,722 - 45,541,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,196,552 - 50,233,292 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,196,551 - 50,233,292NCBI
Celera1942,309,022 - 42,345,751 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,935,689 - 41,971,666 (+)NCBIHuRef
CHM1_11945,507,785 - 45,544,777 (+)NCBICHM1_1
T2T-CHM13v2.01947,826,284 - 47,863,291 (+)NCBIT2T-CHM13v2.0
Relb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,340,142 - 19,363,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,340,142 - 19,363,363 (-)EnsemblGRCm39 Ensembl
GRCm38719,606,217 - 19,629,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,606,217 - 19,629,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,191,571 - 20,214,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,764,744 - 18,787,960 (-)NCBIMGSCv36mm8
Celera717,011,812 - 17,035,368 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.93NCBI
Relb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,060,533 - 2,086,229 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,060,533 - 2,086,229 (+)NCBIChiLan1.0ChiLan1.0
RELB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,160,728 - 51,199,294 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,032,147 - 53,070,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,948,559 - 41,987,121 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,563,164 - 50,590,627 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,554,864 - 50,590,223 (+)Ensemblpanpan1.1panPan2
RELB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,436,677 - 110,466,709 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,436,662 - 110,466,809 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,917,954 - 109,947,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,966,408 - 110,996,642 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,966,393 - 110,996,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,641,652 - 110,671,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,277,051 - 110,306,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,145,641 - 111,175,691 (-)NCBIUU_Cfam_GSD_1.0
Relb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,222,260 - 17,249,483 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,569,756 - 1,596,456 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,569,603 - 1,596,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RELB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,444,664 - 51,480,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,444,670 - 51,480,350 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RELB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,463,414 - 38,500,487 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607318,045,037 - 18,087,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Relb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,806,874 - 1,829,417 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,806,784 - 1,829,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Relb
192 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:734
Count of miRNA genes:269
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000040060, ENSRNOT00000052387, ENSRNOT00000057802, ENSRNOT00000067049, ENSRNOT00000071090, ENSRNOT00000073352
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
RH134992  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,385,822 - 88,386,014 (+)Marker Load Pipeline
mRatBN7.2179,257,846 - 79,258,038 (+)MAPPERmRatBN7.2
Rnor_6.0180,517,187 - 80,517,378NCBIRnor6.0
Rnor_5.0181,783,208 - 81,783,399UniSTSRnor5.0
Celera173,717,369 - 73,717,560UniSTS
RH 3.4 Map1787.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000040060   ⟹   ENSRNOP00000046846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,257,741 - 79,285,507 (-)Ensembl
Rnor_6.0 Ensembl180,517,411 - 80,544,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000052387   ⟹   ENSRNOP00000040300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl180,530,833 - 80,544,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000057802   ⟹   ENSRNOP00000054614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,257,725 - 79,285,507 (-)Ensembl
Rnor_6.0 Ensembl180,517,411 - 80,544,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067049   ⟹   ENSRNOP00000059203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl180,530,760 - 80,544,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073352   ⟹   ENSRNOP00000065904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl180,533,659 - 80,544,825 (-)Ensembl
RefSeq Acc Id: NM_001427140   ⟹   NP_001414069
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,385,717 - 88,413,380 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414069 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046846
  ENSRNOP00000046846.6
  ENSRNOP00000054614.5
Ensembl Acc Id: ENSRNOP00000059203   ⟸   ENSRNOT00000067049
Ensembl Acc Id: ENSRNOP00000054614   ⟸   ENSRNOT00000057802
Ensembl Acc Id: ENSRNOP00000065904   ⟸   ENSRNOT00000073352
Ensembl Acc Id: ENSRNOP00000040300   ⟸   ENSRNOT00000052387
Ensembl Acc Id: ENSRNOP00000046846   ⟸   ENSRNOT00000040060
RefSeq Acc Id: NP_001414069   ⟸   NM_001427140
- UniProtKB: D4A8H1 (UniProtKB/TrEMBL),   D3Z9V1 (UniProtKB/TrEMBL)
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8H1-F1-model_v2 AlphaFold D4A8H1 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2321078 AgrOrtholog
BioCyc Gene G2FUF-60493 BioCyc
Ensembl Genes ENSRNOG00000033235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040060 ENTREZGENE
  ENSRNOT00000040060.7 UniProtKB/TrEMBL
  ENSRNOT00000057802.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/TrEMBL
  NF_Rel_Dor UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RelB UniProtKB/TrEMBL
  RelB_leu_zip UniProtKB/TrEMBL
  RelB_transact UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_CS UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene 100360982 ENTREZGENE
PANTHER PTHR24169 UniProtKB/TrEMBL
  PTHR24169:SF18 UniProtKB/TrEMBL
Pfam RelB_leu_zip UniProtKB/TrEMBL
  RelB_transactiv UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Relb PhenoGen
PRINTS NFKBTNSCPFCT UniProtKB/TrEMBL
PROSITE REL_1 UniProtKB/TrEMBL
  REL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033235 RatGTEx
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A6J8Q8_RAT UniProtKB/TrEMBL
  D3Z9V1 ENTREZGENE, UniProtKB/TrEMBL
  D4A8H1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Relb  RELB proto-oncogene, NF-kB subunit  Relb  v-rel avian reticuloendotheliosis viral oncogene homolog B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Relb  v-rel avian reticuloendotheliosis viral oncogene homolog B  Relb  v-rel reticuloendotheliosis viral oncogene homolog B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Relb  v-rel reticuloendotheliosis viral oncogene homolog B  Relb  avian reticuloendotheliosis viral (v-rel) oncogene related B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-09 Relb  avian reticuloendotheliosis viral (v-rel) oncogene related B  LOC100360982  avian reticuloendotheliosis viral (v-rel) oncogene related B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100360982  avian reticuloendotheliosis viral (v-rel) oncogene related B      Symbol and Name status set to provisional 70820 PROVISIONAL