Ppp1r14a (protein phosphatase 1, regulatory (inhibitor) subunit 14A) - Rat Genome Database

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Gene: Ppp1r14a (protein phosphatase 1, regulatory (inhibitor) subunit 14A) Rattus norvegicus
Analyze
Symbol: Ppp1r14a
Name: protein phosphatase 1, regulatory (inhibitor) subunit 14A
RGD ID: 620536
Description: Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to act upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in cytoplasm. Orthologous to human PPP1R14A (protein phosphatase 1 regulatory inhibitor subunit 14A); INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17 kDa PKC-potentiated inhibitory protein of PP1; CPI-17; Cpi17; protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory subunit 14A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,708,269 - 93,718,218 (+)NCBIGRCr8
mRatBN7.2184,583,127 - 84,590,743 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,586,627 - 84,590,671 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,998,058 - 90,002,196 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,457,866 - 98,462,002 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,753,902 - 91,758,040 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,224,683 - 87,232,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,224,677 - 87,232,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,402,435 - 88,411,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,421,638 - 84,427,235 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,499,748 - 84,505,347 (+)NCBI
Celera178,973,128 - 78,977,227 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
beclomethasone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buspirone  (EXP)
butanal  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chelerythrine  (EXP)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geranylgeraniol  (EXP)
glafenine  (EXP)
L-methionine  (ISO)
levofloxacin  (EXP)
metacetamol  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 12,13-dibutanoate  (EXP)
potassium dichromate  (ISO)
prednisolone  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
Ro 31-8220  (EXP)
SB 431542  (ISO)
simvastatin  (EXP)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Deng JT, etal., Biochem J 2002 Oct 15;367(Pt 2):517-24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, etal., J Cancer Res Clin Oncol. 2017 Apr;143(4):619-629. doi: 10.1007/s00432-016-2324-z. Epub 2016 Dec 29.
4. Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2. Li Z, etal., Mol Biol Rep 2001;28(2):91-101.
5. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Liu QR, etal., Biochem J 2004 Jan 1;377(Pt 1):171-81.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase. Takizawa N, etal., Biochem Biophys Res Commun 2002 Oct 4;297(4):773-8.
Additional References at PubMed
PMID:16267107   PMID:17071121   PMID:18524939   PMID:19373133   PMID:19437030   PMID:19842549   PMID:20046026   PMID:20086008   PMID:22004286   PMID:22275376   PMID:22538237   PMID:23541585  
PMID:24909118   PMID:25502873   PMID:28717991   PMID:38474189  


Genomics

Comparative Map Data
Ppp1r14a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,708,269 - 93,718,218 (+)NCBIGRCr8
mRatBN7.2184,583,127 - 84,590,743 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,586,627 - 84,590,671 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,998,058 - 90,002,196 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,457,866 - 98,462,002 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,753,902 - 91,758,040 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0187,224,683 - 87,232,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,224,677 - 87,232,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,402,435 - 88,411,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,421,638 - 84,427,235 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,499,748 - 84,505,347 (+)NCBI
Celera178,973,128 - 78,977,227 (+)NCBICelera
Cytogenetic Map1q21NCBI
PPP1R14A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,251,237 - 38,256,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,251,237 - 38,256,532 (-)EnsemblGRCh38hg38GRCh38
GRCh371938,741,877 - 38,747,014 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,433,717 - 43,439,012 (-)NCBINCBI36Build 36hg18NCBI36
Build 341943,433,718 - 43,439,012NCBI
Celera1935,544,117 - 35,549,412 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,189,903 - 35,195,254 (-)NCBIHuRef
CHM1_11938,742,221 - 38,747,575 (-)NCBICHM1_1
T2T-CHM13v2.01941,053,408 - 41,058,545 (-)NCBIT2T-CHM13v2.0
Ppp1r14a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,988,732 - 28,992,817 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,988,733 - 28,993,226 (+)EnsemblGRCm39 Ensembl
GRCm38729,289,320 - 29,293,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,289,308 - 29,293,801 (+)EnsemblGRCm38mm10GRCm38
MGSCv37730,074,339 - 30,078,409 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,998,080 - 29,002,150 (+)NCBIMGSCv36mm8
Celera723,860,386 - 23,864,456 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Ppp1r14a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554681,174,961 - 1,179,207 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554681,174,946 - 1,179,289 (+)NCBIChiLan1.0ChiLan1.0
PPP1R14A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22044,537,685 - 44,543,133 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,408,369 - 46,413,721 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,340,934 - 35,346,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11943,913,749 - 43,925,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PPP1R14A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,739,823 - 114,743,663 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,740,117 - 114,741,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01115,339,382 - 115,344,306 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1115,339,397 - 115,347,869 (+)EnsemblROS_Cfam_1.0 Ensembl
Ppp1r14a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934912,862,890 - 12,866,926 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,028,105 - 1,032,282 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,028,246 - 1,038,093 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R14A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,167,118 - 47,174,091 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,167,105 - 47,174,299 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,669,944 - 42,674,708 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R14A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1632,890,160 - 32,895,267 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl632,889,287 - 32,895,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607310,833,635 - 10,838,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r14a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479411,729,086 - 11,733,662 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479411,728,660 - 11,733,704 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r14a
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000028070
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
RH143064  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1841.9UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 37 62 46 21 46 105 51 118 53
Low 104 165 101 48 101 28 45 145 64 27 24
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000028070   ⟹   ENSRNOP00000028070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,586,627 - 84,590,671 (+)Ensembl
Rnor_6.0 Ensembl187,224,677 - 87,232,848 (+)Ensembl
RefSeq Acc Id: NM_130403   ⟹   NP_569087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,714,102 - 93,718,218 (+)NCBI
mRatBN7.2184,586,627 - 84,590,743 (+)NCBI
Rnor_6.0187,228,581 - 87,232,842 (+)NCBI
Rnor_5.0188,402,435 - 88,411,822 (+)NCBI
RGSC_v3.4184,421,638 - 84,427,235 (+)RGD
Celera178,973,128 - 78,977,227 (+)RGD
Sequence:
RefSeq Acc Id: XM_017588644   ⟹   XP_017444133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,708,270 - 93,718,218 (+)NCBI
mRatBN7.2184,583,473 - 84,590,743 (+)NCBI
Rnor_6.0187,224,683 - 87,232,842 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063261307   ⟹   XP_063117377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,708,269 - 93,718,218 (+)NCBI
RefSeq Acc Id: XM_063261318   ⟹   XP_063117388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,710,312 - 93,718,218 (+)NCBI
RefSeq Acc Id: XM_063261331   ⟹   XP_063117401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,708,319 - 93,718,218 (+)NCBI
RefSeq Acc Id: XM_063261338   ⟹   XP_063117408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,708,269 - 93,718,218 (+)NCBI
RefSeq Acc Id: NP_569087   ⟸   NM_130403
- UniProtKB: Q99MC0 (UniProtKB/Swiss-Prot),   A6J9Q5 (UniProtKB/TrEMBL),   A0A8L2QF19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444133   ⟸   XM_017588644
- Peptide Label: isoform X1
- UniProtKB: Q99MC0 (UniProtKB/Swiss-Prot),   A6J9Q5 (UniProtKB/TrEMBL),   A0A8L2QF19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028070   ⟸   ENSRNOT00000028070
RefSeq Acc Id: XP_063117408   ⟸   XM_063261338
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063117377   ⟸   XM_063261307
- Peptide Label: isoform X1
- UniProtKB: Q99MC0 (UniProtKB/Swiss-Prot),   A0A8L2QF19 (UniProtKB/TrEMBL),   A6J9Q5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117401   ⟸   XM_063261331
- Peptide Label: isoform X1
- UniProtKB: Q99MC0 (UniProtKB/Swiss-Prot),   A0A8L2QF19 (UniProtKB/TrEMBL),   A6J9Q5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117388   ⟸   XM_063261318
- Peptide Label: isoform X1
- UniProtKB: Q99MC0 (UniProtKB/Swiss-Prot),   A0A8L2QF19 (UniProtKB/TrEMBL),   A6J9Q5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MC0-F1-model_v2 AlphaFold Q99MC0 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689894
Promoter ID:EPDNEW_R419
Type:multiple initiation site
Name:Ppp1r14a_1
Description:protein phosphatase 1, regulatory subunit 14A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0187,228,573 - 87,228,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620536 AgrOrtholog
BioCyc Gene G2FUF-60183 BioCyc
Ensembl Genes ENSRNOG00000020676 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055033388 UniProtKB/Swiss-Prot
  ENSRNOG00060032904 UniProtKB/Swiss-Prot
  ENSRNOG00065034073 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028070.4 UniProtKB/TrEMBL
  ENSRNOT00055057741 UniProtKB/Swiss-Prot
  ENSRNOT00060057044 UniProtKB/Swiss-Prot
  ENSRNOT00065058548 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CPI-17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPI-17_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114004 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16188 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP1_inhibitor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r14a PhenoGen
RatGTEx ENSRNOG00000020676 RatGTEx
  ENSRNOG00055033388 RatGTEx
  ENSRNOG00060032904 RatGTEx
  ENSRNOG00065034073 RatGTEx
Superfamily-SCOP SSF81790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QF19 ENTREZGENE, UniProtKB/TrEMBL
  A6J9Q5 ENTREZGENE, UniProtKB/TrEMBL
  PP14A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ppp1r14a  protein phosphatase 1, regulatory (inhibitor) subunit 14A    protein phosphatase 1, regulatory (inhibitor) subunit 14a  Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ppp1r14a        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in smooth muscle tissues and brain 633337
gene_protein phosphorylation at Thr38 significantly enhances the inhibitory activity 633337
gene_regulation phosphorylated by p21-activated protein kinase (PAK) 633337