RGD Reference Report - Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma. - Rat Genome Database

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Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma.

Authors: Fautrel, Alain  Andrieux, Lise  Musso, Orlando  Boudjema, Karim  Guillouzo, André  Langouët, Sophie 
Citation: Fautrel A, etal., J Hepatol. 2005 Aug;43(2):288-93. doi: 10.1016/j.jhep.2005.02.020. Epub 2005 Apr 25.
RGD ID: 155598683
Pubmed: PMID:15922480   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jhep.2005.02.020   (Journal Full-text)


BACKGROUND/AIMS: Little is known about the nucleotide excision repair (NER) pathway in the resistance of human hepatocellular carcinoma (HCC) to chemotherapeutics. We investigated expression of several NER genes in human HCC and matching non-tumor tissue (NT) and in normal liver.
METHODS: Expression of CSA, CSB, XPC, hHR23B, XPA, XPB, ERCC1 and p53 genes was analyzed by quantitative RT-PCR and immunoblotting in 26 HCC and 9 normal livers.
RESULTS: The seven NER genes and p53 were frequently overexpressed in HCC compared to matched NT. XPA, XPC, hHR23B and ERCC1 mRNA levels were significantly increased (p<0.05) in HCC arising in cirrhotic livers compared to non fibrotic tissue. Moreover, expression of ERCC1, XPA and XPC mRNA was significantly augmented in HCC, even more in tumors arising in cirrhotic liver. ERCC1, XPC ad XPA mRNA levels were highly correlated in NT and HCC. XPC and ERCC1 protein levels were also increased in HCC.
CONCLUSIONS: Our findings strongly suggest that overexpression of two key genes involved in the early steps of the NER process, ERCC1 and XPC, is associated with liver fibrogenesis and cancer and could be related to the well recognized resistance of HCC to chemotherapeutics.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ERCC1Humanhepatocellular carcinoma  IEP mRNA and protein:increased expression:liver (human)RGD 
Ercc1Rathepatocellular carcinoma  ISOERCC1 (Homo sapiens)mRNA and protein:increased expression:liver (human)RGD 
Ercc1Mousehepatocellular carcinoma  ISOERCC1 (Homo sapiens)mRNA and protein:increased expression:liver (human)RGD 


Genes (Rattus norvegicus)
Ercc1  (ERCC excision repair 1, endonuclease non-catalytic subunit)

Genes (Mus musculus)
Ercc1  (excision repair cross-complementing rodent repair deficiency, complementation group 1)

Genes (Homo sapiens)
ERCC1  (ERCC excision repair 1, endonuclease non-catalytic subunit)