Klk1 (kallikrein 1) - Rat Genome Database

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Gene: Klk1 (kallikrein 1) Rattus norvegicus
Analyze
Symbol: Klk1
Name: kallikrein 1
RGD ID: 2969
Description: Exhibits endopeptidase activity. Involved in several processes, including positive regulation of acute inflammatory response; positive regulation of apoptotic process; and response to nutrient. Localizes to acrosomal vesicle; apical part of cell; and nucleus. Biomarker of hypertension and pancreatitis. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: esterase B; glandular kallikrein-7, submandibular/renal; KAL; KALA; Kallikrein 1 renal/pancreas/salivary; Kallikrein 1, renal/pancreas/salivary; kallikrein 1-like peptidase; kallikrein 1-related peptidase C7; kallikrein 5; kallikrein 7; kallikrein a3; kallikrein-related protein K1; Klk1c7; Klk1l; Klk5; Klk7; Klna3; proteinase A; RATKALA; renal kallikrein; RGK-7; RSKG-7; tissue kallikrein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp154  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2194,642,722 - 94,646,714 (+)NCBI
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01100,131,562 - 100,135,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01101,196,673 - 101,200,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,624,828 - 94,628,822NCBIRGSC3.4rn4RGSC3.4
Celera188,909,593 - 88,913,587 (+)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitroaniline  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
aniline  (ISO)
benzamidine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
dobutamine  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrochlorothiazide  (EXP)
icatibant  (EXP)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
magnesium atom  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
nitric oxide  (EXP)
pentanal  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
propanal  (ISO)
rotenone  (ISO)
S-allylcysteine  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium atom  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
troglitazone  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2183721   PMID:2194829   PMID:3482210   PMID:8662704   PMID:15060002   PMID:15203212   PMID:17366701   PMID:19020030   PMID:19056867   PMID:19124682   PMID:19232384   PMID:19816038  
PMID:23376485   PMID:26252163   PMID:31299611  


Genomics

Comparative Map Data
Klk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2194,642,722 - 94,646,714 (+)NCBI
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01100,131,562 - 100,135,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01101,196,673 - 101,200,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,624,828 - 94,628,822NCBIRGSC3.4rn4RGSC3.4
Celera188,909,593 - 88,913,587 (+)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q22NCBI
KLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1950,819,146 - 50,823,787 (-)EnsemblGRCh38hg38GRCh38
GRCh381950,819,146 - 50,823,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371951,322,402 - 51,327,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,014,216 - 56,018,855 (-)NCBINCBI36hg18NCBI36
Build 341956,014,215 - 56,018,855NCBI
Celera1948,373,507 - 48,378,146 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,656,911 - 47,662,085 (-)NCBIHuRef
CHM1_11951,324,194 - 51,328,835 (-)NCBICHM1_1
Klk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,874,784 - 43,879,046 (+)NCBIGRCm39mm39
GRCm39 Ensembl743,874,784 - 43,879,042 (+)Ensembl
GRCm38744,225,360 - 44,229,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,225,360 - 44,229,618 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,480,807 - 51,484,987 (+)NCBIGRCm37mm9NCBIm37
MGSCv36744,093,479 - 44,097,659 (+)NCBImm8
Celera739,683,707 - 39,687,887 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.74NCBI
Klk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955559457,030 - 461,086 (+)NCBIChiLan1.0ChiLan1.0
KLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11956,677,579 - 56,682,216 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,677,579 - 56,682,216 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01947,784,368 - 47,789,004 (-)NCBIMhudiblu_PPA_v0panPan3
KLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,009,125 - 106,028,331 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,963,564 - 106,028,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,598,741 - 105,603,026 (+)NCBI
ROS_Cfam_1.01106,536,071 - 106,540,357 (+)NCBI
UMICH_Zoey_3.11106,208,615 - 106,212,897 (+)NCBI
UNSW_CanFamBas_1.01105,850,090 - 105,854,369 (+)NCBI
UU_Cfam_GSD_1.01106,690,688 - 106,694,973 (+)NCBI
Klk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,658,123 - 22,661,971 (-)NCBI
SpeTri2.0NW_004936889534,127 - 537,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,570,630 - 55,576,637 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,570,632 - 55,576,398 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,469,507 - 51,475,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,867,629 - 43,873,364 (-)NCBI
ChlSab1.1 Ensembl643,867,596 - 43,872,178 (-)Ensembl
Klk1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248323,869,255 - 3,873,350 (+)NCBI

Position Markers
D1Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01100,133,276 - 100,133,395NCBIRnor6.0
Rnor_5.01101,198,387 - 101,198,506UniSTSRnor5.0
RGSC_v3.4194,626,541 - 94,626,661RGDRGSC3.4
RGSC_v3.4194,626,542 - 94,626,661UniSTSRGSC3.4
RGSC_v3.1194,704,652 - 94,704,772RGD
Celera188,911,307 - 88,911,426UniSTS
RH 3.4 Map1906.0UniSTS
RH 3.4 Map1906.0RGD
RH 2.0 Map1581.8RGD
Cytogenetic Map1q22UniSTS
D1Mit20  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01100,372,157 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,236 - 101,154,356NCBIRnor5.0
Rnor_5.01100,934,189 - 100,934,363NCBIRnor5.0
Rnor_5.01100,934,188 - 100,934,363NCBIRnor5.0
Rnor_5.01100,372,156 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,235 - 101,154,356NCBIRnor5.0
RGSC_v3.4194,582,077 - 94,582,196UniSTSRGSC3.4
RGSC_v3.4194,582,076 - 94,582,196RGDRGSC3.4
RGSC_v3.4194,356,875 - 94,357,049RGDRGSC3.4
RGSC_v3.4194,356,876 - 94,357,049UniSTSRGSC3.4
RGSC_v3.1194,660,187 - 94,660,307RGD
Celera188,866,843 - 88,866,962UniSTS
Celera188,646,815 - 88,646,988UniSTS
RH 3.4 Map1905.2RGD
RH 3.4 Map1905.2UniSTS
Cytogenetic Map1q22UniSTS
D1Mco28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01100,133,248 - 100,133,384NCBIRnor6.0
Rnor_5.01101,198,359 - 101,198,495UniSTSRnor5.0
RGSC_v3.4194,626,513 - 94,626,650RGDRGSC3.4
RGSC_v3.4194,626,514 - 94,626,650UniSTSRGSC3.4
RGSC_v3.1194,704,624 - 94,704,761RGD
Celera188,911,279 - 88,911,415UniSTS
Cytogenetic Map1q22UniSTS
D1Arb51  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01100,133,111 - 100,133,428NCBIRnor6.0
Rnor_5.01101,198,222 - 101,198,539UniSTSRnor5.0
RGSC_v3.4194,626,377 - 94,626,694UniSTSRGSC3.4
RGSC_v3.1194,704,487 - 94,704,805RGD
Celera188,911,142 - 88,911,459UniSTS
Cytogenetic Map1q22UniSTS
RH94541  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0199,403,569 - 99,403,737NCBIRnor6.0
Rnor_6.01100,198,724 - 100,198,892NCBIRnor6.0
Rnor_5.01101,263,835 - 101,264,003UniSTSRnor5.0
Rnor_5.01100,475,598 - 100,475,766UniSTSRnor5.0
RGSC_v3.4194,692,523 - 94,692,691UniSTSRGSC3.4
Celera188,975,923 - 88,976,091UniSTS
RH 3.4 Map1885.69UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)183502376128502376Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)183656882126240667Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185779320130779320Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185917265130917265Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)186776571131776571Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)188634585106002500Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)191093646136093646Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)194225372130917265Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)199983293127203999Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000025831, ENSRNOT00000073513, ENSRNOT00000074179
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073513   ⟹   ENSRNOP00000067273
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074179   ⟹   ENSRNOP00000064005
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)Ensembl
RefSeq Acc Id: NM_012593   ⟹   NP_036725
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2194,642,722 - 94,646,714 (+)NCBI
Rnor_6.01100,131,562 - 100,135,556 (+)NCBI
Rnor_5.01101,196,673 - 101,200,667 (+)NCBI
RGSC_v3.4194,624,828 - 94,628,822 (+)RGD
Celera188,909,593 - 88,913,587 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036725 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41461 (Get FASTA)   NCBI Sequence Viewer  
  P36373 (Get FASTA)   NCBI Sequence Viewer  
  SFW93259 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036725   ⟸   NM_012593
- Peptide Label: precursor
- UniProtKB: P36373 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067273   ⟸   ENSRNOT00000073513
RefSeq Acc Id: ENSRNOP00000064005   ⟸   ENSRNOT00000074179
Protein Domains
Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2969 AgrOrtholog
Ensembl Genes ENSRNOG00000032857 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000045980 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000046267 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064005 UniProtKB/TrEMBL
  ENSRNOP00000066004 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000067273 UniProtKB/TrEMBL
  ENSRNOP00000070080 UniProtKB/TrEMBL
  ENSRNOP00000073798 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071416 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000073513 UniProtKB/TrEMBL
  ENSRNOT00000074179 UniProtKB/TrEMBL
  ENSRNOT00000081095 UniProtKB/TrEMBL
  ENSRNOT00000091964 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24523 UniProtKB/Swiss-Prot
NCBI Gene 24523 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klk1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232167
UniProt A0A0G2JX00_RAT UniProtKB/TrEMBL
  A0A0G2K6G1_RAT UniProtKB/TrEMBL
  G3V8H1_RAT UniProtKB/TrEMBL
  KLK7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IE13_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-15 Klk1  kallikrein 1  Klk1c7  kallikrein 1-related peptidase C7  Name and Symbol changed 629549 APPROVED
2011-06-29 Klk1c7  kallikrein 1-related peptidase C7  Klk1l  kallikrein 1-like peptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Klk1l  kallikrein 1-like peptidase  Klk7  kallikrein 7  Symbol and Name updated 1299863 APPROVED
2006-12-01 Klk7  kallikrein 7  Klk5  kallikrein 5  Symbol and Name updated 1299863 APPROVED
2004-09-10 Klk5  kallikrein 5  Klk1  kallikrein 1  Symbol and Name updated 1299863 APPROVED
2002-11-06 Klk1  kallikrein 1    Kallikrein 1, renal/pancreas/salivary  Name updated 625702 APPROVED
2002-06-10 Klk1  Kallikrein 1, renal/pancreas/salivary      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney and submandibular gland 728960