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Gene: Klk1 (kallikrein 1) Rattus norvegicus
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Symbol: Klk1
Name: kallikrein 1
Description: Exhibits endopeptidase activity. Involved in several processes, including positive regulation of acute inflammatory response; positive regulation of apoptotic process; and response to nutrient. Localizes to the acrosomal vesicle; apical part of cell; and nucleus. Biomarker of hypertension and pancreatitis. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal failure; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1); PARTICIPATES IN kallikrein-kinin cascade pathway; INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: esterase B; glandular kallikrein-7, submandibular/renal; KAL; KALA; Kallikrein 1 renal/pancreas/salivary; Kallikrein 1, renal/pancreas/salivary; kallikrein 1-like peptidase; kallikrein 1-related peptidase C7; kallikrein 5; kallikrein 7; kallikrein a3; kallikrein-related protein K1; Klk1c7; Klk1l; Klk5; Klk7; Klna3; proteinase A; RATKALA; renal kallikrein; RGK-7; RSKG-7; tissue kallikrein
Orthologs:
Homo sapiens (human) : KLK1 (kallikrein 1)  HGNC  Alliance
Mus musculus (house mouse) : Klk1 (kallikrein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klk1 (kallikrein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KLK1 (kallikrein 1)
Canis lupus familiaris (dog) : KLK1 (kallikrein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klk1 (kallikrein 1)
Sus scrofa (pig) : KLK1 (kallikrein 1)
Chlorocebus sabaeus (green monkey) : KLK1 (kallikrein 1)
Heterocephalus glaber (naked mole-rat) : Klk1 (kallikrein 1)
more info ...
Is Marker For: QTLs:   Bp154  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01100,131,562 - 100,135,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,362,304 - 99,373,304 (+)Ensembl
Rnor_6.0 Ensembl1100,047,235 - 100,058,235 (+)Ensembl
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)Ensembl
Rnor_5.01101,196,673 - 101,200,667 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,624,828 - 94,628,822NCBIRGSC3.4rn4RGSC3.4
Celera188,909,593 - 88,913,587 (+)NCBICelera
Cytogenetic Map1q22NCBI
RH 3.4 Map1 RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Klk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2969
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.