Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Irf3 (interferon regulatory factor 3) Rattus norvegicus
Analyze
Symbol: Irf3
Name: interferon regulatory factor 3
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytokine secretion. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC94729
Orthologs:
Homo sapiens (human) : IRF3 (interferon regulatory factor 3)  HGNC  Alliance
Mus musculus (house mouse) : Irf3 (interferon regulatory factor 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf3 (interferon regulatory factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF3 (interferon regulatory factor 3)
Canis lupus familiaris (dog) : IRF3 (interferon regulatory factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf3 (interferon regulatory factor 3)
Sus scrofa (pig) : IRF3 (interferon regulatory factor 3)
Chlorocebus sabaeus (African green monkey) : IRF3 (interferon regulatory factor 3)
Heterocephalus glaber (naked mole-rat) : Irf3 (interferon regulatory factor 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01100,992,244 - 100,997,202 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,992,405 - 100,997,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,056,847 - 102,061,805 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,470,284 - 95,475,078 (+)NCBIRGSC3.4rn4RGSC3.4
Celera189,741,455 - 89,746,249 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Irf3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1549774
Created: 2005-09-15
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.