Gsk3a (glycogen synthase kinase 3 alpha) - Rat Genome Database

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Gene: Gsk3a (glycogen synthase kinase 3 alpha) Rattus norvegicus
Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
RGD ID: 620351
Description: Enables protein kinase A catalytic subunit binding activity; protein serine/threonine kinase activity; and protein serine/threonine kinase binding activity. Involved in negative regulation of dendrite development; negative regulation of insulin receptor signaling pathway; and positive regulation of neuron apoptotic process. Located in microtubule. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha); PARTICIPATES IN glycogen biosynthetic pathway; nuclear factor, erythroid 2 like 2 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide.
Type: protein-coding
Previously known as: FA; factor A; glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,208,062 - 86,217,908 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,759,217 - 94,769,063 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,963,839 - 87,973,686 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Celera175,259,483 - 75,269,362 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cocaine  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
folic acid  (ISO)
Fusaric acid  (ISO)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
IC-87114  (ISO)
indometacin  (ISO)
kenpaullone  (EXP)
lead diacetate  (EXP)
lithium atom  (EXP,ISO)
lithium chloride  (EXP)
lithium hydride  (EXP,ISO)
lonafarnib  (ISO)
LY294002  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
microcystin-LR  (ISO)
N-acetylsphingosine  (ISO)
nicotine  (ISO)
nordihydroguaiaretic acid  (EXP)
paraquat  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium atom  (EXP)
prostaglandin E2  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
rotenone  (EXP)
rottlerin  (EXP)
ruthenium atom  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sphingosine 1-phosphate  (ISO)
sucrose  (EXP)
tacrolimus hydrate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autosome genomic imprinting  (IEA,ISO)
cardiac left ventricle morphogenesis  (IEA,ISO)
cell migration  (IEA,ISO)
cellular response to glucocorticoid stimulus  (IEA,ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-3  (IEA,ISO,ISS)
cellular response to lithium ion  (IEA,ISO)
cellular response to organic cyclic compound  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,IEA,ISO,ISS)
glycogen metabolic process  (IEA)
insulin receptor signaling pathway  (IBA,IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IBA)
negative regulation of cell growth involved in cardiac muscle cell development  (IEA,ISO)
negative regulation of dendrite development  (IMP)
negative regulation of glucose import  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IDA,IEA,ISO)
negative regulation of TOR signaling  (IBA,IEA,ISO)
nervous system development  (IEA)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (IEA,ISO)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of autophagy  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO)
positive regulation of heart contraction  (IEA,ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein targeting to mitochondrion  (IEA,ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
regulation of autophagy of mitochondrion  (IEA,ISO)
regulation of neuron projection development  (IBA)
regulation of systemic arterial blood pressure  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component
axon  (IBA)
cytoplasm  (IBA)
cytosol  (IBA,TAS)
microtubule  (IDA)
mitochondrion  (IEA)
nucleus  (IBA)


References - curated
# Reference Title Reference Citation
1. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Cross DA, etal., Nature. 1995 Dec 21-28;378(6559):785-9.
2. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
3. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Fang X, etal., Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5.
4. Glycogen synthase kinase 3: a key regulator of cellular fate. Forde JE and Dale TC, Cell Mol Life Sci. 2007 Aug;64(15):1930-44.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Different localization of tau protein kinase I/glycogen synthase kinase-3 beta from glycogen synthase kinase-3 alpha in cerebellum mitochondria. Hoshi M, etal., J Biochem. 1995 Oct;118(4):683-5.
7. Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord. Hu JH, etal., J Neurochem. 2003 Apr;85(2):432-42.
8. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. Hurtado DE, etal., J Neurosci. 2012 May 23;32(21):7392-402. doi: 10.1523/JNEUROSCI.0889-12.2012.
9. Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Morris JK, etal., Brain Res. 2008 Nov 13;1240:185-95. doi: 10.1016/j.brainres.2008.08.089. Epub 2008 Sep 11.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Insulin decreases the glycogen synthase kinase-3 alpha mRNA levels by altering its stability in streptozotocin-induced diabetic rat liver. Rao PV, etal., Biochem Biophys Res Commun. 1995 Dec 5;217(1):250-6.
14. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Rezai-Zadeh K, etal., J Cell Mol Med. 2009 Mar;13(3):574-88. doi: 10.1111/j.1582-4934.2008.00344.x. Epub 2008 Apr 9.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Seo YH, etal., Aging Cell. 2008 Dec;7(6):894-907. doi: 10.1111/j.1474-9726.2008.00436.x. Epub 2008 Sep 8.
18. Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. Song B, etal., J Biol Chem. 2010 Dec 24;285(52):41122-34. doi: 10.1074/jbc.M110.130351. Epub 2010 Sep 14.
19. GSK-3alpha/beta-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth. Tan M, etal., J Neurochem. 2013 Jun;125(5):685-97. doi: 10.1111/jnc.12230. Epub 2013 Mar 25.
20. Molecular cloning and expression of glycogen synthase kinase-3/factor A. Woodgett JR EMBO J 1990 Aug;9(8):2431-8.
21. Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. Zhai P, etal., J Biol Chem. 2007 Nov 9;282(45):33181-91. Epub 2007 Sep 12.
22. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:8382613   PMID:10995739   PMID:12055200   PMID:12761548   PMID:14698990   PMID:14730361   PMID:15572200   PMID:15673614   PMID:16537926   PMID:16543145   PMID:16912034   PMID:17569761  
PMID:17986005   PMID:17993264   PMID:18285345   PMID:19583853   PMID:19706605   PMID:19840222   PMID:20371704   PMID:20516643   PMID:21047779   PMID:21266584   PMID:21316358   PMID:22539723  
PMID:23192081   PMID:23246341   PMID:23999152   PMID:24631206   PMID:24912190   PMID:25897075   PMID:25935310   PMID:26514267   PMID:28440874   PMID:29161257  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2180,815,843 - 80,825,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,208,062 - 86,217,908 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,759,217 - 94,769,063 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,963,839 - 87,973,686 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,097,244 - 82,108,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,365,717 - 83,374,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,505,517 - 80,514,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1180,583,627 - 80,592,250 (-)NCBI
Celera175,259,483 - 75,269,362 (-)NCBICelera
Cytogenetic Map1q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381942,230,190 - 42,242,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,226,225 - 42,242,625 (-)EnsemblGRCh38hg38GRCh38
GRCh371942,734,342 - 42,746,754 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,426,178 - 47,438,576 (-)NCBINCBI36Build 36hg18NCBI36
Build 341947,426,177 - 47,438,576NCBI
Celera1939,535,133 - 39,547,532 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,164,764 - 39,177,148 (-)NCBIHuRef
CHM1_11942,736,013 - 42,748,418 (-)NCBICHM1_1
T2T-CHM13v2.01945,049,560 - 45,061,976 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39724,927,683 - 24,937,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,927,683 - 24,937,276 (-)EnsemblGRCm39 Ensembl
GRCm38725,228,258 - 25,237,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,228,258 - 25,237,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,013,278 - 26,022,870 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,937,019 - 24,946,611 (-)NCBIMGSCv36mm8
Celera719,843,563 - 19,853,655 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955555667,973 - 676,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555668,641 - 676,351 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11950,204,206 - 50,216,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,118,330 - 39,130,768 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,710,197 - 47,722,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,710,197 - 47,726,948 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11112,129,116 - 112,138,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,103,825 - 112,138,559 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,555,288 - 111,565,002 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,741,760 - 112,751,476 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,741,641 - 112,751,092 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,295,962 - 112,305,677 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,931,910 - 111,941,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,858,454 - 112,868,171 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934915,919,119 - 15,929,912 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706269,126 - 277,256 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706266,462 - 277,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl649,690,370 - 49,701,189 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,690,319 - 49,700,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,607,906 - 45,618,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1636,434,966 - 36,447,676 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,435,578 - 36,447,633 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,679,200 - 14,692,630 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624907511,889 - 522,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907511,919 - 522,106 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gsk3a
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:3
Interacting mature miRNAs:6
Prediction methods:Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,817,592 - 80,817,772 (+)MAPPERmRatBN7.2
Rnor_6.0182,100,103 - 82,100,282NCBIRnor6.0
Rnor_5.0183,366,607 - 83,366,786UniSTSRnor5.0
RGSC_v3.4180,506,039 - 80,506,218UniSTSRGSC3.4
Celera175,261,262 - 75,261,441UniSTS
RH 3.4 Map1824.5UniSTS
Cytogenetic Map1q21UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,827,014 - 80,827,144 (+)MAPPERmRatBN7.2
Rnor_6.0182,109,527 - 82,109,658NCBIRnor6.0
Rnor_5.0183,376,031 - 83,376,162UniSTSRnor5.0
RGSC_v3.4180,515,463 - 80,515,594UniSTSRGSC3.4
Celera175,270,686 - 75,270,817UniSTS
Cytogenetic Map1q21UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 35 49 33 19 33 5 8 74 35 41 11 5
Low 8 8 8 8 3 3 3
Below cutoff


RefSeq Acc Id: ENSRNOT00000027677   ⟹   ENSRNOP00000027677
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl180,815,850 - 80,825,802 (-)Ensembl
Rnor_6.0 Ensembl182,097,848 - 82,108,083 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084530   ⟹   ENSRNOP00000074376
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl182,097,247 - 82,108,203 (-)Ensembl
RefSeq Acc Id: NM_017344   ⟹   NP_059040
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,815,847 - 80,825,691 (-)NCBI
Rnor_6.0182,097,244 - 82,108,203 (-)NCBI
Rnor_5.0183,365,717 - 83,374,707 (-)NCBI
RGSC_v3.4180,505,517 - 80,514,139 (-)RGD
Celera175,259,483 - 75,269,362 (-)RGD
RefSeq Acc Id: XM_039088512   ⟹   XP_038944440
Rat AssemblyChrPosition (strand)Source
mRatBN7.2180,815,843 - 80,825,732 (-)NCBI
Protein Sequences
Protein RefSeqs NP_059040 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944440 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA37518 (Get FASTA)   NCBI Sequence Viewer  
  EDM08037 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027677
GenBank Protein P18265 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059040   ⟸   NM_017344
- UniProtKB: P18265 (UniProtKB/Swiss-Prot),   A6J947 (UniProtKB/TrEMBL),   A0A8L2QGG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074376   ⟸   ENSRNOT00000084530
RefSeq Acc Id: ENSRNOP00000027677   ⟸   ENSRNOT00000027677
RefSeq Acc Id: XP_038944440   ⟸   XM_039088512
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QGG1 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18265-F1-model_v2 AlphaFold P18265 1-483 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689811
Promoter ID:EPDNEW_R336
Type:initiation region
Description:glycogen synthase kinase 3 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0182,108,178 - 82,108,238EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620351 AgrOrtholog
BioCyc Gene G2FUF-60396 BioCyc
Ensembl Genes ENSRNOG00000020417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027677 ENTREZGENE
  ENSRNOT00000027677.6 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_GSK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50686 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gsk3a PhenoGen
RatGTEx ENSRNOG00000020417 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gsk3a  glycogen synthase kinase 3 alpha      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gsk3a  glycogen synthase kinase 3 alpha      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 51 kDa 70757