Gene: Ercc1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Rattus norvegicus
Analyze
Symbol:
Ercc1
Name:
ERCC excision repair 1, endonuclease non-catalytic subunit
Description:
Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including response to cadmium ion; response to immobilization stress; and response to sucrose. Localizes to the nucleus. Used to study lung carcinoma. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and transient cerebral ischemia. Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit); PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; LOC292673
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ercc1 (excision repair cross-complementing rodent repair deficiency, complementation group 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ercc1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ercc1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Ercc1 (excision repair cross-complementing rodent repair deficiency, complementation group 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ercc1 (excision repair cross-complementation group 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Ercc1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
RAD10
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
ercc-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 1 80,256,973 - 80,268,198 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 1 81,523,234 - 81,534,459 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 1 78,711,249 - 78,722,474 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 1 78,787,675 - 78,800,533 (+) NCBI Celera 1 73,458,746 - 73,469,951 (+) NCBI Celera Cytogenetic Map 1 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
acute myeloid leukemia no_association ISO RGD:1315921 11252173 DNA:SNP: :p.Q504K (human) RGD acute myeloid leukemia ISO RGD:1315921 11252193 DNA:polymorphism: :p.R399Q (human) RGD acute myeloid leukemia treatment ISO RGD:1315921 11252179 RGD acute myeloid leukemia ISO RGD:1315921 11252171 RGD acute myeloid leukemia ISO RGD:1315921 11252170 RGD alcohol use disorder IEP 10045658 RGD anemia treatment ISO RGD:1315921 11252176 associated with Ovarian Neoplasms, DNA:SNP: :rs11615 (human) RGD azoospermia susceptibility ISO RGD:1315921 13207429 DNA:snp:3' utr:c.8092C>A (human) RGD breast cancer susceptibility ISO RGD:1315921 13207317 DNA:snp:3' utr:c.8092C>A (human) RGD Colorectal Neoplasms severity ISO RGD:1315921 13207315 DNA:snp:cds:c.354C>T (human) RGD Colorectal Neoplasms susceptibility ISO RGD:1315921 13207423 DNA:snp:3' utr:c.8092C>A (human) RGD degenerative disc disease ISO RGD:1315922 13207419 associated with Progeria RGD Diabetes Mellitus, Experimental treatment IEP 7296926 RGD Drug-induced Neutropenia treatment ISO RGD:1315921 11340199 associated with Colorectal Neoplasms, DNA:SNP RGD Drug-Related Side Effects and Adverse Reactions treatment ISO RGD:1315921 11252168 associated with Breast Neoplasms, DNA:SNP: :p.Q504K (human) RGD Drug-Related Side Effects and Adverse Reactions treatment ISO RGD:1315921 11252178 associated with Leukemia, Myeloid, Acute RGD esophagus adenocarcinoma susceptibility ISO RGD:1315921 13207314 DNA:snps:cds, 3' utr:c.354C>T, c.8092C>A (human) RGD esophagus squamous cell carcinoma treatment ISO RGD:1315921 11252162 RGD Gastrointestinal Neoplasms disease_progression ISO RGD:1315921 11252166 RGD Inflammation ISO RGD:1315922 10401088 RGD kidney failure treatment ISO RGD:1315921 5688741 associated with Ovarian Neoplasms, DNA:SNPs: :8092C>A, 19007T>C (human) RGD Laryngeal Neoplasms susceptibility ISO RGD:1315921 13207310 DNA:snp:exon:c.354T>C (human) (rs11615) RGD lipodystrophy ISO RGD:1315922 10401088 RGD lung carcinoma IDA 10045659 RGD lung non-small cell carcinoma severity ISO RGD:1315921 13207308 protein:decreased expression:lung (human) RGD lung non-small cell carcinoma severity ISO RGD:1315921 13207428 DNA:silent mutation:cds:p.N118N (human) RGD malignant glioma susceptibility ISO RGD:1315921 13207318 DNA:snp:3'utr:c.8092C>A (human) (rs3212986) RGD multiple myeloma treatment ISO RGD:1315921 10450871 DNA:SNP: :rs735482 (human) RGD myelofibrosis ISO RGD:1315921 11252175 RGD Myeloid Leukemia, Chronic-Phase treatment ISO RGD:1315921 11252165 DNA:SNP: :rs11615 (human) RGD Neoplasm Metastasis disease_progression ISO RGD:1315921 11252177 associated with Melanoma RGD osteoarthritis ISO RGD:1315922 10045611 mRNA:decreased expression:knee, articular cartilage of joint RGD osteoporosis ISO RGD:1315922 10045609 RGD osteosarcoma severity ISO RGD:1315921 13207418 DNA:silent mutation:cds:p.N118N (human) RGD ovarian cancer disease_progression ISO RGD:1315921 11252174 RGD ovary epithelial cancer disease_progression ISO RGD:1315921 13204969 DNA:snp:3' utr:c.8092C>A (human) RGD pancreatic cancer susceptibility ISO RGD:1315921 13207426 DNA:snp:3' utr:c.*197G>T (rs3212986) (human) RGD precursor lymphoblastic lymphoma/leukemia ISO RGD:1315921 11252160 DNA:SNPs: :8092C>A, 19007G>A (human) RGD precursor lymphoblastic lymphoma/leukemia susceptibility ISO RGD:1315921 11340204 DNA:SNPs, haplotypes: :p.R194W, p.R280H, p.R399Q (human) RGD Premature Aging ISO RGD:1315922 10045610 RGD Prostatic Neoplasms disease_progression ISO RGD:1315922 13204968 RGD Reperfusion Injury IMP 2313668 RGD stomach cancer treatment ISO RGD:1315921 11252163 RGD stomach cancer disease_progression ISO RGD:1315921 11340202 DNA:SNP:exon:354C>T (human) RGD stomach cancer no_association ISO RGD:1315921 13207425 DNA:snp:intron:c.-7-277G>T (human) (rs2298881) RGD stomach cancer severity ISO RGD:1315921 13207427 DNA:snp:3' utr:c.*197G>T (rs3212986) (human) RGD stomach cancer severity ISO RGD:1315921 13207309 DNA:snps:exon, intron:c.354T>C, c.-7-277G>T (human) (rs11615, rs2298881) RGD transient cerebral ischemia treatment ISO RGD:1315921 2313668 human gene in a rat model RGD
Imported Annotations - ClinVar
Cerebrooculofacioskeletal Syndrome 4 ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal syndrome 4 ClinVar Cerebrooculofacioskeletal Syndrome 4 ISO RGD:1315921 8554872 ClinVar Annotator: match by OMIM:610758 ClinVar PMID:17273966 Cerebrooculofacioskeletal Syndrome 4 ISO RGD:1315921 8554872 ClinVar Annotator: match by OMIM:610758 ClinVar PMID:17273966 , PMID:23623389 Cerebrooculofacioskeletal Syndrome 4 ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal syndrome 4 ClinVar PMID:23623389 , PMID:25741868 Cockayne syndrome ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Cockayne syndrome ClinVar PMID:17273966 , PMID:23623389 Cockayne syndrome ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Cockayne syndrome ClinVar PMID:23623389 xeroderma pigmentosum ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar xeroderma pigmentosum ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:15213713 more ... xeroderma pigmentosum ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:25741868 xeroderma pigmentosum group D ISO RGD:1315921 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum, group D ClinVar
Imported Annotations - CTD
Arsenic Poisoning ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12569548 Chromosome Aberrations ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24036326 disease of cellular proliferation ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23203453 Genetic Predisposition to Disease ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24036326 Germ Cell and Embryonal Neoplasms ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19956886 Lung Neoplasms ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30453383 lung non-small cell carcinoma ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21553054 , PMID:23912706 melanoma ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21722328 Neoplasm Metastasis ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20801905 peripheral nervous system disease ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20979931 Stomach Neoplasms ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21133646 Testicular Neoplasms ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19956886 Uterine Cervical Neoplasms ISO RGD:1315921 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20934765 Imported Annotations - MGI
XFE progeroid syndrome ISS RGD:1315922 13592920 OMIM:610965 MouseDO Imported Annotations - OMIM
Cerebrooculofacioskeletal Syndrome 4 ISO RGD:1315921 7240710 OMIM
(+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of ERCC1 mRNA CTD PMID:17971868 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1315922 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 17alpha-ethynylestradiol multiple interactions ISO RGD:1315922 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ERCC1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1315921 6480464 decitabine inhibits the reaction [Estradiol results in decreased expression of ERCC1 mRNA] CTD PMID:22082530 17beta-estradiol decreases expression ISO RGD:1315921 6480464 Estradiol results in decreased expression of ERCC1 mRNA CTD PMID:22082530 1H-pyrazole increases expression ISO RGD:1315922 6480464 pyrazole results in increased expression of ERCC1 mRNA CTD PMID:17945193 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:28712647 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:1315921 6480464 2 more ... CTD PMID:26808241 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1315922 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ERCC1 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ERCC1 promoter] CTD PMID:17942748 , PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1315922 6480464 Tetrachlorodibenzodioxin affects the expression of ERCC1 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of ERCC1 mRNA CTD PMID:21346803 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1315922 6480464 tetrabromobisphenol A results in increased expression of ERCC1 mRNA CTD PMID:25172293 3-aminobenzamide multiple interactions ISO RGD:1315921 6480464 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA], 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 protein] CTD PMID:22228707 3-aminobenzamide multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA] CTD PMID:22228707 3-aminobenzamide decreases expression ISO RGD:1315921 6480464 3-aminobenzamide results in decreased expression of ERCC1 mRNA, 3-aminobenzamide results in decreased expression of ERCC1 protein CTD PMID:22228707 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of ERCC1 mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression ISO RGD:1315922 6480464 4-hydroxy-2-nonenal results in decreased expression of ERCC1 mRNA CTD PMID:19191707 4-hydroxyphenyl retinamide increases expression ISO RGD:1315921 6480464 Fenretinide results in increased expression of ERCC1 protein CTD PMID:15059897 4-hydroxyphenyl retinamide increases expression ISO RGD:1315922 6480464 Fenretinide results in increased expression of ERCC1 mRNA CTD PMID:28973697 5-fluorouracil multiple interactions ISO RGD:1315921 6480464 [Cisplatin co-treated with Fluorouracil] results in decreased expression of ERCC1 mRNA more ... CTD PMID:15173087 more ... 5-fluorouracil decreases expression ISO RGD:1315921 6480464 Fluorouracil results in decreased expression of ERCC1 mRNA CTD PMID:17016597 5-formyltetrahydrofolic acid multiple interactions ISO RGD:1315921 6480464 ERCC1 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:17401013 7,12-dimethyltetraphene decreases expression ISO RGD:1315922 6480464 9 more ... CTD PMID:23717041 7,12-dimethyltetraphene multiple interactions ISO RGD:1315922 6480464 [epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 aflatoxin B1 increases expression ISO RGD:1315921 6480464 Aflatoxin B1 results in increased expression of ERCC1 mRNA CTD PMID:22100608 aldehydo-D-glucose multiple interactions ISO RGD:1315921 6480464 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA] more ... CTD PMID:22228707 aldehydo-D-glucose increases expression ISO RGD:1315921 6480464 Glucose results in increased expression of ERCC1 mRNA, Glucose results in increased expression of ERCC1 protein CTD PMID:22228707 amphibole asbestos increases expression ISO RGD:1315921 6480464 Asbestos, Amphibole results in increased expression of ERCC1 protein CTD PMID:20855422 arsane decreases expression ISO RGD:1315921 6480464 Arsenic results in decreased expression of ERCC1 mRNA, Arsenic results in decreased expression of ERCC1 protein CTD PMID:12569548 , PMID:16882524 arsane increases expression ISO RGD:1315921 6480464 Arsenic results in increased expression of ERCC1 mRNA CTD PMID:19661343 arsenic atom increases expression ISO RGD:1315921 6480464 Arsenic results in increased expression of ERCC1 mRNA CTD PMID:19661343 arsenic atom decreases expression ISO RGD:1315921 6480464 Arsenic results in decreased expression of ERCC1 mRNA, Arsenic results in decreased expression of ERCC1 protein CTD PMID:12569548 , PMID:16882524 arsenic(3+) increases expression ISO RGD:1315921 6480464 Arsenic results in increased expression of ERCC1 mRNA CTD PMID:19661343 arsenic(3+) decreases expression ISO RGD:1315921 6480464 Arsenic results in decreased expression of ERCC1 mRNA, Arsenic results in decreased expression of ERCC1 protein CTD PMID:12569548 , PMID:16882524 azathioprine increases expression ISO RGD:1315921 6480464 Azathioprine results in increased expression of ERCC1 mRNA CTD PMID:22623647 benzene affects expression ISO RGD:1315921 6480464 Benzene affects the expression of ERCC1 mRNA CTD PMID:16188086 benzo[a]pyrene affects expression ISO RGD:1315921 6480464 Benzo(a)pyrene affects the expression of ERCC1 mRNA CTD PMID:20624995 benzo[a]pyrene increases expression ISO RGD:1315922 6480464 Benzo(a)pyrene results in increased expression of ERCC1 mRNA CTD PMID:22228805 , PMID:22641617 benzo[a]pyrene affects response to substance ISO RGD:1315921 6480464 ERCC1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:22382310 benzo[a]pyrene increases expression ISO RGD:1315921 6480464 Benzo(a)pyrene results in increased expression of ERCC1 mRNA, Benzo(a)pyrene results in increased expression of ERCC1 protein CTD PMID:19748547 , PMID:21632981 benzo[a]pyrene diol epoxide I affects response to substance ISO RGD:1315921 6480464 ERCC1 gene SNP affects the susceptibility to 7 more ... CTD PMID:30453383 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1315921 6480464 7 more ... CTD PMID:19150397 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ERCC1 mRNA CTD PMID:25181051 cadmium dichloride decreases expression ISO RGD:1315922 6480464 Cadmium Chloride results in decreased expression of ERCC1 mRNA CTD PMID:15501611 cadmium dichloride increases expression ISO RGD:1315921 6480464 Cadmium Chloride results in increased expression of ERCC1 protein CTD PMID:26220685 cadmium dichloride decreases expression ISO RGD:1315921 6480464 Cadmium Chloride results in decreased expression of ERCC1 mRNA, Cadmium Chloride results in decreased expression of ERCC1 protein CTD PMID:22112500 , PMID:26472689 cadmium dichloride multiple interactions ISO RGD:1315921 6480464 [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of ERCC1 mRNA more ... CTD PMID:22112500 cadmium dichloride increases methylation ISO RGD:1315921 6480464 Cadmium Chloride results in increased methylation of ERCC1 promoter CTD PMID:22112500 cadmium dichloride increases expression ISO RGD:1315922 6480464 Cadmium Chloride results in increased expression of ERCC1 mRNA CTD PMID:11958953 cadmium dichloride multiple interactions ISO RGD:1315922 6480464 MT1 affects the reaction [Cadmium Chloride results in increased expression of ERCC1 mRNA], MT2 affects the reaction [Cadmium Chloride results in increased expression of ERCC1 mRNA] CTD PMID:11958953 camptothecin multiple interactions ISO RGD:1315921 6480464 ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]] CTD PMID:21227924 camptothecin decreases expression ISO RGD:1315921 6480464 Camptothecin results in decreased expression of ERCC1 mRNA CTD PMID:24792648 carbon nanotube increases expression ISO RGD:1315922 6480464 Nanotubes, Carbon results in increased expression of ERCC1 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:1315922 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERCC1 gene CTD PMID:20938992 cisplatin affects expression ISO RGD:1315921 6480464 Cisplatin affects the expression of ERCC1 mRNA, Cisplatin affects the expression of ERCC1 protein CTD PMID:21750216 , PMID:24799992 cisplatin multiple interactions EXP 6480464 Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA] CTD PMID:26739623 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of ERCC1 mRNA CTD PMID:26739623 cisplatin increases expression ISO RGD:1315921 6480464 Cisplatin results in increased expression of ERCC1 mRNA, Cisplatin results in increased expression of ERCC1 protein CTD PMID:21165580 more ... cisplatin decreases response to substance ISO RGD:1315922 6480464 ERCC1 results in decreased susceptibility to Cisplatin CTD PMID:21722328 cisplatin increases response to substance ISO RGD:1315921 6480464 ERCC1 protein results in increased susceptibility to Cisplatin CTD PMID:21076943 cisplatin decreases response to substance ISO RGD:1315921 6480464 ERCC1 protein results in decreased susceptibility to Cisplatin, ERCC1 results in decreased susceptibility to Cisplatin CTD PMID:21093896 more ... cisplatin multiple interactions ISO RGD:1315921 6480464 [Cisplatin co-treated with Fluorouracil] results in decreased expression of ERCC1 mRNA more ... CTD PMID:15173087 more ... cobalt atom multiple interactions ISO RGD:1315922 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of ERCC1 mRNA CTD PMID:22147119 cobalt atom increases expression ISO RGD:1315922 6480464 Cobalt results in increased expression of ERCC1 mRNA CTD PMID:22147119 cobalt dichloride decreases expression ISO RGD:1315921 6480464 cobaltous chloride results in decreased expression of ERCC1 mRNA CTD PMID:19320972 , PMID:19376846 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of ERCC1 mRNA CTD PMID:24386269 cobalt(2+) increases expression ISO RGD:1315922 6480464 Cobalt results in increased expression of ERCC1 mRNA CTD PMID:22147119 cobalt(2+) multiple interactions ISO RGD:1315922 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of ERCC1 mRNA CTD PMID:22147119 copper(II) sulfate increases expression ISO RGD:1315921 6480464 Copper Sulfate results in increased expression of ERCC1 mRNA CTD PMID:19549813 curcumin multiple interactions ISO RGD:1315921 6480464 [Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin more ... CTD PMID:21493726 , PMID:22228707 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA] CTD PMID:22228707 curcumin decreases expression ISO RGD:1315921 6480464 Curcumin results in decreased expression of ERCC1 mRNA, Curcumin results in decreased expression of ERCC1 protein CTD PMID:17596214 more ... cyclophosphamide affects expression EXP 6480464 Cyclophosphamide affects the expression of ERCC1 mRNA CTD PMID:11906922 cyclosporin A increases expression ISO RGD:1315921 6480464 Cyclosporine results in increased expression of ERCC1 mRNA CTD PMID:20106945 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ERCC1 mRNA CTD PMID:29038839 D-glucose increases expression ISO RGD:1315921 6480464 Glucose results in increased expression of ERCC1 mRNA, Glucose results in increased expression of ERCC1 protein CTD PMID:22228707 D-glucose multiple interactions ISO RGD:1315921 6480464 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA] more ... CTD PMID:22228707 disodium selenite increases expression ISO RGD:1315921 6480464 Sodium Selenite results in increased expression of ERCC1 mRNA CTD PMID:18175754 dorsomorphin multiple interactions ISO RGD:1315921 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERCC1 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:1315922 6480464 Doxorubicin results in increased expression of ERCC1 mRNA CTD PMID:22712078 elemental selenium increases expression ISO RGD:1315921 6480464 Selenium results in increased expression of ERCC1 mRNA CTD PMID:19244175 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of ERCC1 mRNA CTD PMID:29391264 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ERCC1 mRNA CTD PMID:29038839 finasteride increases expression EXP 6480464 Finasteride results in increased expression of ERCC1 mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of ERCC1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:1315922 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERCC1 gene CTD PMID:20938992 fonofos affects response to substance ISO RGD:1315921 6480464 ERCC1 polymorphism affects the susceptibility to Fonofos CTD PMID:22102698 furan increases expression EXP 6480464 furan results in increased expression of ERCC1 mRNA CTD PMID:22079235 gefitinib multiple interactions ISO RGD:1315921 6480464 ERCC1 gene polymorphism affects the susceptibility to [gefitinib co-treated with Cisplatin] CTD PMID:21264830 gefitinib affects response to substance ISO RGD:1315921 6480464 ERCC1 gene polymorphism affects the susceptibility to gefitinib CTD PMID:21264830 glucose increases expression ISO RGD:1315921 6480464 Glucose results in increased expression of ERCC1 mRNA, Glucose results in increased expression of ERCC1 protein CTD PMID:22228707 glucose multiple interactions ISO RGD:1315921 6480464 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 protein] more ... CTD PMID:22228707 hydrogen peroxide multiple interactions ISO RGD:1315921 6480464 [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of ERCC1 mRNA CTD PMID:21751221 irinotecan decreases expression ISO RGD:1315921 6480464 Irinotecan results in decreased expression of ERCC1 protein CTD PMID:11593056 isotretinoin decreases expression ISO RGD:1315921 6480464 Isotretinoin results in decreased expression of ERCC1 mRNA CTD PMID:20436886 L-methionine multiple interactions ISO RGD:1315922 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ERCC1 gene CTD PMID:20938992 lead nitrate multiple interactions ISO RGD:1315922 6480464 lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA], lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA] CTD PMID:11891201 lipopolysaccharide multiple interactions ISO RGD:1315921 6480464 [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA CTD PMID:22777745 lithium chloride increases expression ISO RGD:1315921 6480464 Lithium Chloride results in increased expression of ERCC1 mRNA CTD PMID:15711924 lovastatin multiple interactions EXP 6480464 Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA] CTD PMID:26739623 lovastatin increases expression EXP 6480464 Lovastatin results in increased expression of ERCC1 mRNA CTD PMID:26739623 MeIQx decreases expression ISO RGD:1315921 6480464 2-amino-3 more ... CTD PMID:22100608 melatonin increases expression ISO RGD:1315921 6480464 Melatonin results in increased expression of ERCC1 protein CTD PMID:24799992 methylseleninic acid increases expression ISO RGD:1315921 6480464 methylselenic acid results in increased expression of ERCC1 mRNA CTD PMID:12517777 microcystin RR decreases expression ISO RGD:1315921 6480464 microcystin RR results in decreased expression of ERCC1 protein CTD PMID:19111056 myristicin decreases expression ISO RGD:1315921 6480464 myristicin results in decreased expression of ERCC1 mRNA CTD PMID:24792648 oxaliplatin multiple interactions ISO RGD:1315921 6480464 ERCC1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with oxaliplatin], ERCC1 gene SNP affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin] CTD PMID:15213713 more ... oxaliplatin increases expression ISO RGD:1315921 6480464 oxaliplatin results in increased expression of ERCC1 mRNA CTD PMID:16773204 oxaliplatin affects response to substance ISO RGD:1315921 6480464 ERCC1 gene polymorphism affects the susceptibility to oxaliplatin, ERCC1 protein affects the susceptibility to oxaliplatin CTD PMID:15041737 more ... paracetamol affects expression ISO RGD:1315922 6480464 Acetaminophen affects the expression of ERCC1 mRNA CTD PMID:17562736 paraquat affects splicing ISO RGD:1315921 6480464 Paraquat affects the splicing of ERCC1 mRNA CTD PMID:23613995 PD 0325901 decreases expression ISO RGD:1315921 6480464 PD 0325901 results in decreased expression of ERCC1 mRNA CTD PMID:21996734 PD 0325901 multiple interactions ISO RGD:1315921 6480464 PD 0325901 inhibits the reaction [Cisplatin results in increased expression of ERCC1 mRNA], PD 0325901 inhibits the reaction [Cisplatin results in increased expression of ERCC1 protein] CTD PMID:21996734 pemetrexed multiple interactions ISO RGD:1315921 6480464 Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 mRNA], Pemetrexed inhibits the reaction [resveratrol results in increased stability of and results in increased expression of ERCC1 protein] CTD PMID:23912706 pemetrexed decreases expression ISO RGD:1315921 6480464 Pemetrexed results in decreased expression of ERCC1 mRNA, Pemetrexed results in decreased expression of ERCC1 protein CTD PMID:23912706 PhIP decreases expression ISO RGD:1315921 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of ERCC1 mRNA CTD PMID:22100608 pinosylvin increases expression ISO RGD:1315921 6480464 pinosylvin results in increased expression of ERCC1 mRNA CTD PMID:23333577 pirinixic acid multiple interactions ISO RGD:1315921 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ERCC1 mRNA CTD PMID:19710929 platinum affects response to substance ISO RGD:1315921 6480464 ERCC1 protein affects the susceptibility to Platinum CTD PMID:15788669 platinum(0) affects response to substance ISO RGD:1315921 6480464 ERCC1 protein affects the susceptibility to Platinum CTD PMID:15788669 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of ERCC1 mRNA CTD PMID:29038839 pyrazinecarboxamide increases expression EXP 6480464 Pyrazinamide results in increased expression of ERCC1 mRNA CTD PMID:22431067 quercetin increases expression ISO RGD:1315921 6480464 Quercetin results in increased expression of ERCC1 mRNA CTD PMID:21632981 quercitrin decreases expression ISO RGD:1315921 6480464 quercitrin results in decreased expression of ERCC1 mRNA CTD PMID:25193878 resveratrol affects response to substance ISO RGD:1315921 6480464 ERCC1 protein affects the susceptibility to resveratrol CTD PMID:23912706 resveratrol multiple interactions ISO RGD:1315921 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [resveratrol results in increased expression of ERCC1 mRNA] more ... CTD PMID:23912706 SB 203580 increases expression ISO RGD:1315921 6480464 SB 203580 results in increased expression of ERCC1 mRNA CTD PMID:21165580 SB 203580 multiple interactions ISO RGD:1315921 6480464 SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA] CTD PMID:21165580 SB 431542 multiple interactions ISO RGD:1315921 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERCC1 mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:1315921 6480464 Selenium results in increased expression of ERCC1 mRNA CTD PMID:19244175 sodium arsenate increases expression ISO RGD:1315922 6480464 sodium arsenate results in increased expression of ERCC1 mRNA CTD PMID:11353140 sodium arsenite multiple interactions ISO RGD:1315921 6480464 [sodium arsenite co-treated with Cisplatin] results in increased expression of ERCC1 protein CTD PMID:21696631 sodium arsenite increases expression ISO RGD:1315922 6480464 sodium arsenite results in increased expression of ERCC1 mRNA CTD PMID:11353140 sodium arsenite decreases expression ISO RGD:1315921 6480464 sodium arsenite results in decreased expression of ERCC1 mRNA, sodium arsenite results in decreased expression of ERCC1 protein CTD PMID:21776218 , PMID:29705342 sodium dichromate decreases expression ISO RGD:1315921 6480464 sodium bichromate results in decreased expression of ERCC1 mRNA CTD PMID:17685462 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of ERCC1 mRNA, Streptozocin results in increased expression of ERCC1 protein CTD PMID:22228707 streptozocin multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA], Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA] CTD PMID:22228707 tetrachloromethane increases expression ISO RGD:1315922 6480464 Carbon Tetrachloride results in increased expression of ERCC1 mRNA CTD PMID:15056808 tetraphene increases expression ISO RGD:1315921 6480464 benz(a)anthracene results in increased expression of ERCC1 mRNA CTD PMID:22236718 theaflavin multiple interactions ISO RGD:1315922 6480464 [theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ... CTD PMID:23717041 trans-pinosylvin increases expression ISO RGD:1315921 6480464 pinosylvin results in increased expression of ERCC1 mRNA CTD PMID:23333577 trichostatin A multiple interactions ISO RGD:1315921 6480464 trichostatin A inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA], trichostatin A inhibits the reaction [Glucose results in increased expression of ERCC1 protein] CTD PMID:22228707 trichostatin A decreases expression ISO RGD:1315921 6480464 trichostatin A results in decreased expression of ERCC1 mRNA, trichostatin A results in decreased expression of ERCC1 protein CTD PMID:22228707 usnic acid multiple interactions ISO RGD:1315921 6480464 [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA CTD PMID:22777745 valproic acid affects expression ISO RGD:1315922 6480464 Valproic Acid affects the expression of ERCC1 mRNA CTD PMID:17292431 valproic acid multiple interactions ISO RGD:1315921 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERCC1 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1315921 6480464 Valproic Acid results in decreased expression of ERCC1 mRNA CTD PMID:26272509 valproic acid affects expression ISO RGD:1315921 6480464 Valproic Acid affects the expression of ERCC1 mRNA CTD PMID:25979313 vancomycin decreases expression ISO RGD:1315922 6480464 Vancomycin results in decreased expression of ERCC1 mRNA CTD PMID:18930951 veliparib multiple interactions ISO RGD:1315921 6480464 ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]] CTD PMID:21227924 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of ERCC1 mRNA CTD PMID:23034163 vitamin E increases expression ISO RGD:1315921 6480464 Vitamin E results in increased expression of ERCC1 mRNA CTD PMID:19244175 Y-27632 increases expression ISO RGD:1315921 6480464 Y 27632 results in increased expression of ERCC1 mRNA CTD PMID:20878077 zinc atom increases expression ISO RGD:1315921 6480464 Zinc results in increased expression of ERCC1 mRNA CTD PMID:15226459 zinc sulfate increases expression ISO RGD:1315921 6480464 Zinc Sulfate results in increased expression of ERCC1 mRNA CTD PMID:15226459 zinc(0) increases expression ISO RGD:1315921 6480464 Zinc results in increased expression of ERCC1 mRNA CTD PMID:15226459
Biological Process cell development ISO RGD:1315922 1624291 MGI:MGI:2158940 RGD MGI:MGI:1859082 , PMID:10834928 cell population proliferation ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:3530719 , PMID:15692571 cell population proliferation IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to DNA damage stimulus ISO RGD:1315922 1624291 MGI:MGI:2183944 , MGI:MGI:2183945 RGD MGI:MGI:2153690 more ... chromosome organization ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:3047512 , PMID:15199134 DNA recombination ISO RGD:1315921 1624291 UniProtKB:P07903 RGD PMID:11707424 DNA recombination ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:2153690 , PMID:11707424 DNA repair ISO RGD:1315922 1624291 MGI:MGI:2158940 RGD MGI:MGI:2446381 , PMID:12466203 DNA repair ISO RGD:1315921 1624291 RGD PMID:25538220 double-strand break repair NOT ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:2153690 , PMID:11707424 double-strand break repair ISO RGD:1315922 1624291 MGI:MGI:2158940 more ... RGD MGI:MGI:3047512 more ... double-strand break repair via nonhomologous end joining ISO RGD:1315921 1624291 RGD PMID:14690602 double-strand break repair via nonhomologous end joining IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic organ development IEP 2313673 RGD germ cell development ISO RGD:1315922 1624291 MGI:MGI:2158940 , MGI:MGI:3617449 RGD MGI:MGI:3770581 , PMID:17912366 interstrand cross-link repair ISO RGD:1315922 1624291 RGD MGI:MGI:5506835 , PMID:23637614 interstrand cross-link repair IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 isotype switching ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:3052883 , PMID:15280420 isotype switching IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 male gonad development ISO RGD:1315922 1624291 MGI:MGI:2158940 , MGI:MGI:3617449 RGD MGI:MGI:3770581 , PMID:17912366 male gonad development IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 meiotic mismatch repair IBA PANTHER:PTN000297520 , SGD:S000004560 13792537 PMID:21873635 GO_Central mitotic recombination ISO RGD:1315921 1624291 RGD PMID:8811092 mitotic recombination IBA PANTHER:PTN000297520 more ... 13792537 PMID:21873635 GO_Central multicellular organism aging ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:3696605 , PMID:17183314 multicellular organism aging IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 multicellular organism growth ISO RGD:1315922 1624291 MGI:MGI:1100494 more ... RGD MGI:MGI:3696605 more ... multicellular organism growth IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of protection from non-homologous end joining at telomere ISO RGD:1315921 1624291 RGD PMID:14690602 negative regulation of protection from non-homologous end joining at telomere IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of telomere maintenance ISO RGD:1315921 1624291 RGD PMID:17055345 nucleotide-excision repair ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:63544 , PMID:8275084 nucleotide-excision repair ISO RGD:1315921 1624291 UniProtKB:P07903 RGD PMID:11707424 , PMID:3290851 nucleotide-excision repair, DNA incision, 3'-to lesion ISO RGD:1315921 1624291 RGD PMID:7657672 nucleotide-excision repair, DNA incision, 3'-to lesion IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleotide-excision repair, DNA incision, 5'-to lesion ISO RGD:1315921 1624291 RGD PMID:7657672 nucleotide-excision repair, DNA incision, 5'-to lesion IBA PANTHER:PTN000297520 more ... 13792537 PMID:21873635 GO_Central oogenesis ISO RGD:1315922 1624291 MGI:MGI:2158940 RGD MGI:MGI:2446381 , PMID:12466203 oogenesis IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of t-circle formation ISO RGD:1315922 1624291 RGD MGI:MGI:5645200 , PMID:22579284 positive regulation of t-circle formation IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 post-embryonic hemopoiesis ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:3530719 , PMID:15692571 post-embryonic hemopoiesis IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 pyrimidine dimer repair by nucleotide-excision repair ISO RGD:1315922 1624291 RGD MGI:MGI:1342943 , PMID:10454634 pyrimidine dimer repair by nucleotide-excision repair IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 replicative cell aging ISO RGD:1315922 1624291 MGI:MGI:2183944 , MGI:MGI:2183945 RGD MGI:MGI:3699021 more ... replicative cell aging IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to cadmium ion IEP 13207321 RGD response to immobilization stress IEP 13207322 RGD response to nutrient IEP 2316276 RGD response to oxidative stress ISO RGD:1315921 1624291 RGD PMID:17614221 , PMID:9256505 response to oxidative stress IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to sucrose IEP 2313670 RGD response to X-ray ISO RGD:1315922 1624291 MGI:MGI:2183944 RGD MGI:MGI:3613277 , PMID:15979950 response to X-ray IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 spermatogenesis ISO RGD:1315922 1624291 MGI:MGI:2158940 RGD MGI:MGI:2446381 , PMID:12466203 spermatogenesis IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 syncytium formation ISO RGD:1315922 1624291 MGI:MGI:2158940 RGD MGI:MGI:1859082 , PMID:10834928 syncytium formation IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 t-circle formation ISO RGD:1315922 1624291 RGD MGI:MGI:5645200 , PMID:22579284 t-circle formation IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 telomeric DNA-containing double minutes formation ISO RGD:1315921 1624291 RGD PMID:14690602 telomeric DNA-containing double minutes formation IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 UV protection ISO RGD:1315922 1624291 MGI:MGI:2158940 more ... RGD MGI:MGI:1342943 more ... UV protection IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 UV-damage excision repair IBA PANTHER:PTN000297520 , WB:WBGene00008665 13792537 PMID:21873635 GO_Central Cellular Component cytosol IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1315921 1624291 RGD GO_REF:0000052 ERCC4-ERCC1 complex ISO RGD:1315921 1624291 RGD PMID:14690602 , PMID:17055345 ERCC4-ERCC1 complex IBA PANTHER:PTN000297520 , UniProtKB:P07992 13792537 PMID:21873635 GO_Central nuclear chromosome, telomeric region ISO RGD:1315921 1624291 RGD PMID:14690602 nuclear chromosome, telomeric region IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1315921 1624291 RGD GO_REF:0000052 nucleotide-excision repair complex ISO RGD:1315921 1624291 RGD PMID:3290851 more ... nucleotide-excision repair factor 1 complex ISO RGD:1315921 1624291 RGD PMID:10413517 nucleotide-excision repair factor 1 complex IBA PANTHER:PTN000297520 more ... 13792537 PMID:21873635 GO_Central nucleus IDA 2313668 RGD transcription factor TFIID complex ISO RGD:1315922 1624291 RGD MGI:MGI:5314556 , PMID:22323595 transcription factor TFIID complex IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function 3' overhang single-stranded DNA endodeoxyribonuclease activity contributes_to ISO RGD:1315921 1624291 RGD PMID:14690602 3' overhang single-stranded DNA endodeoxyribonuclease activity IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 damaged DNA binding ISO RGD:1315921 1624291 RGD PMID:17720715 damaged DNA binding IBA PANTHER:PTN000297520 , UniProtKB:P07992 13792537 PMID:21873635 GO_Central DNA binding contributes_to ISO RGD:1315921 1624291 RGD PMID:14734547 molecular_function ND 1598407 07/2017: no relevant rat data RGD protein binding ISO RGD:1315922 1624291 UniProtKB:Q8K387 , UniProtKB:Q9QZD4 RGD MGI:MGI:5314459 more ... protein binding ISO RGD:1315921 1624291 UniProtKB:P00533 more ... RGD PMID:11058119 more ... protein C-terminus binding ISO RGD:1315921 1624291 UniProtKB:Q92889 RGD PMID:9722633 protein C-terminus binding IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein domain specific binding ISO RGD:1315921 1624291 UniProtKB:P23025 RGD PMID:17720715 protein domain specific binding IEA UniProtKB:P07992 , ensembl:ENSP000000138071600115 GO_REF:0000107 Ensembl GO_REF:0000107 single-stranded DNA binding ISO RGD:1315921 1624291 RGD PMID:16076955 , PMID:17720715 single-stranded DNA binding IBA PANTHER:PTN000297520 more ... 13792537 PMID:21873635 GO_Central single-stranded DNA endodeoxyribonuclease activity contributes_to ISO RGD:1315921 1624291 RGD PMID:7559382 single-stranded DNA endodeoxyribonuclease activity IBA PANTHER:PTN000297520 more ... 13792537 PMID:21873635 GO_Central TBP-class protein binding ISO RGD:1315922 1624291 UniProtKB:P17980 more ... RGD MGI:MGI:5314556 , PMID:22323595 TFIID-class transcription factor complex binding ISO RGD:1315922 1624291 RGD MGI:MGI:5314556 , PMID:22323595 TFIID-class transcription factor complex binding IEA UniProtKB:P07903 , ensembl:ENSMUSP000000036451600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
