Cyp2a1 (cytochrome P450, family 2, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp2a1 (cytochrome P450, family 2, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2a1
Name: cytochrome P450, family 2, subfamily a, polypeptide 1
RGD ID: 2463
Description: Enables steroid hydroxylase activity. Involved in coumarin metabolic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; vitamin A deficiency pathway; caffeine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIIA1; cytochrome P450 2A1; cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1); cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene; cytochrome P450-UT-F; P450-UT-F; RATCYP2A1; Shdl; Shdl_mapped; steroid hormones 7-alpha-hydroxylase; steroid hydroxylase, hepatic; steroid hydroxylase, hepatic (mapped); testosterone 7-alpha-hydroxylase
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,231,611 - 82,244,887 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)Ensembl
Rnor_6.0183,711,223 - 83,725,222 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,925,733 - 84,938,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,006,828 - 82,020,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,084,938 - 82,098,390 (+)NCBI
Celera176,649,089 - 76,662,287 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (EXP,ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-benzylpiperazine  (EXP)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
3-methyleneindolenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-oxo-4-(pyridin-3-yl)butanal  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acenaphthene  (ISO)
acenaphthylene  (ISO)
acetophenones  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amodiaquine  (ISO)
Aroclor 1254  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
biphenyl  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP)
chlorohydrocarbon  (EXP)
cholic acid  (EXP)
chrysin  (ISO)
clofibrate  (EXP)
clomipramine  (EXP)
coumarin  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
DDT  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dichloroacetic acid  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
farnesol  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
Furafylline  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
glafenine  (EXP)
hexamethylphosphoric triamide  (ISO)
imipramine  (EXP)
ketoconazole  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
m-xylene  (EXP)
methimazole  (EXP)
methoxsalen  (EXP,ISO)
methyl tert-butyl ether  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (EXP)
N'-Nitrosoanabasine  (ISO)
N'-Nitrosoanatabine  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylaniline  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosoguvacoline  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
oxycodone  (EXP)
phenanthrene  (ISO)
phenanthrenes  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quinomethionate  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
semicarbazide  (EXP)
senecionine  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
tamoxifen  (EXP)
taurocholic acid  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
tranylcypromine  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2650624   PMID:3436956   PMID:22217848  


Genomics

Comparative Map Data
Cyp2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,231,611 - 82,244,887 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)Ensembl
Rnor_6.0183,711,223 - 83,725,222 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,925,733 - 84,938,423 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,006,828 - 82,020,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1182,084,938 - 82,098,390 (+)NCBI
Celera176,649,089 - 76,662,287 (+)NCBICelera
Cytogenetic Map1q21NCBI
CYP2A13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,088,451 - 41,096,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1941,088,451 - 41,096,195 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,594,356 - 41,602,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,286,208 - 46,293,939 (+)NCBINCBI36hg18NCBI36
Build 341946,286,207 - 46,293,939NCBI
Celera1938,394,537 - 38,402,261 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,026,475 - 38,034,212 (+)NCBIHuRef
CHM1_11941,594,072 - 41,601,816 (+)NCBICHM1_1
Cyp2a22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,631,056 - 26,638,838 (-)NCBIGRCm39mm39
GRCm39 Ensembl726,631,056 - 26,638,809 (-)Ensembl
GRCm38726,931,631 - 26,939,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,931,631 - 26,939,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv37727,716,650 - 27,724,405 (-)NCBIGRCm37mm9NCBIm37
MGSCv36726,640,391 - 26,648,146 (-)NCBImm8
MGSCv36719,166,984 - 19,174,739 (-)NCBImm8
Celera721,502,433 - 21,510,189 (-)NCBICelera
Cytogenetic Map7A3NCBI
CYP2A13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,932,246 - 112,938,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,931,985 - 112,938,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,334,931 - 112,340,932 (-)NCBI
ROS_Cfam_1.01113,530,545 - 113,536,550 (-)NCBI
ROS_Cfam_1.0 Ensembl1113,529,888 - 113,536,652 (-)Ensembl
UMICH_Zoey_3.11113,090,324 - 113,096,328 (-)NCBI
UNSW_CanFamBas_1.01112,722,239 - 112,728,251 (-)NCBI
UU_Cfam_GSD_1.01113,716,309 - 113,722,322 (-)NCBI
CYP2A19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,056,578 - 49,064,107 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,056,579 - 49,064,111 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,872,084 - 44,877,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
D1Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,174,743 - 82,174,945 (+)MAPPERmRatBN7.2
Rnor_6.0183,656,882 - 83,657,083NCBIRnor6.0
Rnor_5.0184,871,364 - 84,871,565UniSTSRnor5.0
RGSC_v3.4181,947,771 - 81,947,972UniSTSRGSC3.4
RGSC_v3.4181,947,770 - 81,947,972RGDRGSC3.4
RGSC_v3.1182,025,881 - 82,026,083RGD
Celera176,593,887 - 76,594,088UniSTS
RH 3.4 Map1826.1UniSTS
RH 3.4 Map1826.1RGD
RH 2.0 Map1515.9RGD
Cytogenetic Map1q21UniSTS
D1Mco22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,230,245 - 82,230,468 (+)MAPPERmRatBN7.2
Rnor_6.0183,709,886 - 83,710,108NCBIRnor6.0
Rnor_5.0184,924,368 - 84,924,590UniSTSRnor5.0
RGSC_v3.4182,005,462 - 82,005,685RGDRGSC3.4
RGSC_v3.4182,005,463 - 82,005,685UniSTSRGSC3.4
RGSC_v3.1182,083,573 - 82,083,796RGD
Celera176,647,724 - 76,647,946UniSTS
Cytogenetic Map1q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000028237
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23 11
Low 17 14 14 2 2 6 1 8 2
Below cutoff 8 17 4 17 4 6 7 24 10 14 6

Sequence


Reference Sequences
RefSeq Acc Id: NM_012692   ⟹   NP_036824
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,231,611 - 82,244,887 (+)NCBI
Rnor_6.0183,711,251 - 83,724,936 (+)NCBI
Rnor_5.0184,925,733 - 84,938,423 (+)NCBI
RGSC_v3.4182,006,828 - 82,020,282 (+)RGD
Celera176,649,089 - 76,662,287 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41020 (Get FASTA)   NCBI Sequence Viewer  
  AAA41030 (Get FASTA)   NCBI Sequence Viewer  
  AAH81848 (Get FASTA)   NCBI Sequence Viewer  
  P11711 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036824   ⟸   NM_012692
- UniProtKB: P11711 (UniProtKB/Swiss-Prot)
- Sequence:

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AF-P11711-F1-model_v2 AlphaFold P11711 1-492 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689839
Promoter ID:EPDNEW_R364
Type:multiple initiation site
Name:Cyp2a1_1
Description:cytochrome P450, family 2, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R365  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,711,245 - 83,711,305EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2463 AgrOrtholog
BioCyc Gene G2FUF-60332 BioCyc
Ensembl Genes ENSRNOG00000020817 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028237 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000028249 UniProtKB/TrEMBL
  ENSRNOP00000068901 UniProtKB/TrEMBL
  ENSRNOP00000071749 UniProtKB/TrEMBL
  ENSRNOP00000074544 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028237 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000028249 UniProtKB/TrEMBL
  ENSRNOT00000084230 UniProtKB/TrEMBL
  ENSRNOT00000085245 UniProtKB/TrEMBL
  ENSRNOT00000092008 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135880 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24894 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93632 IMAGE-MGC_LOAD
NCBI Gene 24894 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp2a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC215723
UniProt A0A0G2JTZ5_RAT UniProtKB/TrEMBL
  A0A0G2K193_RAT UniProtKB/TrEMBL
  A0A0G2K8B6_RAT UniProtKB/TrEMBL
  CP2A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Z4YNS8_RAT UniProtKB/TrEMBL
UniProt Secondary Q642C5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2a1  cytochrome P450, family 2, subfamily a, polypeptide 1  Cyp2a1  cytochrome P450, family 2, subfamily a, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-19 Cyp2a1  cytochrome P450, family 2, subfamily a, polypeptide 1  Cyp2a1  cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-27 Cyp2j5-ps  cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Cyp2a1  Cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Name updated 1299863 APPROVED
2007-04-26 Cyp2a1  Cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Shdl_mapped  steroid hydroxylase, hepatic (mapped)  Data Merged 737654 APPROVED
2005-11-17 Shdl_mapped  steroid hydroxylase, hepatic (mapped)  Shdl  steroid hydroxylase, hepatic  Symbol and Name updated 1556543 APPROVED
2003-04-09 Shdl  steroid hydroxylase, hepatic    Steroid hydroxylase, hepatic  Name updated 629478 APPROVED
2002-06-10 Cyp2a1  Cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Shdl  Steroid hydroxylase, hepatic      Symbol and Name status set to approved 70586 APPROVED