Bcl3 (BCL3, transcription coactivator) - Rat Genome Database

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Gene: Bcl3 (BCL3, transcription coactivator) Rattus norvegicus
Analyze
Symbol: Bcl3
Name: BCL3, transcription coactivator
RGD ID: 1589465
Description: Predicted to enable several functions, including histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in several processes, including intracellular signal transduction; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including defense response to other organism; lymphocyte activation involved in immune response; and regulation of cytokine production. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Predicted to be active in nucleus. Orthologous to human BCL3 (BCL3 transcription coactivator); PARTICIPATES IN nuclear factor kappa B signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell CLL/lymphoma 3; B-cell leukemia/lymphoma 3; LOC680611; similar to B-cell leukemia/lymphoma 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,471,368 - 79,485,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,471,369 - 79,485,607 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,865,812 - 84,880,060 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0193,417,233 - 93,431,531 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,620,930 - 86,635,179 (-)NCBIRnor_WKY
Rnor_6.0180,730,758 - 80,745,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,730,499 - 80,744,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,996,116 - 82,010,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,122,801 - 79,137,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,929,432 - 73,943,668 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
closantel  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
o-anisidine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral response  (ISO)
cellular response to DNA damage stimulus  (ISO)
defense response to bacterium  (ISO)
defense response to protozoan  (ISO)
DNA damage response, signal transduction by p53 class mediator  (ISO)
extracellular matrix organization  (ISO)
follicular dendritic cell differentiation  (ISO)
germinal center formation  (ISO)
humoral immune response mediated by circulating immunoglobulin  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
marginal zone B cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of T cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of translation  (ISO)
positive regulation of type II interferon production  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (IBA,ISO)
regulation of DNA binding  (ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
response to UV-C  (ISO)
response to virus  (ISO)
spleen development  (ISO)
T cell apoptotic process  (ISO)
T-helper 1 type immune response  (ISO)
T-helper 2 cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Bourteele S, etal., Cell Microbiol. 2007 Sep;9(9):2202-17. doi: 10.1111/j.1462-5822.2007.00950.x. Epub 2007 Jun 15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8196632   PMID:9009202   PMID:9133427   PMID:9407099   PMID:10586052   PMID:11387332   PMID:15465827   PMID:16081776   PMID:16108830   PMID:16280327   PMID:16306601   PMID:16384933  
PMID:16732314   PMID:16790793   PMID:16832056   PMID:20391111   PMID:21787835  


Genomics

Comparative Map Data
Bcl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,471,368 - 79,485,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,471,369 - 79,485,607 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,865,812 - 84,880,060 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0193,417,233 - 93,431,531 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,620,930 - 86,635,179 (-)NCBIRnor_WKY
Rnor_6.0180,730,758 - 80,745,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,730,499 - 80,744,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,996,116 - 82,010,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,122,801 - 79,137,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,929,432 - 73,943,668 (-)NCBICelera
Cytogenetic Map1q21NCBI
BCL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,747,705 - 44,760,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,747,705 - 44,760,044 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,251,965 - 45,263,301 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361949,943,820 - 49,955,141 (+)NCBINCBI36Build 36hg18NCBI36
Build 341949,943,870 - 49,955,140NCBI
Celera1942,056,341 - 42,067,659 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,684,123 - 41,695,446 (+)NCBIHuRef
CHM1_11945,254,671 - 45,265,984 (+)NCBICHM1_1
T2T-CHM13v2.01947,573,457 - 47,584,794 (+)NCBIT2T-CHM13v2.0
Bcl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,542,387 - 19,556,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,542,387 - 19,556,695 (-)EnsemblGRCm39 Ensembl
GRCm38719,808,462 - 19,822,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,808,462 - 19,822,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,393,811 - 20,408,104 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,966,984 - 18,981,237 (-)NCBIMGSCv36mm8
Celera717,216,447 - 17,230,740 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.95NCBI
Bcl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,856,250 - 1,911,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,898,280 - 1,911,466 (+)NCBIChiLan1.0ChiLan1.0
BCL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11950,300,536 - 50,313,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,304,171 - 50,313,005 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01941,696,162 - 41,708,485 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BCL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,620,850 - 110,628,830 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,620,827 - 110,654,771 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,101,153 - 110,110,307 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,182,359 - 111,191,517 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,182,355 - 111,191,596 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,824,152 - 110,833,305 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,459,826 - 110,468,966 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,329,233 - 111,338,394 (-)NCBIUU_Cfam_GSD_1.0
Bcl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,070,141 - 17,080,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,416,249 - 1,427,407 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367061,410,848 - 1,427,822 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,256,033 - 51,265,351 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,256,033 - 51,264,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,155,282 - 47,164,826 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,228,137 - 38,243,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607317,792,297 - 17,806,174 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,656,783 - 1,667,575 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,656,803 - 1,666,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl3
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:299
Count of miRNA genes:192
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000025913
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat

Markers in Region
RH142265  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1821.8UniSTS
Cytogenetic Map1q21UniSTS
RH143817  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,471,648 - 79,471,894 (+)MAPPERmRatBN7.2
Rnor_6.0180,731,038 - 80,731,283NCBIRnor6.0
Rnor_5.0181,996,396 - 81,996,641UniSTSRnor5.0
RGSC_v3.4179,123,081 - 79,123,326UniSTSRGSC3.4
Celera173,929,712 - 73,929,957UniSTS
RH 3.4 Map1820.0UniSTS
Cytogenetic Map1q21UniSTS
D1Bda4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,474,400 - 79,474,569 (+)MAPPERmRatBN7.2
Rnor_6.0180,733,790 - 80,733,958NCBIRnor6.0
Rnor_5.0181,999,148 - 81,999,316UniSTSRnor5.0
RGSC_v3.4179,125,833 - 79,126,001UniSTSRGSC3.4
Celera173,932,464 - 73,932,632UniSTS
Cytogenetic Map1q21UniSTS
RH137365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,471,419 - 79,471,599 (+)MAPPERmRatBN7.2
Rnor_6.0180,730,809 - 80,730,988NCBIRnor6.0
Rnor_5.0181,996,167 - 81,996,346UniSTSRnor5.0
RGSC_v3.4179,122,852 - 79,123,031UniSTSRGSC3.4
Celera173,929,483 - 73,929,662UniSTS
RH 3.4 Map1787.4UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 2 5 2 6 3
Low 39 55 39 14 39 5 8 17 35 35 8 5
Below cutoff 4 3 3 55 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025913   ⟹   ENSRNOP00000025913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,471,369 - 79,485,607 (-)Ensembl
Rnor_6.0 Ensembl180,730,499 - 80,744,831 (-)Ensembl
RefSeq Acc Id: NM_001109422   ⟹   NP_001102892
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,471,369 - 79,485,607 (-)NCBI
Rnor_6.0180,730,758 - 80,744,993 (-)NCBI
Rnor_5.0181,996,116 - 82,010,432 (-)NCBI
RGSC_v3.4179,122,801 - 79,137,035 (-)RGD
Celera173,929,432 - 73,943,668 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090517   ⟹   XP_038946445
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,471,368 - 79,485,908 (-)NCBI
RefSeq Acc Id: XM_039090522   ⟹   XP_038946450
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,471,368 - 79,485,898 (-)NCBI
RefSeq Acc Id: XM_039090524   ⟹   XP_038946452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2179,471,368 - 79,479,298 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102892 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946445 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946450 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946452 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08129 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102892   ⟸   NM_001109422
- UniProtKB: D3ZQF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025913   ⟸   ENSRNOT00000025913
RefSeq Acc Id: XP_038946445   ⟸   XM_039090517
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946450   ⟸   XM_039090522
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946452   ⟸   XM_039090524
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQF8-F1-model_v2 AlphaFold D3ZQF8 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589465 AgrOrtholog
BioCyc Gene G2FUF-60483 BioCyc
Ensembl Genes ENSRNOG00000043416 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025913 ENTREZGENE
  ENSRNOP00000025913.6 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025913 ENTREZGENE
  ENSRNOT00000025913.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
NCBI Gene 680611 ENTREZGENE
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
PhenoGen Bcl3 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt D3ZQF8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Bcl3  BCL3, transcription coactivator  Bcl3  B-cell CLL/lymphoma 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bcl3  B-cell CLL/lymphoma 3  Bcl3  B-cell leukemia/lymphoma 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Bcl3  B-cell leukemia/lymphoma 3  LOC686871  similar to B-cell leukemia/lymphoma 3  Data Merged 1643240 APPROVED
2008-03-05 Bcl3  B-cell leukemia/lymphoma 3  LOC680611  similar to B-cell leukemia/lymphoma 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC686871  similar to B-cell leukemia/lymphoma 3      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC680611  similar to B-cell leukemia/lymphoma 3      Symbol and Name status set to provisional 70820 PROVISIONAL