RGD Reference Report - Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. - Rat Genome Database

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Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA.

Authors: Lu, Baocai  Li, Jing  Gao, Qingzu  Yu, Wenfa  Yang, Qinghui  Li, Xiaoyu 
Citation: Lu B, etal., Gene. 2014 May 25;542(1):64-8. doi: 10.1016/j.gene.2014.02.043. Epub 2014 Feb 26.
RGD ID: 13207310
Pubmed: PMID:24582975   (View Abstract at PubMed)
DOI: DOI:10.1016/j.gene.2014.02.043   (Journal Full-text)

Because the molecular mechanisms underlying the development of laryngeal cancer are not well understood, we conducted a case-control study to determine the association between eight common SNPs in NER pathway genes and risk of laryngeal cancer, and the association between genetic polymorphisms and environmental factors. A 1:1 matched case-control study of 176 cases and 176 controls was conducted. Laryngeal cancer cases were more likely to smoke and drink (all P values<0.05). Subjects with the ERCC1 rs11615 CC genotype and C allele had an increased risk of laryngeal cancer. Similarly, individuals with the ERCC5 rs17655 GG genotype and G allele had an increased risk of laryngeal cancer. Gene-gene interaction analysis showed that subjects carrying ERCC1 rs11615 C allele and XPG/ERCC5 rs17655 G allele had a greatly increased risk of breast cancer. Stratified analysis revealed that the interaction between polymorphisms of ERCC1 rs11615 and ERCC5 rs17655 and smoking on cancer risk was statistically significant, and ERCC1 rs11615 polymorphisms also had a significant interaction with drinking habit. In conclusion, our study suggests that ERCC1 rs11615 and ERCC5 rs17655 polymorphisms are associated with increased risk of laryngeal cancer, and that they confer more risk among smokers and drinkers.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ERCC1HumanLaryngeal Neoplasms susceptibilityIAGP DNA:snp:exon:c.354T>C (human) (rs11615)RGD 
Ercc1RatLaryngeal Neoplasms susceptibilityISOERCC1 (Homo sapiens)DNA:snp:exon:c.354T>C (human) (rs11615)RGD 
Ercc1MouseLaryngeal Neoplasms susceptibilityISOERCC1 (Homo sapiens)DNA:snp:exon:c.354T>C (human) (rs11615)RGD 


Genes (Rattus norvegicus)
Ercc1  (ERCC excision repair 1, endonuclease non-catalytic subunit)

Genes (Mus musculus)
Ercc1  (excision repair cross-complementing rodent repair deficiency, complementation group 1)

Genes (Homo sapiens)
ERCC1  (ERCC excision repair 1, endonuclease non-catalytic subunit)