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Gene: Ercc1 (excision repair cross-complementing rodent repair deficiency, complementation group 1) Mus musculus
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Symbol: Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Description: Exhibits TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including DNA metabolic process; gamete generation; and positive regulation of nucleobase-containing compound metabolic process. Predicted to localize to the nucleus. Used to study XFE progeroid syndrome. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); hematologic cancer (multiple); kidney failure; and transient cerebral ischemia. Is expressed in brain; cerebral cortex; and telencephalon. Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit); PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA excision repair protein ERCC-1; Ercc-1; excision repair 1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl719,344,778 - 19,356,524 (+)Ensembl
GRCm38719,344,067 - 19,356,524 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37719,930,420 - 19,941,873 (+)NCBIGRCm37mm9NCBIm37
MGSCv36718,503,628 - 18,515,044 (+)NCBImm8
Celera716,751,825 - 16,763,278 (+)NCBICelera
Cytogenetic Map7 A3NCBI
cM Map79.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ercc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315922
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.