Klk1 (kallikrein 1) - Rat Genome Database

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Gene: Klk1 (kallikrein 1) Rattus norvegicus
Symbol: Klk1
Name: kallikrein 1
RGD ID: 2969
Description: Enables endopeptidase activity. Involved in several processes, including positive regulation of acute inflammatory response; positive regulation of apoptotic process; and response to nutrient. Located in acrosomal vesicle; apical part of cell; and nucleus. Biomarker of hypertension and pancreatitis. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: esterase B; glandular kallikrein-7, submandibular/renal; KAL; KALA; Kallikrein 1 renal/pancreas/salivary; Kallikrein 1, renal/pancreas/salivary; kallikrein 1-like peptidase; kallikrein 1-related peptidase C7; kallikrein 5; kallikrein 7; kallikrein a3; kallikrein-related protein K1; Klk1c7; Klk1l; Klk5; Klk7; Klna3; proteinase A; RATKALA; renal kallikrein; RGK-7; RSKG-7; tissue kallikrein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp154  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2194,642,722 - 94,646,714 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,642,687 - 94,646,754 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,028,087 - 100,032,085 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01108,500,727 - 108,504,721 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01101,791,341 - 101,795,329 (+)NCBIRnor_WKY
Rnor_6.01100,131,562 - 100,135,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,196,673 - 101,200,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,624,828 - 94,628,822NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera188,909,593 - 88,913,587 (+)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-nitroaniline  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
aniline  (ISO)
benzamidine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (EXP)
carbon nanotube  (ISO)
carrageenan  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
dobutamine  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrochlorothiazide  (EXP)
icatibant  (EXP)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
magnesium atom  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
nitric oxide  (EXP)
pentanal  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
procyanidin B2  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium atom  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of two rat renal kallikrein genes. Chen YP, etal., Biochemistry 1988 Sep 20;27(19):7189-96.
2. Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. Chiang WC, etal., Free Radic Biol Med. 2006 Oct 15;41(8):1304-14. Epub 2006 Jul 15.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation. Griesbacher T, etal., Br J Pharmacol. 2003 May;139(2):299-308.
5. Regulatory effects of salt diet on renal renin-angiotensin-aldosterone, and kallikrein-kinin systems. Hettinger U, etal., Int Immunopharmacol. 2002 Dec;2(13-14):1975-80.
6. Rat tissue kallikrein releases a kallidin-like peptide from rat low-molecular-weight kininogen. Hilgenfeldt U, etal., Br J Pharmacol. 2005 Dec;146(7):958-63.
7. Biochemical and immunohistochemical demonstration of tissue kallikrein in the neuronal nuclei of the developing rat brains. Iwadate H, etal., Brain Res. 2000 Apr 28;863(1-2):87-93.
8. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
9. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. Iwai N, etal., J Hypertens. 2004 Jun;22(6):1119-26.
10. Growth-stimulating effect of kallikrein on rat neural stem cells--II. Immunocytochemical analysis and specificity of the enzyme for neural stem cells. Kizuki K, etal., Yakugaku Zasshi. 2007 May;127(5):919-22.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux. Lee-Chen GJ, etal., Kidney Int. 2004 Apr;65(4):1467-72.
13. Tissue kallikrein and bradykinin B2 receptors in the reproductive tract of the male rat. Monsees TK, etal., Andrologia. 2003 Feb;35(1):24-31.
14. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury. Souza DG, etal., Br J Pharmacol. 2003 May;139(1):129-39.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Myocardial expression of rat bradykinin receptors and two tissue kallikrein genes in experimental diabetes. Tschope C, etal., Immunopharmacology. 1999 Oct 15;44(1-2):35-42.
22. Organization and expression of the rat kallikrein gene family. Wines DR, etal., J Biol Chem 1989 May 5;264(13):7653-62.
23. Association of the tissue kallikrein gene promoter with ESRD and hypertension. Yu H, etal., Kidney Int. 2002 Mar;61(3):1030-9.
Additional References at PubMed
PMID:2183721   PMID:2194829   PMID:3482210   PMID:8662704   PMID:15060002   PMID:15203212   PMID:17366701   PMID:19020030   PMID:19056867   PMID:19124682   PMID:19232384   PMID:19816038  
PMID:23376485   PMID:26252163   PMID:31299611   PMID:33355364  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2194,642,722 - 94,646,714 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,642,687 - 94,646,754 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,028,087 - 100,032,085 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01108,500,727 - 108,504,721 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01101,791,341 - 101,795,329 (+)NCBIRnor_WKY
Rnor_6.01100,131,562 - 100,135,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,196,673 - 101,200,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,624,828 - 94,628,822NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera188,909,593 - 88,913,587 (+)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381950,819,146 - 50,823,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1950,819,146 - 50,823,787 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,322,402 - 51,327,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,014,216 - 56,018,855 (-)NCBINCBI36Build 36hg18NCBI36
Build 341956,014,215 - 56,018,855NCBI
Celera1948,373,507 - 48,378,146 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,656,911 - 47,662,085 (-)NCBIHuRef
CHM1_11951,324,194 - 51,328,835 (-)NCBICHM1_1
T2T-CHM13v2.01953,908,789 - 53,913,431 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39743,874,784 - 43,879,046 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,874,784 - 43,879,042 (+)EnsemblGRCm39 Ensembl
GRCm38744,225,360 - 44,229,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,225,360 - 44,229,618 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,480,807 - 51,484,987 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,093,479 - 44,097,659 (+)NCBIMGSCv36mm8
Celera739,683,707 - 39,687,887 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.74NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955559456,932 - 465,704 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955559457,030 - 461,086 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11956,677,579 - 56,682,216 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,677,579 - 56,682,216 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01947,784,368 - 47,789,004 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11106,009,125 - 106,028,331 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,963,564 - 106,028,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,598,741 - 105,603,026 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,536,071 - 106,540,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,520,716 - 106,540,357 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,208,615 - 106,212,897 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,850,090 - 105,854,369 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,690,688 - 106,694,973 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934922,658,123 - 22,661,971 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936889534,127 - 537,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl655,570,635 - 55,576,636 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,570,632 - 55,576,398 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,469,507 - 51,475,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1643,867,629 - 43,873,364 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,867,596 - 43,872,178 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,888,895 - 23,894,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248323,868,465 - 3,873,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,869,255 - 3,873,350 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Klk1
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000025831, ENSRNOT00000073513, ENSRNOT00000074179
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,644,435 - 94,644,553 (+)MAPPERmRatBN7.2
Rnor_6.01100,133,276 - 100,133,395NCBIRnor6.0
Rnor_5.01101,198,387 - 101,198,506UniSTSRnor5.0
RGSC_v3.4194,626,541 - 94,626,661RGDRGSC3.4
RGSC_v3.4194,626,542 - 94,626,661UniSTSRGSC3.4
RGSC_v3.1194,704,652 - 94,704,772RGD
Celera188,911,307 - 88,911,426UniSTS
RH 3.4 Map1906.0UniSTS
RH 3.4 Map1906.0RGD
RH 2.0 Map1581.8RGD
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01100,372,157 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,236 - 101,154,356NCBIRnor5.0
Rnor_5.01100,934,189 - 100,934,363NCBIRnor5.0
Rnor_5.01100,934,188 - 100,934,363NCBIRnor5.0
Rnor_5.01100,372,156 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,235 - 101,154,356NCBIRnor5.0
RGSC_v3.4194,582,077 - 94,582,196UniSTSRGSC3.4
RGSC_v3.4194,582,076 - 94,582,196RGDRGSC3.4
RGSC_v3.4194,356,875 - 94,357,049RGDRGSC3.4
RGSC_v3.4194,356,876 - 94,357,049UniSTSRGSC3.4
RGSC_v3.1194,660,187 - 94,660,307RGD
Celera188,866,843 - 88,866,962UniSTS
Celera188,646,815 - 88,646,988UniSTS
RH 3.4 Map1905.2RGD
RH 3.4 Map1905.2UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,644,407 - 94,644,542 (+)MAPPERmRatBN7.2
Rnor_6.01100,133,248 - 100,133,384NCBIRnor6.0
Rnor_5.01101,198,359 - 101,198,495UniSTSRnor5.0
RGSC_v3.4194,626,513 - 94,626,650RGDRGSC3.4
RGSC_v3.4194,626,514 - 94,626,650UniSTSRGSC3.4
RGSC_v3.1194,704,624 - 94,704,761RGD
Celera188,911,279 - 88,911,415UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,644,270 - 94,644,586 (+)MAPPERmRatBN7.2
Rnor_6.01100,133,111 - 100,133,428NCBIRnor6.0
Rnor_5.01101,198,222 - 101,198,539UniSTSRnor5.0
RGSC_v3.4194,626,377 - 94,626,694UniSTSRGSC3.4
RGSC_v3.1194,704,487 - 94,704,805RGD
Celera188,911,142 - 88,911,459UniSTS
Cytogenetic Map1q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2194,708,771 - 94,708,940 (+)MAPPERmRatBN7.2
Rnor_6.01100,198,724 - 100,198,892NCBIRnor6.0
Rnor_6.0199,403,569 - 99,403,737NCBIRnor6.0
Rnor_5.01101,263,835 - 101,264,003UniSTSRnor5.0
Rnor_5.01100,475,598 - 100,475,766UniSTSRnor5.0
RGSC_v3.4194,692,523 - 94,692,691UniSTSRGSC3.4
Celera188,975,923 - 88,976,091UniSTS
RH 3.4 Map1885.69UniSTS
Cytogenetic Map1q22UniSTS



Reference Sequences
RefSeq Acc Id: ENSRNOT00000073513   ⟹   ENSRNOP00000067273
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074179   ⟹   ENSRNOP00000064005
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091964   ⟹   ENSRNOP00000073798
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,642,687 - 94,646,516 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096913   ⟹   ENSRNOP00000076863
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,642,687 - 94,646,754 (+)Ensembl
RefSeq Acc Id: NM_012593   ⟹   NP_036725
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2194,642,722 - 94,646,714 (+)NCBI
Rnor_6.01100,131,562 - 100,135,556 (+)NCBI
Rnor_5.01101,196,673 - 101,200,667 (+)NCBI
RGSC_v3.4194,624,828 - 94,628,822 (+)RGD
Celera188,909,593 - 88,913,587 (+)RGD
Protein Sequences
Protein RefSeqs NP_036725 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41461 (Get FASTA)   NCBI Sequence Viewer  
  P36373 (Get FASTA)   NCBI Sequence Viewer  
  SFW93259 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036725   ⟸   NM_012593
- Peptide Label: precursor
- UniProtKB: G3V8H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067273   ⟸   ENSRNOT00000073513
RefSeq Acc Id: ENSRNOP00000064005   ⟸   ENSRNOT00000074179
RefSeq Acc Id: ENSRNOP00000076863   ⟸   ENSRNOT00000096913
RefSeq Acc Id: ENSRNOP00000073798   ⟸   ENSRNOT00000091964
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36373-F1-model_v2 AlphaFold P36373 1-261 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2969 AgrOrtholog
BioCyc Gene G2FUF-59799 BioCyc
Ensembl Genes ENSRNOG00000032857 Ensembl
  ENSRNOG00000045980 Ensembl
  ENSRNOG00000046267 Ensembl
  ENSRNOG00000068378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073798.2 UniProtKB/TrEMBL
  ENSRNOP00000076863.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091964.2 UniProtKB/TrEMBL
  ENSRNOT00000096913.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24523 UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klk1 PhenoGen
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC232167
UniProt A0A0G2K6G1_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-15 Klk1  kallikrein 1  Klk1c7  kallikrein 1-related peptidase C7  Name and Symbol changed 629549 APPROVED
2011-06-29 Klk1c7  kallikrein 1-related peptidase C7  Klk1l  kallikrein 1-like peptidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Klk1l  kallikrein 1-like peptidase  Klk7  kallikrein 7  Symbol and Name updated 1299863 APPROVED
2006-12-01 Klk7  kallikrein 7  Klk5  kallikrein 5  Symbol and Name updated 1299863 APPROVED
2004-09-10 Klk5  kallikrein 5  Klk1  kallikrein 1  Symbol and Name updated 1299863 APPROVED
2002-11-06 Klk1  kallikrein 1    Kallikrein 1, renal/pancreas/salivary  Name updated 625702 APPROVED
2002-06-10 Klk1  Kallikrein 1, renal/pancreas/salivary      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney and submandibular gland 728960